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Prolonged acute hepatitis A mimicking autoimmune hepatitis

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World Journal of Gastroenterology 2005年第24期11卷 3791-3793页

作者： Rintaro Mikata Osamu Yokosuka fumio imazeki Kenichi fukai Tatsuo Kanda Hiromitsu Saisho Department of Medicine and Clinical Oncology

AIM: We report a case with a prolonged course of hepatitis A, with alanine aminotransferase (ALT) higher than 500 IU/L for more than 2 mo. METHODS: A middle-aged woman had an elevated IgG level of more than 2 000 mg/dL, positive anti-nudear antibodies (ANA) and anti-smooth muscle antibodies (ASMA), but no evidence of persistent hepatitis A virus (HAV) infection. Liver biopsy findings were compatible with prolonged acute hepatitis, although acute onset of autoimmune hepatitis could not be ruled out. RESULTS: It was assumed that she developed a course of hepatitis similar to autoimmune hepatitis triggered by HAV infection. Ursodeoxycholic acid (UDCA) treatment was initiated and a favorable outcome was obtained. CONCLUSION: We describe a case of a middle-aged woman who showed a prolonged course of acute hepatitis A mimicking autoimmune hepatitis. Treatment with UDCA proved to be effective.

关键词： Prolonged IgG Hepatitis A Autoimmune hepatitis

Hepatitis C virus protease inhibitor-resistance mutations: Our experience and review

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World Journal of Gastroenterology 2013年第47期19卷 8940-8948页

作者： Shuang Wu Tatsuo Kanda Shingo Nakamoto fumio imazeki Osamu Yokosuka Department of Gastroenterology and Nephrology Chiba UniversityGraduate School of MedicineChiba 260-8677Japan Postdoctoral fellow Foreign Researcher of the Japan Society for Promotion of Science (JSPS)Tokyo 102-0083Japan Department of Molecular Virology Chiba UniversityGraduate School of MedicineChiba 260-8677Japan Safety and Health Organization Chiba UniversityChiba 263-8522Japan

Direct-acting antiviral agents(DAAs)for hepatitis C virus(HCV)infection are one of the major advances in its medical *** HCV protease inhibitors boceprevir and telaprevir were the first approved DAAs in the United States,Europe,and *** combined with peginterferon plus ribavirin,these agents increase sustained virologic response rates to70%-80%in treatment-na?ve patients and previoustreatment relapsers with chronic HCV genotype 1 *** peginterferon plus ribavirin,DAA monotherapies increased DAA-resistance *** new DAAs for HCV are now in clinical development and are likely to be approved in the near ***,it has been reported that the use of these drugs also led to the emergence of DAA-resistance mutations in certain ***,these mutations exhibit cross-resistance to multiple *** prevalence of DAA-resistance mutations in HCV-infected patients who were not treated with DAAs is unknown,and it is as yet uncertain whether such variants are sensitive to *** performed a population sequence analysis to assess the frequency of such variants in the sera of HCV genotype 1-infected patients not treated with HCV protease ***,we reviewed the literature on resistance variants of HCV protease inhibitors in treatment na?ve patients with chronic HCV genotype 1,as well as our experience.

关键词： Direct-acting antiviral agent Hepatitis C virus Protease inhibitor Resistance mutation Sequence analysis

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas f.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Effect of lamivudinein in BeAg-positive chronic hepatitis B: Discordant effect on HBeAg and HBV DNA according to pretreatment ALT level

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World Journal of Gastroenterology 2005年第22期11卷 3346-3350页

作者： Tomoko Kurihara fumio imazeki Osamu Yokosuka Kenichi fukai Tatsuo Kanda Shigenobu Kawai Hiromitsu Saisho Department of Medicine and Clinical Oncology Graduate School of Medicine Chiba University 1-8-1 Inohana Chuou Ward Chiba 260-8670Japan

AM: To clarify differences in antiviral effect of the drug in patients with different ALT levels, we examined the changes in HBV markers in patients with high or low ALT levels with or without lamivudine treatment. METHODS: Thirty-seven HBeAg-positive patients were studied. Ten patients with ALT levels higher than 200 IU/L (group 1) and 8 patients with ALT below 200 IU/L (group 2) were treated orally with 100 mg/d of lamivudine. As untreated control, 9 patients with ALT above 200 IU/L (group 3) and 10 patients with ALT below 200 IU/L (group 4) were examined. ALT level, HBeAg/HBeAb status, and HBV DNA level were examined monthly for 11.9±0.4 mo. RESULTS: The ALT level normalized in all 10 patients of group 1, 7/8 of group 2, 4/9 of group 3, and 1/10 of group 4 within 6 mo (groups 1 vs2, P= NS; groups 1 vs 3, P= 0.002; groups 1 vs4, Pfell below the detection limit in all 10 patients of group 1, 7/8 of group 2, 0/9 of group 3, and 0/10 of group 4 within 6 mo (groups 1 vs 2, P - NS). HBeAg became seronegative in 7/10 patients of group 1, 1/8 of group 2, 3/9 of group 3, and 0/10 of group 4 within 12 mo (groups 1 vs2, P= 0.02; groups 1 vs 3, P= NS). CONCLUSION: Our data suggest that HBeAg-positive patients with higher ALT levels can be considered good candidates for lamivudine therapy, probably because lamivudine accelerates the natural seroconversion of HBeAg, accompanied by HBV DNA loss, in these patients.

关键词： Lamivudine Chronic hepatitis B HBeAg HBV DNA ALT

Severe hypercholesterolemia associated with primary biliary cirrhosis in a 44-year-old Japanese woman

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World Journal of Gastroenterology 2004年第17期10卷 2607-2608页

作者： Tatsuo Kanda Osamu Yokosuka Hiroshige Kojima fumio imazeki Keiich Nagao Ichiro Tatsuno Yasushi Saito Hiromitsu Saisho first Department of Medicine Chiba University School of MedicineChiba 260-8670Japan Health Sciences CenterChiba UniversityChiba 260-8670Japan Health Sciences Center Chiba UniversityChiba 260-8670Japan Second Department of Medicine Chiba University School of MedicineChiba 260-8670Japan

A 44-year-old woman developed jaundice and was diagnosed as stage Ⅱ of primary biliary cirrhosis(PBC).She showed a severely high total cholesterol *** article focuses on atypical presentations of PBC and the need to ... 详细信息

关键词： Adult Cholesterol female Humans Hypercholesterolemia Japan Liver Cirrhosis, Biliary Severity of Illness Index

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase

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World Journal of Hepatology 2013年第11期5卷 635-641页

作者： Tatsuo Miyamura Tatsuo Kanda Masato Nakamura Xia Jiang Shuang Wu Shingo Nakamoto Shigeru Mikami Nobuo Takada fumio imazeki Osamu Yokosuka Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine Department of Internal Medicine Kikkoman General Hospital Department of Internal Medicine Toho University Sakura Medical Centre Safety and Health Organization Chiba University

AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compared the treatment response of HCV-infected patients with PNALT to that of patients with *** february 2010 and April2013,278 patients infected with HCV were enrolled in this *** of the patients were treated with peginterferon-alpha 2a or 2b plus *** addition,180μg of peginterferon alpha-2a or 1.5μg/kg peginterferon alpha-2b per week plus weight-based ribavirin(600-1000 mg/d)were typically administered for 24 wk to HCV genotype 2-infected patients or for 48-72 wk to HCV genotype 1-infected *** all of the patients,the IL-28B rs8099917 genotype was determined using a TaqMan single-nucleotide polymorphism *** RNA was measured using the COBAS TaqMan HCV ***:female patients were dominant in the PNALT group(Pfected patients with PNALT,the early virologic response(EVR)rates(Pfected patients with PNALT,multivariate logistic-regression analysis showed that SVR was independently predicted by the IL-28B rs8099917 TT type(Pfected Asian patients with ***:The IL-28B genotype may be useful for selecting HCV genotype 1-infected patients with PNALT who should receive interferon-based treatment.

关键词： Hepatitis C virus Interleukin 28B Persistent normal alanine aminotransferase levels Standard of care Treatment response

Sofosbuvir treatment and hepatitis C virus infection

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World Journal of Hepatology 2016年第3期8卷 183-190页

作者： Masato Nakamura Tatsuo Kanda Yuki Haga Reina Sasaki Shuang Wu Shingo Nakamoto Shin Yasui Makoto Arai fumio imazeki Osamu Yokosuka Department of Gastroenterology and Nephrology Chiba UniversityGraduate School of MedicineChiba 260-8670Japan Department of Molecular Virology Chiba UniversityGraduate School of MedicineChiba 260-8677Japan Safety and Health Organization Chiba UniversityChiba 263-8522Japan

Hepatitis C virus(HCV) infection is a serious problem *** use of interferon-based therapy has made HCV eradication *** recent appearance of direct-acting antiviral agents(DAAs) has changed HCV *** the use of DAAs with peginterferon and ribavirin has improved treatment ***,the combination of different orally administered DAAs has enabled interferon-free therapy with much higher efficacy and *** particular,sofosbuvir,a nucleotide-based NS5 B inhibitor,prevents HCV RNA synthesis by acting as a "chain terminator".Treatment with sofosbuvir has attained an extremely high rate of sustained virologic *** current review summarizes the efficacy and safety of sofosbuvir therapy.

关键词： Hepatitis C virus Interferon Interferonfree Genotype Sofosbuvir

Leveraging ROTI map derived from Indonesian GNSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan N.Muafiry Teguh N.Pratama Angga Y.Putra Suraina Gatot H.Pramono Sidik T.Wibowo febrylian f.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi Research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research Center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GNSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GNSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GNSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GNSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC change index(ROTI)map

维普期刊数据库