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Toward diagnostic relevance of theαVβ5,αVβ3,andαVβ6 integrins in OA:expression within human cartilage and spinal osteophytes

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Bone Research 2020年第4期8卷 458-472页

作者： Edith charlier céline Deroyer Sophie Neuville Zelda Plener Olivier Malaise federica ciregia Philippe gillet gilles Reuter Mallory Salvé Nadia Withofs Roland Hustinx Dominique de Seny Michel g.Malaise Laboratory of Rheumatology GIGA-I3CHULiègeULiègeLiègeBelgium Department of Orthopaedic Surgery CHULiègeLiègeBelgium Department of Neurosurgery CHULiègeLiègeBelgium Department of Nuclear Medicine CHULiègeLiègeBelgium

We previously reported 18fPRgD2 uptake by the coxofemoral lining,intervertebral discs and facet joint osteophytes in OA using PET/ScAN ***,the molecular mechanism by which the PRgD2 tracer interacts with joint tissues and osteophytes in OA remains *** PRgD2 ligands are expected to belong to the RgD-specific integrin family,the purpose of this study was(i)to determine which integrin complexes display the highest affinity for PRgD2-based ligands,(ii)to analyze integrin expression in relevant tissues,and(iii)to test integrin regulation in chondrocytes using OA-related stimuli to increase the levels of fibrosis and ossification *** this end,the affinity of PRgD2-based ligands for five heterodimeric integrins was measured by competition with *** situ analyses were performed in human normal *** cartilage and spinal *** were characterized by(immuno-)histological *** subunit expression was tested in chondrocytes undergoing dedifferentiation,osteogenic differentiation,and inflammatory *** integrinsαVβ5,αVβ3,andαVβ6 presented the highest affinity for PRgD2-based *** situ,the expression of these integrins was significantly increased in OA compared to normal *** osteophytes,the mean integrin expression score was significantly higher in blood vessels,fibrous areas,and cells from the bone lining than in osteocytes and cartilaginous *** vitro,the levels of integrin subunits were significantly increased during chondrocyte dedifferentiation(except forβ6),fibrosis,and osteogenic differentiation as well as under inflammatory *** conclusion,anatomical zones(such as OA cartilage,intervertebral discs,and facet joint osteophytes)previously reported to show PRgD2 ligand uptake in vivo expressed increased levels ofαVβ5,αVβ3,andβ6 integrins,whose subunits are modulated in vitro by OA-associated conditions that increase fibrosis,inflammation,and osteogenic differentiation.T

关键词： cartilage inflammation femoral

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Theoretical prediction of structural,electronic and optical properties of quaternary alloy Zn_(1-x)Be_xS_ySe_(1-y)

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chinese Physics B 2012年第3期21卷 321-327页

作者： Hacini K Meradji H ghemid S El Haj Hassan f Laboratoire LPR D'epartement de PhysiqueFaculté des SciencesUniversité de Annaba Laboratoire de physique des Matériaux Faculté des SciencesUniversité Libanaise

Within density functional theory based on the full potentiM-linearized augmented plane wave method, we carry out the first-principles calculation of the structural, electronic, and optical properties of the zinc blende quaternary alloy Zn1-xBexSySe1-y. The Perdew-Burke-Ernzerhof generaized gradient approximation based on the optimization of total energy and the Engel-Vosko generalized gradient approximation based on the optimization of the corresponding potential are used. Our investigation on the effect of the composition on lattice constants, bulk modulus, band gap, optical dielectric constant, and refractive index shows a non-linear dependence. The energy gap Eg（x, y） has been determined over the entire compositions x and y. In addition, the energy band gap of the technologically important quaternary alloy Znl-xBexSySe1-y in conditions of being lattice matched to ZnS substrate has been investigated. It is noteworthy that the present work is the first theoretical study of the quaternary alloy of interest.

