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Plasma membrane-anchored fluorescent tracker based on boron-dipyrromethene

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Chinese Journal of Chemical Engineering 2024年第8期72卷 220-225页

作者： Yucong Gong Xiangli li Daqing ma lai Wang lin Zhou Caiwei lu Yi Xiao Xinfu Zhang State Key laboratory of fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringDalian University of TechnologyDalian 116024China China Academy of Safety Science and Technology Beijing 100012China

The construction of a stable-membrane tracker has significant implications for the visualization of the membrane in live ***,most current plasma trackers are not suitable for tracking plasma membranes for a long time due to their limited retention ***,Mem580-f-Sulfo is designed to target and anchor cell membranes and therefore track cell membranes for a longer *** tracker is composed of a lipophilic boron-dipyrromethene(BODIPY)derivative and a hydrophilic zwitterion to form an amphiphilic structure,which enables its targeting ability toward cell ***,a reactive ester group is included to bind with proteins through covalent bonds in cell membranes nonspecifically,which extends retention time in cell ***580-f-Sulfo shows intense brightness(94600),with a high molar absorption coefficient of up to about 100000 l·mol^(-1)·cm^(-1)and a fluorescence quantum yield of up to *** shows fast cell membrane targeting ability and long retention up to 90 *** brief,this work has not only developed a tracker with good cell membrane targetability but also provided a new strategy for improving the targeting stability of cell membranes.

关键词： Plasma membrane Protein Tracker Imaging Microstructure

Novel phenanthrene/bibenzyl trimers from the tubers of Bletilla striata attenuate neuroinﬂammation via inhibition of Nf-κB signaling pathway

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Chinese Journal of Natural Medicines 2024年第5期22卷 441-454页

作者： SHAO Siyuan SUN Mohan ma Xianjie JIANG Jianwei TIAN Jinying ZHANG Jianjun YE fei lI Shuai State Key laboratory of Bioactive Substance and function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

five novel(9,10-dihydro)phenanthrene and bibenzyl trimers,as well as two previously identified biphenanthrenes and bibenzyls,were isolated from the tubers of Bletilla *** structures were elucidated through comprehensive analyses of NMR and HRESIMS spectroscopic *** absolute configurations of these compounds were determined by calculating rotational energy barriers and comparison of experimental and calculated ECD *** 5b and 6 exhibited inhibitory effects on lPS-induced NO production in BV-2 cells,with IC_(50) values of 12.59±0.40 and 15.59±0.83μmol·l^(-1),respectively.A mechanistic study suggested that these compounds may attenuate neuroinflammation by reducing the activation of the AKT/IκB/Nf-κB signaling ***,compounds 3a,6,and 7 demonstrated significant PTP1B inhibitory activities,with IC_(50) values of 1.52±0.34,1.39±0.11,and 1.78±0.01μmol·l^(-1),*** investigation revealed that compound 3a might inhibit lPS-induced PTP1B overexpression and Nf-κB activation,thereby mitigating the neuroinflammatory response in BV-2 cells.

关键词： Bletilla striata Phenanthrene/bibenzyl trimer NO inhibition AKT/IκB/Nf-κB signaling pathway PTP1B inhibitory effect

Immune checkpoint inhibitors break whose heart? Perspectives from cardio-immuno-oncology

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Genes & Diseases 2024年第2期11卷 807-818页

作者： Yingying He Hui Yu Shuang Dai Miao He ling ma Zihan Xu feng luo li Wang Oncology Department Deyang People's HospitalDeyangSichuan 618000China Department of Medical Oncology Lung Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610000China Cardiovascular Department Mianyang Central HospitalMianyangSichuan 621000China Department of Rheumatology and Immunology Deyang People's HospitalDeyangSichuan 618000China

