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振源胶囊结合比索洛尔对冠心病心绞痛患者心肌重构和心功能改善效果的研究

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中国医学创新 2025年第1期22卷 39-43页

作者：承卡常州市中医医院GCP办公室江苏常州213003

目的:研究振源胶囊结合比索洛尔对冠心病心绞痛患者的心肌重构和心功能的改善效果。方法:选择2021年8月—2023年9月于常州市中医医院治疗的84例冠心病心绞痛患者,随机分为对照组和研究组,各42例。对照组给予比索洛尔治疗,研究组在对照... 详细信息

目的:研究振源胶囊结合比索洛尔对冠心病心绞痛患者的心肌重构和心功能的改善效果。方法:选择2021年8月—2023年9月于常州市中医医院治疗的84例冠心病心绞痛患者,随机分为对照组和研究组,各42例。对照组给予比索洛尔治疗,研究组在对照组基础上加用振源胶囊治疗。比较两组临床疗效、心绞痛症状及治疗前后心肌重构指标、血管内皮功能参数。结果:研究组心绞痛总有效率、心电图总有效率均高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组心绞痛持续时间均短于治疗前,发作次数均少于治疗前,且研究组心绞痛持续时间短于对照组,发作次数少于对照组,差异均有统计学意义(P<0.05)。治疗后,两组左心室质量(LVM)、左心室质量指数(LVMI)、内皮素-1(ET-1)水平均低于治疗前,一氧化氮(NO)水平均高于治疗前,且研究组LVMI、LVM、ET-1水平均低于对照组,NO水平高于对照组,差异均有统计学意义(P<0.05)。结论:振源胶囊结合比索洛尔可以明显改善冠心病心绞痛患者的心肌重构和心功能,治疗效果良好。

关键词：振源胶囊比索洛尔冠心病心绞痛心肌重构心功能

Performance analysis of visual markers for indoor navigation systems

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frontiers of Information Technology & Electronic Engineering 2016年第8期17卷 730-740页

作者： Gaetano C.LA deLfA Salvatore MONTELEONE Vincenzo CATANIA Juan f.de PAZ Javier BAJO department of Electrical Electronics and Computer Engineering (DIEEI) University of Catania Catania 95125 Italy BISITE Research Group Faculty of Science University of Salamanca Salamanca 37007 Spain department of Artificial Intelligence Polytechnic University of Madrid Madrid 28660 Spain

The massive diffusion of smartphones, the growing interest in wearable devices and the Internet of Things, and the exponential rise of location based services（LBSs） have made the problem of localization and navigation inside buildings one of the most important technological challenges of recent years. Indoor positioning systems have a huge market in the retail sector and contextual advertising; in addition, they can be fundamental to increasing the quality of life for citizens if.deployed inside public buildings such as hospitals, airports, and ***, in emergency situations, they can make the difference between life and death. Various approaches have been proposed in the literature. Recently, thanks to the high performance of smartphones＇ cameras, marker-less and marker-based computer vision approaches have been investigated. In a previous paper, we proposed a technique for indoor localization and navigation using both Bluetooth low energy（BLE） and a 2D visual marker system deployed into the floor. In this paper, we presented a qualitative performance evaluation of three 2D visual markers, Vuforia,Ar Uco marker, and AprilT ag, which are suitable for real-time applications. Our analysis focused on specific case study of visual markers placed onto the tiles, to improve the efficiency of our indoor localization and navigation approach by choosing the best visual marker system.

关键词： Indoor localization Visual markers Computer vision

Endo-microscopy beyond the Abbe and Nyquist limits

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Light(Science & Applications) 2020年第1期9卷 1246-1257页

作者： Lyubov V.Amitonova Johannes f.de Boer LaserLaB Department of Physics and AstronomyVrije Universiteit AmsterdamDe Boelelaan 10811081 HV AmsterdamThe Netherlands Advanced Research Center for Nanolithography(ARCNL) Science Park 1061098 XG AmsterdamThe Netherlands

for several centuries,far-field optical microscopy has remained a key instrument in many scientific disciplines,including physical,chemical,and biomedical ***,far-field imaging has many limitations:the spatial resolution is controlled by the diffraction of light,and the imaging speed follows the Nyquist–Shannon sampling *** recent development of super-resolution techniques has pushed the limits of spatial ***,these methods typically require complicated setups and long acquisition times and are still not applicable to deeptissue ***,we report imaging through an ultra-thin fibre probe with a spatial resolution beyond the Abbe limit and a temporal resolution beyond the Nyquist limit simultaneously in a simple and compact *** use the random nature of mode coupling in a multimode fibre,the sparsity constraint and compressive sensing *** new approach of super-resolution endo-microscopy does not use any specific properties of the fluorescent label,such as depletion or stochastic activation of the molecular fluorescent state,and therefore can be used for label-free *** demonstrate a spatial resolution more than 2 times better than the diffraction limit and an imaging speed 20 times faster than the Nyquist *** proposed approach can significantly expand the realm of the application of nanoscopy for bioimaging.

