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Preparation,quality control and biodistribution of [^(61)Cu]-doxorubicin for PET imaging

Nuclear Science and Techniques 2009年第3期20卷 157-162页

作者： JALILIAN Amir reza YOUSEFNIA Hassan faghihi reza AKHLAGHI Mehdi ZANDI Hassan Nuclear Medicine Research Group Agricultural Medical and Industrial Research School Karaj Iran Department of Nuclear Engineering School of Engineering Shiraz University Shiraz Iran

This work was conducted for radiolabeling of an anticancer antibiotic, i.e. doxorubicin with 61Cu for production of possible tracer used in PET oncology. 61Cu was prepared with natural zinc target and 22 MeV150 μA protons via natZn(p, xn)61Cu reaction with a yield of 123.2 MBq·μA-1·h-1. Optimization reactions were performed for pH, temperature and concentration. Biodistribution of the tracer was studied in normal and fibrosarcoma bearing mice. At the optimized conditions, ITLC showed that radiochemical purity was over 97% with a specific activity of 2.22× 103MBq ·mmol-1·L-1. This was kept unchanged even with presence of human serum as well as room temperature for 5 h. Biodistribution of the tracer in fibrosarcoma bearing mice demonstrated significant tumor uptake after 2 h. This tracer can be used in the detection of various tumors responding to doxorubicin chemotherapy using PET scan and/or determination of tumor therapy response to doxorubicin chemotherapy.

关键词：放射性元素研究核技术 ^61Cu

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Comparison of the predictive value of the Helsinki,Rotterdam,and Stockholm CT scores in predicting 6-month outcomes in patients with blunt traumatic brain injuries

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Chinese Journal of Traumatology 2023年第6期26卷 357-362页

作者： Nushin Moussavi Biuki Hamid reza Talari Mohammad Hossein Tabatabaei Masoumeh Abedzadeh-Kalahroudi Hossein Akbari Mahsa Masjedi Esfahani Reihaneh faghihi Department of Surgery Trauma Research CenterKashan University of Medical SciencesKashanIran Department of Radiology Kashan University of Medical SciencesKashanIran Trauma Research Center Kashan University of Medical SciencesKashanIran Department of Biostatistics Trauma Research CenterKashan University of Medical SciencesKashanIran

Purpose:Despite advances in modern medicine,traumatic brain injuries(TBIs)are still a major medical *** diagnosis of TBI is crucial for clinical decision-making and *** study aims to compare the predictive value of Helsinki,Rotterdam,and Stockholm CT scores in predicting the 6-month outcomes in blunt TBI ***:This cohort study was conducted on blunt TBI patients of 15 years or *** of them were admitted to the surgical emergency department of Shahid Beheshti Hospital in Kashan,Iran from 2020 to 2021 and had abnormal trauma-related findings on brain CT *** patients’demographic data such as age,gender,history of comorbid conditions,mechanism of trauma,Glasgow coma scale,CT images,length of hospital stay,and surgical procedures were *** Helsinki,Rotterdam,and Stockholm CT scores were simultaneously determined according to the existing *** included patients'6-month outcome was determined using the Glasgow outcome scale extended.M Data were analyzed by SPSS software version ***,specificity,negative/positive predictive value and the area under the receiver operating characteristic curve were calculated for each *** Kappa agreement coefficient and Kuder Richardson-20 were used to compare the scoring ***:Altogether 171 TBI patients met the inclusion and exclusion criteria,with the mean age of(44.9±20.2)*** patients were male(80.7%),had traffic related injuries(83.1%)and mild TBIs(64.3%).Patients with lower Glasgow coma scale had higher Helsinki,Rotterdam,and Stockholm CT scores and lower Glasgow outcome scale extended *** all the scoring systems,the Helsinki and Stockholm scores showed the highest agreement in predicting patients’outcomes(kappa=0.657,p<0.001).The Rotterdam scoring system had the highest sensitivity(90.1%)in predicting death of TBI patients,whereas the Helsinki scoring system had the highest sensitivity(89.8%)in predicting the 6-month outcome in TBI

关键词： Brain injuries,traumatic Traumatic Rotterdam CT scoring system Helsinki CT scoring system Stockholm CT scoring system CT scan Glasgow outcome scale extended

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