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氙气在小鼠大脑中动脉短暂性梗塞模型上的神经元保护作用

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国外医学（麻醉学与复苏分册） 2004年第1期25卷 60-63页

作者： H.Mayumi Homi Noriko Yokoo DaqingMa David S.Warner Nicholas p.franks MervynMaze M.B.ch.B. f.r.c.p. f.r.c.A. Hilaryp.Grocott f.r.c.p.c. 朱珊珊曾因明 DepartmentofAnesthesiology（MultidisciplinaryNeuroprotectionLaboratories） DukeUniversityMedicalCenter. DepartmentsofAnestheticsandBiologicalSciences ImperialCollegeofScienceTechnologyandMedicineLondonUaitedKingdom. 徐州医学院江苏省麻醉学重点实验室221002

麻醉气体，其特性包括相对较高的心血管安全性(同等或优于传统麻醉药)，与其他大多数气体相比较好的药物动力学或药效学特点。越来越多的临床和实验研究表明，氙气作为一种气体麻醉药，具有镇痛、诱导苏醒迅速和对心血管影响小的特点。... 详细信息

麻醉气体，其特性包括相对较高的心血管安全性(同等或优于传统麻醉药)，与其他大多数气体相比较好的药物动力学或药效学特点。越来越多的临床和实验研究表明，氙气作为一种气体麻醉药，具有镇痛、诱导苏醒迅速和对心血管影响小的特点。另外，由于其对环境影响小，因此适用于吸入麻醉。但是，由于其价格昂贵，在临床应用中也因此受到了限制。

关键词：氙气小鼠大脑动脉短暂性梗塞动物模型神经元保护麻醉

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(OrfBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric OrfBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric OrfBs.

关键词： redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Serological surveillance for SArS-coV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G pinheiro Gabriela G O Alves Maria Eduarda r conde Sofia L costa regina c S Sant’Anna Isa M f Antunes Mônica c carneiro fabio S ronzei Julia c Scaffo felipe r pinheiro Lialyz S Andre Helvecio c povoa Valéria T Baltar fabíola Giordani Eduarda S Hemerly Gisele c Alexandre Karla c de paula Márcio Watanabe Antonio claudio L da Nóbrega Jackeline christiane p Lobato fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil pathology program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of physiology and pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAcKGrOUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SArS-coV-2),which led to the outbreak of coronavirus disease 2019(cOVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SArS-coV-2 antibodies could indicate the immunoreactive profile during the cOVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SArS-coV-2 antibodies in individuals within a university setting during the cOVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-rJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of cOVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(Or)=1.16,95%cI:1.02-1.31](pcontact with a cOVID-19-positive case(Or=3.49,95%cI:2.34-5.37)(preceived the cOVID-19 vaccine(Or=2.33,95%cI:1.61-3.35)(pcial isolation(Or=0.59,95%cI:0.41-0.84)(pf sho

关键词： Serological surveillance SArS-coV-2 antibodies cOVID-19 Serological rapid test risk factors for cOVID-19

Acquired sensorineural hearing loss,oxidative stress,and microrNAs

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Neural regeneration research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding rNA sequences known as microrNAs(mirNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamirs,""hypoxia,""microrNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** mir-34a and mir-29b levels increase with age in *** mirNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIrT1/p Gc-1α),SIrT

关键词： hearing loss hypoxia microrNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural regeneration research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Effect of multi-walled carbon nanotube addition on the microstructures and mechanical properties of Ti(c,N)-based cermets

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Journal of Advanced ceramics 2018年第1期7卷 58-63页

作者： p.WU S.c.LIU X.r.JIANG college of chemistry and Materials Science Longyan University

The surface modification of multi-walled carbon nanotubes(MWcNTs) was carried out using plasma treatment. The microstructures of the prepared cermets with different additions of MWcNTs were investigated by scanning electron microscopy(SEM), transmission electron microscopy(TEM), energy dispersive X-ray analysis(EDX), and X-ray diffraction(XrD). Mechanical properties such as transverse rupture strength(TrS), fracture toughness(K_(Ic)), and hardness(HrA) were measured. The results showed that some reactive groups were successfully modified on the surface of MWcNTs, resulting in the improvement of dispersibility. Most of the amorphous carbons and impurities were peeled from the MWcNTs. Increasing MWcNT addition decreased the dissolution of tungsten, titanium, and molybdenum in the binder phase. The cermet with 0.5 wt% MWcNT addition showed the highest TrS and fracture toughness. The strengthening mechanisms were attributed to the finer grain size, the homogeneous microstructure, and the higher volume fraction of binder phase in the binder. The toughening mechanisms were characterized by bridging and pulling-out.