关键词： beyond limit fibre

棘突间移植物治疗腰椎关节突关节退变的初期结果

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中华骨科杂志 2009年第9期29卷 811-816页

作者：刘宝戈 Giovanni Alessi Hendrik fransen f.de Waele 比利时根特Sint-Lucas总医院脊柱中心

目的评价棘突间移植物-DIAM（device for intervertebral assisted motion）对腰椎关节突关节退变的治疗效果及相关术中、术后并发症。方法对2005年8月至2006年4月接受DIAM移植的22例患者进行回顾性分析。女14例，男8例；平均年龄38．5... 详细信息

目的评价棘突间移植物-DIAM（device for intervertebral assisted motion）对腰椎关节突关节退变的治疗效果及相关术中、术后并发症。方法对2005年8月至2006年4月接受DIAM移植的22例患者进行回顾性分析。女14例，男8例；平均年龄38．5（24-59）岁。单节段14例，双节段8例；单发腰椎关节突关节退变诱发腰痛16例（其中3例为腰椎人工间盘置换术后残留腰痛），腰椎间盘突出3例，腰椎管狭窄伴间歇性跛行2例，腰椎间盘后路摘除术后1例。结果手术时间为25min（单节段）和35min（双节段）。术后所有患者随访16-28个月，平均17个月。术后影像学检查显示移植物无明显迁移。正位X线片显示移植物撑开了棘突间间隙，侧位X线片显示神经根管高度、椎间隙后高度术前及术后66周的比较差异有统计学意义（P〈0．01）。术后症状改善程度采用Odom评估法，优7例，良10例，可1例，差4例；优良率77.3％。视觉模拟评分由术前平均（7．09±0．92）分改善至术后66周平均（3．23±1．82）分，差异有统计学意义（P〈0．01）。随访期间未发生症状加重、移植物松脱及术后翻修。结论应用棘突间移植物技术治疗单发的腰椎关节突关节退变，保留了腰椎后柱结构稳定性，操作简单。通过棘突间撑开作用降低了关节突关节的应力，增加了神经根管高度，恢复了腰椎后柱高度。

关键词：腰椎腰痛椎关节突关节假体和植人物治疗结果

哮喘患者全血在尘螨主要过敏原刺激下辅助性T淋巴细胞1/辅助性T淋巴细胞2细胞内细胞因子的表达与偏移

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上海医学 2005年第8期28卷 637-639页

作者：邵洁 A.Purohit 石学耕俞善昌邓伟吾 f.de Blay 上海第二医科大学附属瑞金医院儿科法国Louis Pasteur大学肺和变态反应科上海第二医科大学生物物理研究室上海第二医科大学附属瑞金医院肺科

目的对尘螨过敏的哮喘儿童外周全血体外持续给予尘螨主要过敏原der p和der f刺激,观察辅助性T淋巴细胞(Th)内细胞因子的表达,探讨过敏原暴露对Th1/Th2偏移的影响。方法选择尘螨皮试阳性的哮喘患者23例,采集全血,体外与尘螨主要过敏原de... 详细信息

目的对尘螨过敏的哮喘儿童外周全血体外持续给予尘螨主要过敏原der p和der f刺激,观察辅助性T淋巴细胞(Th)内细胞因子的表达,探讨过敏原暴露对Th1/Th2偏移的影响。方法选择尘螨皮试阳性的哮喘患者23例,采集全血,体外与尘螨主要过敏原der p、der f共同孵育培养8h,以单克隆抗体对T淋巴细胞表面抗原、细胞内白介素(IL)-4,干扰素(IfN)-γ进行标记,应用流式细胞技术检测Th细胞内细胞因子的表达。结果哮喘患者全血体外der p、der f持续暴露后(过敏原暴露组),Th0、Th1、Th2表达率分别为(0.83±0.45)%、(10.70±4.42)%、(2.16±1.17)%,非过敏原暴露组Th0、Th1、Th2表达率分别为(0.93±0.52)%、(9.19±3.75)%、(1.67±0.82)%。过敏原暴露组Th2表达率显著高于非过敏原暴露组(P0.05)。过敏原暴露组因Th2增高,Th1/Th2比例降低,Th1/Th2平衡向Th2偏移,与非过敏原暴露组的差异有显著性(Pder p、der f对Th细胞有明显的选择性,过敏原的持续暴露促进Th2优势表达,Th1/Th2平衡向Th2转化,可能是引起哮喘症状反复和加重的机制之一。因此,过敏原的回避和特异性的脱敏治疗也是哮喘治疗的措施之一,应予以必要的重视。

