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Signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda S.f.Matthees Carsten Hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany friedrich-Schiller-Universitat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(CasR)within the Gprotein-coupled receptor(GPCR)family C,gained attention due to pioneering research led by Georgios Skiniotis ... 详细信息

关键词： Stanford gained Skin

Evaluation of sodium borocaptate(BSH)and boronophenylalanine(BPA)as boron delivery agents for neutron capture therapy(NCT)of cancer:an update and a guide for the future clinical evaluation of new boron delivery agents for NCT

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Cancer Communications 2024年第8期44卷 893-909页

作者： Rolf f.Barth Nilendu Gupta Shinji Kawabata Department of Pathology The Ohio State UniversityColumbusOhioUSA Department of Radiation Oncology The Ohio State UniversityColumbusOhioUSA Department of Neurosurgery Osaka Medical and Pharmaceutical UniversityTakatsukiOsakaJapan

Boron neutron capture therapy(BNCT)is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron-10,a stable isotope,is irradiated with neutrons of the appropriate energy to produce boron-11 in an unstable form,which undergoes instantaneous nuclear fission to produce high-energy,tumoricidal alpha *** primary purpose of this review is to provide an update on the first drug used clinically,sodium borocaptate(BSH),by the Japanese neurosurgeon Hiroshi Hatanaka to treat patients with brain tumors and the second drug,boronophenylalanine(BPA),which first was used clinically by the Japanese dermatologist Yutaka Mishima to treat patients with cutaneous ***,BPA has become the primary drug used as a boron delivery agent to treat patients with several types of cancers,specifically brain tumors and recurrent tumors of the head and neck *** focus of this review will be on the initial studies that were carried out to define the pharmacokinetics and pharmacodynamics of BSH and BPA and their biodistribution in tumor and normal tissues following administration to patients with high-grade gliomas and their subsequent clinical use to treat patients with highgrade ***,wewill summarize the studies thatwere carried out in Japan with BSH and subsequently at our own institution,The Ohio State University,and those of several other ***,we will describe studies carried out in Japan with BPA and then in the United States that have led to its use as the primary drug that is being used clinically for ***,although there have been intense efforts to develop new and better boron delivery agents for BNCT,none of these have yet been evaluated *** present reportwill provide a guide to the future clinical evaluation of new boron delivery agents prior to their clinical use for BNCT.

关键词： Boron neutron capture therapy(BNCT) boronophenylalanine(BPA) brain tumors head and neck cancer sodium borocaptate(BSH)

A C-shaped hinge for displacement magnification in MEMS rotational structures

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Microsystems & Nanoengineering 2024年第1期10卷 55-66页

作者： Naga Manikanta Kommanaboina Teferi Sitotaw Yallew Alvise Bagolini Maria f.Pantano Department of Civil Environmental and Mechanical EngineeringUniversity of Trentovia Mesiano 7738123 TrentoItaly fondazione Bruno Kessler(fBK) Microsystems Technology(MST)via S.Croce 7738122 TrentoItaly

The design,analysis,fabrication,and characterization of two distinct MEMS rotational structures are provided;these structures include a classical symmetrical lancet structure and a novel symmetrical C-shaped structure provided with a tilted arm,and both are actuated by thermal *** proposed C-shaped structure implemented a curved beam mechanism to enhance the movement delivered by the thermal *** geometrical parameters of our proposed device were optimized using the design of experiment(DOE)***,the analytical modeling based on Castigliano’s second theorem and the simulations based on the finite element method(fEM)were used to predict the behavior of the symmetrical C-shaped structure;the results were in good agreement with each *** MEMS-based rotational structures were fabricated on silicon-on-insulator(SOI)wafers using bulk micromachining technology and deep reactive ion etching(DRIE)*** fabricated devices underwent experimental characterization;our results showed that our proposed MEMS rotational structure exhibited a 28%improvement in the delivered displacement compared to the symmetrical lancet ***,the experimental results showed good agreement with those obtained from numerical *** proposed structures have potential applications in a variety of MEMS devices,including accelerometers,gyroscopes,and resonators,due to their ability to maximize displacement and thus enhance sensitivity.

关键词： shaped displacement structures

Nonlinear corrections for the nuclear gluon distribution in eA processes

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Chinese Physics C 2024年第3期48卷 52-64页

作者： G.R.Boroun B.Rezaei f.Abdi Department of Physics Razi UniversityKermanshah 67149Iran.

An analytical study with respect to the nonlinear corrections for the nuclear gluon distribution function in the next-to-leading order approximation at small x is *** consider the nonlinear corrections to the nuclear gluon distribution functions at low values of x and Q^(2) using the parametrization f_(2)(x,Q^(2))and the nuclear modification factors obtained from the Khanpour-Soleymaninia-Atashbar-Spiesberger-Guzey *** CT18 gluon distribution is used for the baseline proton gluon density at Q^(2)_(0)=*** discuss the behavior of the gluon densities in the next-to-leading order and the next-to-next-to-leading order approximations at the initial scale Q^(2)_(0),as well as the modifications due to the nonlinear *** find that the QCD nonlinear corrections are more significant for the next-to-leading order accuracy than the next-to-next-to-leading order for light and heavy *** results of the nonlinear GLR-MQ evolution equation are similar to those obtained with the Rausch-Guzey-Klasen gluon upward and downward evolutions within the *** magnitude of the gluon distribution with the nonlinear corrections increases with a decrease in x and an increase in atomic number A.

