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Effect of silicone oil removal on central corneal thickness

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 374-376页

作者： Gul Arikan Zeynep Ozbek f Hakan oner Ismet Durak A Osman Saatci Department of Ophthalmology Dokuz Eylul UniversityIzmirTurkey

AIM:To evaluate the effect of silicone oil removal(SOR) on central corneal thickness(CCT) in aphakic and pseudophakic eyes prospectively.· METHODS:Patients who underwent SOR surgery between June 2005-August 2007 were included in this *** oil was actively removed behind the posterior capsule through the pars plana sclerotomy site(posterior approach) in pseudophakic eyes and through the pupil and the corneal tunnel incision(anterior approach) in aphakic eyes with the 18-gauge *** was assessed with Orbscan II corneal topography system preoperatively and at one month and three months postoperatively.A total of 34 eyes of 34 patients(26 males,8 females) comprised the study *** age was(55.6±12.3) years(Range:25-80 years).Twenty-six eyes(76.5%) were pseudophakic and 8(23.5%) *** time between silicone oil injection and removal was(15.1±13.6) months(Range:5-54 months).At baseline,CCT was 576.4±46.0μm in pseudophakic eyes and 611.6±36.2μm in aphakic eyes.· RESULTS:At the first postoperative month CCT was(573.3±40.1)μm and(630.9±72.9)μm in pseudophakic and aphakic eyes *** the third postoperative month,CCT was(582.7±49.5)μm and(614.5±82.4)μm in pseudophakic and aphakic eyes *** was no statistically significant difference in CCT measurements one month and 3 months after SOR when compared to preoperative values in both aphakic and pseudophakic eyes(P> 0.05).· CONCLUSION:Active SOR either by anterior or posterior approach did not affect the CCT.·

关键词： Aphakia central corneal thickness silicone oil pseudophakia

Umbilical cord derived mesenchymal stem cell implantation in retinitis pigmentosa: a 6-month follow-up results of a phase 3 trial

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1423-1429页

作者： Neslihan Sinim Kahraman Ayse oner Department of Ophthalmology Kayseri Acibadem HospitalKayseri 38030Turkey

AIM:To investigate the efficacy and the safety of umbilical cord derived mesenchymal stem cell(UC-MSC)implantation in patients with retinitis pigmentosa(RP).METHODS:This prospective,single-center,phase 3 clinical study enrolled 124 eyes of 82 RP *** patients received 5 million UC-MSCs to the suprachoroidal area with a surgical *** were evaluated on the 1st day,1st,and 6th months *** corrected visual acuity(BCVA),anterior segment and fundus examinations,color photography,optical coherence tomography(OCT),and visual field(Vf)tests were carried out at each *** fluorescein angiography(ffA)and multifocal electroretinography(mfERG)recordings were performed at the end of the 6th *** and systemic adverse events of the surgical procedure were also ***:All of the 82 patients completed the 6-month follow-up *** of them had any serious systemic or ocular *** were statistically significant improvements in BCVA and Vf during the study(all Pf the P1 waves in the central areas showed significant improvements in mfERG *** were also significant increases in implicit times of P1 waves in the central ***:Suprachoroidal administration of UC-MSCs has beneficial effect on BCVA,Vf,and mfERG measurements during the 6-month follow-up *** mediated therapy based on the secretion of growth factors(Gfs)seems to be an effective and safe option for degenerative retinal diseases.

关键词： cell mediated therapy retinitis pigmentosa suprachoroidal umbilical cord derived mesenchymal stem cells visual function

Neutrosophic N-Structures Applied to Sheffer Stroke BL-Algebras

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Computer Modeling in Engineering & Sciences 2021年第10期129卷 355-372页

作者： Tugce Katican Tahsin oner Akbar Rezaei florentin Smarandache Department of Mathematics Ege UniversityIzmir35100Turkey Department of Mathematics Payame Noor UniversityTehran19395-4697Iran Department of Mathematics and Science University of New MexicoGallup87301NMUSA

In this paper,we introduce a neutrosophic N-subalgebra,a(ultra)neutrosophic N-filter,level sets of these neutrosophic N-structures and their properties on a Sheffer stroke *** defining a quasi-subalgebra of a Sheffer stroke BL-algebra,it is proved that the level set of neutrosophic N-subalgebras on the algebraic structure is its quasi-subalgebra and vice *** we show that the family of all neutrosophic N-subalgebras of a Sheffer stroke BL-algebra forms a complete distributive *** that a(ultra)neutrosophic N-filter of a Sheffer stroke BL-algebra is described,we demonstrate that every neutrosophic N-filter of a Sheffer stroke BL-algebra is its neutrosophic N-subalgebra but the inverse is generally not ***,it is presented that a level set of a(ultra)neutrosophic N-filter of a Sheffer stroke BL-algebra is also its(ultra)filter and the inverse is always ***,some features of neutrosophic N-structures on a Sheffer stroke BL-algebra are investigated.

