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Breast Cancer Diagnosis Using feature Selection Approaches and Bayesian Optimization

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Computer Systems Science & Engineering 2023年第5期45卷 1017-1031页

作者： Erkan Akkur fuat turk Osman Erogul Department of Biomedical Engineering TOBB University of Economics and TechnologyAnkara06560Turkey Deparment of Computer Engineering Karatekin UniversityÇankırı18100Turkey

Breast cancer seriously affects many *** breast cancer is detected at an early stage,it may be *** paper proposes a novel classification model based improved machine learning algorithms for diagnosis of breast cancer at its initial *** has been used by combining feature selection and Bayesian optimization approaches to build improved machine learning *** Vector Machine,K-Nearest Neighbor,Naive Bayes,Ensemble Learning and Decision Tree approaches were used as machine learning *** experiments were tested on two different datasets,which are Wisconsin Breast Cancer Dataset(WBCD)and Mammographic Breast Cancer Dataset(MBCD).Experiments were implemented to obtain the best classification ***,Least Absolute Shrinkage and Selection Operator(LASSO)and Sequential forward Selection were used to determine the most relevant features,*** machine learning models were optimized with the help of Bayesian optimization approach to obtain optimal hyperparameter *** results showed the unified feature selection-hyperparameter optimization method improved the classification performance in all machine learning *** the various experiments,LASSO-BO-SVM showed the highest accuracy,precision,recall and f1-score for two datasets(97.95%,98.28%,98.28%,98.28%for MBCD and 98.95%,97.17%,100%,98.56%for MBCD),yielding outperforming results compared to recent studies.

关键词： Breast cancer machine learning Bayesian optimization feature selection

Aberrant cholesterol metabolism in colorectal cancer represents a targetable vulnerability

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Genes & Diseases 2023年第4期10卷 1172-1174页

作者： Jingwu Xie Chi Mai Nguyen Anita turk Hongmei Nan Thomas f.Imperiale Michael House Kun Huang Jing Su Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN 46202USA Department of Statistics and Data Science Indiana University School of MedicineIndianapolisIN 46202USA Division of Medical Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202USA Department of Global Health Richard M.Fairbanks School of Public HealthIndiana UniversityIndianapolisIN 46202USA Division of Gastroenterology and Hepatology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202USA Department of Surgery Indiana University School of MedicineIndianapolisIN 46202USA

Colorectal cancer(CRC)is the second most deadly adult cancer in men and women combined,accountable 9.2%of all cancer deaths.^(1)Drug resistance to chemotherapies,such as 5-fU-related regimens,remains a major cause of cancer recurrence and death in patients with *** metabolic changes in cancer cells are a significant cancer hallmark.

关键词： metabolism cancer colorectal

Solving Two-Dimensional Moving-Boundary Problems with Meshless and Level Set Method

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Journal of Energy and Power Engineering 2010年第1期4卷 51-55页

作者： L. Vrankar G. turk f. Runovc faculty of Natural Sciences and Engineering University of LjubljanaSlovenian SI-1001 Ljubljana Slovenia faculty of Civil and Geodetic Engineering University of Ljubljana Jamova cesta 2 1000 Ljubljana Slovenia faculty of Natural Sciences and Engineering University of Ljubljana Askerceva cesta 12 1000 Ljubljana Slovenia

During the past decade, increasing attention has been given to the development of meshless methods using radial basis functions for the numerical solution of Partial Differential Equations （PDEs）. A level set method is a promising design tool for tracking, modelling and simulating the motion of free boundaries in fluid mechanics, combustion, computer animation and image processing. In the conventional level set methods, the level set equation is solved to evolve the interface using a capturing Eulerian approach. The solving procedure requires an appropriate choice of the upwind schemes, reinitialization, etc. Our goal is to include Multiquadric Radial Basis functions （MQ RBfs） into the level set method to construct a more efficient approach and stabilize the solution process with the adaptive greedy algorithm. This paper presents an alternative approach to the conventional level set methods for solving moving-boundary problems. The solution was compared to the solution calculated by the exact explicit lime integration scheme. The examples show that MQ RBfs and adaptive greedy algorithm is a very promising calculation scheme.

