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多参数MRI中成像及组织学因素对前列腺癌检出影响的前瞻性研究

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国际医学放射学杂志 2013年第5期 498-498页

作者： f.bratan E.Niaf C.Melodelima A.L.Chesnais R.Souchon f.MègeLechevallier 张翔 Service de Radiologie Urinaire et Vasculaire Pavillon PHpital E.Herriot

摘要目的评价多参数(T2加权、扩散加权及动态增强扫描)MR成像检测前列腺癌的影响因素。方法 175例行前列腺全切术的前列腺癌病人被纳入研究,由2名放射学医师对使用(n=58)或不使用(n=117)直肠表面线圈的1.5 T(n=71)及3.0 T(n=104)的MRI... 详细信息

摘要目的评价多参数(T2加权、扩散加权及动态增强扫描)MR成像检测前列腺癌的影响因素。方法 175例行前列腺全切术的前列腺癌病人被纳入研究,由2名放射学医师对使用(n=58)或不使用(n=117)直肠表面线圈的1.5 T(n=71)及3.0 T(n=104)的MRI影像进行独立分析,采用5分制的主观评价标准(SSS)对所有可疑的局灶性病灶进行评价,将MR表现与全标本包埋病理切片进行对照。结果 2名放射学医师发现362个中的192～214个为癌灶,其中130～155个为假3

关键词：前列腺癌多参数恶性病灶 MRI

进展期前列腺外周带癌多厂家设备多参数MRI定量分析

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国际医学放射学杂志 2016年第5期 562-562页

作者： A.H.Dinh C.Melodelima R.Souchon J.Lehaire f.bratan f.Mège-Lechevallier 陈斌 Université Lyon 1 Faculté de Médecine Lyon Est

摘要目的确定不同厂家3 T MR数据系统多参数成像检测Gleason评分不低于7分的前列腺外周带(PZ)癌定量模型的差异。方法回顾性分析经伦理委员会前瞻性批准的数据库中257例已签署知情同意书、并在前列腺切除术前行T2加权成像、扩散加权成... 详细信息

摘要目的确定不同厂家3 T MR数据系统多参数成像检测Gleason评分不低于7分的前列腺外周带(PZ)癌定量模型的差异。方法回顾性分析经伦理委员会前瞻性批准的数据库中257例已签署知情同意书、并在前列腺切除术前行T2加权成像、扩散加权成像和动态增强扫描的病人资料。研究包括2位放射科医师分别独立怀疑为恶性、边缘清楚的病

关键词：外周带厂家 MRI AUC 前列腺男生殖器加权成像数据集

多参数MR成像评估前列腺癌体积到底有多精确?

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国际医学放射学杂志 2015年第3期 280-280页

作者： f.bratan C.Melodelima R.Souchon A.Hoang Dinh f.Mege-Lechevallier S.Crouzet 俞瀛一 Departments of Urinary and Vascular Radiology Hospices Civils de Lyon Hpital Edouard Herriot5 place d'Arsonval69437 Lyon Cedex 03 France

目的评估影响多参数MR成像估算前列腺癌组织学体积(Vh)精确性的因素。方法对202例病人组成的前瞻性数据库进行回顾性研究,这些病人在行根治性前列腺切

关键词：前列腺癌多参数 MR

Control and vibration analyses of a sandwich doubly curved micro-composite shell with honeycomb,truss,and corrugated cores based on the fourth-order shear deformation theory

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1773-1790页

作者： f.SHIRDELAN M.MOHAMMADIMEHR f.BARGOZINI Department of Solid Mechanics Faculty of Mechanical EngineeringUniversity of KashanKashan 87317-53153Iran

Curved shells are increasingly utilized in applied engineering due to their shared characteristics with other sandwich structures,flexibility,and attractive ***,the inability of controlling and regulating vibrations and destroying them afterward is a challenge to *** this paper,the curve shell equations and a linear quadratic regulator are adopted for the state feedback design to manage the structure vibrations in state space forms.A five-layer sandwich doubly curved micro-composite shell,comprising two piezoelectric layers for the sensor and actuator,is modeled by the fourth-order shear deformation *** core(honeycomb,truss,and corrugated)is analyzed for the bearing of transverse shear *** results show that the honeycomb core has a greater effect on the *** the parameters related to the core and the weight percentage of graphene increase,the frequency *** uniform distribution of graphene platelets results in the lowest natural frequency while the natural frequency ***,without taking into account the piezoelectric layers,the third-order shear deformation theory(TSDT)and fourth-order shear deformation theory(fOSDT)align ***,when the piezoelectric layers are incorporated,these two theories diverge significantly,with the frequencies in the fOSDT being lower than those in the TSDT.

关键词： vibration and control doubly curved shell micro-composite honeycomb truss corrugate core

Bolstering integrity in environmental data science and machine learning requires understanding socioecological inequity

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frontiers of Environmental Science & Engineering 2024年第5期18卷 171-179页

作者： Joe f.Bozeman III School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA30332USA School of Public Policy Georgia Institute of TechnologyAtlantaGA30332USA

Socioecological inequity in environmental data science—such as inequities deriving from data-driven approaches and machine learning(ML)—are current issues subject to debate and *** is growing consensus around embedding equity throughout all research and design domains—from inception to administration,while also addressing procedural,distributive,and recognitional ***,practically doing so may seem onerous or daunting to *** current perspective helps to alleviate these types of concerns by providing substantiation for the connection between environmental data science and socioecological inequity,using the Systemic Equity framework,and provides the foundation for a paradigmatic shift toward normalizing the use of equity-centered approaches in environmental data science and ML *** the integrity of environmental data science and ML is just beginning from an equity-centered tool development and rigorous application *** this end,this perspective also provides relevant future directions and challenges by overviewing some meaningful tools and strategies—such as applying the Wells-Du Bois Protocol,employing fairness metrics,and systematically addressing irreproducibility;emerging needs and proposals—such as addressing data-proxy bias and supporting convergence research;and establishes a ten-step path ***,the work that environmental scientists and engineers do ultimately affect the well-being of us all.

关键词： Equity Bias Machine Learning Data Science Justice Systemic Equity

Premature axon-oligodendrocyte interaction contributes to stalling of experimental axon regeneration after injury to the white matter

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Neural Regeneration Research 2024年第3期19卷 469-470页

作者： Ephraim f.Trakhtenberg Department of Neuroscience University of Connecticut School of MedicineFarmingtonCTUSA

Studies from nearly 3 decades ago suggested that,in the central nervous system(CNS),myelination of axons by oligodendrocytes not only helps improve axonal conductivity but also stabilizes circuitry(Colello and Schwab,1994).Over the years,myelin sheaths produced by oligodendrocytes have been found to contain multiple molecules that are inhibitory to axonal growth(e.g.,MAG,NogoA,OMgp,Semaphorins)(Yiu and He,2006;Silver et al.,2014).After white matter injury in the adult CNS,myelin debris from damaged axons and dead oligodendrocytes accumulates in the forming glial scar and exposes these myelin-associated axon growth-inhibitory molecules to the injured axonal stumps,thereby contributing to the inhibition of axonal *** development,CNS axons reach their postsynaptic targets and stop growing before oligodendrocytes appear and myelinate them(foran and Peterson,1992;Dangata et al.,1996).Therefore,myelin-associated axon growth-inhibitory molecules interacting with already grown axons during myelination were thought to block axons from promiscuous sprouting and miswiring,thereby stabilizing neural circuitry in the CNS(Colello and Schwab,1994).

关键词： thereby white injury

An unexpected cellular fountain of youth:platelets provide factors rejuvenating brain functions

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Signal Transduction and Targeted Therapy 2024年第1期9卷 16-18页

作者： Harald f.Langer Department of Cardiology AngiologyHaemostaseology and Medical Intensive CareUniversity Medical Centre MannheimMedical Faculty MannheimHeidelberg UniversityMannheimGermany German Centre for Cardiovascular Research(DZHK) Partner Site Heidelberg/MannheimMannheimGermany European Center for Angioscience Medical Faculty MannheimHeidelberg UniversityMannheimGermany Cardiovascular systems biology Medical Clinic IUniversity Heart Center LübeckLübeckGermany

In a recent manuscript published in Nature,Schroer et *** that platelets and in particular platelet derived Pf-4(CXCL4)are a novel factor,which can rejuvenate the mammalian neuronal system.1 These findings have the potential to trigger an entire new field of research opening new platelet-derived candidate effector molecules for supporting regeneration.

关键词： supporting platelets finding

The viscous strip approach to simplify the calculation of the surface acoustic wave generated streaming

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 711-724页

作者： f.JAZINI DORCHEH M.GHASSEMI fuel Cells and Nano Systems(fCNS)Laboratory Department of Mechanical EngineeringK.N.Toosi University of TechnologyTehran 19697Iran

In recent decades,the importance of surface acoustic waves,as a biocompatible tool to integrate with microfluidics,has been proven in various medical and biological *** numerical modeling of acoustic streaming caused by surface acoustic waves in microchannels requires the effect of viscosity to be considered in the equations which complicates the *** this paper,it is shown that the major contribution of viscosity and the horizontal component of actuation is concentrated in a narrow region alongside the actuation *** the inviscid equations are considerably easier to solve,a division into the viscous and inviscid domains would alleviate the computational load *** particles'traces calculated by this approximation are excellently alongside their counterparts from the completely viscous *** is also shown that the optimum thickness for the viscous strip is about 9-fold the acoustic boundary layer thickness for various flow patterns and amplitudes of actuation.

关键词： surface acoustic wave microfluidics numerical simulation particle tracing acoustic streaming

Langmuir-Schaefer film Investigation and Density functional Theory Band Gap Calculations of Calix[n]arene-Para-Aminobenzoic Acid for Drug Nanosensor Application

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： WONG Yeong Yi f L Supian A Radzwan M Musa N f N Abd Karim Department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the Langmuir method and first-principle density functional theory(DfT).Using the Langmuir-Schaefer(LS)technique,an ultrathin film composed of calix[n]arenes and their complexes with PABA was deposited on various *** on the Langmuir study,the PABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the LS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),fourier-transform infrared spectroscopy(fTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHNS).The band gap reduction obtained in the DfT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory Langmuir-Schaefer PABA sensor