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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

THERMODYNAMIc VARIATIONAL APPROAcH fOR cLIMB Of AN EDGE DISLOcATION

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Acta Mechanica Solida Sinica 2009年第5期22卷 426-435页

作者： A.c.f.cocks Department of Engineering Science University of OxfordParks RoadOxfordOX1 3PJUK

A general thermodynamic variational approach is applied to study the force on an edge dislocation, which drives the dislocation to climb. Our attention is focused on the physical mechanism responsible for dislocation climb. A dislocation in a material element climbs as a result of vacancies diffusing into or out from the dislocation core, with the dislocation acting as a source or a sink for vacancy diffusion in the material element. The basic governing equations for dislocation climb and the climb forces on the dislocation are obtained naturally as a result of the present thermodynamic variational approach.

关键词： dislocation climb driving forces variational principle

High Strain Rate Superplasticity in a Micro-grained Al-Mg-Sc Alloy with Predominant High Angle Grain Boundaries

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Journal of Materials Science & Technology 2012年第11期28卷 1025-1030页

作者： f. c. Liu Z.Y. Ma f. c. Zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004China

friction stir processing （fSP） was applied to extruded AI-Mg-Sc alloy to produce fine-grained microstructure with a grain size of 2.2μm. Electron backscatter diffraction （EBSD） result showed that the grain boundary misorientation distribution was very close to a random grain assembly for randomly oriented cubes. Super- plastic investigations in the temperature range of 425-500 ℃ and strain rate range of 1x100^-2-1x10 s^-1 showed that a maximum elongation of 1500% was achieved at 475 ℃ and a high strain rate of 1x100^-2-1x10 s^-1. The fSP AI-Mg-Sc exhibited enhanced superplastic deformation kinetics compared to that predicted by the constitutive relationship for superplasticity in fine-grained aluminum alloys. The origin for enhanced superplas- tic deformation kinetics in the fSP alloy can be attributed to its high fraction of high angle grain boundaries （HAGBs）. The analyses of the superplastic data and scanning electron microscopy （SEM） examinations on the surfaces of deformed specimens indicated that grain boundary sliding is the main superplastic deformation mechanism for the fSP AI-Mg-Sc alloy.

关键词： Superplasticity friction stir processing Aluminum Microstructure friction stir welding

Engineering vibration monitoring by GPS:long duration records

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Earthquake Engineering and Engineering Vibration 2009年第3期8卷 459-467页

作者： f.casciati c.fuggini Department of Structural Mechanics University of PaviaItaly

Monitoring the performance of any structure requires real-time measurements of the change of position of critical points. Different techniques can be used for this purpose, each one offering advantages and disadvantages. The technique based on satellite positioning systems （GPS, GLONASS and the future GALILEO） seems to be very promising at least for long period structures. The GPS in particular provides sampling rates that are able to track dynamic displacements with high accuracy. Its service ability is independent of atmospheric conditions, temperature variations and visibility of the monitored object. This paper investigates the reliability and accuracy of the measurements of dual frequency GPS receivers. A linear electromagnetic motor moves an object along a given direction. The changes of position are compared witb their estimates as recorded by a GPS receiver, whose antenna is located on the reference object. The comparison is based on sufficiently long records.

关键词： infrastructure monitoring global positioning system (GPS) delay positioning errors multi-path error signal geometric dilution of precision linear motor amplitudes power spectral densities

Exact Time-Dependent Wave functions of a confined Time-Dependent Harmonic Oscillator with Two Moving Boundaries

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communications in Theoretical Physics 2009年第11期52卷 820-824页

作者： c.f.Lo Institute of Theoretical Physics and Department of Physics The Chinese University of Hong Kong

By applying the standard analytical techniques of solving partial differential equations, we have obtained the exact solution in terms of the fourier sine series to the time-dependent Schrodinger equation describing a quantum one-dimensional harmonic oscillator of time-dependent frequency confined in an infinite square well with the two walls moving along some parametric trajectories. Based upon the orthonormal basis of quasi-stationary wave functions, the exact propagator of the system has also been analytically derived. Special eases like （i） a confined free particle, （ii） a confined time-independent harmonic oscillator, and （iii） an aging oscillator are examined, and the corresponding time- dependent wave functions are explicitly determined. Besides, the approach has been extended to solve the case of a confined generalized time-dependent harmonic oscillator for some parametric moving boundaries as well.