关键词： Moving boundary problems level set method multiquadric greedy algorithm exact time integration scheme

CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients

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World Journal of Hepatology 2017年第25期9卷 1073-1080页

作者： Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri Investigador Asistente-CONICET Instituto Investigaciones Biomédicas en Retrovirus y SIDA INBIRS Universidad de Buenos Aires Instituto INBIRS UBA-CONICET Hospital Juan A fernández fundación Huésped Laboratorio de fisiopatología de la Inmunidad Innata Instituto de Biología y Medicina Experimental Departamento de Química Biológica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires

AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected *** Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR f0-f2 and G2, patients with METAVIR f3-f4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(fITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(fITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-fas L(PE), anti CD94(fITC). flow cytometry data acquisition was performed on BD fACSCanto, analyzed using flow Jo software. frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were *** Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damag

关键词： CD4^+ T cell Human immunodeficiency virus/hepatitis C virus-coinfection fibrosis Biomarker Natural killer cells

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流感杆菌的致病性

国外医学(微生物学分册) 1985年第5期 214-217页

作者： turk DC 王韧

1892年Pfeiffer就已提出流感杆菌是流行性感冒的病因,但直至1930～1960年才弄清其真实的致病范围,有关流感杆菌感染的预防和治疗问题还远未解决,近年来有了一些引人注目的发现。一、所致疾病和发病年龄仅少数流感杆菌具有多糖荚膜,根... 详细信息

1892年Pfeiffer就已提出流感杆菌是流行性感冒的病因,但直至1930～1960年才弄清其真实的致病范围,有关流感杆菌感染的预防和治疗问题还远未解决,近年来有了一些引人注目的发现。一、所致疾病和发病年龄仅少数流感杆菌具有多糖荚膜,根据荚膜糖多,本菌可分为六型(a～f),其中b型的致病性与其它五型明显不同。人是流感杆菌的唯一宿主,其分布和所致疾病见下表。

关键词：流感杆菌致病性发病年龄菌血症局部炎症大鼠粘附作用肺炎球菌耳炎粘附能力

Increased Expression and Altered Subcellular Distribution of Cathepsin B in Microglia Induces Cognitive Impairment through Oxidative Stress and Inflammatory Response in Mice

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神经药理学报 2018年第2期 27-28页

作者： NI Jun-jun WU Zhou Veronika Stoka Christoph Peters QING Hong Vito turk Hiroshi Nakanishi Department of Aging Science and Pharmacology Faculty of Dental ScienceKyushu University Department of Biochemistry and Molecular and Structural Biology J.Stefan Institute Institute für Molekulare Medizin und Zellforshung Albert-Ludwigs-Universit?t Freiburg Beijing Key Laboratory of Separation and Analysis in Biomedical and Pharmaceuticals Department of Biomedical EngineeringSchool of Life ScienceBeijing Institute of Technology

Objective:During normal aging,innate immunity progresses to a chronic state. However,how oxidative stress and chronic neuroinflammation arise during aging remain unclear. In this study,we intended to demonstrate the novel function of Cathepsin B（ CatB） in the age related oxidative stress and chronic neuroinflammation. Methods:（1）2 month-old and 20 month-old wild-type and CatB;mice were used for learning and memory tests by step through passive avoidance tests. The cumulative potentiation of the field excitatory postsynaptic potential（ f EPSP） slope and dendritic spine density were also examined.（2）Inflammation were examined by immunoblotting of interleukin-1β（ IL-1β）,tumor necrosis factor-α（ TNf-α） and inducible nitric oxide synthase（ i NOS）,and oxidative stress were examined by checking the level of 8-oxo-7,8-dihydro-2’-deoxyguanosine（ 8-oxo-d G） and 4-hydroxynonenal（ 4-HNE） in the hippocampal lysate of 2 month-old and 20 month-old wild-type and CatB;mice.（3）Intra-lateral ventricle transplantation of CatB over-expressed microglia in middleaged mice,learning and memory were examined by Y-maze and novel objective tests. Results:（1）The retention latencies of both aged groups were significantly longer than those in the acquisition trial. The retention latency of four consecutive trials was significantly longer in aged CatB;mice than in aged wild-type mice. furthermore,the mean relative f EPSP slope measured at 30 min after stimulationwith 25,50 and 100 Hz in the aged CatB;mice was significantly larger than that in the aged wildtype mice. The mean dendritic spine density of CA1 neurons in the aged CatB;mice was significantly larger than that in the aged wild-type mice.（2）The mean levels of CatB,i NOS,IL-1β and TNf-α in the hippocampus were significantly higher in aged wild-type mice than in younger animals. furthermore,their mean levels in the hippocampus of aged CatB;mice were significantly lower than those in aged wild-type mice. The mean amounts of these oxidative ma

