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Non Hodgkin lymphomas (NHl) in the Pediatric Oncology Unit of the Gabriel TouréTeaching Hospital, Bamako Mali

Open Journal of Pediatrics 2019年第4期9卷 309-316页

作者： B.Togo P.Togo O.Kone f.Traore A.K.Doumbia A.Toure A.A.diakite O.Coulibaly H.Diall1 B.Maiga K.Sacko A.Dembele Y.A.Coulibaly D.Konate M.E.Cisse A.A.Ba f.l.diakite l.N.Sidib A.Doumbia H.Konare l.B.Maiga C.B.Traore Department of Pediatrics Gabriel TouréTeaching HospitalBamakoMali National Institute of Research in Public health BamakoMali Pathology Service of Point G Teaching Hospital BamakoMali

Background :Non-Hodgkin lymphomas are the first childhood cancer in sub-Saharan Africa. Objective: The purpose of this study was to assess non-Hodgkin lymphomas cases in our setting. Methodology: A retrospective and descriptive study carried out in the pediatric oncology unit of the Gabriel Touré Teaching Hospital Bamako over 10 years from 1st January 2005 to 31th December 2015. Results: We exploited 274 (21.6%) cases of Non-Hodgkin lymphoma out of 1295 cancer cases registered, the age group 6 - 10 years was the most represented (46.4%);the male sex was predominant with a sex-ratio of 1.8;digestive signs were the most common signs of discovery (44.2%) followed by maxillary swelling (42.7%);the majority of patients (52.9%) consulted between 1 and 3 months after the onset of signs;the malnutrition rate was 39.8%, of which 24.1% were severe cases and 15.7% were moderate rate. Abdominal localization was the most common (43.1%) followed by maxillofacial localization (33.9%). Almost all were Burkitt type cytology (92.7%), the majority (73.4%) were in Murphy stage III. Almost all (96%) had received chemotherapy and the modified lMB 01 protocol was widely used (62.4%). The majority of patients (85%) were chemosensitive at day 7 or after the third cyclophosphamide injection but at the end of induction only 31% were in complete remission. Gastrointestinal toxicity was the most common (37.13%) followed by hematologic toxicity 35.09 %;9.12 % of patients were lost of follow-up and 22.26% died. Tumor progression was the most common cause of death (60.66%) followed by infection (21.31%). Conclusion: In light of these findings, the late diagnosis and the poor management of NHl, as well as the limited ability to primarily treat metabolic complications, explain the high case-fatality rate, hence the important role of early diagnosis and treatment multidisciplinary.

关键词： Childhood lymphomas Gabriel TOURE Teaching Hospital Mali

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Epidemio-Clinical Characteristics of Perinatal Anoxia and Immediate Outcome of Patients at Hospital Teaching Gabriel Toure of Bamako

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Open Journal of Pediatrics 2019年第4期9卷 326-336页

作者： l.N.Sidibe H.Diall1,D.Konate O.Coulibaly f.l.diakite K.Sacko f.Traore O.H.Diallo l.Maiga I.Ahamadou I.Traore I.Kone1,B.Maiga P.Togo A.K.Doumbia A.Toure E.M.Cisse A.Dembele Y.A.Coulibaly A.Doumbie A.Konare1,A.A.diakite B.Togo M.Sylla f.DickoTraore Department of Pediatrics CHU Gabriel ToureBamakoMali faculty of Medicine and Odonto-Stomatology of Mali BamakoMali

Introduction: Neonatal asphyxia (NA) is one of the most likely causes of neuro-developmental abnormalities in children. In Mali it is responsible for half of the early deaths and the third of neonatal mortality. Updated data would help understand and improve intervention strategies to reduce mortality. Objective: It is the study of epidemiological and clinical characteristics, the immediate outcome and the factors associated with newborn (NB) mortality with NA. Material and Methods: This was a prospective cross-sectional study from June 27th to September 3rd 2016 about the NBs admitted for NA in the Hospital Teaching Gabriel Touré of Bamako. The clinical and biological data including the prognosis were collected from the health records of women, the liaison sheets and the medical file. The analysis was done using the software Epi info version 3.5.1. Results: 76 NBs were included which represented 23.45% of hospitalizations. The majority (89.5%, n = 68) were admitted to less than 24 hours of life for NA grade III according to the Sarnat classification (43.4%, n = 33). The average age of mothers was 24.17 ± 5.5 years. Almost half (41.3%, n = 31) were primigravida. The most common obstetrical event was dystocia (64.5%, n = 49). The prognosis was poor in grade III anoxia in our patients (56%) of deaths. Conclusion: The périnatal anoxia (PA) is a major health issue in Mali because of its frequency and severity. Monitoring of pregnancies, delivery assisted by skillful and qualified personnel, mastery of neonatal resuscitation techniques are good means of prevention.

