检索结果-南通市图书馆

A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren Jingying hu fan Dong Yan Xu Yang Peng Yuping Qian Guanmeng zhang Min Wang Yuguang Wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic ***,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune *** this basis,the editor can be combined with optical therapy to improve patient *** this study,the metal ratio was regulated in response to the nanocarrier of acid response ***,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell *** on these results,the nanoparticles were cracked in an acidic environment and then released copper ***,the nanoparticles contributed to cuprotosis and immunogenic *** addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without *** rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for ***,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell *** all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A DNA force Circuit for Exploring Protein-Protein Interactions at the Single-Molecule Level

引用

Chinese Journal of Chemistry 2024年第13期42卷 1456-1464页

作者： Kangkang Ma Luoan Xiong zhuofei Wang Xin hu Lihua Qu Xuetong zhao Yao Li zhongbo Yu State Key Laboratory of Medicinal Chemical Biology Frontiers Science Center for Cell Responsesand College of PharmacyNankai University38 Tongyan RoadTianjin 300350China School of Physics and Key Laboratory of functional Polymer Materials of Ministry of Education Nankai Universityand Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300071China

Protein-protein interactions(PPls)play a crucial role in drug discovery and disease ***,the development of effective drugs targeting PPls remains challenging due to limited methodologies for probing their spatiotemporal ***,we propose a single-molecule approach using a unique force circuit to investigate Ppl dynamics and anisotropy under mechanical *** conventional techniques,this approach enables the manipulation and real-time monitoring of individual proteins at specific amino acids with defined geometry,offering insights into molecular mechanisms at the single-molecule *** DNA force circuit was constructed using click chemistry conjugation methods and genetic code expansion techniques,facilitating orthogonal conjugation between proteins and nucleic *** SET domain of the MLL1 protein and the tail of histone H3 were used as a model system to demonstrate the application of the DNA force *** the use of atomic force microscopy and magnetic tweezers,optimized assembly procedures were *** DNA force circuit provides an exceptional platform for studying the anisotropy of PPis and holds promise for advancing drug discovery research targeted at PPIs.

关键词： Single-molecule studies Protein-protein interactions Click chemistry Genetic code expansion Molecular dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phase transfer-based high-efficiency recycling of precious metal electrocatalysts

引用

Green Chemical Engineering 2024年第1期5卷 68-74页

作者： Qing zeng Shaonan Tian Yu zhang hui Liu Dong Chen Xinlong Tian Chaoquan hu Jun Yang State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchool of Chemical Engineering and TechnologyHainan UniversityHaikou570228China Nanjing IPE Institute of Green Manufacturing Industry Nanjing211100China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China

Recycling precious metals with high-efficiency is undoubtedly beneficial to optimize resource utilization for environmental remediation and sustainable ***,we report an efficient route to recycle the palladium(Pd)and platinum(Pt)electrocatalysts using a phase transfer *** strategy involves acidic dissolution of deactivated precious metal(Pd/Pt)electrocatalysts from their loading substrates,mixing with an ethanolic solution of dodecylamine(DDA),subsequent extraction of metal ions into a non-polar organic phase,and final reduction by sodium borohydride to reproduce high-performance electrocatalysts towards typical electrochemical reactions,e.g.,oxygen reduction reaction(ORR)and ethanol oxidation reaction(EOR).In specific,the transfer efficiencies are up to 98%and the final recovery rate is over 85%for Pd and Pt electrocatalysts in each *** approach symbolizes a facile and efficient way to recover precious metals,which might be applied to recycling a wide range of metals in various realms after appropriate modifications.

