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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel f.López-Aranda Juan f.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNf).A knockdown of BDNf gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNf-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

Uncovering the epidemiology of bladder cancer in the Arab world: A review of risk factors, molecular mechanisms, and clinical features

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Asian Journal of Urology 2024年第3期11卷 406-422页

作者： Noura f.Abbas Marc R.Aoude Hampig R.Kourie Humaid OAl-Shamsi Department of Hematology-Oncology Hotel Dieu De France HospitalSaint Joseph University of BeirutRiad El SolhLebanon Department of Oncology Burjeel Cancer InstituteBurjeel Medical CityAbu DhabiUnited Arab Emirates Innovation and Research Center Burjeel Cancer InstituteBurjeel Medical CityAbu DhabiUnited Arab Emirates College of Medicine University of SharjahSharjahUnited Arab Emirates Emirates Oncology Society DubaiUnited Arab Emirates College of Medicine Gulf Medical UniversityAjmanUnited Arab Emirates

Objective:Bladder cancer(BC)is a significant public health concern in the Middle East and North Africa,but the epidemiology and clinicopathology of the disease and contributors to high mortality in this region remain poorly *** aim of this systematic review was to investigate the epidemiological features of BC in the Arab world and compare them to those in Western countries in order to improve the management of this ***:An extensive electronic search of the PubMed/PMC and Cochrane Library databases was conducted to identify all articles published until May 2022,following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.A total of 95 articles were included in the final analysis after title,abstract,and full-text screening,with additional data obtained from the GLOBOCAN and WHO 2020 databases.

关键词： Bladder cancer Epidemiology Risk factor Biomarker Schistosomiasis Arab world Urology

GliomaCNN: An Effective Lightweight CNN Model in Assessment of Classifying Brain Tumor from Magnetic Resonance Images Using Explainable AI

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2425-2448页

作者： Md.Atiqur Rahman Mustavi Ibne Masum Khan Md Hasib M.f.Mridha Sultan Alfarhood Mejdl Safran Dunren Che Department of Computer Science and Engineering Ahsanullah University of Science and TechnologyDhaka1208Bangladesh Department of Computer Science and Software Engineering The University of Western AustraliaPerthWA 6009Australia Department of Computer Science American International University-BangladeshDhaka1229Bangladesh Department of Computer Science College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia School of Computing Southern Illinois UniversityCarbondale62901USA

Brain tumors pose a significant threat to human lives and have gained increasing attention as the tenth leading cause of global *** study addresses the pressing issue of brain tumor classification using Magnetic resonance imaging(MRI).It focuses on distinguishing between Low-Grade Gliomas(LGG)and High-Grade Gliomas(HGG).LGGs are benign and typically manageable with surgical resection,while HGGs are malignant and more *** research introduces an innovative custom convolutional neural network(CNN)model,*** stands out as a lightweight CNN model compared to its *** research utilized the BraTS 2020 dataset for its *** with the gradient-boosting algorithm,GliomaCNN has achieved an impressive accuracy of 99.1569%.The model’s interpretability is ensured through SHapley Additive exPlanations(SHAP)and Gradient-weighted Class Activation Mapping(Grad-CAM++).They provide insights into critical decision-making regions for classification *** challenges in identifying tumors in images without visible signs,the model demonstrates remarkable performance in this critical medical application,offering a promising tool for accurate brain tumor diagnosis which paves the way for enhanced early detection and treatment of brain tumors.

关键词： Deep learning magnetic resonance imaging convolutional neural networks explainable AI boosting algorithm ablation

Evaluating transient behaviour of large-scale photovoltaic systems during lightning events using enhanced finite difference time domain method with variable cell size approach

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High Voltage 2024年第3期9卷 636-647页

作者： Ibrahim Hetita Diaa-Eldin A.Mansour Yang Han Ping Yang Congling Wang Mohamed M.f.Darwish Matti Lehtonen Amr S.Zalhaf School of Mechanical and Electrical Engineering University of Electronic Science and Technology of China(UESTC)ChengduChina Electrical Power and Machines Engineering Department Faculty of EngineeringHelwan UniversityCairoEgypt Electrical Power and Machines Engineering Department Faculty of EngineeringTanta UniversityTantaEgypt Department of Electrical Power Engineering Faculty of EngineeringEgypt-Japan University of Science and TechnologyAlexandriaEgypt Department of Electrical Engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of Electrical Engineering and Automation School of Electrical EngineeringAalto UniversityEspooFinland

