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Mathematical Modeling in Social Network Analysis： Using TOPSIS to find Node Influences in a Social Network

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Journal of Mathematics and System Science 2013年第10期3卷 531-541页

作者： William P fox Sean f. Everton Department of Defense Analysis Naval Postgraduate School Monterey CA 93943 USA

In a social network analysis the output provided includes many measures and metrics. for each of these measures and metric, the output provides the ability to obtain a rank ordering of the nodes in terms of these measures. We might use this information in decision making concerning disrupting or deceiving a given network. All is fine when all the measures indicate the same node as the key or influential node. What happens when the measures indicate different key nodes？ Our goal in this paper is to explore two methodologies to identify the key players or nodes in a given network. We apply TOPSIS to analyze these outputs to find the most influential nodes as a function of the decision makers＇ inputs as a process to consider both subjective and objectives inputs through pairwise comparison matrices. We illustrate our results using two common networks from the literature： the Kite network and the Information flow network from Knoke and Wood. We discuss some basic sensitivity analysis can may be applied to the methods. We find the use of TOPSIS as a flexible method to weight the criterion based upon the decision makers＇ inputs or the topology of the network.

关键词： Social network analysis multi-attribute decision making Analytical hierarchy process (AHP) weighted criterion TOPSIS node influence

Procedure to Calculate the Efficiency of Three-Category Classification

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通讯和计算机（中英文版） 2011年第4期8卷 252-258页

作者： Teresa Rivas Moya f. fElix Caballero Dept. of Psychobiology and Methodology of Behavioral Sciences University of Malaga Spain

Phytotherapy in diabetes: Review on potential mechanistic perspectives

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World Journal of Diabetes 2014年第2期5卷 176-197页

作者： Hanan S El-Abhar Mona f Schaalan Department of Pharmacology and Toxicology Faculty of Pharmacy Cairo University Department of Clinical Pharmacy and Pharmacy Practice Faculty of Pharmacy Misr International University

Diabetes mellitus(DM) is a widely spread epidemic dis ease that results from the absence of insulin, decreased secretion and/or impaired function. Since DM is a multi factorial disease, the available pharmaceuticals, despite their sensible treatment, target mostly one pathway to control hyperglycemia and encounter several side effects. Therefore, new therapeutic paradigms aim to hit several pathways using only one agent. Tradition ally, antidiabetic plants and/or their active constituents may fulfill this need. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests without digging far for the exact mode of action. Searching among the differen literature resources and various database and in view o the above aspects, the present article provides a com prehensive review on the available antidiabetic plants that have been approved by pharmacological and clini cal evaluations, and which their mechanism(s) of ac tion is assured. These plants are categorized according to their proved mode of action and are classified into those that act by inhibiting glucose absorption from in testine, increasing insulin secretion from the pancreasinhibiting glucose production from hepatocytes, or enhancing glucose uptake by adipose and muscle tissues. The current review also highlights those that mimic in their action the new peptide analogs, such as exenatide, liraglutide and dipeptidylpeptidase-4 inhibitors that increase glucagon-like peptide-1 serum concentration and slow down the gastric emptying.

关键词： Hypoglycaemic nutraceuticals Antidiabetic phyto-constituents Medicinal plants Phytotherapy Diabetes mellitus

Importance of Viral Disease in Dairy Cow fertility

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Engineering 2020年第1期6卷 26-33页

作者： D.Claire Wathes Chike f.Oguejiofor Carole Thomas Zhangrui Cheng Royal Veterinary College Hatfield AL97TAUK faculty of Veterinary Medicine University of NigeriaNsukka 410001Nigeria

Many viral diseases are endemic in cattle populations worldwide. The ability of many viruses to cross the placenta and cause abortions and fetal malformations is well understood. There is also significant evidence that viral infections have additional actions in dairy cows, which are reflected in reduced conception rates. These effects are, however, highly dependent on the time at which an individual animal first contracts the disease and are less easy to quantify. This paper reviews the evidence relating to five viruses that can affect fertility, together with their potential mechanisms of action. Acute infection with non-cytopathic bovine viral diarrhea virus (BVDV) in mid-gestation increases abortion rates or causes the birth of persistently infected calves. BVDV infections closer to the time of breeding can have direct effects on the ovaries and uterine endometrium, which cause estrous cycle irregularities and early embryo mortality. fertility may also be reduced by BVDV-induced immunosuppression, which increases the susceptibility to bacterial infections. Bovine herpesvirus (BHV)-1 is most common in pre-pubertal heifers, and can slow their growth, delay breeding, and increase the age at first calving. Previously infected animals subsequently show reduced fertility. Although this may be associated with lung damage, ovarian lesions have also been reported. Both BHV-1 and BHV-4 remain latent in the host following initial infection and may be reactivated later by stress, for example associated with calving and early lactation. While BHV-4 infection alone may not reduce fertility, it appears to act as a co-factor with established bacterial pathogens such as Escherichia coli and Trueperella pyogenes to promote the development of endometritis and delay uterine repair mechanisms after calving. Both Schmallenberg virus (SBV) and bluetongue virus (BTV) are transmitted by insect vectors and lead to increased abortion rates and congenital ***-8 also impairs t

