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国际医学放射学杂志 2018年第1期 120-121页

作者： R.Romaniello f.arrigoni E.Panzeri A.Poretti A.Micalizz A.Citterio 汤若薇 Neuropsychiatry and Neurorehabilitation Unit Scientific InstituteIRCCS Eugenio Medea

摘要目的探究微管蛋白基因突变相关性小脑发育不良(CD)及其他后颅窝畸形的神经影像学模式,及其临床表现及基因学相关性。方法采用1.5 T(10例)或3.0 T(18例)

关键词：微管蛋白发育不良相关性

胼胝体上方纵束异常的MR表现、发病机制及相关临床分型

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国际医学放射学杂志 2016年第5期 593-593页

作者： f.arrigoni R.Romaniello D.Peruzzo A.Righini C.Parazzini P.Colombo 郑烋 Neuroimaging Laboratory Scientific Institute IRCCS Eugenio Medea

摘要目的本研究旨在分析年轻智力障碍病人胼胝体(CC)一种独特畸形的MRI表现及其结构特点。方法研究一组胼胝体上方纵束异常病人的常规MRI及扩散张量成像(DTI),发现中线层面CC背侧突出的三角形结构,同时收集临床评估、微阵列比较基因组... 详细信息

摘要目的本研究旨在分析年轻智力障碍病人胼胝体(CC)一种独特畸形的MRI表现及其结构特点。方法研究一组胼胝体上方纵束异常病人的常规MRI及扩散张量成像(DTI),发现中线层面CC背侧突出的三角形结构,同时收集临床评估、微阵列比较基因组杂交技术(CGH)及遗传学检测

关键词：胼胝体大脑皮质 MR 纵束

Bolstering integrity in environmental data science and machine learning requires understanding socioecological inequity

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frontiers of Environmental Science & Engineering 2024年第5期18卷 171-179页

作者： Joe f.Bozeman III School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA30332USA School of Public Policy Georgia Institute of TechnologyAtlantaGA30332USA

Socioecological inequity in environmental data science—such as inequities deriving from data-driven approaches and machine learning(ML)—are current issues subject to debate and *** is growing consensus around embedding equity throughout all research and design domains—from inception to administration,while also addressing procedural,distributive,and recognitional ***,practically doing so may seem onerous or daunting to *** current perspective helps to alleviate these types of concerns by providing substantiation for the connection between environmental data science and socioecological inequity,using the Systemic Equity framework,and provides the foundation for a paradigmatic shift toward normalizing the use of equity-centered approaches in environmental data science and ML *** the integrity of environmental data science and ML is just beginning from an equity-centered tool development and rigorous application *** this end,this perspective also provides relevant future directions and challenges by overviewing some meaningful tools and strategies—such as applying the Wells-Du Bois Protocol,employing fairness metrics,and systematically addressing irreproducibility;emerging needs and proposals—such as addressing data-proxy bias and supporting convergence research;and establishes a ten-step path ***,the work that environmental scientists and engineers do ultimately affect the well-being of us all.

关键词： Equity Bias Machine Learning Data Science Justice Systemic Equity

射频消融术与MR引导聚焦超声手术微创治疗骨样骨瘤的倾向评分匹配法研究

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国际医学放射学杂志 2016年第5期 590-590页

作者： C.Masciocchi L.Zugaro f.arrigoni G.L.Gravina S.Mariani A.L.Marra 张晓飞 Department of Biotechnological and Applied Clinical Sciences University of L’Aquila

摘要目的采用倾向评分匹配法比较MR引导聚焦超声治疗(MRgfUS)和射频消融术(RfA)对骨样骨瘤病人疼痛缓解和运动功能恢复的影响。方法经伦理委员会(IRB)审查通过,纳入30例骨样骨瘤病人。采用倾向评分匹配设计,15例经MRgfUS治疗,匹配的15例... 详细信息

摘要目的采用倾向评分匹配法比较MR引导聚焦超声治疗(MRgfUS)和射频消融术(RfA)对骨样骨瘤病人疼痛缓解和运动功能恢复的影响。方法经伦理委员会(IRB)审查通过,纳入30例骨样骨瘤病人。采用倾向评分匹配设计,15例经MRgfUS治疗,匹配的15例经RfA治疗。评价治疗后完全

关键词：骨样骨瘤病人射频消融术微创治疗 MR 倾向评分匹配

Premature axon-oligodendrocyte interaction contributes to stalling of experimental axon regeneration after injury to the white matter

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Neural Regeneration Research 2024年第3期19卷 469-470页

作者： Ephraim f.Trakhtenberg Department of Neuroscience University of Connecticut School of MedicineFarmingtonCTUSA

Studies from nearly 3 decades ago suggested that,in the central nervous system(CNS),myelination of axons by oligodendrocytes not only helps improve axonal conductivity but also stabilizes circuitry(Colello and Schwab,1994).Over the years,myelin sheaths produced by oligodendrocytes have been found to contain multiple molecules that are inhibitory to axonal growth(e.g.,MAG,NogoA,OMgp,Semaphorins)(Yiu and He,2006;Silver et al.,2014).After white matter injury in the adult CNS,myelin debris from damaged axons and dead oligodendrocytes accumulates in the forming glial scar and exposes these myelin-associated axon growth-inhibitory molecules to the injured axonal stumps,thereby contributing to the inhibition of axonal *** development,CNS axons reach their postsynaptic targets and stop growing before oligodendrocytes appear and myelinate them(foran and Peterson,1992;Dangata et al.,1996).Therefore,myelin-associated axon growth-inhibitory molecules interacting with already grown axons during myelination were thought to block axons from promiscuous sprouting and miswiring,thereby stabilizing neural circuitry in the CNS(Colello and Schwab,1994).