Immune checkpoint inhibitors (ICIs) are monoclonal antibody antagonists,which can block cytotoxic T lymphocyte antigen-4 (CTlA-4),programmed death-1/ligand-1 (PD-1/PD-l1) pathways,and other molecules exploited by tumor cells to evade T cell-mediated immune *** have transformed the treatment landscape for various cancers due to their amazing *** anti-tumor therapies,including targeted therapy,radiotherapy,and chemotherapy,combine ICIs to make the treatment more ***,the off-target immune activation caused by ICIs may lead to a broad spectrum of immune-related adverse events (irAEs) affecting multiple organ *** irAEs,cardiotoxicity induced by ICIs,uncommon but fatal,has greatly offset survival benefits from ICIs,which is heartbreaking for both patients and ***,such cardiotoxicity requires special vigilance,and it has become a common challenge both for patients and *** article reviewed the clinical manifestations and influence of cardiotoxicity from the view of patients and clinicians,elaborated on the underlying mechanisms in conjunction with animal studies,and then attempted to propose management strategies from a cardio-immuno-oncology multidisciplinary perspective.

关键词： Cancer management Cardio-immuno-oncology multidisciplinary Cardiotoxicity Immune checkpoint inhibitors Immune tolerance

magmatic-hydrothermal Evolution and Mineralization Mechanisms of the Wangjiazhuang Cu(-Mo)Deposit in the Zouping Volcanic Basin,Shandong Province,China:Constraints from fluid Inclusions

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 679-700页

作者： SHU lei YANG Renchao SHEN Kun YANG Deping maO Guangzhou lI Min lIU Pengrui ma Xiaodong Shandong Provincial Key laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and TechnologyQingdaoShandong 266590China Key laboratory of Gold Mineralization Processes and Resource Utilization MNR/Key Laboratory of Metallogenic Geological Processes and Resource UtilizationShandong Province/Shandong Institute of Geological SciencesJinan 250013China laboratory for marine Mineral Resources Qingdao Marine Science and Technology CenterQingdaoShandong 266237China

The Wangjiazhuang Cu(-Mo)deposit,located within the Zouping volcanic basin in western Shandong Province,China,is unique in this area for having an economic *** order to expound the metallogenetic characteristics of this porphyry-like hydrothermal deposit,a detailed fluid inclusion study has been conducted,employing the techniques of representative sampling,fluid inclusion petrography,microthermometry,Raman spectroscopy,lA-ICP-MS analysis of single fluid inclusions,as well as cathode fluorescence spectrometer analysis of host mineral *** deposit contains mainly two types of orebodies,***-dissemination-stockwork orebodies in the K-Si alteration zone and pegmatiticquartz sulfide veins above *** addition,minor breccia ore occurs *** types of fluid inclusions in the deposit and altered quartz monzonite are identified:l-type one-or two-phase aqueous inclusions,V-type vapor-rich inclusions with V/l ratios greater than 50%-90%,D-type multiphase fluid inclusions containing daughter minerals or solids and S-type silicate-bearing fluid inclusions containing mainly muscovite and *** petrography and fluid inclusion study has revealed a three-stage mineralization process,driven by magmatic-hydrothermal fluid activity,as ***,a hydrothermal fluid,separated from the parent magma,infiltrated into the quartz monzonite,resulting in its extensive K-Si alteration,as indicated by silicate-bearing fluid inclusions trapped in altered quartz *** is followed by the early mineralization,the formation of quartz veinlets and dissemination-stockwork *** the main mineralization stage,due to the participation and mixing of meteoric groundwater with magmatic-sourced hydrothermal fluid,the cooling and phase separation caused deposition of metals from the hydrothermal *** a result,the pegmatitic-quartz sulfide-vein ores *** the late mineralization stage,decreasing fluid salinity led to the formation of l-type aqueous

关键词： fluid inclusions fluid immiscibility mineralization mechanisms Wangjiazhuang Cu(-Mo)deposit

Anti-inflammatory mechanism of the non-volatile ingredients performance liquid chromatography-heated electron spray ionization-high resolution mass spectroscope and cell metabolomics

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Journal of Traditional Chinese Medicine 2024年第2期44卷 260-267页