关键词： Bovine viral diarrhea virus Bovine herpesvirus-1 Bovine herpesvirus-4 Schmallenberg virus Bluetongue virus Immunosuppression Embryo mortality

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Asia inside out.

Asia inside out.

A MULTIPLE STRUCTURE RECONSTRUCTION ALGORITHM BASED ON WIRE fRAME MODEL

作者： edited by Eric Tagliacozzo Helen f. Siu Peter C. Perdue.

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Computer Aided Drafting,Design and Manufacturing 1997年第1期7卷 36-44页

作者： Du Jiangchuan Paul W.f. Poon

A “LAG & RLC” visualization algorithm has been presented to display a clear three dimensional structure from stereo slice data which has the characteristics of multiple layer structure. This algorithm is based on wire frame model which can do multiple logical operations and has multiple display effects. It has wide use in biomedical science and computer graphics. The practical system is based on PC with a TVGA adapter at least 512k byte display memory and 2M byte extended memory.

关键词： LAG & RLC visualization three dimensional reconstruction wire frame model multiple structure

Cerium oxide nanoparticles as promising ophthalmic therapeutics for the treatment of retinal diseases

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World Journal of Ophthalmology 2015年第1期5卷 23-30页

作者： Svetlana V Kyosseva James f Mc Ginnis Department of Biochemistry and Molecular Biology University of Arkansas for Medical Sciences Little Rock AR 72205 United States Department of Ophthalmology/Dean McGee Eye Institute and Department of Cell Biology Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States

Nanotechnology offers exciting new approaches for biology and medicine. In recent years, nanoparticles,particularly those of the rare metal cerium, are showing potential for a wide range of applications in *** oxide nanoparticles or nanoceria are antioxidants and possess catalytic activities that mimic those of super oxide dismutase and catalase, thereby protecting cellsfrom oxidative stress. The retina is highly susceptible to oxidative stress because of its high oxygen consumption and high metabolic activity associated with exposure to light. Many retinal diseases progress through oxidative stress as a result of a chronic or acute rise in reactive oxygen species. Diseases of the retina are the leading causes of blindness throughout the world. Although some treatments may delay or slow the development of retinal diseases, there are no cures for most forms of blinding diseases. In this review is summarized evidence that cerium oxide nanoparticles can function as catalytic antioxidants in vivo in rodent models of age-related macular degeneration and inherited retinal degeneration and may represent a novel therapeutic strategy for the treatment of human eye diseases. This may shift current research and clinical practice towards the use of nanoceria, alone or in combination with other therapeutics.

关键词： Nanoceria Age-related macular degeneration Inherited retinal degeneration Oxidative stress Antioxidant

A Role for Histone Chaperones in Regulating RNA Polymerase II

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Advances in Biological Chemistry 2015年第2期5卷 35-44页

作者： JoDi Lynn Osborn Susanna f. Greer Department of Biology Georgia State University Atlanta USA

Transcription is a highly regulated cellular process in which dysfunction leads to disease. One level of regulation is chromatin structure which protects promoters from transcription factor binding. To circumvent this blockade, histone chaperones aid in displacement of nucleosomes. In particular, the histone chaperone complex HUCA, consisting of Hira, Ubn1, Cabin1, and ASf1a, replaces histone variant H3.1 with H3.3 in front of actively transcribing RNA Polymerase II (RNAPII). The 26S proteasome is a major degrader of proteins within the cell and plays both proteolytic and non- proteolytic roles in transcriptional regulation. One major role is the degradation of irreversibly arrested RNAPII. Several interactions between HUCA, the 26S proteasome, and RNAPII have been characterized individually;we now present observations from our lab and others which directly associate elongating RNAPII with the degradation machinery through observations of involvement with the HUCA complex. Our short report presents these ideas and discusses their importance in transcriptional regulation as well as implications in disease manifestation.

关键词： Histone Chaperones RNA Polymerase II 26S Proteasome Transcriptional Regulation

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