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Origin of potential errors in the quantitative determination of terahertz optical properties in time-domain terahertz spectroscopy

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Chinese Optics Letters 2015年第9期13卷 82-86页

作者：梁启军 Gregor Klatt Nico krau? Oleksii Kukharenko Thomas Dekorsy Department of Physics and Center for Applied Photonics University of Konstanz Laser Quantum GmbH faculty of Physics National Taras Shevchenko University of Kyiv

We demonstrate theoretically and experimentally how changes of a terahertz （THz） beam induced by the sample affect the accuracy of the determination of THz dielectric properties in THz time-domain transmission spectros- copy （TDTs）. We apply a Gaussian beam and the ABCD matrix formalism to describe the propagation of the THz beam in a focused beam setup. The insertion of the sample induces a focus displacement which is absent in the reference t without a sample. We show how the focus displacement can be corrected. The THz optical properties after focus displacement correction reported in this Letter are in quantitative agreement with those obtained using collimated beam THz-TDTsinpreviouswork.

关键词： THz Origin of potential errors in the quantitative determination of terahertz optical properties in time-domain terahertz spectroscopy time

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Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition

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Cancer Communications 2022年第4期42卷 360-364页

作者： Christian schneeweis Zonera HassanKatja Ascherl Matthias Wirth stella Koutsouli felix Orben Lukas krauß Carolin schneider Rupert Ollinger Oliver HKrämer Roland Rad Maximilian Reichert Maria sRobles Dieter saur Günter schneider Medical Clinic and Polyclinic II Klinikum rechts der IsarTechnical University MunichMunich 81675Germany Department of Hematology Oncology and Tumor ImmunologyCharite-Universitatsmedizin BerlinCorporate Member of Freie Universitat BerlinHumboldt-Universitat zu Berlin and Berlin Institute of HealthBerlin 12203Germany Institute of Medical Psychology and Biomedical Center(BMC) Faculty of MedicineLMU MunichMunich 80336Germany Institute of Molecular Oncology and functional Genomics TUM School of MedicineTechnical University MunichMunich 81675Germany Department of Toxicology University of Mainz Medical CenterMainz 55131Germany German Cancer Research Center(DKfZ)and German Cancer Consortium(DKTK) Heidelberg 69120Germany Center for Protein Assemblies(CPA) Technical University of MunichGarching 85747Germany Institute for Translational Cancer Research and Experimental Cancer Therapy Technical University MunichMunich 81675Germany Department of General Visceral and Pediatric SurgeryUniversity Medical Center GottingenGottingen 37075Germany

Dear Editor,Pancreatic ductal adenocarcinoma(PDAC)remains a significant health problem with an increase in the incidence and a five-year survival rate of only 10%[1].The Phosphoinositide 3-kinase-protein kinase-B-mechanistic target of rapamycin(PI3K-AKT-mTOR)pathway is a driver pathway in PDAC and an important therapeutic target[2].We[3]and others[4–6]have demonstrated that the mTOR kinase is a therapeutic target in PDAC,and rationally designed mTOR inhibitor(mTORi)-based combination therapies are emerging[2].

关键词： rapamycin therapeutic adenocarcinoma

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