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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes flexible transparent memory

Merging bound states in the continuum in an open acoustic resonator

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Science china(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang chen Shen Almas f.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BIcs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIc is very sensitive to the structure ***,we report merging acoustic BIcs in a single open resonator,robust against the structure *** find that both symmetry-protected BIc and friedrich-Wintgen BIc are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BIcs move toward each other and merge into a single one at a critical *** to an individual BIc,the merged BIc is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BIcs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of Energy chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim School of Electrical Engineering Korea University computational Electronics and Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao chavan School of Rural Development Shivaji University

Organic solar cells(OScs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OScs can be complex, expensive, and time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OScs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PcE) of ternary OScs(TOScs) based on a PM6 ***, we collected the device parameters of PM6-based TOScs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different ML algorithms for analysis and prediction. for the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction ML algorithms in predicting the output performance of PM6-based TOScs. finally, we validated the ML outcomes by fabricating PM6-based TOScs. Our study presents a rapid strategy for assessing a high PcE while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

THERMODYNAMIc VARIATIONAL APPROAcH fOR cLIMB Of AN EDGE DISLOcATION

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Acta Mechanica Solida Sinica 2009年第5期22卷 426-435页

作者： A.c.f.cocks Department of Engineering Science University of OxfordParks RoadOxfordOX1 3PJUK

A general thermodynamic variational approach is applied to study the force on an edge dislocation, which drives the dislocation to climb. Our attention is focused on the physical mechanism responsible for dislocation climb. A dislocation in a material element climbs as a result of vacancies diffusing into or out from the dislocation core, with the dislocation acting as a source or a sink for vacancy diffusion in the material element. The basic governing equations for dislocation climb and the climb forces on the dislocation are obtained naturally as a result of the present thermodynamic variational approach.

关键词： dislocation climb driving forces variational principle

High Strain Rate Superplasticity in a Micro-grained Al-Mg-Sc Alloy with Predominant High Angle Grain Boundaries

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Journal of Materials Science & Technology 2012年第11期28卷 1025-1030页

作者： f. c. Liu Z.Y. Ma f. c. Zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004China

friction stir processing （fSP） was applied to extruded AI-Mg-Sc alloy to produce fine-grained microstructure with a grain size of 2.2μm. Electron backscatter diffraction （EBSD） result showed that the grain boundary misorientation distribution was very close to a random grain assembly for randomly oriented cubes. Super- plastic investigations in the temperature range of 425-500 ℃ and strain rate range of 1x100^-2-1x10 s^-1 showed that a maximum elongation of 1500% was achieved at 475 ℃ and a high strain rate of 1x100^-2-1x10 s^-1. The fSP AI-Mg-Sc exhibited enhanced superplastic deformation kinetics compared to that predicted by the constitutive relationship for superplasticity in fine-grained aluminum alloys. The origin for enhanced superplas- tic deformation kinetics in the fSP alloy can be attributed to its high fraction of high angle grain boundaries （HAGBs）. The analyses of the superplastic data and scanning electron microscopy （SEM） examinations on the surfaces of deformed specimens indicated that grain boundary sliding is the main superplastic deformation mechanism for the fSP AI-Mg-Sc alloy.

关键词： Superplasticity friction stir processing Aluminum Microstructure friction stir welding

Engineering vibration monitoring by GPS:long duration records

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Earthquake Engineering and Engineering Vibration 2009年第3期8卷 459-467页

作者： f.casciati c.fuggini Department of Structural Mechanics University of PaviaItaly

Monitoring the performance of any structure requires real-time measurements of the change of position of critical points. Different techniques can be used for this purpose, each one offering advantages and disadvantages. The technique based on satellite positioning systems （GPS, GLONASS and the future GALILEO） seems to be very promising at least for long period structures. The GPS in particular provides sampling rates that are able to track dynamic displacements with high accuracy. Its service ability is independent of atmospheric conditions, temperature variations and visibility of the monitored object. This paper investigates the reliability and accuracy of the measurements of dual frequency GPS receivers. A linear electromagnetic motor moves an object along a given direction. The changes of position are compared witb their estimates as recorded by a GPS receiver, whose antenna is located on the reference object. The comparison is based on sufficiently long records.

关键词： infrastructure monitoring global positioning system (GPS) delay positioning errors multi-path error signal geometric dilution of precision linear motor amplitudes power spectral densities

Exact Time-Dependent Wave functions of a confined Time-Dependent Harmonic Oscillator with Two Moving Boundaries

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communications in Theoretical Physics 2009年第11期52卷 820-824页

作者： c.f.Lo Institute of Theoretical Physics and Department of Physics The Chinese University of Hong Kong

By applying the standard analytical techniques of solving partial differential equations, we have obtained the exact solution in terms of the fourier sine series to the time-dependent Schrodinger equation describing a quantum one-dimensional harmonic oscillator of time-dependent frequency confined in an infinite square well with the two walls moving along some parametric trajectories. Based upon the orthonormal basis of quasi-stationary wave functions, the exact propagator of the system has also been analytically derived. Special eases like （i） a confined free particle, （ii） a confined time-independent harmonic oscillator, and （iii） an aging oscillator are examined, and the corresponding time- dependent wave functions are explicitly determined. Besides, the approach has been extended to solve the case of a confined generalized time-dependent harmonic oscillator for some parametric moving boundaries as well.

关键词： infinite square well harmonic oscillator moving boundaries fourier series