关键词： Increased Expression and Altered Subcellular Distribution of Cathepsin B in Microglia Induces Cognitive Impairment through Oxidative Stress and Inflammatory Response in Mice HNE

Effect of taxifolin on cold-shock damages in spermatozoa in rabbits

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亚太生殖杂志:英文版 2023年第5期12卷 239-248页

作者： Irfan Yılmaz Gaffari turk Aslıhan Cakir Cihangiroglu Tutku Can Acisu Ibrahim Halil Gungor GozdeArkali Edanur Guler Ekmen firat University Faculty of Veterinary MedicineDepartment of Reproduction and Artificial InseminationElazigTur kiye firat University Faculty of Veterinary MedicineDepartment of PhysiologyElazıgTurkiye

Objective:To investigate the effect of taxifolin added to rabbit semen on freezing-induced cold-shock damages in ***:Semen was collected from six adult New Zealand rabbits once a week by artificial *** collected semen was pooled at 38℃ and divided into four equal *** were diluted with 0,50,100 and 200μM taxifolin-containing Tris+egg yolk extender at 38℃ and their temperatures were lowered to 4℃.following equilibration,semen drawn into 0.25 mL straws were frozen in an automatic semen freezing device and stored in liquid nitrogen container at-196℃.Samples were thawed in 38℃ water for 25 s and the analyses of motility,kinematic parameters,morphological deformities,changes in membrane integrity,mitochondrial membrane potential,dead-live ratio,acrosomal damages and as well as oxidative stress analyses were performed in ***:Addition of 50μM taxifolin significantly improved motility(total,progressive,rapid and static),high mitochondrial membrane potential and the ratios of spermatozoa with acrosomal damage compared to the control *** to the control group,malondialdehyde(MDA)levels in the 50 and 100μM taxifolin groups were significantly lower,while the MDA level was high and viable spermatozoa ratio was low in the 200μM taxifolin *** were no significant differences between the groups in terms of kinematic parameters,morphological deformities,membrane integrity and antioxidant ***:The low dose of taxifolin(50μM)has a positive effect and the high dose(200μM)has a negative ***,it is concluded that the addition of low-dose(50μM)taxifolin to the extenders would be a useful additive in reducing cold-shock damage that occurs during freezing of rabbit semen.

关键词： Taxifolin Semen freezing Cold-shock Oxidative stress Rabbit

猛禽监测计划:确定英国顶级掠食者化学污染物的风险

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AMBIO－人类环境杂志 2008年第6期37卷 447-452页

作者： Lee A. Walker Richard f. Shore Anthony turk M.Glória Pereira Jenniter Best 曲善庆生态与水文中心 "自然英格兰(Nature England)"证据小组

猛禽监测计划是一项长期的(40年以上)、遍及英国的暴露监测计划,目的是确定猛禽肝脏和卵中指定杀虫剂和污染物的浓度。本文描述了猛禽监测计划的工作过程,尤其侧重描述其中一些用以监测猛禽体内污染物的重要科学和政策动因,以及猛禽监... 详细信息

猛禽监测计划是一项长期的(40年以上)、遍及英国的暴露监测计划,目的是确定猛禽肝脏和卵中指定杀虫剂和污染物的浓度。本文描述了猛禽监测计划的工作过程,尤其侧重描述其中一些用以监测猛禽体内污染物的重要科学和政策动因,以及猛禽监测计划的特别目标、范围和方法。我们还发布了过去未曾发表的数据,这些数据充分说明猛禽监测计划在逆转化学污染物产生的影响中是一项成功的缓解措施,且猛禽监测计划能够确定并评估化学物质对具有高保护价值物种的风险,并最终宣告和提炼出监测方法理论。另外,我们讨论了这项计划如何用于更广泛的保护需求。

关键词：化学污染物监测猛禽风险英国保护价值缓解措施化学物质

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad f. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos f. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.f. Allen C.A. Allendes flores P.P. Allport A. Aloisio f. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli f. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-f. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu f. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene f. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING