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Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function

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Cellular & Molecular Immunology 2021年第2期18卷 328-338页

作者： Juan Huang Jian Peng James Alexander Pearson Georgios Efthimiou Youjia Hu Ningwen Tai Yanpeng Xing Luyao Zhang Jianlei Gu Jianping Jiang Hongyu Zhao Zhiguang Zhou f.susan wong Li Wen National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology(Central South University)Ministry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya HospitalCentral South UniversityChangshaHunanChina Section of Endocrinology Department of Internal MedicineSchool of MedicineYale UniversityNew HavenCTUSA Division of Infection and Immunity School of MedicineCardiff UniversityCardiffUK Department of Microbiology University of HullHullUK Department of Gastrointestinal Surgery of the first Hospital of Jilin University ChangchunJilinChina Department of Biostatistics Data Science&GeneticsYale School of Public HealthNew HavenCTUSA

Innate immunity mediated by Toll-like receptors(TLRs),which can recognize pathogen molecular patterns,plays a critical role in type 1 diabetes ***7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells;however,its role in type 1 diabetes development remains *** our study,we discovered that Tlr7-deficient(Tlr7^(−/−))nonobese diabetic(NOD)mice,a model of human type 1 diabetes,exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient(Tlr7^(+/+))NOD *** investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin ***,Tlr7^(−/−)NOD B cells were found to suppress diabetogenic CD4^(+)T-cell responses and protect immunodeficient NOD mice from developing diabetes induced by diabetogenic T *** addition,we found that Tlr7 deficiency suppressed the antigen-presenting functions of B cells and inhibited cytotoxic CD8^(+)T-cell activation by downregulating the expression of both nonclassical and classical MHC class I(MHC-I)molecules on B *** data suggest that TLR7 contributes to type 1 diabetes development by regulating B-cell functions and subsequent interactions with T ***,therapeutically targeting TLR7 may prove beneficial for disease protection.

关键词： Type 1 diabetes Toll-like receptor 7 B cell

短期去除B细胞对自身免疫糖尿病致病性T细胞的影响

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短期去除B细胞对自身免疫糖尿病致病性T细胞的影响

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

中华医学会糖尿病学分会第十六次全国学术会议

作者：向宇飞 Ningwen Tai peng Jian Changyun Hu 周智广 f.susan wong Li Wen 美国耶鲁大学医学院内分泌系中南大学湘雅二医院代谢内分泌研究所英国卡迪夫大学医学院内分泌与糖尿病中心

目的hCDNOD是一种B细胞表达人CD的拟人化转基因小鼠,因此使用抗人的CD单抗-2H可以将小鼠的B细胞去除。BDCNOD小鼠是一种TCR转基因小鼠,其TCR特异性识别胰岛抗原,可被人工合成抗原mimotope特异性激活,其淋巴细胞过继到免疫缺陷(SCID)小...

目的hCDNOD是一种B细胞表达人CD的拟人化转基因小鼠,因此使用抗人的CD单抗-2H可以将小鼠的B细胞去除。BDCNOD小鼠是一种TCR转基因小鼠,其TCR特异性识别胰岛抗原,可被人工合成抗原mimotope特异性激活,其淋巴细胞过继到免疫缺陷(SCID)小鼠后可迅速诱发自身免疫糖尿病。将hCDNOD小鼠与BDCNOD小鼠进行交配得到hCDBDCNOD小鼠,因此可在动物模型中采用抗人的CD

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina Lam Carlos Garcia-Esperon Yash Gawarikar Ronak Patel Matthew Lee-Archer Andrew wong Michael Roizman Amanda Gilligan Andrew Lee Kee Meng Tan susan Day Christopher Levi Stephen M Davis Mark Parsons Bernard Yan Melbourne Brain Centre at Royal Melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of Medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia flinders University College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(Af)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1month in patients commenced on early(fewer ischaemic lesions and more haemorrhages in the early anticoagulant group at 1-month *** A prospective multicentre,observational cohort study was performed at 11 Australian stroke *** and MRI data were collected at baseline and follow-up,with blinded imaging assessment performed by two *** of commencement of anticoagulation was at the discretion of the treating stroke *** We recruited 276 patients of whom 208 met the eligibility *** average age was 74.2 years(SD±10.63),and 79(38%)patients were *** National Institute of Health Stroke Scale score was 5(IQR 1–12).Median baseline ischaemic lesion volume was 5mL(IQR 2–17).There were a greater number of new ischaemic lesions on follow-up MRI in patients commenced on anticoagulation≥4days after index event(17%vs 8%,p=0.04),but no difference in haemorrhage rates(22%vs 32%,p=0.10).Baseline ischaemic lesion volume of≤5mL was less likely to have a new haemorrhage at 1month(p=0.02).There was no difference in haemorrhage rates in patients with an initial ischaemic lesion volume of>5mL,regardless of anticoagulation *** Commencing anticoagulationfter stroke or TIA is associated with fewer ischaemic lesions at 1month in Af *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

Cytokine analysis of livers from patients with seronegative viral hepatitis

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Cytokine analysis of livers from patients with seronegative ...