关键词： gluon distribution nonlinear corrections light and heavy nuclei low x physics

Connections Between Induction Generator Effect and Open-loop Modal Proximity to Cause Sub-synchronous Oscillations in Series-compensated Power System

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 963-973页

作者： Wenjuan Du Yang Wang H.f.Wang Tao Zhao Tim Littler College of Electrical Engineering Sichuan UniversityChengduChina School of Electrical Engineering the Queen’s University of BelfastBelfastUK IEEE

The induction generator effect(IGE)and the openloop modal proximity(OLMP)are two different reasons why subsynchronous oscillations(SSOs)in a series-compensated power system(SCPS)may *** IGE attributes the growing SSOs to negative resistance,while the OLMP explains the SSO mechanism from the standpoint of modal *** this paper,we investigate the connections between the IGE and the OLMP through equivalent RLC circuit and open-loop modal *** investigation is conducted for two types of seriescompensated power systems where either a synchronous generator or a DfIG is connected at the sending *** investigation reveals the conditions,in which the IGE and the OLMP may jointly cause the growing SSOs,i.e.,both the IGE and the OLMP can explain why the growing SSOs ***,the investigation indicates that the IGE and the OLMP may be totally irrelevant and lead to growing SSOs *** implies that it is possible that in a SCPS,the growing SSOs are only due to the IGE,and the OLMP is non-existent,and vice ***,when the growing SSOs occurs in a SCPS,examination based on both the IGE and the OLMP should be carefully conducted in order to find if the oscillatory instability is due to the IGE,or the OLMP,or both of them.

关键词： Induction generator effect open-loop modal proximity series compensation sub-synchronous oscillations

All-electron basis sets for H to Xe specific for ZORA calculations:Applications in atoms and molecules

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Chinese Physics B 2024年第8期33卷 238-246页

作者： C.S.Gomes f.E.Jorge A.Canal Neto Departamento de fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for H through Xe was developed to be used in conjunction with the ZORA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZORA-CCSD(T)/QZP-ZORA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZORA and Douglas–Kroll–Hess Hamiltonians were made for each property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from H to Xe CCSD(T)method atomic and molecular properties

Radiative loss of coherence in free electrons:a long-range quantum phenomenon

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Light(Science & Applications) 2024年第2期13卷 294-301页

作者： Cruz I.Velasco Valerio Di Giulio f.Javier García de Abajo ICfO-Institut de Ciencies fotoniques The Barcelona Institute of Science and Technology08860Castelldefels(Barcelona)Spain ICREA-InstitucióCatalana de Recerca i Estudis Avançats Passeig Lluís Companys 2308010BarcelonaSpain

Quantum physics rules the dynamics of small objects as they interact over microscopic length ***,quantum correlations involving macroscopic distances can be observed between entangled photons as well as in atomic gases and matter waves at low *** long-range nature of the electromagnetic coupling between charged particles and extended objects could also trigger quantum phenomena over large ***,we reveal a manifestation of quantum mechanics that involves macroscopic distances and results in a nearly complete depletion of coherence associated with which-way free-electron interference produced by electron-radiation coupling in the presence of distant extended *** is a ubiquitous effect that we illustrate through a rigorous theoretical analysis of a two-path electron beam interacting with a semi-infinite metallic plate and find the inter-path coherence to vanish proportionally to the path separation at zero temperature and exponentially at finite *** investigated regime of large distances originates in the coupling of the electron to radiative modes assisted by diffraction at material structures but without any involvement of material *** the fundamental interest of this macroscopic quantum phenomenon,our results suggest an approach to measuring the vacuum temperature and nondestructively sensing the presence of distant objects.

关键词： temperature quantum macroscopic

Application of novel constrained friction processing method to produce fine grained biomedical Mg-Zn-Ca alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 516-529页

作者： Ting Chen Banglong fu Junjun Shen Uceu f.H.R.Suhuddin Björn Wiese Yuanding Huang Min Wang Jorge f.dos Santos Jean Pierre Bergmann Benjamin Klusemann Solid State Materials Processing Institute of Material MechanicsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany functional Magnesium Materials Institute of Metallic BiomaterialsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Shanghai Key Laboratory of Materials Laser Processing and Modification Shanghai Jiao Tong UniversityDongchuan Road 800Shanghai 200240China Applied Materials and Manufacturing Energy and Environment DivisionPacific Northwest National LaboratoryPO Box 999RichlandWA 99352USA Production Technology Group Technisiche Universität IlmenauGustav-Kirchhoff-Platz 2Ilmenau 98693Germany Institute for Production Technology and Systems Leuphana University of LüneburgUniversitätsallee 1Lüneburg 21335Germany

In order to obtain Mg alloys with fine microstructures and high mechanical performances,a novel friction-based processing method,name as“constrained friction processing(CfP)”,was *** CfP,defect-free Mg-Zn-Ca rods with greatly refined grains and high mechanical properties were *** to the previous as-cast microstructure,the grain size was reduced from more than 1 mm to around 4μm within 3 s by a single process *** compressive yield strength was increased by 350%while the ultimate compressive strength by 53%.According to the established material flow behaviors by“tracer material”,the plastic material was transported by shear *** the base material to the rod,the material experienced three stages,*** by the tool,upward flow with additional tilt,followed by upward *** microstructural evolution was revealed by“stop-action”*** microstructural development at regions adjacent to the rod is mainly controlled by twinning,dynamic recrystallization(DRX)as well as particle stimulated nucleation,while that within the rod is related to DRX combined with grain growth.

关键词： Constrained friction processing Magnesium alloys Microstructure Mechanical properties Grain refinement Plastic deformation

failure to Rescue as a Quality Metric in Congenital Heart Surgeries in a High-Complexity Service Provider Institution Located in a Middle-Income Country

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Congenital Heart Disease 2024年第2期19卷 207-218页

作者： Gustavo Cruz Santiago Pedroza Juan f.Vélez Jessica Largo Juan f.Tejada Jorge H.Mejía-Mantilla Departamento de Anestesiología Fundación Valle del LiliCali760032Colombia Centro de Investigaciones Clínicas Fundación Valle del LiliCali760032Colombia Departamento de Cardiología Pediátrica Fundación Valle del LiliCali760032Colombia facultad de Medicina Universidad IcesiCali760031Colombia Unidad de Cuidado Intensivo Fundación Valle del LiliCali760032Colombia

Background:failure to rescue has been an effective quality metric in congenital heart ***,mor-bidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality *** aim to measure the complications,mortality,and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar ***:A retrospective observational study was conducted in a high-complexity service provider institution,in Cali,*** pediatric patients undergoing any congenital heart surgery between 2019 and 2022 were *** main outcomes evaluated in the study were complication,mortality,and failure to rescue *** and multivariate logistic regression analysis was performed with mortality as the outcome ***:We evaluated 308 congenital heart *** the outcomes,201(65%)complications occurred,23(7.5%)patients died,and the fTR of the entire cohort was 11.4%.The presence of a postoperative complication(OR 14.88,CI 3.06–268.37,p=0.009),age(OR 0.79,CI 0.57–0.96,p=0.068),and urgent/emergent surgery(OR 8.14,CI 2.97–28.66,pficant variables in predicting ***:failure to rescue is an effective and comparable quality measure in healthcare institutions and is the major contributor to postoperative mortality in congenital heart *** our higher mortality and complication rate,we obtained a comparable failure to rescue rate to high-income countries’health institutions.

关键词： Congenital heart surgery complication mortality failure to rescue quality metric

Niche differentiation among facultative filter feeders: Insights from invasive Ponto-Caspian mysids

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Current Zoology 2024年第4期70卷 513-521页

作者： Péter Borza Varsha Rani Csaba f.Vada Institute of Aquatic Ecology Centre for Ecological ResearchKarolina ut 29.1113 BudapestHungary Doctoral School of Biology Institute of BiologyEotvos Lorand UniversityPazmany Péter sétany 1/C1117 BudapestHungary

The degree of dietary specialization has a fundamental impact on the ecological function and interactions of suspension *** niche differentiation by food particle size is common among obligate suspension feeders,its role is not evident in facultative *** this study,we aimed at providing new insights on the matter by focusing on sympatric mysid *** mysids use different mechanisms for raptorial and filter-feeding,they represent a more adequate model system than for example,the more extensively studied *** made morpholog-ical measurements on the 4 coexisting invasive Ponto-Caspian mysid species to determine the areas and mesh sizes of their *** also quantified their clearance rates on the microalga Cryptomonas *** a laboratory experiment to reveal how morphological differences manifest in their overall filtering *** found relatively small but consistent differences in the primary filter area among the species,indicating that morphological constraints due to the enclosed position of the setae might limit the possibility for *** primary filter mesh sizes were small in all 4 species(0.69-2.73μm)with moderate but consistent intraspecific differences,suggesting that the benefit of being able to capture small particles might outweigh the pressure for *** observed clearance rates were in accordance with the morphological characteristics of the species,highlighting that auxiliary filters(present in one of the species,Limnomysis benedeni)are needed to increase filtering capacity *** study confirmed that food particle size can contribute to the niche differentiation of facultative filter feeders,but also indicated that they can tolerate a higher overlap than obligate *** observed differences were related to the habitat preferences and predatory potentials of the species,suggesting that complementarity among the different niche axes might further facilitate theircoexistence.

关键词： clearance rate coexistence filter area filtermesh size.