关键词： Sheffer stroke BL-algebra (ultra)filter neutrosophic N-subalgebra (ultra)neutrosophic N-filter

COVID-19 and cardiac complications:Myocarditis and multisystem inflammatory syndrome in children

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World Journal of Cardiology 2024年第5期16卷 260-268页

作者： Muhammed Gunes oner Ozdemir Department of Pediatric Cardiology Research and Training Hospital of SakaryaAdapazarı54100SakaryaTürkiye Department of Pediatric Allergy and Immunology Research and Training Hospital of SakaryaSakarya University Medical FacultyAdapazarı54100SakaryaTürkiye

Coronavirus is an important pathogen causing disease in humans and *** the end of 2019,an investigation into an increase in pneumonia cases in Wuhan,Hubei Province,China,found that the cause was a new *** disease,which spread rapidly across China and caused an outbreak worldwide,resulted in a *** this virus has previously been referred to as 2019-nCoV,which causes coronavirus disease 2019(COVID-19),later it was named severe acute respiratory syndrome coronavirus *** were usually asymptomatic and rarely severely *** April 2020,reports from the United Kingdom indicated that children may have Kawasaki disease or a clinical condition similar to toxic shock *** clinical picture was later defined as multisystem inflammatory syndrome in *** then,similarly affected children as well as cases with other cardiac complications have been reported in other parts of the *** this review,we aimed to evaluate COVID-19 in terms of cardiac involvement by reviewing the literature.

关键词： COVID-19 Cardiac complication Myocarditis Multisystem inflammatory syndrome in children SARS-CoV-2

Endoscopic tympanoplasty

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Journal of Otology 2017年第2期12卷 62-67页

作者： Abdulvahap Akyigit oner Sakallioglu Turgut Karlidag Elazig Education and Research Hospital Clinic of ENTElazigTurkey firat University Faculty of MedicineDepartment of OtolaryngologyElazigTurkey

Middle ear surgery is usually performed using a surgical microscope. Initially, in otorhinolaryngology practice, endoscopes were used for paranasal sinus surgeries. It was only later that they were applied in the area of otology. In otologic surgeries, endoscopes were first used to visualize the middle ear, before being used to assist with visualization of instruments during cholesteatoma surgeries, although they are still not used alone in various otologic surgeries. As in other surgical fields, there is also a trend towards minimally invasive intervention in the field of otorhinolaryngology. Smaller incisions performed under the guidance of endoscopes are preferred over conventional large incisions. Using this approach, improved outcomes can be achieved and postoperative morbidities can be reduced. In addition, the outcomes of grafts performed using the endoscopic approach are similar to that achieved by the microscopic approach. Therefore, endoscopic ear surgery implementations are becoming increasingly popular.

关键词： Endoscopic Tympanoplasty Myringoplasty

Immediate intraocular pressure rise after intravitreal injection of ranibizumab and two doses of triamcinolone acetonide

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 402-405页

作者： Gul Arikan Ali Osman Saatci ferit Hakan oner Department of Ophthalmology School of Medicine Dokuz Eylul University

AIM: To evaluate prospectively immediate intraocular pressure (IOP) changes after the intravitreal injection of ranibizumab, 2 and 4mg triamcinolone acetonide. METHODS: Patients who underwent intravitreal injection of 0.1mL (4mg) triamcinolone acetonide (TA, Group T4), 0.05mL (2mg) TA (Group T2) and 0.05mL (0.5mg) ranibizumab (Group R) comprised the study population. Overall, 229 eyes of 205 patients were injected. fifty-four eyes (23.6%) were in Group T4, 69 eyes (30.1%) in Group T2 and 106 eyes (46.3%) in Group R. If IOP was less than 26mmHg immediately after the injection no further measurement was performed. If IOP was ≥26mmHg, IOP was remeasured till the reading was below 26mmHg at 5, 15 and 30 minutes. RESULTS: Immediately after the injection, the IOP of 28 eyes (51.9%) in Group T4, 22 eyes (31.9%) in Group T2 and 51 eyes (48.1%) in Group R were over 25mmHg. At 30 minutes, IOP of one eye (1.9%) in group T4, two eyes (2.9%) in group T2 and two eyes (1.9 %) in Group R were over 25mmHg. Immediate post-injection IOP was significantly higher in Group T4 and Group R when compared to Group T2 (P ficantly higher in eyes without vitreous reflux when compared to those with vitreous reflux in all groups (P fter the intravitreal injection of 2 or 4mg triamcinolone acetonide, and 0.5mg ranibizumab. Absence of vitreous reflux is the most important predicting factor for immediate IOP rise after the injection.