Photovoltaic(PV)arrays are usually installed in open areas;hence,they are vulnerable to lightning strikes that can result in cell degradation,complete damage,service disruption,and increased maintenance *** a result,it is imperative to develop an effective and efficient lightning protection system by evaluating the transient behaviour of PV arrays during lightning *** aim is to evaluate the transient analysis of large-scale PV systems when subjected to lightning strikes using the finite difference time domain(fDTD)*** overvoltages are calculated at various points within the mounting *** optimise the fDTD method's execution time and make it more suitable for less powerful hardware,a variable cell size approach is ***,larger cell dimensions are used in the earthing system and smaller cell dimensions are used in the mounting *** fDTD method is utilised to calculate the temporal variation of transient overvoltages for large-scale PV systems under different scenarios,including variations in the striking point,soil resistivity,and the presence of a metal *** results indicate that the highest transient overvoltages occur at the striking point,and these values increase with the presence of a PV metal frame as well as with higher soil ***,a comparison is performed between the overvoltage results obtained from the fDTD approach and the partial element equivalent circuit(PEEC)method at the four corner points of the mounting systems to demonstrate the superior accuracy of the fDTD ***,a laboratory experiment is conducted on a small-scale PV system to validate the simulation *** calculated overvoltages obtained from the fDTD and PEEC methods are compared with the measured values,yielding a mean absolute error of 5%and 11%for the fDTD and PEEC methods,respectively,thereby confirming the accuracy of the fDTD simulation model.

关键词： transient behaviour finite

Towards efficient strain engineering of 2D materials:A four-points bending approach for compressive strain

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Nano Research 2024年第6期17卷 5317-5325页

作者： Hao Li félix Carrascoso Ana Borrás Gloria P.Moreno francisco J.Aparicio Ángel Barranco Andrés Castellanos Gómez Campus de Cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnology on Surfaces and Plasma Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Departamento de física Aplicada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

Strain engineering,as a powerful strategy to tune the optical and electrical properties of two-dimensional(2D)materials by deforming their crystal lattice,has attracted significant interest in recent years.2D materials can sustain ultra-high strains,even up to 10%,due to the lack of dangling bonds on their surface,making them ideal brittle *** remarkable mechanical resilience,together with a strong strain-tunable band structure,endows 2D materials with a broad optical and electrical response upon ***,strain engineering based on 2D materials is restricted by their nanoscale and strain quantification *** this study,we have modified a homebuilt three-points bending apparatus to transform it into a four-points bending apparatus that allows for the application of both compressive and tensile strains on 2D *** approach allows for the efficient and reproducible construction of a strain system and minimizes the buckling effect caused by the van der Waals interaction by adamantane encapsulation *** results demonstrate the feasibility of introducing compressive strain on 2D materials and the potential for tuning their optical and physical properties through this approach.

关键词： uniaxial compressive strain polymer encapsulation differential reflectance spectroscopy exciton tunability

An intrinsically self-healing and anti-freezing molecular chains induced polyacrylamide-based hydrogel electrolytes for zinc manganese dioxide batteries

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Journal of Energy Chemistry 2024年第2期89卷 565-578,I0013页

作者： Haiyang Liao Wenzhao Zhong Chen Li Jieling Han Xiao Sun Xinhui Xia Ting Li Abolhassan Noori Mir f.Mousavi Xin Liu Yongqi Zhang Institute of fundamental and frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Mechanical Engineering Hunan University of TechnologyZhuzhou 412007HunanChina School of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Department of Chemistry Faculty of Basic SciencesTarbiat Modares UniversityTehran 14117-13116Iran State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina

The anti-freezing strategy of hydrogels and their self-healing structure are often contradictory,it is vital to break through the molecular structure to design and construct hydrogels with intrinsic anti-freezing/self-healing for meeting the rapid development of flexible and wearable devices in diverse service ***,we design a new hydrogel electrolyte(Af/SH-Hydrogel)with intrinsic anti-freezing/self-healing capabilities by introducing ethylene glycol molecules,dynamic chemical bonding(disulfide bond),and supramolecular interaction(multi-hydrogen bond)into the polyacrylamide molecular *** to the exceptional freeze resistance(84%capacity retention at-20℃)and intrinsic self-healing capabilities(95%capacity retention after 5 cutting/self-healing cycles),the obtained Af/SH-Hydrogel makes the zinc||manganese dioxide cell an economically feasible battery for the state-of-the-art *** Zn||Af/SH-Hydrogel||MnO_(2)device offers a near-theoretical specific capacity of 285 m A h g^(-1)at 0.1 A g^(-1)(Coulombic efficiency≈100%),as well as good self-healing capability and mechanical flexibility in an ice *** work provides insight that can be utilized to develop multifunctional hydrogel electrolytes for application in next generation of self-healable and freeze-resistance smart aqueous energy storage devices.

