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Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry

World Journal of Critical Care Medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal Mayank Sharma Allison M LeMahieu Andrew C Hanson Phillip J Schulte Marija Bogojevic Neha Deo Simon Zec Diana J Valencia Morales Katherine A Belden Smith f Heavner Margit Kaufman Sreekanth Cheruku Valerie C Danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie Syed A Khan Lynn Retford Karen Boman Vishakha KKumar John C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix School of Medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care Medicine Mount ProspectIL 60056United States Division of Infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care Medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental *** studies previously suggested a link between climatological factors and COVID-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** In this observational analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COVID-19 Hospital-free days Latitude Outcomes

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In vitro inhibitory effects on a-glucosidase and a-amylase level and antioxidant potential of seeds of Phoenix dactylifera L.

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 322-329页

作者： Shah Alam Khan Amira Rashid Al Kiyumi Manal Saif Al Sheidi Tagreed salim Al Khusaibi Noura Mohammed Al Shehhi Tanveer Alam Department of Pharmacy Oman Medical College Oman Medicinal Plants & Marine Natural Products University of Nizwa

Objective:To evaluate and compare the antioxidant activity,total phenolic contents(TPCs) and in vitro antidiabetic activity of various pits extracts obtained from five Omani date ***:Sun-dried mature fruits of five Omani date varieties,namely,fardh,Naghal,Khalas,Khinazi and Khasab were purchased from the local market in Muscat,Oman in the month of September *** seed extracts ***,ethanol,methanol and acetone were prepared for each date variety and their antioxidant activities were investigated by 1,1-diphenyl-2-picrylhydrazyl,hydrogen peroxide scavenging method and reducing power assay method,*** vitro antidiabetic activity of the date pit extracts was evaluated by measuring their inhibitory effect on a-glucosidase and aamylase *** were also quantified ***:The results indicated that TPC of date seeds was solvent ***,ethanol and methanol were found to be significantly better solvents than water in extracting phenolic compounds from the date *** extracts exhibited moderate to good in vitro antioxidant activity and increased reducing *** all date pit extracts,water extract exhibited significant in vitro antidiabetic activity in comparison to standard drug,***:The present study confirms that disposed waste of Omani dates is a rich source of dietary antioxidant because of its high *** pits due to their inhibitory effects on a-glucosidase and a-amylase level could be used as a monotherapy along with an appropriate diabetic diet and exercise or might be in conjunction with antidiabetic therapy to manage and prevent progression of diabetes.

关键词： Phoenix dactylifera L. Antioxidant In vitro antidiabetic activity Date pits

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现场条件下痰涂片查抗酸杆菌石炭酸复红染色方法的差异

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国际结核病与肺部疾病杂志 2006年第3期1卷 121-127页

作者： A. Van Deun A. Hamid salim K. J. M. Aung Md. A. Hossain N. Chambugonj Md. A. Hye A. Kawria E. Declercq 张宗德（译）屠德华（校）张立兴（审） Mycobacteriology Unit Institute of Tropical Medicine Antwerpen Belgium International Union against Tuberculosis and Lung Disease Paris France Damien foundation Bangladesh Dhaka Bangladesh Damien foundation Belgium Brussels Belgium 不详

地点:孟加拉国现场项目。目的:比较常规使用的石炭酸复红染色法改变的有效性。设计:75个现场临床检查地点,使用常规1％碱性复红加热15分钟的萋-尼氏染色法(ZN)。盲法对照检查ZN 1％与ZN 0．3％碱性复红染色5分钟,或ZN 1％5分钟与Kinyou... 详细信息