作者： JING Wenguang lIN Xiaoyu lI Chu ZHAO Xiaoliang CHENG Xianlong WANG Penglong WEI feng ma Shuangcheng Institute of Control of Chinese Traditional Medicine and Ethnic Medicine National Institutes for Food and Drug ControlBeijing 102629China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Beijing Key laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To explore the anti-inflammatory components and mechanism of the non-volatile ingredients of ***:High performance liquid chromatographyheated electron spray ionization-high resolution mass spectroscope(HPlC-HESI-HRMS)was used to analyze the chemical constituents of the non-volatile ingredients of *** anti-inflammatory activity of ingredients was evaluated using lipopolysaccharide(lPS)induced RAW264.7 cell inflammation model,and the antiinflammatory mechanism was investigated using multivariate statistical analysis of cell ***:The non-volatile ingredients of patchouli were characterized by HPlC-HESI-HRMS,and 36 flavonoids and 18 other components were *** ingredients of patchouli not only had a good protective effect on the lPS-induced inflammation model of RAW264.7 cells,but also regulated the expression levels of arginine,l-leucine,cholesterol,fructose and sorbitol by down-regulating arginine metabolism,aminoacyl-tRNA biosynthesis,polyol/sorbitol pathway,so as to reduce inflammation and reduce cell ***:The non-volatile ingredients of patchouli had good anti-inflammatory effect and exerted its curative effect by regulating endogenous metabolic pathway to reduce inflammatory response.

关键词： Pogostemon non-volatile ingredients anti-inflammatory cell metabolomics

Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo fGfR1 mutations

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Asian Journal of Andrology 2024年第4期26卷 426-432页

作者： Yu-fan Yang Hai-lu ma Xi Wang Min Nie Jiang-feng mao Xue-Yan Wu Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China.

fibroblast growth factor receptor 1(fGfR1)mutations are associated with congenital hypogonadotropic hypogonadism(CHH)through inheritance or spontaneous *** detected fGfR1 mutations in a Chinese cohort of 210 CHH patients at Peking Union Medical College Hospital(Beijing,China)using next-generation and Sanger *** assessed missense variant pathogenicity using six bioinformatics tools and compared clinical features and treatment outcomes between inherited and de novo mutation *** 19 patients with fGfR1 mutations,three were recurrent,and 16 were novel *** of the novel mutations were likely pathogenic according to the American College of Medical Genetics and Genomics(ACMG)guidelines,with the prevalent P366l *** majority of fGfR1 mutations was inherited(57.9%),with frameshift mutations exclusive to the de novo mutation *** inherited mutation group had a lower incidence of cryptorchidism,short stature,and skeletal *** the inherited mutation group,luteinizing hormone(lH)levels were 0.5 IU l−1,follicle-stimulating hormone(fSH)levels were 1.0 IU l−1,and testosterone levels were 1.3 nmol l−*** contrast,the de novo group had lH levels of 0.2 IU l−1,fSH levels of 0.5 IU l−1,and testosterone levels of 0.9 nmol l−1,indicating milder hypothalamus–pituitary–gonadal axis(HPGA)functional deficiency in the inherited *** inherited mutation group showed a tendency toward higher spermatogenesis *** conclusion,this study underscores the predominance of inherited fGfR1 mutations and their association with milder HPGA dysfunction compared to de novo mutations,contributing to our understanding of the genetic and clinical aspects of fGfR1 mutations.

关键词： congenital hypogonadotropic hypogonadism de novo fGfR1 inherited

磷化镍修饰磷掺杂氧化镓可见光催化水分解产氢

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无机化学学报 2024年第4期40卷 736-750页

作者：杨博吕功煊马建泰中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室兰州730000 中国科学院大学北京100049 兰州大学化学化工学院兰州730000

以Ga_(2)O_(3)半导体为前驱体,用浸渍加低温磷化法制备了P掺杂Ga_(2)O_(3)表面修饰Ni_(2)P光催化剂(x-Ni_(2)P/Ga_(2)O_(3)-P_(y),x代表Ni^(2+)和Ga_(2)O_(3)的物质的量之比,y代表NaH_(2)PO·H_(2)O与Ga_(2)O_(3)的物质的量之比)。5%-Ni_(2)P/Ga_(2)O_(3)-P_(6)催化剂展现出在纯水中光催化析氢的高活性,在430 nm光照下的光量子效率为0.22%。机理研究结果表明Ni_(2)P修饰和P掺杂扩展了催化剂的光响应范围,同时提升了载流子分离迁移效率,其长周期光催化反应稳定性明显优于未磷化催化剂。

关键词：氧化镓磷掺杂磷化镍光催化产氢

DOA estimation of high-dimensional signals based on Krylov subspace and weighted l_(1)-norm

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Journal of Systems Engineering and Electronics 2024年第3期35卷 532-540,F0002页

作者： YANG Zeqi lIU Yiheng ZHANG Hua ma Shuai CHANG Kai lIU Ning lYU Xiaode Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China National Key laboratory of Microwave Imaging Technology Beijing 100190China School of Electronic Electrical and Communication Engineering University of Chinese Academy of SciencesBeijing 100049China Northern Institute of Electronic Equipment Beijing 100191China

With the extensive application of large-scale array antennas,the increasing number of array elements leads to the increasing dimension of received signals,making it difficult to meet the real-time requirement of direction of arrival(DOA)estimation due to the computational complexity of *** subspace algorithms require estimation of the covariance matrix,which has high computational complexity and is prone to producing spurious *** order to reduce the computational complexity of DOA estimation algorithms and improve their estimation accuracy under large array elements,this paper proposes a DOA estimation method based on Krylov subspace and weighted l_(1)-*** method uses the multistage Wiener filter(MSWf)iteration to solve the basis of the Krylov subspace as an estimate of the signal subspace,further uses the measurement matrix to reduce the dimensionality of the signal subspace observation,constructs a weighted matrix,and combines the sparse reconstruction to establish a convex optimization function based on the residual sum of squares and weighted l_(1)-norm to solve the target *** results show that the proposed method has high resolution under large array conditions,effectively suppresses spurious peaks,reduces computational complexity,and has good robustness for low signal to noise ratio(SNR)environment.

关键词： direction of arrival(DOA) compressed sensing(CS) Krylov subspace l_(1)-norm dimensionality reduction

New insights into the interactions between the gut microbiota and the inflammatory response to ulcerative colitis in a mouse model of dextran sodium sulfate and possible mechanisms of action for treatment with PE&AfWE

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Animal Models and Experimental Medicine 2024年第2期7卷 83-97页

作者： Qianhui fu Xiaoqin ma Shuchun li Mengni Shi Tianyuan Song Jian Cui Key laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijingChina

Background:Inflammatory bowel disease(IBD),comprising Crohn's disease(CD)and ulcerative colitis(UC),is a heterogeneous state of chronic intestinal *** innate immunity,including innate immune cells,defends against pathogens and excessive entry of gut microbiota,while preserving immune tolerance to resident intestinal microbiota,and may be characterized by its capacity to produce a rapid and nonspecific *** association between microbiota dysbiosis and the pathogenesis of IBD is complex and *** the intestinal ecosystem is in dysbiosis,the reduced abundance and diversity of intestinal gut microbiota make the host more vulnerable to the attack of exogenous and endogenous pathogenic gut *** aim of our study was to comprehensively assess the relationship between microbial populations within UC,the signaling pathways of pathogenic gut microbe therein and the inflammatory response,as well as to understand the effects of using PE&AfWE(poppy extract[Papaver nudicaule l.]and Artemisia frigida ***)on UC ***:A UC mouse model was established by inducing SPf-grade C57Bl/6 mice using dextrose sodium sulfate(DSS).Based on metagenomic sequencing to characterize the gut microbiome,the relationship between gut microbiota dysbiosis and gut microbiota was further studied using random forest and Bayesian network analysis methods,as well as histopathological ***:(1)We found that the 5 gut microbiota with the highest relative abundance of inflammatory bowel disease UC model gut microbiota were consistent with the top 5 ranked natural *** were three types of abundance changes in the model groups:increases(Chlamydiae/Proteobacteria and Deferribacteres),decreases(firmicutes),and no significant changes(Bacteroidetes).The UC model group was significantly different from the control group,with 1308 differentially expressed species with abundance changes greater than or equal to 2-fold.(2)The proportion

关键词： Arachidonic acid metabolism Gut microbiota Microbial dysbiosis Proteobacteria