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羊八井50m^2RPC地毯性能研究YBJ-ARGO合作组(英文)

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高能物理与核物理 2001年第1期25卷 79-85页

作者：何会海 C.Bacci 包克智 f.barone B.Bartoli P.Bernardini S.Bussino E. Calloni R. Cardarelli S.Catalanotti S.Cavaliere f.Cesaroni 查敏 P.Creti 单增罗布 B.D'Ettorre Piazzoli M.DeVincenzi T.DiGirolamo G.DiSciascio 冯振勇傅宇高晓宇庚庆喜郭宏伟何瑁黄庆 M.I 中国科学院高能物理研究所宇宙线和高能天体物理开放实验室 INfN and Dipartimento di fisica dell’ Universtià di Roma Tre 郑州大学物理系 INfN and Dipartimento di fisica dell'Università di Napoli INfN and Dipartimento di fisica dell'Università di Lecce INfN and Dipartimento di fisica dell’ Universtivà di Roma Tre INfN and Dipartimento di fisica dell'Università di Napoli INfN and Dipartimento di fisica dell'Università di Roma "Tor Verga" INfN and Dipartimento di fisica dell'Università di Lecce 西藏大学数理系拉萨850000 西南交通大学物理系山东大学物理系云南大学物理系西藏大学数理系 Istituto di Cosmogeofisica del CNR and INfN Università della Basilicata INfN and Dipartimento di fisica dell'Università di Padova

利用羊八井５０ｍ２ＲＰＣ地毯（ＹＢＪ－ＡＲＧＯ实验原型）的测试数据对其性能进行了分析研究，包括原初粒子方位角分布、天顶角分布、地毯的角分辨、探测时间系统误差对方位角分布的正弦调制、探测时间系统误差的离线修正、几何不对... 详细信息

利用羊八井５０ｍ２ＲＰＣ地毯（ＹＢＪ－ＡＲＧＯ实验原型）的测试数据对其性能进行了分析研究，包括原初粒子方位角分布、天顶角分布、地毯的角分辨、探测时间系统误差对方位角分布的正弦调制、探测时间系统误差的离线修正、几何不对称的小型地毯探测器上原初粒子到达方向重建误差造成的方位角分布的不均匀性等．

关键词： γ射线天文广延大气簇射 RPC 小型地毯探测器

Brain insulin resistance: an early risk factor for Alzheimer's disease development in Down syndrome

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Neural Regeneration Research 2022年第2期17卷 333-335页

作者： Eugenio barone Department of Biochemical Sciences“A.Rossi-fanelli” Sapienza University of RomePiazzale A.MoroRomaItaly

Down syndrome(DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21(HSA21)(Tramutola et al., 2020;Lanzillotta et al., 2021). Every year, approximately 6000 children are born with DS and most of them do not have an autonomous life.

关键词： al. Alzheimer Down

Angiotensin-converting enzyme 2 and AMPK/mTOR pathway in the treatment of liver fibrosis:Should we consider further implications?

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World Journal of Gastroenterology 2024年第18期30卷 2391-2396页

作者： Michele barone Section of Gastroenterology Department of Precision and Regenerative Medicine-Jonian Area-University of BariBari 70124Italy

This editorial contains comments on the article by Zhao et al in print in the World Journal of *** mechanisms responsible for hepatic fibrosis are also involved in ***,we recapitulated the complexity of the renin-angiotensin system,discussed the role of hepatic stellate cell(HSC)autophagy in liver fibrogenesis,and analyzed the possible implications in the development of hepatocarcinoma(HCC).Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers definitively contribute to reducing hepatic fibrogenesis,whereas their involvement in HCC is more evident in experimental conditions than in human ***-converting enzyme 2(ACE2),and its product Angiotensin(Ang)1-7,not only regulate HSC autophagy and liver fibrosis,but they also represent potential targets for unexplored applications in the field of ***,ACE2 overexpression inhibits HSC autophagy through the AMP-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR)*** this case,Ang 1-7 acts binding to the MasR,and its agonists could modulate this ***,since AMPK utilizes different targets to suppress the mTOR downstream complex mTOR complex 1 effectively,we still need to unravel the entire pathway to identify other potential targets for the therapy of fibrosis and liver cancer.

