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Olfactory receptors in neural regeneration in the central nervous system

Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael franco Claudia Garrigós Toni capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Effects of application date and rate of foliar-applied glyphosate on pine seedlings in Turkey

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Journal of forestry Research 2018年第3期29卷 583-591页

作者： Mehmet Can cap Derya Essn Department of forest Engineering Faculty of ForestryDüzce UniversityKonuralp Yerleskesi81620 DüzceTurkey

Glyphosate is the herbicide most extensively used for site preparation and conifer release. It is a broadspectrum herbicide and therefore crop safety is a critical issue. This study assessed the early effects of 14 different treatments, including no weed control, manual weed control, and 12 foliar-applied herbicide treatments at low,intermediate, high, and highest application rates and application timing on glyphosate phytotoxicity of containerized seedlings of Austrian pine(Pinus nigra ***.), Scots pine(P. sylvestris L.) and maritime pine(*** Aiton), conifer species widely used for afforestation and supplementary plantings in Turkish forestry. In general, Scots pine seedlings were tolerant to glyphosate compared to the other species. Glyphosate phytotoxicity varied significantly according to the time and rate of application. Seedlings were relatively tolerant to glyphosate in April whereas they were intolerant in May. The highest herbicide rate(1.2% v:v) was consistently phytotoxic to all species. Moreover, the effect of herbicide rate on seedling survival and growth varied significantly according to application date(i.e., application rate 9 date interaction). Seedlings appeared tolerant to glyphosate at low and intermediate rates(0.2, 0.4% v:v) between midspring and mid-summer, whereas they demonstrated significant sensitivity to the highest rate across all time periods. Glyphosate at the high rate(0.8% v:v) was particularly more phytotoxic when applied in May. Application of glyphosate at rates up to 0.8% could be recommended for weed control without significant pine damage in midspring when the needles presumably have a dense leaf epicuticular wax layer limiting herbicide *** of 0.8 and 1.2% v:v are not recommended during May–June.

关键词： Application date and rate Glyphosate screening Pines Seedling tolerance

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Investigation of calcium phosphate (cap) tribofilms from commercial automatic transmission fluids (ATfs) and their correlation with antishudder performance

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friction 2020年第5期8卷 882-892页

作者： Zechao di Jingjing XU Yang LIU Yu JIANG Dongsheng HUANG Haitao CUI Zhongguo LIU Zhiyu ZHAO Shaohui LI Dalian Lubricating Oil Research&Development Institute PetroChinaDalian 116032China

The friction properties of wet clutches are highly dependent on the surface tribofilms formed by automatic transmission fluids (ATfs). Here, four commercial ATfs were evaluated with a disc-on-disc tribometer to study tribofilm formation on steel surfaces and the effects of tribofilms on the friction properties. The chemical composition, stoichiometry, structure, and thickness of the tribofilms were investigated by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), secondary ion mass spectrometry (SIMS), and X-ray photoelectron spectroscopy (XPS). Calcium phosphate (cap) tribofilms form on the friction surface with all ATfs, which contributes to their antishudder characteristics. The thickness and surface coverage of cap tribofilms are positively correlated with their antishudder properties.

关键词： tribofilm commercial ATf antishudder hydroxyapatite

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评价散寒化湿颗粒与奈玛特韦-利托那韦对照治疗轻型/中型新型冠状病毒感染有效性和安全性的随机、开放、多中心临床研究

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Science Bulletin 2024年第12期69卷 1954-1963页

作者：邹晓辉常康范国辉郑欢伟神和正唐亮杨映映王业明赵林华吕红周昕沈小明陈利强仝小林曹彬 National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesLaboratory of Clinical Microbiology and Infectious DiseasesDepartment of Pulmonary and Critical Care MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical Research and Data Management Center of Respiratory MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Shijiazhuang Hospital of Traditional Chinese Medicine Shijiazhuang 050051China Linyi Traditional Chinese Medicine Hospital Linyi 276000China Wuxi Traditional Chinese Medicine Hospital Wuxi 214071China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Traditional Chinese Medicine for Pulmonary DiseasesCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Institute of Metabolic diseases Guang’anmen Hospital of ChinaAcademy of Chinese Medical SciencesBeijing 100053China Taicang Traditional Chinese Medicine Hospital Taicang 215400China The first Hospital of Qiqihar Qiqihar 161005China The Second Affiliated Hospital of Jiaxing University Jiaxing 314000China Huizhou first Hospital Huizhou 516003China National Center for Integrated Traditional Chinese Medicine and Western Medicine China-Japan Friendship HospitalBeijing 100029China

Sanhan Huashi granules(SHG)demonstrated therapeutic effects against coronavirus disease 2019(COVID-19)in observational *** order to compare the effectiveness and safety of SHG and nirmatrelvir–ritonavir in treating adults with mild-to-moderate COVID-19,we conducted a randomized,activecontrolled,open-label,multi-center trial conducted between february and July in *** patients were randomized in a 1:1 ratio to the SHG group and the nirmatrelvir–ritonavir group.A total of 400participants were randomized,among which 200 participants ultimately received SHG and 198 received nirmatrelvir–*** primary outcome was time to sustained clinical recovery through day *** significantly shortened the median time to sustained clinical recovery compared to nirmatrelvir–ritonavir(6.0(95%CI,5.0 to 6.0)vs.8.0(95%CI,6.0 to 9.0)d;P=0.001),particularly for individual symptoms including fever,sore throat,cough and *** participants in either group died and incidence of severe COVID-19 showed no difference between two *** who received nirmatrelvir–ritonavir demonstrated a higher rate of virus clearance on day 5 compared to those received SHG(46.4%(95%CI,39.1 to 53.7)vs.65.6%(95%CI,58.3 to 72.4);Pfter 5 d of treatment(Chinese Clinical Trial Registry Identifier:Chi CTR2300067872).

关键词： Traditional Chinese medicine COVID-19 Nirmatrelvir-Ritonavir Sustained clinical recovery

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Restoration of Ultimate Strength of Dented Hemispheres Under External Hydrostatic Pressure

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China Ocean Engineering 2022年第3期36卷 500-507页

作者： HUANG Chen ZHANG Jian WANG fang di Chen-yang School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Shanghai Engineering Research Center of Hadal Science and Technology Shanghai Ocean UniversityShanghai 201306China

This study aimed to restore the ultimate strength of dented stainless-steel hemispheres with a radius of 90 mm and a thickness of 0.86 *** of the hemispheres were subjected to external hydrostatic *** stainless-steel stiffened caps were used to eliminate the effect of indention on the ultimate *** caps had a radius of 36 mm,a thickness of 0.76 mm,and a height of 10.44 *** hemispherical samples,including two intact hemispheres,two dented hemispheres without stiffening,and two dented hemispheres with stiffening,were *** hemi-sphere was geometrically measured for shape and thickness,hydrostatically tested for destruction,and numerically evaluated for *** experimental and numerical data agreed well with each *** a result,a spherical cap can effectively restore the ultimate strength of dented hemispheres under external hydrostatic *** proposed restoration approach can be used to strengthen underwater pressure hulls with large local geometric imperfections.

关键词： hemisphere restoration ultimate strength hydrostatic pressure buckling

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2022年四川芦山M_(S)6.1地震前应力状态研究

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地震研究 2024年第4期47卷 483-492页

作者：张致伟曾宪伟王迪路茜王玮铭杨鹏龙锋四川省地震局四川成都610041 成都理工大学四川成都610059 宁夏回族自治区地震局宁夏银川750001

为研究2022年6月1日四川芦山M_(S)6.1地震的孕育和发生过程,采用cap方法反演了2013年芦山M_(S)7.0主震及M_(S)≥5.0余震的震源机制解,并基于应力张量方差与b值时空分布特征,探讨了芦山M_(S)6.1地震的力学机制和震源区的应力状态。结果表... 详细信息

为研究2022年6月1日四川芦山M_(S)6.1地震的孕育和发生过程,采用cap方法反演了2013年芦山M_(S)7.0主震及M_(S)≥5.0余震的震源机制解,并基于应力张量方差与b值时空分布特征,探讨了芦山M_(S)6.1地震的力学机制和震源区的应力状态。结果表明:2022年芦山M_(S)6.1地震震源机制表现出与2013年芦山M_(S)7.0主震和5级余震相似的逆冲型破裂特征,压应力轴方位与龙门山断裂带南段区域应力场一致。2013年芦山M_(S)7.0地震后震中及附近的应力张量方差和b值长期处于低值状态,2022年芦山M_(S)6.1地震前震中及附近出现了应力张量方差和b值的低值异常,表明芦山余震区处于较高的应力水平。分析认为:巴颜喀拉块体持续东向运动受到华南块体的阻挡,震中所在区域长期受挤压逆冲作用,从而使芦山余震区长期处于应力积累的状态,芦山M_(S)6.1地震也是在这种动力学背景下发生的。

关键词：芦山M_(S)6.1地震芦山M_(S)7.0地震震源机制解应力张量方差 b值应力状态

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B2C类型网站购物体验对购买意愿的影响研究——以成都地区来华留学生为例

B2C类型网站购物体验对购买意愿的影响研究——以成都地区来华留...

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作者： cap THI LAN ANH 西南交通大学

学位级别：硕士

自从中国改革开放以来,来华外国人越来越多,他们已经成为消费者中不可忽视的一个群体。来华留学生作为其中一个特殊群体,一直都有学者对其进行研究,但是多数研究还是停留在来华学习动机和跨文化适应问题上,几乎没有学者对于来华留学生... 详细信息