关键词： Precious metal Phase transfer Extraction Recovery Electrocatalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Repeat-pass space-surface bistatic SAR tomography:accurate imaging and first experiment

引用

Science China(Information Sciences) 2024年第9期67卷 245-262页

作者： zhiyang CHEN Yuanhao LI Cheng hu Shenglei WANG Xinpeng CHEN Mihai DATCU Andrea Virgilio MONTI-GUARNIERI Radar Technology Research Institute School of Information and Electronics Beijing Institute of Technology Beijing Key Laboratory of Embedded Real-Time Information Processing Technology Beijing Institute of Technology Advanced Technology Research Institute Beijing Institute of Technology CEOSpace Tech University Politehnica of Bucharest Dipartimento di Elettronica Informazione e Bioingegneria Politecnico di Milano

Space-surface bistatic synthetic aperture radar(SS-BiSAR) offers an additional observation angle for monostatic spaceborne SAR, making it a promising technology for high-accuracy deformation retrieval technology in local regions. Repeat-pass SS-BiSAR tomography can accurately estimate the surfaces of buildings and steep areas, effectively removing terrain phases during deformation retrieving. However, inaccuracies in the orbital ephemeris can lead to image geometry distortion, reducing image pair coherence,introducing interferometric phase errors, and consequently deteriorating tomographic precision. This paper precisely models the image geometry distortion and interferometric phase error caused by repeat-pass ephemeris error. We propose an ephemeris correction method based on the chirp-z transform to address these issues. furthermore, we introduce an accurate tomography model to improve 3D reconstruction *** first SS-BiSAR tomography experiment, conducted using the Chinese Lutan-1 satellite, demonstrates that the correlation coefficient is improved by 0.16 after ephemeris error correction. Moreover, the density and precision of the tomographic point cloud are improved by 13.7% and 12.1%, respectively.

关键词： space-surface SAR tomography orbit error image distortion Lutan-1

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Dual-functional POM@IL complex modulate hole transport layer properties and interfacial charge dynamics for highly efficient and stable perovskite solar cells

引用

Chinese Chemical Letters 2024年第7期35卷 461-464页

作者： Boyuan hu Jian zhang Yulin Yang Yayu Dong Jiaqi Wang Wei Wang Kaifeng Lin Debin Xia MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China

The severe interfacial charge recombination as well as the stability issues brought by the Li-TfSI still hinder the commercialization of high-performance perovskite solar cells(PSCs).Here,a polyoxometalates(POMs)-based complex,POM@ionic liquid(IL),is synthesized and applied as an effective additive that simultaneously enhances the performance and stability of *** interactions between POM@IL complex and Li-TfSI inhibit the aggregation of *** synergistic oxidation of POM@IL complex and Li-TfSI towards 2,2,7,7-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9'-spirobifluorene(Spiro-OMeTAD)effectively enhances the electrical properties of hole transport layer film and the photovoltaic performances of *** champion device modified with the POM@IL complex yields an excellent power conversion efficiency(PCE)of 22.73%.Moreover,the incorporation of POM@IL improves the humidity stability of *** storing under high humidity conditions(25℃,60%RH)for 1200 h,the POM@IL modified device retained a remarkable 81.2%of its initial *** work provides new insight into constructing POMs-based materials for high-performance photovoltaic devices.

关键词： Polyoxometalates Ionic liquid Perovskite solar cells Energy alignment humidity stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strain engineering in electrocatalysis:Strategies,characterization,and insights

引用

Nano Research 2024年第5期17卷 3603-3621页

作者： Qibo Deng Peng Xu Hassanien Gomaa Mohamed A.Shenashen Sherif A.El-Safty Cuihua An Li-hua Shao Ning hu School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China Department of Chemistry Faculty of ScienceAl-Azhar University71524AssiutEgypt Department of Petrochemical Egyptian Petroleum Research Institute(EPRI)Nasr City11727CairoEgypt Center for functional Materials National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki-ken305-0047Japan State Key Laboratory of Reliability and Intelligence Electrical Equipment Key Laboratory of Advanced Intelligent Protective Equipment TechnologyMinistry of Educationand School of Mechanical EngineeringHebei University of TechnologyTianjin 300401China National Key Laboratory of Strength and Structural Integrity Institute of Solid MechanicsSchool of Aeronautic Science and EngineeringBeihang UniversityBeijing100191China Advanced Equipment Research Institute Co. Ltd.of HEBUTTianjin 300401China

Strain engineering,as a cutting-edge method for modulating the electronic structure of catalysts,plays a crucial role in regulating the interaction between the catalytic surface and the adsorbed *** electrocatalytic performance is influenced by the electronic structure,which can be achieved by introducing the external forces or stresses to adjust interatomic spacing between surface *** challenges in strain engineering research lie in accurately understanding the mechanical impact of strain on *** paper first introduces the basic strategy for generating the strain,summarizes the different strain generation forms and their advantages and *** progress in researching the characterization means for the lattice strains and their applications in the field of electrocatalysis is also ***,the challenges of strain engineering are introduced,and an outlook on the future research directions is provided.

关键词： strain electrocatalysis characterization chemical reaction kinetics lattice mismatch

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mycorrhizae and sustainable soil solutions

引用

Pedosphere 2024年第2期34卷 267-268页

作者： Junli hu fayuan WANG Junling zHANG Liangdong GUO Marcel G.A.VAN DER HEIJDEN State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042(China) National Academy of Agriculture Green Development State Key Laboratory of Nutrient Use and ManagementCollege of Resources and Environment SciencesChina Agricultural UniversityBeijing 100193(China) State Key Laboratory of Microbial Diversity and Innovative Utilization Institute of MicrobiologyChinese Academy of SciencesBeijing 100101(China) Department of Agroecology and Environment Plant-Soil InteractionsAgroscopeZürich 8046(Switzerland) Department of Plant and Microbial Biology University of ZürichZürich 8057(Switzerland)

Mycorrhizae are the most widespread symbioses in nature,involving plants and specialized soil *** recent years,mycorrhizal research has made remarkable *** in genomics and other modern techniques have opened new windo... 详细信息

关键词： soil specialized sustainable

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Versatile BenzimidazoleSubstituted Spirolactam Mechanophore:When Excited State Intramolecular Proton Transfer Couples with Rhodamine

引用

CCS Chemistry 2024年第7期6卷 1798-1809页

作者： huan hu Xin Cheng zhimin Ma Qingyuan Yang Rint PSijbesma zhiyong Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 College of Engineering Peking UniversityBeijing 100871 Department of Chemical Engineering and Chemistry Institute for Complex Molecular SystemsEindhoven University of Technology5600 MBEindhoven

Exploration of multicolor mechanochromic bulk polymers based on a single mechanophore is a big challenge to ***,we report a versatile benzimidazole-substituted spirolactam mechanophore where excited state intramolecular proton transfer(ESIPT)coupled with *** mechanophore was facilely synthesized and then covalently linked to polyurethane(PU)*** PU film containing the mechanophore(1@PU)showed cooperative photochromism upon irradiation involving simultaneous enhancement of normalized enol and rhodol emissions based on a cooperative ESIPT process and the ring-opening reaction of ***,the film exhibited dual-mode multicolor mechanochromism upon stretching and *** normalized intensity of enol emission increased and the fluorescence turned from light green to cyan after stretching,then red coloration appeared from colorless after *** experiments and density functional theory calculations confirmed that the stretch-induced increase of enol emission was attributed to torsion of the dihedral angle between xanthene and benzimidazole in the mechanophore via force-induced disaggregation and direct force action on the isolated *** of the dihedral angle and the ring-opening reaction of spirolactam in a single mechanophore occurred sequentially during compression,resulting in an observed red *** study might provide a glimpse into the design of novel multicolor mechanochromic mechanophores.

