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Chinese Chemical Letters 2024年第8期35卷 498-502页

作者： Zhao-Xia lian Xue-Zhi Wang Chuang-wei zhou Jiayu li Ming-De li Xiao-Ping zhou Dan li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China College of Chemistry and Chemical Engineering Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China

The development of circularly polarized luminescence(CPL)materials with high performance is signifi-cantly ***,we develop a facial strategy for fabricating a CPL-active system by employing an achiral luminescent metal-organic cage(MOC)and chiral boron dipyrromethene(BODIPY)*** is achieved by taking advantage of the radiative energy transfer process,in which BODIPY molecules act as energy acceptors and MOCs act as *** CPL performance(maximum luminescence dissymme-try factor up to±1.5×10^(−3))can be tuned by adjusting the ratio between MOCs and ***-light emission with the CPL feature is obtained by using a ternary system including MOC,chiral BODIPY,and Rhodamine *** present work provides a facile and universal strategy to construct a CPL-active system by integrating achiral luminophores and chiral molecules.

关键词： Circularly polarized luminescence Metal-organic cage Radiative energy transfer Chiral small molecules Bodipy Chirality

Pre-mating nitenpyram exposure in male mice leads to depression-like behavior in offspring by affecting tryptophan metabolism in gut microbiota

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Journal of Environmental Sciences 2024年第3期137卷 120-130页

作者： Sen Yan wei Sun Sinuo Tian Zhiyuan Meng Jinling Diao Zhiqiang zhou li li Wentao Zhu Innovation Center of Pesticide Research Department of Applied ChemistryCollege of ScienceChina Agricultural UniversityBeijing 100193China College of Plant Protection/Joint International Research Laboratory of Agriculture&Agri-Product Safety Yangzhou UniversityYangzhou 225009China College of Plant Protection Shanxi Agricultural UniversityTaiyuan 030031China

Several studies have confirmed that the health status of the paternal affects the health of the offspring,however,it remains unknown whether paternal exposure to pesticides affect the offspring ***,we used untargeted metabolomics and 16S rRNA sequencing technology,combined with tail suspension test and RT-qPCR to explore the effects of paternal exposure to nitenpyram on the neurotoxicity of *** results found that the paternal exposure to nitenpyram led to the offspring’s depressive-like behaviors,accompanied by the reduction of tryptophan content and the disorder of microbial abundance in the gut of the ***,we determined the expression of tryptophan metabolism-related genes tryptophanase(tnaA)and tryptophan hydroxylase 1(TpH1)in gut bacteria and colonic *** found that tryptophan is metabolized to indoles rather than being absorbed into colonocytes,which coursed the reduce of tryptophan availability after nitenpyram *** conclusion,our study deepens our understanding of the intergenerational toxic effects of pesticides.

关键词： Nitenpyram Depressive-like behaviors Gut microbiota Tryptophan metabolism

Supermassive black holes triggered by QCD axion bubbles

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Communications in Theoretical Physics 2024年第5期76卷 134-139页

作者： Hai-Jun li Ying-Quan Peng wei Chao Yu-Feng zhou Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Center for Advanced Quantum Studies Department of PhysicsBeijing Normal UniversityBeijing 100875China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Beijing/HangzhouChina

Supermassive black holes(SMBHs)are ubiquitous in the center of galaxies,although the origin of their massive seeds is still *** this paper,we investigate the formation of SMBHs from the quantum chromodynamics(QCD)axion *** this case,primordial black holes(PBHs)are considered as the seeds of SMBHs,which are generated from the QCD axion bubbles due to an explicit Peccei–Quinn(PQ)symmetry breaking after *** QCD axion bubbles are formed when the QCD axion starts to oscillate during the QCD phase *** consider a general case in which the axion bubbles are formed with the bubble effective angle θ_(eff)∈(0,π],leading to the minimum PBH mass∼■(10^(4)−10^(7))M⊙for the axion decay constant f_(a)∼■(10^(16))*** PBHs at this mass region may account for the seeds of SMBHs.