关键词： Renin-angiotensin system Liver fibrosis Hepatic stellate cells Autophagy Hepatocellular carcinoma

Risk of hepatic decompensation from hepatitis B virus reactivation in hematological malignancy treatments

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World Journal of Gastroenterology 2024年第25期30卷 3147-3151页

作者： Michele barone Section of Gastroenterology Department of Precision and Regenerative Medicine-Jonian Area-University of BariBari 70124Italy

In this editorial,we discussed the apparent discrepancy between the findings described by Colapietro et al,in their case report and data found in the *** et al reported a case of hepatitis B virus(HBV)-related hepatic decompensation in a patient with chronic myeloid leukemia and a previously resolved HBV infection who was receiving Bruton’s tyrosine kinase(BTK)inhibitor *** of all,we recapitulated the main aspects of the immune system involved in the response to HBV infection in order to underline the role of the innate and adaptive response,focusing our attention on the protective role of *** then carefully analyzed literature data on the risk of HBV reactivation(HBVr)in patients with previous HBV infection who were treated with either tyrosine kinase inhibitors or BTK inhibitors for their hematologic *** on literature data,we suggested that several factors may contribute to the different risks of HBVr:The type of hematologic malignancy;the type of therapy(BTK inhibitors,especially second-generation,seem to be at a higher risk of HBVr than those with tyrosine kinase inhibitors);previous exposure to an anti-CD20 as first-line therapy;and ethnicity and HBV ***,the warning regarding HBVr in the specific setting of patients with hematologic malignancies requires further investigation.

关键词： Hematological malignancy Hepatitis Hepatitis B virus-DNA Bruton’s tyrosine kinase Previously resolved hepatitis B virus infection

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas f.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Diesel and welding aerosols in an underground mine

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International Journal of Mining Science and Technology 2020年第4期30卷 449-454页

作者： Aleksandar D.Bugarski Teresa L.barone Jon A.Hummer National Institute for Occupational Safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA

Researchers from the National Institute for Occupational Safety and Health(NIOSH)conducted a study in an isolated zone of an underground mine to characterize aerosols generated by:(1)a diesel-powered personnel carrier vehicle operated over a simulated light-duty cycle and(2)the simulated repair of existing equipment using manual metal arc welding(MMAW).Both the diesel-powered vehicle and MMAW process contributed to concentrations of nano and ultrafine aerosols in the mine *** welding process also contributed to aerosols with electrical mobility and aerodynamic mobility count median diameters of approximately 140 and 480 nm,*** welding particles collected on the filters contained carbon,iron,manganese,calcium,and aluminum.

关键词： Diesel aerosols Welding aerosols Underground mining Size distribution

HBsAg clearance by Peg-interferon addition to a long-term nucleos(t)ide analogues therapy

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World Journal of Gastroenterology 2014年第26期20卷 8722-8725页

作者： Michele barone Andrea Iannone Alfredo Di Leo Gastroenterology Unit Department of Medical and Surgical ScienceUniversity of Foggia Gastroenterology Unit Department of Emergency and Organ Transplantation (D.E.T.O.)University of Bari

The ideal endpoint of hepatitis B virus(HBV)antiviral therapy is HBsAg loss,a difficult goal to obtain,especially in HBeAg negative ***,we report the results obtained by the addition of peg-interferonα-2a to a long-lasting nucleos(t)ide analogues therapy in a HBeAg negative,genotype D patient with steadily HBV-DNA negative/HBsAg positive *** 2002,our Caucasian 44-year-old male patient received lamivudine and,4 years later,added adefovir because of a virological *** 2011,considering his young age,liver stiffness(4.3 kPa)and HBsAg levels(3533IU/mL),we added Peg-interferonα-2a for six months(3in combination with nucleos(t)ide analogues followed by 3 mo of Peg-interferonα-2a monotherapy).A decrease of HBsAg levels was observed after 1 mo(1.21log)of Peg-interferon and 3 mo(1.88 log)after the discontinuation of all ***,a complete clearance of HBsAg was obtained with steadily undetectable HBVDNA serum levels(f a short course of Peg-interferonα-2a represents an important result with clinical and pharmacoeconomic implications,considering that nucleos(t)ide analogues therapy in HBeAg negative chronic hepatitis B patients is considered a long-lasting/life-long treatment.

关键词： Addition HBeAg negative HBsAg clearance Nucleos(t)ide analogues Peg-interferon

Sicilian serpentinite xenoliths containing abiotic organics with nanodiamond clusters as key model for prebiotic processes

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Geoscience frontiers 2021年第1期12卷 255-263页

作者： Sergei K.Simakov Vittorio Scribano Nikolai N.Mel’Nik Germana barone LLC“ADAMANT”Skolkovo Participant Tikhoretsky 10/1-61St.Petersburg194064Russia Department of Biological Geological and Environmental SciencesUniversity of CataniaCorso Italia 55-I-95129 CataniaItaly Lebedev Physics Institute Russian Academy of SciencesLeninsky Pr.53Moscow119991Russia

Rock fragments from the deepest parts of a buried hydrothermal system belonging to the Mesozoic Tethys Ocean entered as xenoliths in a Miocenic diatreme,hence brought to the surface,in the Hyblean Plateau(Sicily).Some xenoliths consist of strongly serpentinized ultramafic rocks bearing blebs of abiotic organic matter,where clusters of amorphous carbon nanoparticles,including nanodiamonds,are *** an occurrence conjures up established hypotheses that diamond surfaces are suitable catalytic platforms stimulating the assemblage of complex bio-organic molecules relevant to the emergence of life on *** appearance of bio-organic molecules under primitive Earth conditions is one of the major unsolved questions on the origin of *** we report new micro-Raman spectra on blebs of abiotic organic matter from a selected *** bands were related to hydrogenated nanocrystalline diamonds,with size of nearly 1-1.6 nm,formed from organics at low pressures and *** particular,diamond surfaces can give rise to crystalline interfacial water layers that may have played a fundamental role in the early biosphere evolution as a good medium for rapidly transporting positive charges in the form of hydrated ***,proton gradients in alkaline hydrothermal vents along oceanic ridges are generally viewed as key pre-biotic *** general,serpentinites span the entire geological record,including prebiotic *** hydrous ultramafic rocks often display evidence of abiotic carbon species,both organic and inorganic,including nanodiamonds,being also capable to give rise to chemiosmotic processes and proton gradients necessary to the organisms,such as the"Last Universal Common Ancestor"(LUCA),in the prebiotic Earth.

关键词： Hydrothermal systems Nanocarbons Sulfides fr-t synthesis Abiogenesis LUCA,Sicily Micro-Raman

Materials for the study of the locus operandi in the search for missing persons in Italy

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forensic Sciences Research 2022年第3期7卷 371-377页

作者： Pier Matteo barone Rosa Maria Di Maggio Silvia Mesturini Archaeology and Classics Program American University of RomeRomeItaly Geoscienze forensi ItaliaVR-forensic Geoscience RomeItaly Comitato Scientifico Ricerca Scomparsi RomeItaly Studio Legale e Criminologico Mesturini LivornoItaly

Geographic profiling,or locus operandi,is a scientific approach that has been applied to forensic investigations for several ***,it has never been applied to a phenomenon as complex as the search for missing *** article presents three Italian case studies in which geographic profiling was used to narrow the areas to search for missing *** geographical data were mapped and processed on a geographic information system platform using computational geometry ***,these disappearances occurred during the Italian lockdown period,imposed to address the COVID-19 outbreak,which made the searches slower and more complex than usual.

关键词： forensic sciences geographic profiling locus operandi geographic information systems missing persons