关键词： anti-VEGf agents glaucoma intraocular pressure intravitreal injection steroids

Resonant production of color octet muons at future Circular Collider-based muon-proton colliders

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Chinese Physics C 2018年第8期42卷 99-107页

作者： Y.C.Acar U.Kaya B.B.oner Department of Material Science and Nanotechnology TOBB University of Economics and Technology Department of Physics Ankara University

We investigate the resonant production of color octet muons in order to explore the discovery potential of future Circular Collider（fCC）-based μp *** is shown that the search potentials of μp colliders essentially... 详细信息

关键词： leptogluons lepton-hadron interactions composite models muon-proton colliders color octet muon,beyond the standard model

Comparison of the effects of intravitreal bevacizumab and dexamethasone in experimental posterior penetrating eye injury

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 575-579页

作者： Ayse oner Nisa Kahraman Saim Ozdamar Esra Balcioglu Department of Ophthalmology Faculty of Medicine Erciyes University Department of Histology and Embryology Faculty of Medicine Erciyes University

AIM： To compare the effects of intravitreal anti-vascular endothelial growth factor（VEGf） and dexamethasone in an experimental rabbit model of posterior penetrating ocular ***： Thirty white New Zealand rabbits were included in the study. A posterior penetrating ocular injury was performed at the superotemporal quadrant. They were randomly divided into three groups. The rabbits in group 1 received intravitreal dexamethasone, in group 2 they received intravitreal bevacizumab and those in group 3 received intravitreal physiological saline solution in both eyes. All eyes were examined ophthalmologically on the 1^st, 3^rd, 7^th, 14^th and 28^th days following the injury and the clinical findings were scored. On the day 28, the eyes were enucleated, evaluated and scored macroscopically, histopathologically and scanning electron ***： The median clinical score on the 14 th and 28 th days and the median macroscopic score of the dexamethasone group was significantly better than that of control（P=0.004, 0.018）. Dexamethasone group was also better than that of bevacizumab group but the differences did not reach statistical significance. Retinal detachment rate was 8.3%, 16.6% and 12.5% in the dexamethasone group, bevacizumab group and control group, respectively（P=0.476）. More extensive fibrocelluler proliferations were observed in controls compared with dexamethasone and bevacizumab groups. But these differences did not reach the statistical significance（P=0.538）. In scanning electron microscopy all groups showed fibreous stalk and dense collagen fibrils in vitreous. CONCLUSION： This study shows that intravitreal injection of both dexamethasone and bevacizumab may reduce the intraocular fibrous proliferation after an experimental posterior penetrating ocular injury in rabbits.

关键词： posterior penetrating ocular injury experimental dexamethasone bevacizumab proliferative vitreoretinopathy

Low-fluence photodynamic therapy combinations in the treatment of exudative age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 377-383页

作者： Taylan Ozturk Hakan oner Ali Osman Saatci Suleyman Kaynak Department of Ophthalmology Dr.Behet Uz Children's HospitalIzmirTurkey Department of Ophthalmology School of MedicineDokuz Eylul University IzmirTurkey

AIM:To compare the efficacy of low-fluence photodynamic therapy(PDT) combinations in the treatment of age-related macular degeneration(AMD).· METHODS:forty-five previously untreated eyes of 45 patients with exudative AMD whose best-corrected visual acuity(BCVA) was ≥0.3(Snellen) were enrolled.15 patients in Group I underwent low-fluence PDT(25J/cm2-300mW/cm2-83sec) and intravitreal pegaptanib combination,15 patients in Group II underwent PDT(50J/cm2-600mW/cm2-83sec) and intravitreal pegaptanib combination while,15 patients in Group III underwent intravitreal pegaptanib *** ophthalmologic examinations were performed in pre and post treatment visits,and the results were statistically analised.A clinical activity score(CAS) was calculated by using changes in lesion size,amount of hemorrhage,staining pattern in fA and OCT measurement of intra/subretinal fluid.≤3 logMAR lines of decrease in BCVA and decrease in CAS were considered as successful treatment.· RESULTS:The mean age of 19 female(42.2%) and 26 male(57.8%) patients was(72.82±8.02) *** follow-up was(13.93±5.87) *** type was occult in 28 eyes(62.2%).Treatment success rates according to BCVA assessments were 86.7%,80%,60% and mean BCVA decrease were 0.3,1.0,2.2 logMAR lines in Group I,II and III,respectively(P >0.05).According to the changes in central macular thickness and CAS,no difference was found among the study groups(P =0.850 and P =0.811,respectively).Patients treated with combination regimens had lower intravitreal injection frequencies(P =0.015).· CONCLUSION:Combination regimen with intravitreal pegaptanib and low-fluence PDT seems to be safe and effective in stabilizing the clinical activity and BCVA in exudative AMD.·

关键词： age-related macular degeneration photodynamic therapy low-fluence photodynamic therapy anti-VEGf