关键词： thereby white injury

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An unexpected cellular fountain of youth:platelets provide factors rejuvenating brain functions

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Signal Transduction and Targeted Therapy 2024年第1期9卷 16-18页

作者： Harald f.Langer Department of Cardiology AngiologyHaemostaseology and Medical Intensive CareUniversity Medical Centre MannheimMedical Faculty MannheimHeidelberg UniversityMannheimGermany German Centre for Cardiovascular Research(DZHK) Partner Site Heidelberg/MannheimMannheimGermany European Center for Angioscience Medical Faculty MannheimHeidelberg UniversityMannheimGermany Cardiovascular systems biology Medical Clinic IUniversity Heart Center LübeckLübeckGermany

In a recent manuscript published in Nature,Schroer et *** that platelets and in particular platelet derived Pf-4(CXCL4)are a novel factor,which can rejuvenate the mammalian neuronal system.1 These findings have the potential to trigger an entire new field of research opening new platelet-derived candidate effector molecules for supporting regeneration.

关键词： supporting platelets finding

The viscous strip approach to simplify the calculation of the surface acoustic wave generated streaming

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 711-724页

作者： f.JAZINI DORCHEH M.GHASSEMI fuel Cells and Nano Systems(fCNS)Laboratory Department of Mechanical EngineeringK.N.Toosi University of TechnologyTehran 19697Iran

In recent decades,the importance of surface acoustic waves,as a biocompatible tool to integrate with microfluidics,has been proven in various medical and biological *** numerical modeling of acoustic streaming caused by surface acoustic waves in microchannels requires the effect of viscosity to be considered in the equations which complicates the *** this paper,it is shown that the major contribution of viscosity and the horizontal component of actuation is concentrated in a narrow region alongside the actuation *** the inviscid equations are considerably easier to solve,a division into the viscous and inviscid domains would alleviate the computational load *** particles'traces calculated by this approximation are excellently alongside their counterparts from the completely viscous *** is also shown that the optimum thickness for the viscous strip is about 9-fold the acoustic boundary layer thickness for various flow patterns and amplitudes of actuation.

关键词： surface acoustic wave microfluidics numerical simulation particle tracing acoustic streaming

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Antimicrobial,antibiofilm,angiogenesis,anti-inflammatory,and wound healing activities of zinc nanoparticles green synthesized using ferula macrecolea extract

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 259-268页

作者： Sultan f.Alnomasy Department of Medical Laboratories Sciences College of Applied Medical SciencesShaqra UniversityAl-Quwayiyah 19257Saudi Arabia

Objective:To assess the antimicrobial,antibiofilm,anti-inflammatory,angiogenic,and wound healing activities of zinc nanoparticles(ZNPs)green synthesized using ferula macrecolea ***:The green synthesis was conducted using the precipitation ***,the minimum inhibitory concentration(MIC),minimum bactericidal concentration(MBC),and minimum biofilm inhibition concentration 50%(MBIC50)of ZNPs against Staphylococcus aureus(***)and Pseudomonas aeruginosa(***)were *** effects of ZNPs on the gene expressions of Staphylococcus spp.[intracellular adhesion A(icaA)and D(icaD)]and ***(rhlI and rhlR)were investigated using quantitative real-time *** addition,the effects of ZNPs on wound healing,angiogenesis,and anti-inflammatory markers were ***:The green-synthesized ZNPs demonstrated significant antimicrobial efficacy against *** and *** biofilm formation in *** and *** was also inhibited by ZNPs with MBIC50 values of 3.30μg/mL and 2.08μg/mL,***,ZNPs downregulated the expression of biofilm-related genes icaA,icaD,rhlI,and rhlR in the tested *** also demonstrated promising in vitro wound healing effects by promoting fibroblast cell proliferation and wound closure in a dose-dependent manner.A significant increase in the expression of HLA-G5 and VEGf-A genes as well as a marked decrease in the expression of Nf-κB,IL-1β,and TNf-αgenes were observed in cells treated with ZNPs compared to the control group(Pffects against *** and *** and wound-healing effects by inhibiting biofilm formation,inducing angiogenesis,and reducing ***,further studies must be conducted to specify the accurate mechanisms of action and toxicity of ZNPs.

关键词： Wound healing Antibacterial Angiogenesis Nanomedicine ferula macrecolea Inflammation

Cognition and movement in neurodegenerative disorders:a dynamic duo

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Neural Regeneration Research 2024年第10期19卷 2101-2102页

作者： Marit f.L.Ruitenberg Department of Health Medical and NeuropsychologyLeiden UniversityLeidenthe Netherlands Leiden Institute for Brain and Cognition Leidenthe Netherlands

People with neurodegenerative disorders often experience problems across a variety of functional domains,including cognition,movement,and psychosocial *** classification of these disorders is based on the phenotypical manifestations that represent the most prominent clinical *** example,Parkinson's disease and Huntington's disease are typically regarded as movement disorders,whereas Alzheimer's disease(AD) and other dementias are regarded as cognitive disorders.

关键词： disorders Huntington degenerative

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