地点:孟加拉国现场项目。目的:比较常规使用的石炭酸复红染色法改变的有效性。设计:75个现场临床检查地点,使用常规1％碱性复红加热15分钟的萋-尼氏染色法(ZN)。盲法对照检查ZN 1％与ZN 0．3％碱性复红染色5分钟,或ZN 1％5分钟与Kinyoun冷染色法的双份涂片的结果。结果不符时进行复检。结果:假阳性的数目可对照时,Kinyoun氏法的敏感性比ZN 1％5分钟低的多(85．6％对93．0％, P<0．001)。ZN 1％5分钟的敏感性不比0．3％5分钟染色高(89．9％对86．5％)。常规使用的1％15分钟的ZN检查法比本研究中的其它方法查出的阳性教都要高。结论:Kinyoun氏冷染色法在现场临床条件下的敏感性不令人满意。WHO/IUATLD推荐的0．3％复红5分钟的敏感性和原来的1％ZN法5分钟没明显区别,但1％15分钟加热染色法更好。降低复红浓度、减少染色时间可能会增加出错的机会。结核项目中使用的较高浓度和较长时间的热ZN法不应当鼓励去改变。

关键词：萋-尼氏石炭酸复红显微镜染色

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Merkel细胞的抗角蛋白20染色有助于鉴别皮肤纤维瘤的基底细胞样增殖和基底细胞癌

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 12-12页

作者： Mahmoodi M. Asad H. salim S. 党倩丽 Drexel University Collage of Medicine Pathology Department New Collage Building 245 N 15th Street Philadelphia PA 19102 United States

Background: Basaloid epidermal proliferations (BEP), morphologically resembling basal cell carcinoma (BCC), have been described overlying dermatofibromas. Distinguishing the two is important because of non-aggressiveness of BEP and local aggressiveness of BCC. The aim of this study is to determine whether CK20 antibody staining for Merkel cells can be used as an adjunct method to differentiate BEP from BCC. Methods: Ten cases of BEP overlying dermatofibromas were selected. Ten cases of BCC were used as control. The two groups were stained with CK20 antibody. Numerical density of CK20 stained Merkel cells in peri-lesional epidermis, BEP and BCC was determined by examining 300 cells at 400X in two separate areas by three independent pathologists. To determine statistical significance, the results were compared using t-test method. Results: Density of Merkel cells in peri-lesional epidermis was 0.2-0.3%. No merkel cells were detected in the BCC. BEP overlying dermatofibromas showed an obvious increase in CK 20 stained Merkel cells. The difference was statistically significant(P ficant increase in CK20 stained Merkel cells in BEP overlying dermatofibromas as compared to BCC. CK20 antibody staining for Merkel cells can be used as an adjunct method to differentiate BEP overlying dermatofibromas from BCC.

关键词：基底细胞癌皮肤纤维瘤 Merkel细胞角蛋白鉴别诊断皮损周围镜下计数病理医师数密度有显著性差异

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坎地沙坦对心力衰竭患者非致死性心肌梗死和心血管死亡的影响

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美国医学会杂志（中文版） 2006年第5期25卷 302-306页

作者： Catherine Demers John J. V. McMurray Karl Swedberg Marc A. Pfeffer Christopher B Bertil Olofsson Robert S. McKelvie Jan OEstergren Eric L. Michelson Peter A. Johansson Duolao Wang salim Yusuf, MBBS, DPhil 孙艺红（译）胡大一（校） McMaster University Hamilton Ontario University of Glasgow Glasgow Scotland Sahlgrenska University Hospital/Ostra G6teborg Sweden Cardiovascular Division Brigham and Women＇s Hospital Boston Mass Duke University Medical Center Durham NC AstraZeneca Research and Development MOlndal Sweden Karolinska Hospital Stockholm Sweden AstraZeneca LP Wilmington Del London School of Hygiene and Tropical Medicine London England 不详

背景：血管紧张素转换酶（angiotensin-converting enzyme，ACE）抑制剂可降低心肌梗死（myocardial infarction，MI）的危险，但是还不清楚血管紧张素受体拮抗剂是否具有同样的效果。目的：评价血管紧张素受体拮抗剂坎地沙坦对心力衰... 详细信息