关键词： mechanophore rhodamine excited state intramolecular proton transfer cooperative photochromism dual-mode mechanochromism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lightweight,Strong and High Heat-Resistant Poly(lactide acid)foams via Microcellular Injection Molding with Self-Assembly Nucleating Agent

引用

Chinese Journal of Polymer Science 2024年第6期42卷 739-750页

作者： Xiao-hu Bing Wen-Yu Ma Ming-hui Wu Peng Gao Xiao zhou Hai-Bin Luo Long Wang Wen-Ge zheng School of materials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(lactide acid)(PLA)foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams,such as polystyrene(PS)***,PLA foam typically suffers from low heat-resistance and poor cellular structure stemming from its inherent slow crystallization rate and low melt *** this study,a high-performance PLA foam with well-defined cell morphology,exceptional strength and enhanced heat-resistance was successfully fabricated via a core-back microcellular injection molding(MIM)*** scanning calorimetry(DSC)results revealed that the added hydrazine-based nucleating agent(HNA)significantly increased the crystallization temperature and accelerated the crystallization process of ***,the addition of a 1.5 wt%of HNA led to a significant reduction in PLA’s cell size,from 43.5µm to 2.87µm,and a remarkable increase in cell density,from 1.08×10^(7)cells/cm^(3)to 2.15×10^(10)cells/cm^(3).This enhancement resulted in a final crystallinity of approximately 55.7%for the PLA blend foam,a marked improvement compared to the pure PLA ***,at 1.5 wt%HNA concentration,the tensile strength and tensile toughness of PLA blend foams demonstrated remarkable improvements of 136%and 463%,***,the Vicat softening temperature of PLA blend foam increased significantly to 134.8°C,whereas the pure PLA foam exhibited only about 59.7℃.These findings underscore the potential for the preparation of lightweight injection-molded PLA foam with enhanced toughness and heat-resistance,which offers a viable approach for the production of high-performance PLA foams suitable for large-scale applications.

关键词： Poly(lactide acid) Nucleating agent Microcellular injection molding Heat-resistance Toughness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metal–Organic Gel Leading to Customized Magnetic‑Coupling Engineering in Carbon Aerogels for Excellent Radar Stealth and Thermal Insulation Performances

引用

Nano-Micro Letters 2024年第3期16卷 36-52页

作者： Xin Li Ruizhe hu zhiqiang Xiong Dan Wang zhixia zhang Chongbo Liu Xiaojun zeng Dezhi Chen Renchao Che Xuliang Nie Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Environmental and Chemical Engineering Nanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Department of Materials Science and Collaborative Innovation Center of Chemistry for Energy Materials and Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438People’s Republic of China School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403People’s Republic of China College of Chemistry and Materials Jiangxi Agricultural UniversityNanchang 330045People’s Republic of China

Metal–organic gel(MOG)derived composites are promising multi-functional materials due to their alterable composition,identifiable chemical homogeneity,tunable shape,and porous ***,stable metal–organic hydrogels are prepared by regulating the complexation effect,solution polarity and curing ***,collagen peptide is used to facilitate the fabrication of a porous aerogel with excellent physical properties as well as the homogeneous dispersion of magnetic particles during ***,two kinds of heterometallic magnetic coupling systems are obtained through the application of Kirkendall ***/nitrogen-doped carbon(NC)aerogel demonstrates an ultra-strong microwave absorption of−85 dB at an ultra-low loading of 5%.After reducing the time taken by atom shifting,a feCo/fe3O4/NC aerogel containing virus-shaped particles is obtained,which achieves an ultra-broad absorption of 7.44 GHz at an ultra-thin thickness of 1.59 mm due to the coupling effect offered by dual-soft-magnetic ***,both aerogels show excellent thermal insulation property,and their outstanding radar stealth performances in J-20 aircraft are confirmed by computer simulation *** formation mechanism of MOG is also discussed along with the thermal insulation and electromagnetic wave absorption mechanism of the aerogels,which will enable the development and application of novel and lightweight stealth coatings.

关键词： Metal-organic gels Heterometallic magnetic coupling Radar stealth Thermal insulation Computer simulation technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：