关键词： supermassive black holes primordial black holes quantum chromodynamics axion

Software Defect Prediction Method Based on Stable Learning

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Computers, Materials & Continua 2024年第1期78卷 65-84页

作者： Xin fan Jingen Mao liangjue lian li Yu wei Zheng Yun Ge College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing210012China School of Software Nanchang Hangkong UniversityNanchang330029China Software Testing and Evaluation Center Nanchang Hangkong UniversityNanchang330029China

The purpose of software defect prediction is to identify defect-prone code modules to assist software quality assurance teams with the appropriate allocation of resources and *** previous software defect prediction studies,transfer learning was effective in solving the problem of inconsistent project data ***,target projects often lack sufficient data,which affects the performance of the transfer learning *** addition,the presence of uncorrelated features between projects can decrease the prediction accuracy of the transfer learning *** address these problems,this article propose a software defect prediction method based on stable learning(SDP-SL)that combines code visualization techniques and residual *** method first transforms code files into code images using code visualization techniques and then constructs a defect prediction model based on these code *** the model training process,target project data are not required as prior *** the principles of stable learning,this paper dynamically adjusted the weights of source project samples to eliminate dependencies between features,thereby capturing the“invariance mechanism”within the *** approach explores the genuine relationship between code defect features and labels,thereby enhancing defect prediction *** evaluate the performance of SDP-SL,this article conducted comparative experiments on 10 open-source projects in the PROMISE *** experimental results demonstrated that in terms of the F-measure,the proposed SDP-SL method outperformed other within-project defect prediction methods by 2.11%-44.03%.In cross-project defect prediction,the SDP-SL method provided an improvement of 5.89%-25.46% in prediction performance compared to other cross-project defect prediction ***,SDP-SL can effectively enhance within-and cross-project defect predictions.

关键词： Software defect prediction code visualization stable learning sample reweight residual network

Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

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Food Science and Human Wellness 2024年第4期13卷 1886-1905页

作者： wei li Haihong Chen hongliang Chen Ziyin li wei Hu Qinxuan zhou Bing Xu Yi Wang Xinhui Xing Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Affiliated Dongguan Hospital Southern Medical University(Dongguan People’s Hospital)Dongguan 523059China

Hyperuricemia(HUA)is a vital risk factor for chronic kidney diseases(CKD)and development of functional foods capable of protecting CKD is of *** paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides(ADBP)on HUA-induced kidney *** the present study,we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide *** vitro results found that ADBP protected uric acid(UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant *** vivo results indicated that ADBP effectively ameliorated renal injury in HUA-induced CKD mice,evidenced by a remarkable decrease in serum UA,creatinine and blood urea nitrogen,improving kidney UA excretion,antioxidant defense and histological kidney *** analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney ***,ADBP restored the gut microbiome homeostasis in CKD mice,especially with respect to the elevated helpful microbial abundance,and the decreased harmful bacterial *** study demonstrated that ADBP displayed great nephroprotective effects,and has great promise as a food or functional food ingredient for the prevention and treatment of HUA-induced CKD.

关键词： Andrias davidianus bone peptides Hyperuricemia Uric acid Chronic kidney disease Gut microbiota

Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms

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Journal of Molecular Cell Biology 2024年第1期16卷 15-28页

作者： Te li Min liu fan Yu Song Yang weiwen Bu Kai liu Jia Yang Hua Ni Mulin Yang Hanxiao Yin Renjie hong Dengwen li Huĳie Zhao Jun zhou Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Protein ScienceCollege of Life SciencesNankai UniversityTianjin 300071China Laboratory of Tissue Homeostasis Haihe Laboratory of Cell EcosystemTianjin 300462China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongShandong Provincial Key Laboratory of Animal Resistance BiologyCollege of Life SciencesShandong Normal UniversityJinan 250014China

