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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施: 整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 46-56页

作者： Bruna f.Sebastiao Raquel M.Hortelao Sara S.Granadas Jose M.faria Joana R.Pinto Helga Rafael Henriques Nursing School of Lisbon LisbonPortugal Hospital Center of Central Lisbon Portugal CUf Tejo Hospital LisbonPortugal University Hospital Center of Northern Lisbon LisbonPortugal Nursing Research Innovation and Development Centre of Lisbon(CIDNUR)LisbonPortugal

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法2023年3月 ,系统检索CINAHL、Medline、Academie Search Complete .Scopus、WebofScience、Cochrane图书馆、乔安娜布里格斯研究所(JoannaBriggsInstitute,JBI)循证实践数据库,以及GoogleScholar。对纳人研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素) ,教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队.提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进--步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations

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Genes & Diseases 2023年第6期10卷 2252-2255页

作者： Congling Qiu Joyce Tsz Wai Chan David Wei Zhang io Nam Wong Yaling Zeng Betty Yuen Kwan Law Simon Wing fai Mok Ivo Ricardo De Seabra Rodrigues Dias Wenfeng Liu Liang Liu Vincent Kam Wai Wong Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao SAR 999078China Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhouGuangdong 510000China faculty of Medicine Macao University of Science and TechnologyMacao SAR 999078China School of Biotechnology and Health Sciences Wuyi UniversityJiangmenGuangdong 529000China

Rheumatoid arthritis(RA)is a chronic inflammatory disease characterized by cartilage and bone damage with the presence of pannus formation which causes uncontrollable proliferation and invasion of fibroblast-like synoviocytes(fLS).Since rheumatoid arthritis is a chronic disorder,the patients normally need to undergo prolonged antirheumatic treatment with the use of disease-modifying antirheumatic drugs(DMARDs),steroids,and nonsteroidal anti-inflammatory drugs(NSAIDs).The efficacy of such long-term pharmaceutical intervention can be significantly affected by the development of drug resistance.The pathological relationship between rheumatoid arthritis and cancer hinted that some chemotherapeutic drugs,such as methotrexate(MTX),could be used for RA treatment.This idea was reinforced by the analysis of mutations in p53 tumor suppressor gene.Around 50%of p53 somatic mutations observed from various cancers are also identified in the synovium of RA patients1(fig.1A).Of note,the hyperplastic synovium in RA with overexpressed p53 mutants contributed to the destruction of joints in patients with erosive RA.

关键词： patients drugs rheumatoid

Resolution pattern of jaundice among children presenting with severe malaria in rural South-West Nigeria

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Asian Pacific Journal of Tropical Biomedicine 2012年第7期2卷 551-553页

作者： Osonuga OA Osonuga A Osonuga AA Osonuga io Department of Pharmacology and Physiology University of Cape Coast School of Medical Sciences University of Cape Coast Department of Nursing University of Cape Coast Olabisi Onabanjo University Remo Campus

Objective:To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.Methods:Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities.They were divided into two groups:'Q' and 'A',receiving quinine and artemether.respectively.Jaundice was assessed by clinical examination.Results:Sixteen out of 32 children recruited(representing50%) presented with jaundice on the dav of recruitment.The mean age was(7.00±2.56) years.On day 3,tour patients in 'A' and six patients in 'O' had jaundice.By day 7.no child had jaundice.Conclusion:The study has shown that hoth drugs resolve jaundice although artemether relatively resolves it faster by the third day.

关键词： Jaundice Quinine Artemether Severe malaria South-west Nigeria

Temperature-and thickness-dependence of robust out-of-plane ferroelectricity in CVD grown ultrathin van der Waals a-In2Se3 layers

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Nano Research 2020年第7期13卷 1897-1902页

作者： Weng fu io Shuoguo Yuan Sin Yi Pang Lok Wing Wong Jiong Zhao Jianhua Hao Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina

Two-dimensional(2D)ferroelectric materials with unique structure and extraordinary optoelectrical properties have attracted intensive research in the field of nanoelectronic and optoelectronic devices,such as optical sensors,transistors,photovoltaics and non-volatile memory devices.However,the transition temperature of the reported ferroelectrics in 2D limit is generally low or slightly above room temperature,hampering their applications in high-temperature electronic devices.Here,we report the robust high-temperature ferroelectricity in 2D a-In2Se3,grown by chemical vapor depostion(CVD),exhibiting an out-of-plane spontaneous polarization reaching above 200℃.The polarization switching and ferroelectric domains are observed in In2Se;nanoflakes in a wide temperature range.The coercive field of the CVD grown ferroelectric layers ilustrates a room-temperature thickness dependency and increases drastically when the film thickness decreases;whereas there is no large variance in the coercive field at dfterent termperature from the samples with identical thickness.The results show the stable ferroelectricit of In2Se3 nanoflakes maintained at high temperature and open up the opportunities of 2D materials for novel applications in high-temperature nanoelectronic devices.

关键词： ln2Se3 two-dimensional(2D)materials ferroelectricity high-temperature coercive field

Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 493-495页

作者： Osonuga io Osonuga OA Osonuga A Onadeko AA Osonuga AA Department of Physiology Olabisi Onabanjo University Department of Pharmacology Olabisi Onabanjo University School of Medical Sciences University of Cape Coast Department of Nursing University of Cape Coast

Objective:To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats.Methods:Sixty five albino rats with body weight of 190-220 g were used for the four-phased study. The animals were randomly divided into five groups. The first-four groups of 15 rats were further divided into 3 subgroups of 5 rats. The drug was administered orally at sub-optimal, therapeutic, and high doses of 25, 50 and 75 mg/kg bw,respectively to the rats for 1 day, 2 days and 3 days. Blood samples were collected by cardio-puncture from the rats for hematology at the end of each phase. The last group served as control,and they were given waterad libitum.Results:Artemether caused significant reduction(Pf the hematological profile of the animals in a dose dependent manner. Discontinuation of the drug use however showed gradual recovery of the depressed indices of the blood parameters.Conclusions:The results suggest that artemether can induce reversible changes in hematological profiles of rats by extension man. This can probably aggravate anemia when artemether is administered to malaria patients. Hence, the study supports the use of the drug with cautione specially in patients prone to anemic tendencies.

关键词： Artemether Anemia Antimalaria Hematology Hematological profile Malaria Anemic tendency

fabrication of 3D air-core MEMS inductors for very-highfrequency power conversions

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Microsystems & Nanoengineering 2018年第1期4卷 509-517页

作者： Hoa Thanh Le io Mizushima Yasser Nour Peter Torben Tang Arnold Knott Ziwei Ouyang flemming Jensen Anpan Han National Center for Micro-and Nanofabrication DanchipTechnical University of Denmark2800 Kongens LyngbyDenmark Department of Electrical Engineering Technical University of Denmark2800 Kongens LyngbyDenmark IPU Nils Koppels Allé2800 Kongens LyngbyDenmark

We report a fabrication technology for 3D air-core inductors for small footprint and very-high-frequency power conversions.Our process is scalable and highly generic for fabricating inductors with a wide range of geometries and core shapes.We demonstrate spiral,solenoid,and toroidal inductors,a toroidal transformer and inductor with advanced geometries that cannot be produced by wire winding technology.The inductors are embedded in a silicon substrate and consist of through-silicon vias and suspended windings.The inductors fabricated with 20 and 25 turns and 280-350μm heights on 4-16 mm2 footprints have an inductance from 34.2 to 44.6 nH and a quality factor from 10 to 13 at frequencies ranging from 30 to 72 MHz.The air-core inductors show threefold lower parasitic capacitance and up to a 140% higher-quality factor and a 230% higher-operation frequency than silicon-core inductors.A 33 MHz boost converter mounted with an air-core toroidal inductor achieves an efficiency of 68.2%,which is better than converters mounted with a Si-core inductor(64.1%).Our inductors show good thermal cycling stability,and they are mechanically stable after vibration and 2-m-drop tests.

关键词： MEMS inductor PwrSoC TSVs very high frequency 3D

Sexual Behaviour and Contraceptive Usage of Secondary School Adolescents in Ibadan, Nigeria

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Journal of Reproduction and Contraception 2007年第4期18卷 279-288页

作者： A Oladokun io Morhason-Bello CA Enakpene KM Owonikoko JO Akinyemi KA Obisesan Department of Obstetrics & Gynaecology University College Hospital Ibadan Nigeria Department of Epidemiology Medical Statistics and Environmental Health College of Medicine University of Ibadan Nigeria

Objective To determine the prevalence and pattern of sexual activity as well as the contraceptive practices among the selected secondary school adolescents in Ibadan, Nigeria. Methods A descriptive cross-sectional study was conducted among the selected senior secondary school students in Ibadan, following a stratified multistage random sampling technique. Results There were 695 respondents out of which the females constituted 51% and the males were 49%. Less than one third （28.3%） of the respondents have had previous sexual exposure at the time of the study. The median age of sexual debut among the sexually exposed was 15 years in both the males and the females. Bivariate analysis of sociodemographic characteristics of respondents with previous sexual exposure showed that, sex, religion, father＇s and mother＇s educational background and level of class were statistically significant（P〈0. 001）. further analysis using logistic regression model revealed that male respondents were 3 times more likely than females （95% CI 1.92-4.56） to have had sexual experience while those whose mother had tertiary educational background were less likely to have had previous sexual experience compared with those with secondary and lower educational background （OR= 1.76, 95% CI 1.11-2.77）. Of all the sociodemographic characteristics of respondents considered with the age of sexual partners using bivariate analysis showed that only level of class was significant （P=0. 018）. Less than half of the sexually active males （44.2%） were using various methods of contraception, while 54.4% of the sexually active females were using different types of modern methods.Conclusion It is quite obvious that risky sexual behaviours are in practice among the secondary school students studied and by extension in the country. It therefore means that reproductive health issues especially concerning the adolescents will have to be openly discussed by all with our youths while abstinence/chastity should be cherished.

关键词： adolescents sexual health contraceptive usage

钙热还原制备Sm_(2)Co_(17)合金及磁性能研究

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稀土 2023年第4期44卷 202-213,I0007页

作者：刘东辉张小林牛飞杨幼明江西理工大学材料冶金化学学部江西赣州341000 江西理工大学江西省闪速绿色开发与循环利用重点实验室江西赣州341000 离子型稀土资源开发及应用教育部重点实验室江西赣州341000

钙作为还原剂无法直接还原Smf_(3)制备金属钐。本文以无水Smf_(3)为原料,对钴诱导Smf_(3)钙热还原制备Sm_(2)Co_(17)合金进行了热力学计算与实验研究。通过电感耦合等离子体光谱仪、X射线衍射仪、扫描电子显微镜及能谱仪和X射线光电子... 详细信息

钙作为还原剂无法直接还原Smf_(3)制备金属钐。本文以无水Smf_(3)为原料,对钴诱导Smf_(3)钙热还原制备Sm_(2)Co_(17)合金进行了热力学计算与实验研究。通过电感耦合等离子体光谱仪、X射线衍射仪、扫描电子显微镜及能谱仪和X射线光电子能谱仪等测试方法对合金产物的化学组成、结构、形貌、元素分布和化学价态等进行了分析与表征。结果表明:钴诱导Smf_(3)钙热还原制备Sm_(2)Co_(17)合金在热力学上是可行的,还原产物为Sm_(2)Co_(17)合金与Caf_(2)。当Smf_(3)与Ca用量分别为摩尔比1.1与1.2,保温时间30 s时,获得合金产物中钐质量分数为22.98%,与Sm_(2)Co_(17)合金的理论成分几乎相同。铸态合金产物主要由Th_(2)Zn_(17)结构的2∶17相及CaCu_(5)结构的1∶5相组成。结合电负性原理与XPS分析结果研究了制备Sm_(2)Co_(17)合金的钴诱导机理。Sm_(2)Co_(17)合金快淬带的剩余磁化强度为0.47 T,内禀矫顽力为0.45 kA·m^(-1),最大磁能积为5.23 kJ·m^(-3)。与传统混熔工艺相比,此工艺在每生产一吨Sm_(2)Co_(17)合金中,金属钐制备成本节省约40%。该方法制备的钐钴合金可作为烧结稀土钐钴永磁材料的原料。

关键词：氟化钐 Sm_(2)Co_(17) 钙热还原诱导机理磁性能

DESCRIPTioN Of THREE NEW GENERA AND THREE NEW SPECIES Of MEMBRACIDAE fROM CHINA (Homoptera: Membracidae)

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昆虫分类学报 1982年第3期 178-181页

作者： Chou io Yuan feng(Northwestern College of Agriculture)

Three new genera and three new species of Membracidae from China are described in this paper. All type specimens are kept or temporarily kept in the insect collection of the Northwestern College of Agriculture.Tribulo... 详细信息

关键词： than high head Homoptera Membracidae DESCRIPTioN Of THREE NEW GENERA AND THREE NEW SPECIES Of MEMBRACIDAE fROM CHINA