关键词： Anoxia Newborn Epidemiology Clinical Outcome

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Non-isothermal Decomposition Mechanism and Kinetics of liClO_4 in Nitrogen

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Chemical Research in Chinese Universities 2010年第2期26卷 300-303页

作者： diakite Kahirou College of Chemistry and Molecular Sciences Wuhan University

The non-isothermal decomposition kinetics of liClO4 in flow N2 atmosphere was studied. TG-DTA curves show that the decomposition proceeded through two well-defined steps below 900℃, and the mass loss was in agreement with the theoretical value. XRD profile demonstrates that the product of the thermal decomposition at 500℃ is liCI. for the decomposition kinetics study, the activation energies calculated with the friedman method were considered as the initial values for non-linear regression and were used for verifying the correctness of the fired models. The decomposition process was fitted by a two-step consecutive reaction： extended Prout-Tompkins equation[Bna, f（α） is （1-α）^nα^α] followed by a lth order reaction（f1）. The activation energies were （215.6±0.2） and （251.6±3.6） kJ/mol, respectively. The exponentials n and a for Bna reaction were （0.25±0.05） and （0.795±0.005）, respectively. The reaction types and activation energies were in agreement with those obtained from the isothermal method, but the exponentials were optimized for better firing and prediction.

关键词： liClO4 Decomposition mechanism Non-isothermal kinetics Non-linear regression

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

frontotemporal dementia and amyotrophic lateral sclerosis:frontotemporal dementia(f T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with fTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Kinetics of the Thermal Decomposition of Magnesium Salicylate Powder in Air

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Chemical Research in Chinese Universities 2006年第5期22卷 617-620页

作者： diakite Kahirou HONG Jian-he ZHAN Dan ZHANG Ke-li College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 P. R. China Research Center of Nanoscience and Nanotechnology Wuhan University Wuhan 430072 P. R. China

Simultaneous thermogravimetry-differential thermal analysis （TG-DTA） was used to study the kinetics and the degradation of magnesium salicylate（ C14H10MgO6 ） in air. The results show that the decomposition proceeds through two steps. The kinetics of the first decomposition step was studied. The activation energies were calculated by using the friedman and flynn Wall Ozawa（fWO） methods, and the most probable kinetic model function was estimated using the multiple linear regression method. The values of the correlated kinetic parameters for the first decomposition step are E = 152.97 kJ/mol, lg（A/S^-1 ） = 10. 78, f（α） = （ 1 - α）^n（ 1 ＋Kcatα）, n =0. 691, and Kcat = 1. 3048.

关键词： Magnesium salicylate TG-DTA Thermal decomposition Mechanism Kinetics

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Convolutional Neural Network for Hyperspectral Image Classification

Convolutional Neural Network for Hyperspectral Image Classif...

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作者： diakite AlOU 浙江理工大学

学位级别：硕士

Hyperspectral images（HSI）have been used in many domains such as agriculture,healthcare,food security,*** the recent development in hyperspectral imaging technology,hyperspectral images’ spectral and spatial resolutions have improved considerably and provided opportunities to characterize objects on the Earth’s surface with high *** the progress of deep learning techniques in computer vision,convolutional neural networks（CNNs）have been widely used for hyperspectral image ***,most of these methods are inefficient in real-world application due to the high dimensionality of the hyperspectral data,lack of large-labeled datasets,and spatial information *** this thesis,several convolutional neural networks have been explored and optimized for hyperspectral image classification,including crop *** first approach focuses on combining a 3D-2D convolutional neural network（CNN）in an end-to-end manner to mitigate the long-training times of hyperspectral *** this purpose,a fast-learning block based on 3D depth-wise convolution layer,a dimension reduction block followed by a 2D convolutional neural network was introduced to extract spectral-spatial *** experiments on four datasets showed that the proposed approach increases the classification performance and can significantly reduce the network parameters compared to some state-of-art *** our knowledge,this approach was the first attempt in the literature to use an end-to-end 3D-2D convolutional neural network for HSI *** was also the first-time using 3D depthwise separable convolutional neural network in HSI *** second approach proposes an extended morphological profile cube（EMPC）and a new densenet to tackle the limited training samples issue of hyperspectral image *** addition,the 3D densely connected network uses spectral-spatial dense connectivity blocks for early features fusion and the dimension reduc

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force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-fET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-fET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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