关键词：屋尘螨过敏原辅助性T淋巴细胞1 辅助性T淋巴细胞2 流式细胞术辅助性T淋巴细胞细胞内细胞因子尘螨过敏哮喘患者过敏原 Th1/Th2比例

AdS/QCD and light front holography: A new approximation to QCD

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Chinese Physics C 2010年第9期34卷 1229-1235页

作者： Stanley J.Brodsky Guy f.de Téramond SLAC National Accelerator Laboratory Stanford University Universidad de Costa Rica

The combination of Anti-de Sitter space （AdS） methods with light-front holography leads to a semi-classical first approximation to the spectrum and wavefunctions of meson and baryon light-quark bound *** from the bound-state Hamiltonian equation of motion in QCD,we derive relativistic lightfront wave equations in terms of an invariant impact variable ζ which measures the separation of the quark and gluonic constituents within the hadron at equal light-front *** equations of motion in physical space-time are equivalent to the equations of motion which describe the propagation of spin-J modes in anti–de Sitter （AdS） *** eigenvalues give the hadronic spectrum,and its eigenmodes represent the probability distributions of the hadronic constituents at a given *** to the light meson and baryon spectra are *** predicted meson spectrum has a string-theory Regge form M^ 2 = 4κ ^2 （n＋L＋S/2）;i.e.,the square of the eigenmass is linear in both L and n,where n counts the number of nodes of the wavefunction in the radial variable ζ.The space-like pion and nucleon form factors are also well *** thus obtains a remarkable connection between the description of hadronic modes in AdS space and the Hamiltonian formulation of QCD in physical space-time quantized on the light-front at fixed light-front time τ.The model can be systematically improved by using its complete orthonormal solutions to diagonalize the full QCD lightfront Hamiltonian or by applying the Lippmann-Schwinger method in order to systematically include the QCD interaction terms.

关键词： gauge/gravity correspondence light-front dynamics strongly coupled QCD meson and baryon spectrum meson and nucleon form factors

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水电厂的频率调节

水电站机电技术 1987年第2期 59-66页

作者： f.de Leva 刘兴文

本文阐述了水电厂压力管道和发电机的设计对频率调节的影响。提供了在某一特定的频率调节品质下估算压力管道及发电机参数的方法。对稳定性和频率调节品质进行校核是水电厂设计的一个重要方面

关键词：时间常数发电机方框图频率调节调频比转速比转数水电厂调速器速度调节器混流式水轮机法兰西斯式水轮机反击式水轮机压力管道压力水管输水建筑物频率响应频率特性

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of.demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Anomalous transport of light at the phase transition to localization:strong dependence with incident angle

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Photonics Research 2018年第10期6卷 929-942页

作者： ERNESTO JIMENEZ-VILLAR M.C.S.XAVIER NIKLAUS U.WETTER VALdeCI MESTRE WELITON S.MARTINS GABRIEL f.BASSO V.A.ERMAKOV f.C.MARQUES GILBERTO f.de SA Instituto de Pesquisas Energeticas e Nucleares CNEN_IPENSao PauloSP 05508-000Brazil departamento de ffsica Universidade Federal da ParaibaJoao PessoaPB 58051-970Brazil departamento de fisica Universidade Estadual da ParaibaArarunaPB 58233-000Brazil CCEA Universidade Estadual da ParaibaPatosPB 58706-560Brazil departamento de fisica Universidade Federal Rural de PernambucoRecifePE 52171-900Brazil departamento de Informatica Universidade Federal da ParaibaJoao PessoaPB 58055-000Brazil departamento de fisica Aplicada Universidade Estadual de CampinasCampinasSP 13083-859Brazil Quimica fundamental Universidade Federal de PernambucoRecifePE 50670-901Brazil

There has been a growing interest in disordered optical media in recent years due to their potential applications in solar collectors, random lasers, light confinement, and other advanced photonic functions. This paper studies the transport of light for different incidence angles in a strongly disordered optical medium composed of core-shell TiO_2@Silica nanoparticles suspended in an ethanol solution. A decrease of optical conductance and an increase of absorption near the input border are reported when the incidence angle increases. The specular reflection, measured for the photons that enter the sample, is lower than the effective internal reflection undergone by the coherently backscattered photons in the exact opposite direction, indicating a nonreciprocal propagation of *** study represents a novel approach in order to understand the complex physics involved at the phase transition to localization.

关键词：光学介质太阳能通讯技术发展现状