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采用开放式低场机行MRI引导下胆汁引流术:首次临床经验

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Oncology and Translational Medicine 2001年第1期 60-60页

作者： f.k.wacker S.faiss k.Reither 关健华中科技大学同济医学院附属同济医院

目的:测试用开放式:MPI机在磁共振成像(MRI)引导下对患者行经皮胆汁引流术的可行性。方法:对6例存在机械性胆汁淤积的患者,用开放式低场MRI机行磁共振胆管造影(MRC),通过在MRI引导下的介入方法,行胆管系统穿刺术和导管插入术。将

关键词： MRI 低场引流术胆汁开放式

腹主动脉瘤病人行多层CT血管逆行灌注成像的最佳进动速度

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国际医学放射学杂志 2013年第6期 596-596页

作者： T.Werncke C.von falck M.Wittmann T.Elgeti f.k.wacker B.C.Meyer 朱珊张亚楠 klinik für Radiologie Charité Universit?tsmedizin BerlinCampus Benjamin Franklin Hindenburgdamm 3012200 BerlinGermany

摘要目的评估进行下肢CT血管逆行成像(run-offCTA)检查的腹主动脉瘤病人采用不同扫描床进动速度(Tf)对血管增强和影像质量的影响。方法本回顾性研究纳入了经机

关键词：多层CT 腹主动脉瘤回顾性研究血管成像下肢

feeding the vasculature with cruciferous vegetables:a secret for organ protection

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Signal Transduction and Targeted Therapy 2024年第3期9卷 828-830页

作者： Priya Veluswamy Jens Wippermann Max wacker Heart Surgery Research Department of Cardiothoracic SurgeryOtto-von-Guericke University HospitalMagdeburgGermany

Two very recent back-to-back papers published in Nature1,2 decipher the holistic role of the aryl hydrocarbon receptor(AHR)/dietary-ligand axis,in enteric and pulmonary vasculature to emphasize tolerance induction and vessel integrity during homeostasis,sterile inflammation and *** studies spectacularly highlight the significance of endothelium in orchestrating tissue tolerance by demonstrating the multifaceted activities of endothelial-expressed AHR that protects the vasculature to maintain organ homeostasis.

关键词： maintain sterile homeostasis

Effects of plant species richness on stand structure and productivity

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Journal of Plant Ecology 2009年第2期2卷 95-106页

作者： Luca wacker Oksana Baudois Susann Eichenberger-Glinz Bernhard Schmid Institute of Environmental Sciences University of ZurichWinterthurerstrasse 190CH-8057 ZurichSwitzerland

Aims Aboveground biomass production commonly increases with species richness in plant biodiversity *** is known about the direct mechanisms that cause this *** tested if by occupying different heights and depths above and below ground,and by optimizing the vertical distribution of leaf nitrogen,species in mixtures can contribute to increased resource uptake and,thus,increased productivity of the community in comparison with *** We grew 24 grassland plant species,grouped into four nonoverlapping species pools,in monoculture and 3-and 6-species mixture in spatially heterogeneous and uniform soil nutrient *** harvests of above-and belowground biomass,as well as leaf nitrogen and light measurements,were taken to assess vertical canopy and root space *** findings The distribution of leaf mass was shifted toward greater heights and light absorption was correspondingly enhanced in *** ever,only some mixtures had leaf nitrogen concentration profiles predicted to optimize whole-community carbon gain,whereas in other mixtures species seemed to behave more‘selfish’.Nevertheless,even in these communities,biomass production increased with species *** distribution of root biomass below ground did not change from monocultures to three-and six-species mixtures and there was also no indication that mixtures were better than monocultures at extracting heterogeneously as compared to homogeneously distributed soil *** conclude that positive biodiversity effect on aboveground biomass production cannot easily be explained by a single or few common mechanisms of differential space ***,it seems that mechanisms vary with the particular set of species combined in a community.