Carbohydrate metabolism disorders(CMDs),such as diabetes,galactosemia,and mannosidosis,cause ciliopathy-like multiorgan ***,the mechanistic link of cilia to CMD complications is still poorly ***,we describe significant cilium disassembly upon treatment of cells with pathologically relevant aldoses rather than the corresponding sugar ***,environmental aldehydes are able to trigger cilium disassembly by the steric hindrance effect of their formyl *** studies reveal that aldehydes stimulate extracellular calcium influx across the plasma membrane,which subsequently activates the calmodulin-Aurora A-histone deacetylase 6 pathway to deacetylate axonemal microtubules and triggers cilium *** vivo experiments further show that Hdac6 knockout mice are resistant to aldehyde-induced disassembly of tracheal cilia and sperm *** findings reveal a previously unrecognized role for formyl group-mediated cilium disassembly in the complications of CMDs.

关键词： carbohydrate metabolism disorder aldose aldehyde cilium disassembly formyl group calcium influx HDAC6

Community Incidence Estimates of Five Pathogens Based on Foodborne Diseases Active Surveillance—China,2023

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China CDC weekly 2024年第24期6卷 574-579,I0002页

作者： Penghui fan Haihong Han Jikai liu Xiaochen Ma Ronghua Zhang hong liu Yijing zhou Zunhua Chu Jian Wen li lin weiwei li Yunchang Guo NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijingChina Beijing Center for Disease Prevention and Control BeijingChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Shanghai Center for Disease Control and Prevention ShanghaiChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Shandong Province Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Guangdong Province Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Sichuan Province Center for Disease Control and Prevention Chengdu CitySichuan ProvinceChina

What is already known about this topic?Foodborne diseases,representing significant food safety and public health challenges globally,are not welldocumented in terms of incidence,particularly for cases characterized by acute gastroenteritis(AGI)in *** is added by this report?This study developed a pyramid model to estimate the incidence of five pathogens,stratified by gender and *** estimated incidences per 100,000 people with 95%uncertainty intervals(UI)are as follows:Norovirus,3,188.28(95%UI:2,518.03,7,296.96);Salmonella spp.,1,295.59(95%UI:1,002.62,1,573.11);diarrheagenic ***(DEC),782.62(95%UI:651.19,932.05);Vibrio parahaemolyticus,404.06(95%UI:342.19,468.93);and Shigella spp.,26.73(95%UI:21.05,33.46).What are the implications for public health practice?This study elucidates the incidence rates across various gender and age groups,thereby identifying priority populations for targeted preventive interventions aimed at reducing disease *** insights are crucial for the development of public health policies and management of food safety risks.

关键词： acute diseases stratified

Effect of Molecular weight on Thermoelectric Performance of P3HT Analogues with 2-Propoxyethyl Side Chains

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 268-281页

作者：董得福 WANG wei ZHAN Chun li Chenglong zhou Qisheng 肖生强 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

By replacing hexyl chains in poly(3-hexylthiophene)(P3HT)with 2-propoxyethyls,four poly(3-(2-propoxyethyl)thiophene)(P3POET)homopolymers with comparable polydispersity indexes(PDI)and regioregularities were prepared herein in addition with step increment of about 7 kDa on numberaverage molecular weight(M_(n))from around 11 to 32 kDa(accordingly denoted as P11k,P18k,P25k,and P32k).When doped in film by FeCl_(3)at the optimized conditions,the maximum power factor(PF_(max))increases greatly from 4.3μW·m^(-1)·K^(-2)for P11k to 8.8μW·m^(-1)·K^(-2)for P18k,and further to 9.7μW·m^(-1)·K^(-2)for P25k,followed by a slight decrease to 9.2μW·m^(-1)·K^(-2)for *** close Seebeck coefficients(S)at PF_(max)are observed in these doped polymer films due to their consistent frontier orbital energy levels and Fermi *** main contribution to this PF_(max)evolution thus comes from the corresponding conductivities(σ).Theσvariation of the doped films can be rationally correlated with their microstructure evolution.