关键词： infinite square well harmonic oscillator moving boundaries fourier series

Biofuel-driven trigeneration systems for non-residential building applications:A holistic assessment from the energy,environmental and economic perspectives

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Building Simulation 2023年第4期16卷 557-576页

作者： K.f.fong c.K.Lee Division of Building Science and Technology College of EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

In the metropolises,it is unlikely to use merely solar and wind energy to pursue zero carbon building ***,it would become possible if biofuel-driven trigeneration systems(BDTS)are *** is thus essential to assess the application opportunity of BDTS in a holistic *** this study,BDTS offered definite primary energy saving of up to 15%and carbon emissions reduction of at least 86%in different types of non-residential buildings as compared to the conventional *** 24/7 operation for the hotel and hospital buildings,the corresponding BDTS could even achieve zero carbon *** the BDTS primed with compression-ignition internal combustion engine were not economically viable even in running cost due to the high local biodiesel price *** BDTS primed with spark-ignition engine and fueled by biogas,however,would have economic merit when carbon price was considered for the conventional systems that fully utilize fossil *** of carbon tax and social cost could have the payback ceilings of 8 years and 2 years respectively for most of building ***,the results could reflect the application potential of BDTS for non-residential buildings,leading the pathway to carbon neutrality for sustainable sub-tropical cities.

关键词： trigeneration biofuel dynamic simulation carbon tax social cost economic analysis

The Kirkendall effect on erosion resistance of chrome-coated 25cr3Mo2WNiV and 30SiMn2MoV gun barrel steels

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Journal of Materials Science & Technology 2024年第10期177卷 246-255页

作者： c.H.Dou P.f.Jin c.Z.Wang J.J.Li c.Zhang J.f.Huang c.Zhang Key Laboratory for Advanced Materials Processing State State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China National Joint Engineering Research center for Abrasion control and Molding of Metal Materials School of Materials Science and EngineeringHenan University of Science and TechnologyLuoyang 471003China

This study aimed to investigate the erosion behavior and mechanism of a newly developed 25cr3Mo2WNiV steel with a chrome coating using promoted ignition combustion *** erosion threshold pressure and temperature of the chrome-coated 25cr3Mo2WNiV steel were determined to be 0.2 MPa and 254.3 K higher than those of traditional chrome-coated 30SiMn2MoV ***,Kirkendall voids and inter-diffusion between the cr coating and matrix were first observed before *** improved erosion resistance of the chrome-coated 25cr3Mo2WNiV steel was attributed to the suppression of the Kirkendall effect,which minimized heat generation at the cr/matrix interface by pre-venting oxygen diffusion and reducing oxygen affinity.

关键词： Erosion resistance Kirkendall effect cr coating Gun steel

New Nanocomposite Materials by Incorporation of Nanocrystalline TiO_2 Particles into Polyaniline conductive films

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Journal of Materials Science & Technology 2014年第5期30卷 449-454页

作者： f.J.feliciano O.c.Monteiro Department of chemistry and Biochemistry and cQB Faculty of SciencesUniversity of LisbonCampo Grande1749-016 LisbonPortugal

This work is focused on the combination of two building-blocks, nanocrystalline TiO2 particles and polyaniline conductive films （PAni）. The preparation of new nanostructured composite materials, displaying electron- and proton-conductive properties, to be used for the fabrication of new and superior energy storage devices was envisaged. The semiconducting TiO2 nanoparticles were obtained by means of a hydrothermal route. The PAni films were prepared on glassy carbon electrodes by electrochemical polymerization, under potential dynamic conditions. After characterization by X-ray diffraction, transmission electron microscopy or scanning electron microscopy and electrochemical techniques, the nanocrystalline particles were immobilized in the polymer matrix. The incorporation of the TiO2 was achieved using two distinct approaches： during the polymer growth or by deposition over previously prepared PAni films. The results demonstrate that the PAni morphology depends on the experimental conditions used during the polymer growth. After TiO2 immobilization, the best electrochemical response was obtained for the nanocomposite structure produced through the TiO2 incorporation after the PAni film synthesis. The modified electrodes were structurally and morphologically characterized and their electro-catalytic activity towards the hydrogen evolution reaction was analyzed. A new electrochemical performance related with the oxidation of molecular hydrogen entrapped in the PAni-TiO2 matrix was observed for the modified electrode after TiO2 incorporation. This behavior can be directly associated with the synergetic combination of the TiO2 and PAni, and is dependent on the amount of the semiconductor.

关键词： PolyaniHne (PAni) Nanosized TiO2 Nanocomposites Hydrogen trapping