关键词： biodiversity effects heterogeneous nutrient distribution leaf nitrogen allocation root biomass distribution spatial niche separation

Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes

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Bone Research 2019年第1期7卷 41-53页

作者： Delphine B.Maurel Tsutomu Matsumoto Julian A.Vallejo Mark L.Johnson Sarah L.Dallas Yukiko kitase Marco Brotto Michael J.wacker Marie A.Harris Stephen E.Harris Lynda f.Bonewald Department of Oral and Craniofacial Sciences University of Missouri-Kansas City School of DentistryKansas CityMOUSA Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisINUSA Bone.Muscle Collaborative Sciences College of Nursing and Health InnovationUniversity of Texas at ArlingtonArlingtonUSA Department of Biomedical Sciences University of Missouri-Kansas City School of MedicineKansas CityMOUSA University of Texas Health Science Center San AntonioTXUSA Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisINUSA Pharmaceutical Sciences Department Universite de BordeauxBio-TisINSERM Unité1026 BioTis146 Rue Léo Saignat33076 BordeauxFrance

Transgenic mice are widely used to delete or overexpress genes in a cell specific manner to advance knowledge of bone biology,function and *** numerous Cre models exist to target gene recombination in osteoblasts and osteoclasts,few target osteocytes specifically,particularly mature *** goal was to create a spatial and temporal conditional Cre model using tamoxifen to induce Cre activity in mature osteocytes using a Bac construct containing the 5’and 3’regions of the Sost gene(Sost ERT2 Cre).four founder lines were crossed with the Ai9 Cre reporter *** founder line showed high and specific activity in mature *** and organs were imaged and fluorescent signal *** no activity was observed in 2 day old pups,by 2 months of age some osteocytes were positive as osteocyte Cre activity became spontaneous or‘leaky’with *** percentage of positive osteocytes increased following tamoxifen injection,especially in males,with 43%to 95%positive cells compared to 19%to 32%in *** signal was observed in any bone surface cell,bone marrow,nor in muscle with or without tamoxifen *** spontaneous signal was observed in any other ***,with tamoxifen injection,a few positive cells were observed in kidney,eye,lung,heart and *** other organs,28 in total,were negative with tamoxifen ***,with age,a muscle phenotype was apparent in the Sost-ERT2 Cre ***,although this mouse model may be useful for targeting gene deletion or expression to mature osteocytes,the muscle phenotype may restrict the use of this model to specific applications and should be considered when interpreting data.

关键词： cell knowledge model

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In vivo detection of mucosal healing-involved histiocytes by confocal laser endomicroscopy

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World Journal of Gastroenterology 2012年第32期18卷 4447-4449页

作者： Gheorghe Hundorfean Abbas Agaimy Mircea T Chiriac Walter GeiBdrfer Jochen wacker Markus f Neurath Jonas Mudter Medical ClinicⅠ University of ErlangenNuremberg91054 ErlangenGermany Institute of Pathology University of Erlangen-Nuremberg91054 ErlangenGermany Microbiology Institute-Clinical Microbiology Immunology and HygieneUniversity of Erlangen-Nuremberg91054 ErlangenGermany Medical Clinic Ⅲ University of Erlangen-Nuremberg91054 ErlangenGermany

Histiocytes have a pivotal role in wound repair and intestinal epithelial recovery-the most important goal to sustain gut ***,an in vivo description of colonic histiocytes by confocal laser endomicroscopy(CLE) is ***,we report the case of a 45-yearsold male patient who was referred to our clinic with weight loss and a history of two consecutive Clostridium difficile colitis episodes,the latter cured 3 wk before present *** microbiology was *** colonoscopy showed atrophy and a light mucosal oedema in the distal *** on-going endoscopy,we performed a fluorescein-aided CLE which revealed large polygonal(histiocytes-like) cells with copious cytoplasm and large nuclei in the lamina propria of the sigmoid colon as well as regenerative epithelial *** assessment of biopsies from the same areas confirmed the endomicroscopical findings:Periodic acid-Schiff-and CD68-positive foamy histiocytes in the colonic lamina propria and an advanced epithelial *** stool microbiology was repeatedly negative and polymerase chain reaction-analysis from colonic biopsies could not detect any mRNA for Thropheryma whippleii and common pathogens,we interpreted this particular setting as a mucosal healing process after consecutive Clostridium difficile *** conclusion,by describing these colonic histiocytes,we highlight the clinical usefulness of CLE in describing the entity of histiocytes in vivo and in real-time during the process of post-infectious mucosal healing in the colon.

关键词： Endomicroscopy Mucosal healing Advanced colonic imaging Colonic histiocytes

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钛合金网架髋臼重建术

中华骨科杂志 2000年第4期20卷 207-209页

作者：任先军 GA fuchs Juergen wacker 第三军医大学新桥医院骨科重庆400037 德国拜罗伊特医学中心骨科

目的观察自体植骨 ,钛合金网架重建内陷性髋臼的临床效果。方法1993年1月～1995年8月 ,25侧内陷性髋臼应用局部自体植骨 ,钛合金网架重建术。男11髋 ,女14髋 ,年龄45～76岁 ,平均69岁。术前诊断类风湿性关节炎11髋 ,骨关节炎8髋 ,股骨... 详细信息

目的观察自体植骨 ,钛合金网架重建内陷性髋臼的临床效果。方法1993年1月～1995年8月 ,25侧内陷性髋臼应用局部自体植骨 ,钛合金网架重建术。男11髋 ,女14髋 ,年龄45～76岁 ,平均69岁。术前诊断类风湿性关节炎11髋 ,骨关节炎8髋 ,股骨头缺血性坏死4髋 ,髋臼发育不良2髋。平均随访4.5年 (3～5年 )。结果25髋按Merled Aubigne标准评分,平均为10.2分 ,优良率88 % ,全部植骨获得骨性融合。无髋臼帽松动 ,髋臼内壁无一发生骨折或金属网架断裂。结论自体植骨同时用钛合金网架加固 ,能有效重建内陷性髋臼。

关键词：内陷性髋臼髋假体钛合金网架髋臼重建术

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圆周振动清粮装置的试验研究

农业工程学报 2002年第6期18卷 81-83页

作者：尹文庆 H.D.kutzbach P.wacker 南京农业大学霍恩海姆大学

为了提高清粮装置的工作能力 ,在双摇杆清粮装置试验台上 ,将筛面的驱动机构改为双曲柄机构 ,使筛子在铅垂面内作圆周运动 ,对筛子的振动频率、振幅、倾角、鱼鳞筛开度和谷粒喂入量等参数对清粮损失率和清洁度的影响进行了单因素试验 ,... 详细信息

为了提高清粮装置的工作能力 ,在双摇杆清粮装置试验台上 ,将筛面的驱动机构改为双曲柄机构 ,使筛子在铅垂面内作圆周运动 ,对筛子的振动频率、振幅、倾角、鱼鳞筛开度和谷粒喂入量等参数对清粮损失率和清洁度的影响进行了单因素试验 ,分析了圆周振动清粮装置的工作特性。

关键词：联合收割机清粮装置圆周振动筛振动频率筛面倾角鱼鳞筛开度谷粒流量

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扩散张量成像和示踪图评估异体移植肾功能障碍——初步研究

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国际医学放射学杂志 2012年第1期 95-96页

作者： k.Hueper M.Gutberlet T.Rodt W.Gwinner f.Lehner f.wacker 夏艺 SourceHannover Medical School-Germany Institute for Diagnostic and Interventional RadiologyCarl-Neuberg-Str.130625 HannoverGermany

目的评价MR扩散张量成像(DTI)作为无创性的诊断方法,检测急性及慢性移植肾功能障碍和器官微结构改变的能力。方法在1.5TMR设备上对15例异体移植肾功能障碍病人和14名健康志愿者行脂肪抑制平面回波DTI序列(扩散敏感梯度场施加在6个方向... 详细信息

目的评价MR扩散张量成像(DTI)作为无创性的诊断方法,检测急性及慢性移植肾功能障碍和器官微结构改变的能力。方法在1.5TMR设备上对15例异体移植肾功能障碍病人和14名健康志愿者行脂肪抑制平面回波DTI序列(扩散敏感梯度场施加在6个方向上,b值为0、600s/mm2)成

关键词：肾移植扩散张量成像各项异性磁共振扩散成像肾小球滤过率