关键词： density functional theory full potential-linearized augmented plane wave method qua-ternary alloy lattice-matched substrate

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血液循环力学

血液循环力学

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作者： c.g.·卡罗(c.g. caro)等

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Intraguild predation and competitive displacement between Nesidiocoris tenuis and Dicyphus maroccanus, two biological control agents in tomato pests

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Insect Science 2017年第5期24卷 809-817页

作者： Nadia g. Salas gervassio Meritxell Perez-Hedo Maria g. Luna Alberto Urbaneja centro de Estudios Parasitol6gicos y de Vectores (cEPAVE -ccT La Plata- cONIcET-UNLP) Boulevard 120 el 60 y 64 1900 La PlataArgentina centro de Proteccion Vegetal y Biotecnologia Instituto Valenciano de Investigaciones Agrarias (IVlA) Unidad Asociada de Entomologia UJI-IVIA Carretera de Moncada - N&quera Km. 4.5 46113 Moncada Valencia Spain Unitat Associada d'Entomologia UJI-IVIA Departament de Ciencies Agr&ries i del Medi Natural Universitat Jaume I UJI Campus del Riu Sec E-12071 Castello de laPlana Spain

Dicyphus maroccanus Wagner and Nesidiocoris tenuis Reuter （Hemiptera： Miridae） are 2 biological control agents in tomatoes. Through the crop seasons, a natural shift in the occurrence of both mirids in favor ofN. tenuis has been observed at the end of the cropping cycle in eastern Spain. To better optimize their conservation, the reasons for the observed change, such as intraguild interactions （IgP） or the influence of environmental conditions, are worth elucidating. To do this, we first studied the IgP of adult females on heterospecific nymphs in the laboratory. We next studied exploitative competition between adults and nymphs of each species when feeding on Ephestia kueniella Zeller （Lepidoptera： Pyralidae） eggs in the laboratory. finally, to analyze the competitive displacement between both mirids, we conducted a semifield experiment in which both predators were released together. All experiments were conducted at 2 temperature regimes （20 and 25~c）. Adult- to-nymph intraguild interactions occurred only at 25 ~c at very low levels, showing that N. tenuis attacked and consumed a greater proportion ofheterospecific nymphs. Nesidiocoris tenuis was a better competitor than D. maroccanus when feeding on the shared prey in the presence of its heterospecific nymph at 25 ~c. In semifield conditions, N. tenuis showed a competitive advantage over D. maroccanus at both temperatures. We conclude that there is not direct interference between both species, however, N. tenuis has a greater ability to outcompete, since it is best adapted to higher temperatures and it is able to remove food sources for D. maroccanus.

关键词： competition Mediterranean crops Miridae temperature tomato

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Level-direction decomposition analysis with a focus on image watermarking framework

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frontiers of Information Technology & Electronic Engineering 2016年第11期17卷 1199-1217页

作者： M.f.KAZEMI M.A.POURMINA A.H.MAZINAN Department of Electrical and computer Engineering Science and Research Branch Islamic Azad University Department of control Engineering Faculty of Electrical Engineering South Tehran Branch Islamic Azad University

This research addresses the new level-direction decomposition in the area of image watermarking as the further development of investigations. The main process of realizing a watermarking framework is to generate a watermarked image with a focus on contourlet embedding representation. The approach performance is evaluated through several indices including the peak signal-to-noise ratio and structural similarity, whereby a set of attacks are carried out using a module of simulated attacks. The obtained information is analyzed through a set of images, using different color models, to enable the calculation of normal correlation. The module of the inverse of contourlet embedding representation is correspondingly employed to obtain the present watermarked image, as long as a number of original images are applied to a scrambling module, to represent the information in disorder. This allows us to evaluate the performance of the proposed approach by analyzing a complicated system, where a decision making system is designed to find the best level and the corresponding direction regarding contourlet embedding representation. The results are illustrated in appropriate level-direction decomposition. The key contribution lies in using a new integration of a set of subsystems, employed based upon the novel mechanism in contourlet embedding representation, in association with the decision making system. The presented approach is efficient compared with state-of-the-art approaches, under a number of serious attacks. A number of benchmarks are obtained and considered along with the proposed framework outcomes. The results support our ideas.

关键词： Level-direction decomposition analysis Watermarking framework contourlet embedding representation Scrambling module Simulated attacks

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Magnetic resonance studies of jets in a gas-solid fluidised bed

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Particuology 2012年第2期10卷 161-169页

作者： Meenal Pore Thusara c. chandrasekera Daniel J. Holland Aining Wang fei Wang Qussai Marashdeh Michael D. Mantle Andrew J. Sederman Liang-Shih fan Lynn f. gladden John S. Dennis Department of chemical Engineering and Biotechnology University of Cambridge Pembroke Street Cambridge CB2 3RA United Kingdom The William g. Lowrie Department of chemical and Biomolecular Engineering Ohio State University Columbus OH 43210 USA

Magnetic resonance imaging （MRI） has been used to study the behaviour Of jets at the distributor of a 50 mm diameter fluidised bed of 0.5 mm diameter poppy seeds. Two perforated-plate distributors were examined, containing either 10 or 14 holes, each 1 mm diameter. Ultra-fast MR imaging was able to show the transient nature of the upper parts of the jets, where discrete bubbles are formed. Imaging in 3D showed that the central jets were the longest for flow rates below minimum fluidisation. Above minimum fluidisation, the outer jets, nearest the wall of the fluidised bed, arched inward towards the central axis. In this latter case, interpretation of the time-averaged 3D image required the use of ultra-fast MR imaging to identify the approximate height above the distributor at which discrete bubbles were formed. The apparently continuous void extending along the central axis above this height in the time-averaged 3D image was thus identified, using ultra-fast MR imaging, as representing the averaged paths of released bubbles. Time-averaged MR velocity mapping was also used to identify dead zones of stationary particles resting on the distributor between the jets. The dead zones could be observed when the superficial velocity of the gas approached minimum fluidisation, but they were smaller than those observed at lower gas superficial velocity. comparable images of a single jet through 1.2 mm diameter poppy seeds from MRI and electrical capacitance volume tomography （EcVT） are also demonstrated.

关键词： fluidised bedMRIEcVTJetsDistributor design

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ISOTHERMAL VAPOUR-LIQUID PHASE DIAgRAMS DETERMINED STATIcALLY BY MEANS Of SPEcTROScOPIc ANALYSIS

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化学学报 1957年第4期 271-279页

作者： g. ScHAY, g. VARSANYI and f. BILLES (Institute of Physical chemistry, Technical Univ. Budapest)

SUMMARY: Exact thermodynamical relations are derived by which isothermal vapour pressure diagrams of liquid mixtures can be constructed and activity coefficients calculated, based solely on the knowledge of the volume concentrations of the components in the saturated vapour. An optical method for determining these concentrations is described. Application to the actual system benzene-chlorobenzene proves that data determined statically by this method correspond to true *** equilibrium, as they comply with the gibbs-Duhem relation.

关键词： ISOTHERMAL VAPOUR-LIQUID PHASE DIAgRAMS DETERMINED STATIcALLY BY MEANS Of SPEcTROScOPIc ANALYSIS

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computational screening of transition metal-doped cdS for photocatalytic hydrogen production

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npj computational Materials 2022年第1期8卷 2190-2198页

作者： Yuting Li Daniel Bahamon Mutasem Sinnokrot Lourdes f.Vega Research and Innovation center on cO_(2) and Hydrogen(RIcH) Khalifa UniversityPO Box 127788Abu DhabiUAE chemical Engineering Department.Khalifa University PO Box 127788Abu DhabiUAE chemistry Department Khalifa UniversityPO Box 127788Abu DhabiUAE