自从中国改革开放以来,来华外国人越来越多,他们已经成为消费者中不可忽视的一个群体。来华留学生作为其中一个特殊群体,一直都有学者对其进行研究,但是多数研究还是停留在来华学习动机和跨文化适应问题上,几乎没有学者对于来华留学生的网络购物体验状况进行实证研究。而中国要想真正的成为一个包容万物的大国,就必须重视外国人在中国的网络购物体验。本研究通过调查39个国家和地区的来华留学生,基于“刺激—机体—反应”(S-O-R)模型,结合强化理论和期望理论,从消费者心理学的角度,对来华留学生群体在B2C类型网站上的顾客体验状况进行调查。同时,以成都来华留学生群体为调查样本,探索顾客体验对购买意愿的影响,消费情绪在顾客体验与购买意愿之间的中介作用,以及顾客价值倾向对购物体验、消费情绪、购买意愿之间关系的调节作用。运用层次分析法进行数据分析发现:(1)顾客体验对购买意愿有显著正向影响。(2)顾客体验对积极情绪有显著正向影响;对消极情绪有显著负向影响。(3)积极情绪在顾客体验与购买意愿的关系中起到部分中介作用。(4)情感价值倾向在顾客体验与积极情绪之间起到正向调节作用;功能价值倾向在顾客体验与购买意愿之间起到正向调节作用。具体而言,当顾客的情感价值倾向水平越高,良好的顾客体验产生的积极情绪越多;反之,越少。当顾客的功能价值倾向水平越高,顾客体验与购买意愿之间的正向相关关系更强。本文开启了对来华留学生的消费体验和行为的探索与研究。本文的研究结果可以为中国各类网络购物网站的发展完善提供指导建议,有利于中国电子商务企业为国外用户打造一个更有吸引力的消费平台。另一方面,本研究也启发中国企业在考虑用户感受的时候,需要适当地考虑外国用户,为中国企业更快更好地走向世界做好铺垫。最后,本文还总结分析了本研究的局限性,并指出未来的研究可以从顾客体验和购买意愿的跨文化对比研究、以及消费情绪研究方面进行积极探索。

关键词：来华留学生顾客体验消费情绪购买意愿顾客价值倾向

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世界不平等上升了还是下降了——一个虚假的争论吗?

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世界经济文汇 2005年第3期 37-53页

作者： Bart cap.au Andr Decoster 王丽娜

在这个全球化的年代,世界不平等是上升了还是下降了的问题是一个热门话题。研究经济不平等的测量的前沿学者发展了各种方法来实证地估计世界居民的福利分配。尽管他们使用了类似的方法,但是并没有形成一致的结论。目前的论文已经形成两... 详细信息

在这个全球化的年代,世界不平等是上升了还是下降了的问题是一个热门话题。研究经济不平等的测量的前沿学者发展了各种方法来实证地估计世界居民的福利分配。尽管他们使用了类似的方法,但是并没有形成一致的结论。目前的论文已经形成两种完全相反的观点。SalaiMartin(2002a,b)认为,从二十世纪七十年代末到二十世纪九十年代末,世界不平等在下降是毋庸置疑的。Milanovic(2002a,b,c)并不否认这一点,但是他以经验为依据阐明了国家内部(尤其是城镇和农村之间)不平等趋势的重要性,估计了真实世界的不平等,并且得到了与前者相反的结论。然而,大家(尤其这里所引述的文献)对世界收入分配不平等的测量上是一致的。我们的结果表明,至少对于国际不平等,我们有经验证据证明一般的熵方法测量的不平等的排序发生了变化,并且我们希望这对于世界不平等也是正确的。然而,关于使用哪一种不平等测量方法来估算真实的世界不平等的规范的争论还没有正式开始。

关键词：世界下降争论上升二十世纪九十年代虚假经济不平等福利分配七十年代收入分配证据证明测量方法全球化估计使用经验真实热门居民 Mi 农村城镇内部国际

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内环倒扣瓶盖四面内抽芯脱模机构设计

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塑料 2019年第3期48卷 82-86页

作者：肖天非贵州电子信息职业技术学院

针对某容器带内环倒扣瓶盖的注塑成型要求,设计了 1 模 8 腔点浇口三板模注塑模具。模具分 5 次分型,单腔中,塑件采用单点点浇口进行浇注。针对 4 个环形倒扣,设计了依靠模板驱动的四面内抽芯机构,实现了塑件上4 个环形倒扣特征的脱模... 详细信息

针对某容器带内环倒扣瓶盖的注塑成型要求,设计了 1 模 8 腔点浇口三板模注塑模具。模具分 5 次分型,单腔中,塑件采用单点点浇口进行浇注。针对 4 个环形倒扣,设计了依靠模板驱动的四面内抽芯机构,实现了塑件上4 个环形倒扣特征的脱模。四面内抽芯机构主要构件包括中央四面斜燕尾槽抽芯块、侧抽芯活动镶件、活动镶件架;机构依靠中央四面斜燕尾槽抽芯块的侧面燕尾槽与侧抽芯活动镶件滑动联结,用于驱动侧抽芯活动镶件内收抽芯。模具结构设计新颖,借助于四面内抽芯脱模机构设计,实现了塑件的自动化注塑生产;机构动作可靠,加工装配简单。

关键词：四面抽芯内环倒扣机构设计注塑模具脱模

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经典中的精品—梦幻之星网络版

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网迷 2002年第3期 131-135页

作者： cap

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