背景：血管紧张素转换酶（angiotensin-converting enzyme，ACE）抑制剂可降低心肌梗死（myocardial infarction，MI）的危险，但是还不清楚血管紧张素受体拮抗剂是否具有同样的效果。目的：评价血管紧张素受体拮抗剂坎地沙坦对心力衰竭患者MI和其他冠脉事件的影响。设计、地点和参试者：“坎地沙坦治疗心力衰竭：降低病死率和发病率评价”（Candesartan in Heart failure：Assessment of Reduction in Mortality and Morbidity，CHARM）计划是一项随机、安慰剂对照研究。研究入选有纽约心脏病协会分级Ⅱ至Ⅳ级症状的患者（平均年龄，66[SD，11]岁）。在心力衰竭最佳治疗的基础上，随机接受坎地沙坦（目标剂量，32mg每天一次）或匹配的安慰剂。患者入选期为1999年3月至2001年3月。分组的7599例患者中，4004例（53％）有MI病史，1808例（24％）患有心绞痛。基线时，服用ACE抑制剂3125例（41％）；服用β-阻滞剂4203（55％）例；降脂药物3153例（42％）；阿斯匹林4246例（56％）；利尿药6286例（83％）。主要观测指标：该分析的主要终点为坎地沙坦或安慰剂组心力衰竭患者心血管死亡和非致死性MI复合发生率。结果：在37．7个月的中位随访期间，坎地沙坦组（775例患者[20．4％]）心血管死亡和非致死性MI主要终点的发生率明显低于安慰剂组（868[22．9％]）（风险比[hazard ratio，HR]，0．87；95％可信区间[confidence interval，CI]，0．79-0．96；P=0．004；所需治疗例数[numbe rneeded to treat，NNT]，40）。与安慰剂组（522[13．8％]）比较，坎地沙坦组（459[12．1％]）单纯非致死性MI也明显降低（HR，0．86；95％CI，0．75-0．97；P=0．02；NNT，59）。在CHARM试验预先设定的不同亚组和分析间，心血管死亡和非致死性MI危险的降低相似。坎地沙坦对不稳定心绞痛或冠脉血运重建导致的住院没有影响。结论：坎地沙坦能明显降低心力衰竭患者发生心血管死亡或非致死性MI复合终点的危险。

关键词：心力衰竭患者致死性心肌梗死坎地沙坦心血管死亡血管紧张素转换酶安慰剂对照 ACE抑制剂

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Current systematic reviews and meta-analyses of COVID-19

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World Journal of Virology 2021年第4期10卷 182-208页

作者： Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States Department of Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt(IDCARE)Cairo 11221Outside of the USEgypt Department of Medicine Division of NephrologyUniversity of Tennessee Health Science CenterKnoxville CityTN 38103United States Department of Medical St.George's UniversityWest Indies 38901Grenada Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11221Egypt Department of Oncology Broomfiled HospitalMid and South Essex NHS Foundation TrustESSEXChelmsford 12422United Kingdom Department of Critical Care Unit Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States

BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million *** the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of *** To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be *** We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS *** included studies were extracted from Embase,Medline,and Cochrane *** publication timeframe of included studies ranged between January 01,2020,to October 30,*** that were published in languages other than English were not considered for this systematic *** finalized full-text articles are freely accessible in the public *** Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 *** inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 *** screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and ***,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stro

关键词： Systematic review Meta-analyses COVID-19 Review Coronavirinae

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玉米或高粱干酒糟及其可溶物对交叉繁殖的肉牛品种生长性能和胴体品质的影响

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饲料博览 2011年第11期21卷 8-8页

作者： Wood K M salim H McEwenP L Mandell I B Miller S P Swanson K C 不详

应用裂区设计,对60头交叉繁殖肉牛(安格斯,n=36和夏洛来,n=24)喂食玉米或高粱干酒糟可溶物,研究其对肉牛生长肥育生长性能和胴体性状的影响。肉牛随机分配到各组,在两个饲养阶段中分为3个处理:对照组为豆粕型日粮(n=20,CON);CDDGS组在... 详细信息

应用裂区设计,对60头交叉繁殖肉牛(安格斯,n=36和夏洛来,n=24)喂食玉米或高粱干酒糟可溶物,研究其对肉牛生长肥育生长性能和胴体性状的影响。肉牛随机分配到各组,在两个饲养阶段中分为3个处理:对照组为豆粕型日粮(n=20,CON);CDDGS组在饲料中添加玉米干酒糟及其可溶物200g·kg-1(n=20,CDDGS);SDDGS组在饲料中添加高粱干酒糟及其可溶物200g·kg-1(n=20,SDDGS)。肉牛喂养青贮玉米的基础日粮(750g·kg-1)56d,然后换成高的谷物日粮(150g·kg-1)。测定采食量,每28d进行动物称重和通过超声引导估计背膘。结果表明,对于平均日增重(ADG),各组结果为CON组1.56±0.04kg·d-1,CDDGS组1.54±0.04kg·d-1,SDDGS组1.51±0.04kg·d-1,处理间没有显著差异(P>0.68)。不同干物质日粮组成水平对生长性能无显著影响(P>0.14),但CON组ADG水平低于SDDGS组(P=0.008)和CDDGS组(P=0.02)。成长阶段饲养中CDDGS和SDDGS组有一个较低增长(P=0.04)。在后期阶段,玉米或高粱DDGS的加入对平均日增重、料肉比无显著影响(P>0.41),SDDGS组比CDDGS组(P=0.03)和CON组(P=0.05)需要较少饲料量达到目标背膘性屠宰。结果表明,添加高粱干酒糟及其可溶物200g·kg-1,效果类似玉米酒糟及其可溶性,在生长期和后期中不影响整体增长或负胴体性状,尽管玉米青贮饲料的喂养可能会导致早期育肥效果。

关键词：胴体特性生长性能酒糟肉牛高粱

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Prevalence,awareness and control of hypertension in Malaysia from 1980-2018:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2020年第4期8卷 320-344页

作者： Man Jun Soo Zhen Yee Chow Siew Mooi Ching Chun Han Tan Kai Wei Lee Navin Kumar Devaraj Hani Syahida salim Vasudevan Ramachandran Poh Ying Lim Dhashani Sivaratnam fan Kee Hoo Ai Theng Cheong Yook Chin Chia Department of family Medicine Universiti Putra MalaysiaSerdang 43400Malaysia Hospital Seberang Jaya Perai 13700Malaysia Malaysian Research Institute on Ageing Universiti Putra MalaysiaSerdang 43400Malaysia Department of Community Health Universiti Putra MalaysiaSerdang 43400Malaysia Department of Surgery Universiti Putra MalaysiaSerdang 43400Malaysia Department of Medicine Universiti Putra MalaysiaSerdang 43400Malaysia Department of Medical Sciences Sunway UniversityBandar Sunway 47500Malaysia

BACKGROUND Hypertension is a common public health problem worldwide and is a well-known risk factor for increased risk of cardiovascular diseases,contributing to high morbidity and ***,there has been no systematic review and meta-analysis of a multiethnic population such as that of *** To determine the trend in prevalence,awareness and control rate of hypertension in *** Systematic searches were conducted in six databases(PubMed,Scopus,Ovid,CINAHL,Malaysian Medical Repository and Malaysia Citation Index)for articles published between 1980 and *** authors reviewed the studies and performed quality assessment and data extraction *** estimates of hypertension prevalence,awareness and control rate were calculated using the DerSimonian-Laird random-effects *** and sensitivity analyses were *** We included 56 studies involving a total of 241796 *** overall pooled prevalence of hypertension aged≥18 years was 29.7%.The prevalence of hypertension was the lowest in the 1980s(16.2%,95%confidence interval(CI):13.4,19.0),increasing up to 36.8%(95%CI:6.1,67.5)in the 1990s,then decreasing to 28.7%(95%CI:21.7,35.8)in the 2000s and 26.8%(95%CI:21.3,32.3)in the *** prevalence of awareness was 51.4%(95%CI:46.6,56.3),while 33.3%(95%CI:28.4,38.2)of those on treatment had achieved control of their blood *** In Malaysia,three in ten adults aged≥18 years have hypertension,while four in ten adults aged≥30 years have *** out of ten people are aware of their hypertension status and only one-third of those under treatment achieved control of their *** efforts by policymakers and healthcare professionals to improve awareness and control of hypertension should be of high priority.

关键词： Prevalence Awareness Control Hypertension Blood pressure Malaysia Systematic review Meta-analysis

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