关键词： conjugated polymer molecular weight microstructure thermoelectric performance

Work-function-induced interfacial electron redistribution of MoO_(2)/WO_(2) heterostructures for high-efficiency electrocatalytic hydrogen evolution reaction

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Rare Metals 2024年第2期43卷 489-499页

作者： Tong-Fei li Jing li Lu-Ping Zhang Jia-wei Ke Meng-Xing fan li-fang Zhang Cheng-wei Deng Yi Sun Tao Qian Cheng-lin Yan School of Chemistry and Chemical Engineering Nantong UniversityNantong226019China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023China Aerospace Hydrogen Energy Technology(Shanghai)Co.Ltd. Shanghai201800China Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou215006China light Industry Institute of Electrochemical Power Sources Suzhou215006China

The engineering of the electronic configurations of active sites,together with the production of more accessible active sites through heterostructure design,has been established as a forceful methodology for boosting water electrolysis ***,a facile approach is developed to fabricate well-dispersed MoO_(2) and WO_(2) nanoparticles with abundant heterointerfaces entrapped in N,P-doped carbon nanofibers(referred to as MoO_(2)/WO_(2)@N,P-CNFs hereafter)as hydrogen evolution reaction(HER)electrocatalysts in alkaline and acidic *** spectroscopic analyses and theoretical findings manifest that the heterointerface formed by the work function modulation of MoO_(2)/WO_(2) triggers the spontaneous electron redistribution from MoO_(2)to WO_(2) and a built-in electric field,which is essential to promote water adsorption,optimize the H-intermediate adsorption energy,result in the enhanced charge transfer efficiency,and ultimately increase the intrinsic HER ***,the intimate confinement of MoO_(2)/WO_(2) heterostructures in the porous carbon substrate can restrain the active sites from unfavorable coarsening and detachment,thus ensuring facilitated HER kinetics and outstanding structural *** a result,MoO_(2)/WO_(2)@N,P-CNFs exhibit superior catalytic HER performance in acidic and basic solutions,requiring 118 and 95 mV overpotentials to achieve 10 mA·cm^(−2),respectively,surpassing a number of reported non-noble metal-based *** work provides guidelines for the rational design and construction of special metallic heterocomponents with optimized interfacial electronic structure for various electrochemical technologies.

关键词： Electrospinning MoO_(2)/WO_(2) heterostructure Work function Hydrogen evolution reaction

Binary Program Vulnerability Mining Based on Neural Network

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Computers, Materials & Continua 2024年第2期78卷 1861-1879页

作者： Zhenhui li Shuangping Xing lin Yu Huiping li fan zhou Guangqiang Yin Xikai Tang Zhiguo Wang School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu611731China School of Electrical and Computer Engineering University ofWaterlooWaterlooN2L 3G1Canada

Software security analysts typically only have access to the executable program and cannot directly access the source code of the *** poses significant challenges to security *** it is crucial to identify vulnerabilities in such non-source code programs,there exists a limited set of generalized tools due to the low versatility of current vulnerability mining ***,these tools suffer from some *** terms of targeted fuzzing,the path searching for target points is not streamlined enough,and the completely random testing leads to an excessively large search ***,when it comes to code similarity analysis,there are issues with incomplete code feature extraction,which may result in information *** this paper,we propose a cross-platform and cross-architecture approach to exploit vulnerabilities using neural network obfuscation *** leveraging the Angr framework,a deobfuscation technique is introduced,along with the adoption of a VEX-IR-based intermediate language conversion *** combination allows for the unified handling of binary programs across various architectures,compilers,and compilation ***,binary programs are processed to extract multi-level spatial features using a combination of a skip-gram model with self-attention mechanism and a bidirectional Long Short-Term Memory(LSTM)***,the graph embedding network is utilized to evaluate the similarity of program *** on these similarity scores,a target function is determined,and symbolic execution is applied to solve the target *** solved content serves as the initial seed for targeted *** binary program is processed by using the de-obfuscation technique and intermediate language transformation method,and then the similarity of program functions is evaluated by using a graph embedding network,and symbolic execution is performed based on these similarity *** approach facilitates

关键词： Vulnerability mining de-obfuscation neural network graph embedding network symbolic execution