关键词： flexible aqueous battery Hydrogel electrolyte Anti-freezing Self-healing Dual-dynamic reversible bond

Novel Sustainable Cellulose Acetate Based Biosensor for Glucose Detection

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Journal of Renewable Materials 2024年第2期12卷 369-380页

作者： M.f.Elkady E.M.El-Sayed Mahmoud Samy Omneya A.Koriem H.Shokry Hassan Chemical and Petrochemical Engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt fabrication Technology Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt Department of Public Works Engineering Faculty of EngineeringMansoura UniversityMansoura35516Egypt Environmental Engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Electronic Materials Research Department Advanced Technology and NewMaterials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt

In this study,green zinc oxide(ZnO)/polypyrrole(Ppy)/cellulose acetate(CA)film has been synthesized via solvent *** film was used as supporting material for glucose oxidase(GOx)to sensitize a glucose *** nanoparticles have been prepared via the green route using olive leaves extract as a ***/Ppy nanocomposite has been synthesized by a simple in-situ chemical oxidative polymerization of pyrrole(Py)monomer using ferric chloride(feCl3)as an oxidizing *** produced materials and the composite films were characterized using X-ray diffraction analysis(XRD),scanning electron microscope(SEM),fourier transform infrared(fTIR)and thermogravimetric analysis(TGA).Glucose oxidase was successfully immobilized on the surface of the prepared film and then ZnO/Ppy/CA/GOx composite was sputtered with platinum electrode for the current determination at different initial concentrations of *** measurements proved the suitability and the high sensitivity of the constructed biosensor for the detection of glucose levels in different *** performance of the prepared biosensor has been assessed by measuring and comparing glucose concentrations up to 800 *** results affirmed the reliability of the developed biosensor towards real samples which suggests the wide-scale application of the proposed biosensor.

关键词： Biosensors composite films glucose polypyrrole green ZnO cellulose acetate

Effect of solidification cooling rate on microstructure and tribology characteristics of Zn-4Si alloy

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 362-373页

作者： f.Akbari M.Golkaram S.Beyrami G.Shirazi K.Mantashloo R.Taghiabadi M.Saghafi Yazdi I.Ansarian Department of Metallurgy and Material Science Imam Khomeini International University(IKIU)Qazvin ***Iran

The main objective of this work was to modify the microstructure and enhance the tribological properties of a new Zn-4Si al-loy through a high solidification cooling rate(SCR).According to the results,by increasing the SCR from 2.0 to 59.5℃/s the average size of primary Si particles and that of the grains reduced from 76.1 and 3780μm to less than about 14.6 and 460μm,***-ing the SCR also enhanced the microstructural homogeneity,decreased the porosity content(by 50%),and increased the matrix hardness(by 36%).These microstructural changes enhanced the tribological *** instance,under the applied pressure of 0.5 MPa,an in-crease in the SCR from 2.0 to 59.5℃/s decreased the wear rate and the average friction coefficient of the alloy by 57%and 23%,*** wear mechanism was also changed from the severe delamination,adhesion,and abrasion in the slowly-cooled alloy to the mild tribolayer delamination/abrasion in the high-cooling-rate-solidified sample.

关键词： zinc-silicon alloy primary silicon solidification cooling rate tribology sliding wear

Boron neutron capture therapy of cancer:where do we stand now?

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Cancer Communications 2024年第8期44卷 889-892页

作者： Rolf f.Barth Gong Wu Maria da Graca H.Vicente John C Grecula Nilendu Gupta Department of Pathology The Ohio State UniversityColumbusOhioUSA Mass Spectrometry and Proteomics facility The Ohio State UniversityColumbusOhioUSA Department of Chemistry Louisiana State UniversityBaton RougeLouisianaUSA Department of Radiation Oncology The Ohio State UniversityColumbusOhioUSA

1 INTRODUCTION,This is the third Editorial/Commentary that one of us(***)has written relating to boron neutron capture therapy(BNCT)[1,2].for those readers who are unfamiliar with BNCT we would refer them to several recent comprehensive reviews[3–5].The second Editorial ended on a hopeful note that with the introduction of acceleratorbased neutron sources(ABNSs),BNCT would enter into the mainstream of radiation therapy[2].

关键词： boron 1,2 neutron