第三届全国重型肝病及人工肝血液净化学术年会

作者： susan wong Atanu Basu Neal S.Young Kevin E.Kevin. Hematology Branch NHLBIBethesdaMD 20892

Although the hepatitis viruses A,B,C,D and E account for the majority of cases of acute viral hepatitis,the etiology is unknown in～3% of *** addition,the etiological agent of hepatitis-associated aplastie anemia (HAA,severe bone marrow failure following an episode of acute hepatitis),and most cases of fulminant hepatitis (fH) is unknown,but does not appear to be caused by any of the known hepatitis agents,and including B19V, HGV,TTV,SENV,herpesviruses (including CMV,EBV and HHV-6/7),or adenoviruses (Brown et al NEJM 1997,wong et al,JID 2003,Brown et al Br J Haematol 1997,Umemura et al JID,2003,our unpublished

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快餐业用极端食品激发消费者

商业周刊（中文版） 2013年第9期 34-35页

作者： susan Berfield Venessa wong 永年(译)

非同寻常的搭配、大量奶酪以及熏肉都是年轻男性食客们的最爱“如果消费者对某一商品产生兴趣，你必须以某种方式刺激他们的想象”对美国人而言，如果他最近没有参加过州展览会，或是不熟悉保拉·迪恩（PaulaDeen）“南方舒适食物”式... 详细信息

非同寻常的搭配、大量奶酪以及熏肉都是年轻男性食客们的最爱“如果消费者对某一商品产生兴趣，你必须以某种方式刺激他们的想象”对美国人而言，如果他最近没有参加过州展览会，或是不熟悉保拉·迪恩（PaulaDeen）“南方舒适食物”式的食物风格，下面的消息可能让他感到吃惊：有些人用甜甜圈来制作三明治。

关键词：消费者快餐业激发食品美国人展览会食物商品

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香港能否实现软着陆？

商业周刊（中文版） 2010年第10期 18-18,20页

作者：布鲁斯·艾因霍恩（Bruce Einhorn）苏珊·李（susan Li）凯尔文·王（Kelvin wong）夏芳（译）

特区政府正在抛售土地，以遏制飞涨的房价“许多人都认为房价已达到不可理喻的程度”为了给深圳、上海及其他内地城市的房地产市场降温，中国金融监管当局采取了提高利率的措施，并要求银行在发放房屋贷款时进行更为严格的审查。中国香... 详细信息

特区政府正在抛售土地，以遏制飞涨的房价“许多人都认为房价已达到不可理喻的程度”为了给深圳、上海及其他内地城市的房地产市场降温，中国金融监管当局采取了提高利率的措施，并要求银行在发放房屋贷款时进行更为严格的审查。中国香港的房价也是一路飙升，但当地政府施行的措施有所不同，它正在通过加速出售手中巨大的土地储备来增加供应，以达到抑制房价的目的。

关键词：中国香港软着陆特区政府土地储备房地产市场内地城市金融监管房屋贷款

Evaluation of computer aided detection during colonoscopy among Veterans:Randomized clinical trial

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Artificial Intelligence in Medical Imaging 2023年第1期4卷 1-9页

作者： Mike T Wei Yu Chen susan Y Quan Jennifer Y Pan Robert J wong Shai friedland Department of Gastroenterology and Hepatology Stanford University Medical CenterPalo AltoCA 94305United States Department of Gastroenterology and Hepatology Veterans Affairs Palo Alto Health Care SystemPalo AltoCA 94305United States

BACKGROUND There has been significant interest in use of computer aided detection(CADe)devices in colonoscopy to improve polyp detection and reduce miss *** To investigate the use of CADe amongst *** Between September 2020 and December 2021,we performed a randomized controlled trial to evaluate the impact of *** at Veterans Affairs Palo Alto Health Care System presenting for screening or low-risk surveillance were randomized to colonoscopy performed with or without *** outcomes of interest included adenoma detection rate(ADR),adenomas per colonoscopy(APC),and adenomas per *** addition,we measured serrated polyps per colonoscopy,non-adenomatous,non-serrated polyps per colonoscopy,serrated polyp detection rate,and procedural *** A total of 244 patients were enrolled(124 with CADe),with similar patient characteristics(age,sex,body mass index,indication)between the two *** of CADe was found to have decreased number of adenomas(1.79 vs 2.53,P=0.030)per colonoscopy compared to without *** was no significant difference in number of serrated polyps or non-adenomatous non-serrated polyps per colonoscopy between the two ***,use of CADe was found to have lower ADR(68.5%vs 80.0%,P=0.041)compared to without use of *** polyp detection rate was lower with CADe(3.2%vs 7.5%)compared to without CADe,but this was not statistically significant(P=0.137).There was no significant difference in withdrawal and procedure times between the two groups or in detection of adenomas per extraction(71.4%vs 73.1%,P=0.613).No adverse events were *** While several randomized controlled trials have demonstrated improved ADR and APC with use of CADe,in this RCT performed at a center with high ADR,use of CADe was found to have decreased APC and *** studies are needed to understand the true impact of CADe on performance quality among endoscopists as well as determine criteria for endoscopis

关键词： Colonoscopy Colorectal cancer prevention Artificial intelligence Computer aided detection Adenoma detection rate

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护理临床研究中干预方案的制定

中国护理管理 2014年第10期14卷 1109-1112页

作者：王少玲黄金月周家仪香港理工大学护理学院

干预方案的设计是实验性研究中的一个重要环节,直接影响护理和研究的质量和结局。有效护理干预方案的制定须经历一个严谨的过程。本文借助笔者的设计经验提出护理临床研究中干预方案的制定的三个重要步骤:1围绕研究主题建立干预的概念框... 详细信息

干预方案的设计是实验性研究中的一个重要环节,直接影响护理和研究的质量和结局。有效护理干预方案的制定须经历一个严谨的过程。本文借助笔者的设计经验提出护理临床研究中干预方案的制定的三个重要步骤:1围绕研究主题建立干预的概念框架;2建立以循证为基础的干预方案,包含目标群体、实施方法、干预特性、护理剂量(成分、数量、频次和周期)、干预者和干预管理;3实施前对干预方案进行审核和测试。

关键词：护理研究干预方案设计

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. flenniken, Ann M. Ji, Xiao Teboul, Lydia wong, Michael D. White, Jacqueline K. Meehan, Terrence f. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院