关键词： Ti(c,N)-based cermets microstructure mechanical property fracture toughness

Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

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World Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew G Garas Luis calzadilla-Bertot Briohny W Smith Luc Delriviere Byron Jaques Lingjun Mou Leon A Adams Gerry c MacQuillan George Garas Gary p Jeffrey Michael c Wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BAcKGrOUND Hepatocellular carcinoma(Hcc)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of Hcc recurrence is generally reported as 8%-20%in the *** predictors of Hcc have already been researched,however,to our knowledge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of Hcc recurrence in a contemporary Western Australian LT *** We performed a retrospective cohort study of all liver transplants in patients with Hcc at Sir charles Gairdner Hospital between 2006 and *** was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of Hcc patients post-LT,stratified for recurrence,was calculated by Kaplan Meier *** and multivariate cox regression was used to determine predictors of Hcc recurrence *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with Hcc.8.4%of subjects developed recurrent Hcc after LT with median follow-up time of 5.4 *** median time to recurrence was 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(p=0.001),vascular invasion(p=0.003)and poorly differentiated Hcc(p=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with Hcc recurrence compared to those without Hcc recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank pcONcLUSION Hcc recurrence was low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT *** studies are requir

关键词： Liver cancer recurrence Liver transplantation Hepatocellular carcinoma predictors post-transplant survival Australian data

Influence of B4c and ZrB2 reinforcements on microstructural,mechanical and wear behaviour of AA 2014 aluminium matrix hybrid composites

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Defence Technology（防务技术） 2024年第10期40卷 242-254页

作者： ramesh Babu r rajendran c Saiyathibrahim A rajkumar Velu Department of Mechanical Engineering Karpagam Institute of TechnologyCoimbatore 641105India Department of Mechanical Engineering Sri Krishna College of Engineering and TechnologyCoimbatore 641008India Department of Mechanical Engineering Indian Institute of Technology JammuJammu and Kashmir 181221India

considering their affordability and high strength-to-weight ratio,lightweight aluminium alloys are the subject of intensive research aimed at improving their properties for use in the aerospace *** research effort aims to develop novel hybrid composites based on AA 2014 alloy through the use of liquid metallurgy stir casting to reinforce dual ceramic particles of Zirconium Diboride(ZrB_(2))and Boron carbide(B4c).The weight percentage(wt%)of ZrB_(2) was varied(0,5,10,and 15),while a constant 5 wt%of B4c was maintained during this *** as-cast samples have been assessed using an Optical Microscope(OM)and a Scanning Electron Microscope(SEM)with Energy Dispersive Spectroscopy(EDS).The properties such as hardness,tensile strength,and wear characteristics of stir cast specimens were assessed to examine the impact of varying weight percentages of reinforcements in AA 2014 *** particular,dry sliding wear behaviour was evaluated considering varied loads using a pin-on-disc *** the weight%of ZrB_(2) grew and B4c was incorporated,hybrid composites showed higher hardness,tensile strength,and wear ***,the incorporation of a cumulative reinforcement consisting of 15 wt%ZrB_(2) and 5 wt%B4c resulted in a significant 31.86%increase in hardness and a 44.1%increase in tensile strength compared to AA 2014 *** addition,it has been detected that wear resistance of hybrid composite pin(containing 20 wt%cumulative reinforcement)is higher than that of other stir cast wear test pins during the whole range of applied *** surfaces of tensile specimens showed ductile fracture in the AA 2014 matrix and mixed mode for hybrid *** surfaces obtained employing higher applied load indicated abrasive wear with little plastic deformation for hybrid composites and dominant adhesive wear for matrix ***,the superior mechanical and tribological performance of hybrid composites can be attributed to dual reinforcement pa

关键词： AA 2014 alloy Stir casting Hybrid composite Hardness Tensile strength Specific wear rate

combined carriership of TLr9 -1237c and cD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis

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World Journal of Gastroenterology 2005年第46期11卷 7323-7329页

作者： KM Lammers S Ouburg SA Morré JBA crusius p Gionchetti f rizzello c Morselli E caramelli r conte G poggioli M campieri AS pea Department of Internal Medicine and Gastroenterologypoliclinico S.Orsola University of BolognaBolognaItaly Laboratory of ImmunogeneticsVU University Medical center AmsterdamThe Netherlands Institute of Histology and General EmbryologyUniversity of Bologna BolognaItaly Department of Immunohaematology and Blood Transfusionpoliclinico S.Orsola University of BolognaBolognaItaly Department of Surgery and Organ Transplantationpoliclinic S.Orsola University of BolognaBolognaItaly Laboratory of ImmunogeneticsVU University Medical center AmsterdamThe Netherlands Laboratory of Immunogenetics and Department of GastroenterologyVU University Medical CenterAmsterdamThe Netherlands

AIM： To investigate the single nucleotide polymorphisms （SNps） in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity. METHODS： Analyses of cD14 -260c〉T, cArD15/ NOD2 3020insc, Toll-like receptor （TLr）4 ＋896A〉G, TLr9 -1237T〉c, TLr9＋2848G〉A, and IrAKM ＋ 22148G〉A SNps were performed in 157 ileal-pouch anal anastomosis （IpAA） patients （79 patients who did not develop pouchitis, 43 infrequent pouchitis patients, 35 chronic relapsing pouchitis patients） and 224 Italian caucasian healthy controls. rESULTS： No significant differences were found in SNp frequencies between controls and IpAA patients. However, a significant difference in carriership frequency of the TLrg-1237c allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [p = 0.028, odd＇s ratio （Or） = 3.2, 95%cI = 1.2-8.6]. This allele uniquely represented a 4-locus TLr9 haplotype comprising both studied TLr9 SNps in caucasians. carrier trait analysis revealed an enhanced combined carriership of the alleles TLr9 -1237c and cD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group （p = 0.018, Or = 4.1, 95%cI = 1.4 -12.3）. There is no evidence that the SNps predispose to the need for IpAA surgery. The significant increase of the combined carriershoip of the cD14-260T and TLr9-1237c alleles in the chronic relapsing pouchitis group suggests that these markers identift a subgroup of IpAA patients with a rish of developing chronic or refractory pouchitis.

关键词： pouchitis Innate immunity Single nucleotide polymorphisms cD14 TLr9