A novel computational screening study of single transition metal(TM),TM-doped,and dual TMs-doped on cdS(110)surfaces via DfT calculations is presented,focusing on their stability and catalytic activity,searching for efficient photocatalysts for hydrogen *** based on key performance descriptors allowed to fine-tune the *** indicate that TM dopants can reduce the energy band gap and enhance impurity ***,Rh,and Pd were found to be the best dopants in TM-doped cdS,since their|Δg_(H)|is 80%smaller compared to the pristine cdS ***,TM1-TM2-co-doped cdS catalysts show better performance for the hydrogen evolution reaction(HER)due to synergistic effects of the two TMs,where co-Pt,Pd-Pt and co-Rh co-doping cdS significantly reduced|ΔgH|to less than 0.1 *** point out four promising novel co-catalysts(i.e.,co,co-Pt,co-Rh,Rh-Ag)with very good performance in HER,to be further explored in experimental studies.

关键词： surface transition allowed

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A coupled Soil-fluid-Structure Simulation of the Near-field Earthquake Effects on gravity Type Quay-Walls

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china Ocean Engineering 2013年第4期27卷 481-494页

作者： M.Zeinoddini H.Matin Nikoo f.Ahmadpour faculty of civil Engineering K.N.Toosi University of Technology

This study focuses on non-linear seismic response of concrete gravity quay-wall structures subjected to near-fault ground motions, a subject which seems not to have received much attention in the literature. A two-dimensional coupled fluid-structure-soil finite element modelling is employed to obtain the quay-wall response. The seawater medium is represented by acoustic type, potential based fluid elements. The elasto-plastic behavior of the soil medium is idealized using Drucker-Prager yield criterion based on associated flow rule assumption. four nodded plane strain elements are used to model the concrete wall, foundation, subsoil, backfill and seabed zones. fluid Structure Interface （fSI） elements are considered between the seawater interfaces with the quay-wall and the seabed. frictional contact elements are employed between the wall and soil interfaces. The numerical model is validated using field measurements available for permanent drifts in a quay-wall damaged during Kobe earthquake. Reasonable agreements are obtained between the model predictions and the field measurements. Non-linear seismic analyses of the selected quay-wall subjected to both near-fault and far-fault ground motions are performed. An incremental dynamic analysis approach （IDA） is used. In general, at least for models examined in the current study, the gravity quay-walls are found to be more vulnerable to near-field, in comparison with the corresponding far-field, earthquakes.

关键词： coastal structure gravity quay-wall near-fault earthquake Incremental Dynamic Analysis (IDA)

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Numerical analysis for peristaltic transport of carreau-Yasuda fluid with variable thermal conductivity and convective conditions

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Journal of central South University 2015年第11期22卷 4467-4475页

作者： f.M.Abbasi T.Hayat B.Ahmad Department of Mathematics Comsats Institute of Information Technology Department of Mathematics Quaid-I-Azam University 45320 Nonlinear Analysis and Applied Mathematics (NAAM) Research group Faculty of Science King Abdulaziz University

Peristalsis of carreau-Yasuda fluid is investigated. Analysis is carried out in the presence of velocity slip and convective boundary conditions. Thermal conductivity of the fluid is taken to be temperature dependent. Lubrication analysis is used in the formulation of the problem. Resulting nonlinear system of equations is solved numerically. Impact of embedded parameters on the quantities of interest is examined through graphs and tables. comparison of the behavior of the carreau-Yasuda, carreau and Newtonian fluid models is presented. Results show that the heat transfer rate at the wall for the carreau fluid model is large when compared with the Newtonian or the carreau-Yasuda fluid model. Also the heat transfer rate at the wall decreases with increase in the velocity slip and variable thermal conductivity parameters. further, an increase in the Biot number reduces the fluid temperature by a considerable amount.

关键词： peristaltic transport carreau-Yasuda fluid variabl

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