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Tumor metastasis is regulated via microRNA-200/ZEB1 axis control of PD-L1 expression on tumor cells and intratumoral immunosuppression

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Tumor metastasis is regulated via microRNA-200/ZEB1 axis con...

第九届全国免疫学学术大会

作者： f.xiao-feng Qin Department of Immunology The University of Texas MD Anderson Cancer Center Center of Systems Medicine Chinese Academy of Medical Sciences

Immunosuppression of tumor-infiltrating lymphocytes(TIL)is a common feature of advanced epithelial tumors,but its biological basis has remained *** multiple mouse models,we demonstrate a molecular link between epithelial-to-mesenchymal transition(EMT)and intratumoral CD8T cell immunosuppression,two key drivers of malignant

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Regulatory T cell dynamics in host response to tumor development

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Regulatory T cell dynamics in host response to tumor develop...

第六届全国免疫学学术大会

作者： f.xiao-feng Qin Department of Immunology University of TexasMD Anderson Cancer CenterHoustonTXUSA 77030

Regulatory T cells (Tregs) exPressing the forkhead transcription factor foxp3 play a central role in the dominant control of immunological tolerance.

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Profiling antigenic and immunological status of tumor microenvironment for guiding cancer immunotherapy

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Profiling antigenic and immunological status of tumor microe...

第十一届全国免疫学学术大会

作者： f.xiao-feng Qin Center for Systems Medicine Chinese Academy of Medical Sciences & Suzhou Institute of Systems Medicine

Anti-PD-1 and PD-L1 checkpoint blockade therapy is emerging to be highly successful across broad spectrum different of cancers,leading to durable antitumor responses and even cure of the ***,not all patients treated b...

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Evolutionary characteristics of SARS-CoV-2 Omicron subvariants adapted to the host

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2478-2480页

作者： Haijun Tang Yun Shao Yi Huang Shigang Qiao Jianzhong An Ruhong Yan Xin Zhao fang Meng xiaohong Du f.xiao-feng Qin Institute of Systems Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou Institute of Systems MedicineSuzhou215123China Shengli Clinical Medical College Fujian Medical UniversityCenter for Experimental Research in Clinical MedicineFujian Provincial HospitalFuzhou350001China Institute of Clinical Medicine Research Suzhou HospitalAffiliated Hospital of Medical SchoolNanjing UniversitySuzhou215153China

Dear Editor,As the COVID-19 epidemic proceeds,new variants of SARS-CoV-2 continue to emerge.^(1)Particularly the B.1.1.529(Omicron)variant emerged and spread globally,surpassing the previously dominant B.1.617.2(Delta)***,the original Omicron variant continued to mutate into numerous Omicron ***,the infectious and immune characteristics of newly-emerged Omicron sublineages that have evolved to adapt to the host remain unclear.

关键词： adapted variants globally

Omicron adopts a different strategy from Delta and other variants to adapt to host

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Signal Transduction and Targeted Therapy 2022年第3期7卷 616-618页

作者： xiaohong Du Haijun Tang Long Gao Zhao Wu fang Meng Ruhong Yan Shigang Qiao Jianzhong An Chen Wang f.xiao-feng Qin Institute of Clinical Medicine Research Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical UniversitySuzhou 215153China Institute of Systems Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou Institute of Systems MedicineSuzhou 215123China Deportment of Infectious Disease The First Affiliated Hospital of Anhui Medical UniversityHefei 230000China

Dear Editor,With the ongoing of Corona Virus Disease 2019(COVID-19)epidemic,new strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)are continuously *** Delta(B.1.617.2)identified in India,Lambda(C.37),Mu(B.1.621),and Omicron(B.1.1.529)were successively found in Peru,Colombia,and Botswana/South Africa,and subsequently defined as variant of interest(VOI)or variant of concern(VOC).

关键词： acute respiratory Delta

Mechanism of PD-L1 dependent and independent pathways for driving CD8+ T cell suppression and exhaustion during cancer metastasis

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Mechanism of PD-L1 dependent and independent pathways for dr...

第十届全国免疫学学术大会

作者： f.xiao-feng Qin Anfei Huang Di Peng xiaoyun Li Yingying Ben Center for Systems Medicine Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College

Metastasis is the primary cause of cancer related *** is becoming the most promising new modality for cancer treatment,which can lead to complete and long-lasting treatment response,central for preventing cancer metastasis and disease *** trials with monoclonal antibodies to immune checkpoint inhibitory receptor PD-1and its ligand PD-L1 have shown remarkable clinical response in melanoma,renal carcinoma and non-small-cell lung cancer patients with unprecedented survival *** therapeutic effect has been found to be associated with increased

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New evidence for the epigenetic regulation of skeletal stem cells

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Science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zhao Jun xiao Charles K.f.Chan Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanford CA 94305USA Department of Surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Department of Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Skeletal stem cells(SSCs)are crucial for skeletal development and regeneration,yet the epigenetic regulation of these cells remains poorly *** studies have delineated the epigenetic landscape across the developmental trajectory of SSCs,highlighting the involvement of Ptip in regulating SSC *** skeletal system undergoes dynamic remodeling throughout *** stem cells(SSCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to foster development and maintain skeletal *** categorized within the broader mesenchymal stromal/stem cells(MSCs).

关键词： skeletal involvement maintain

Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms

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Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hep...

第九届全国免疫学学术大会

作者： Yongzhi Chen Shanshan Wang Zhaohong Yi Huabin Tian Saba Aliyari Yanhua Li Gang Chen Ping Liu Jin Zhong Xinwen Chen Peishuang Du Lishan Su f.xiao-feng Qin Hongyu Deng Genhong Cheng CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of Sciences Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory for Biocontrol School of Life SciencesSun Yat-Sen University Department of Microbiology Immunology and Molecular GeneticsUniversity of California Los AngelesCA 90095USA Institute of Quality Standard and Testing Technology for Agro-products CAAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of Sciences State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of Sciences

Cholesterol 25-hydroxylase(CH25H)as an interferon-stimulated gene(ISG)has recently been shown to exert broad antiviral activity through the production of 25-hydroxycholesterol(25HC),which is believed to inhibit the virus-cell membrane fusion during viral *** the present study,we have found that although 25HC produced by CH25H can

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： S.Tan Q.Wang Y.Chen W.B.Yao C.Z.xiao J.f.Myatt School of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and Computational Mathematics Beijing 100094China School of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and Computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(SRSS)is observed for the first time via two-dimensional(2D)particle-in-cell(PIC)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order SRSS and estimate its *** rescattering process is identified by the 2D PIC simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order SRSS propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order SRSS,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that SRSS and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering