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比较增强彩色多普勒超声定位活检与系统性组织活检对前列腺癌检出的效能

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国际医学放射学杂志 2011年第1期34卷 95-页

作者： M.J.Mitterberger f.aigner W.Horninger H.Ulmer S.Cavuto E.J.Halpern 乔辉 Department of Urology Medical University Innsbruck

目的比较增强彩色多普勒超声(CECD-US)定位活检与系统性组织活检(SB)在1776例男性病人中检出前列腺癌的效能。

关键词：前列腺癌前列腺活检超声对比剂

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Neuroplasticity, limbic neuroblastosis and neuro-regenerative disorders

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Neural Regeneration Research 2018年第8期13卷 1322-1326页

作者： Mahesh Kandasamy Ludwig aigner Laboratory of Stem Cells and Neuroregeneration Department of Animal Science School of Life Sciences Bharathidasan University faculty Recharge Programme University Grants Commission (UGC-FRP) Institute of Molecular Regenerative Medicine Salzburg Paracelsus Medical University Spinal Cord Injury and Tissue Regeneration Center Salzburg Paracelsus Medical University

The brain is a dynamic organ of the biological renaissance due to the existence of neuroplasticity. Adult neurogenesis abides by every aspect of neuroplasticity in the intact brain and contributes to neural regeneration in response to brain diseases and injury. The occurrence of adult neurogenesis has unequivocally been witnessed in human subjects, experimental and wildlife research including rodents, bats and cetaceans. Adult neurogenesis is a complex cellular process, in which generation of neuroblasts namely, neuroblastosis appears to be an integral process that occur in the limbic system and basal ganglia in addition to the canonical neurogenic niches. Neuroblastosis can be regulated by various factors and contributes to different functions of the brain. The characteristics and fate of neuroblasts have been found to be different among mammals regardless of their cognitive functions. Recently, regulation of neuroblastosis has been proposed for the sensorimotor interface and regenerative neuroplasticity of the adult brain. Hence, the understanding of adult neurogenesis at the functional level of neuroblasts requires a great scientific attention. Therefore, this mini-review provides a glimpse into the conceptual development of neuroplasticity, discusses the possible role of different types of neuroblasts and signifies neuroregenerative failure as a potential cause of dementia.

关键词： neuroplasticity adult neurogenesis neuroblasts reactive neuroblastosis hippocampus ultrasound neuroregenerative disorders neotrophy echolocation

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Nanophotonics shines light on hyperbolic metamaterials

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Light(Science & Applications) 2022年第2期11卷 145-148页

作者： Andreas aigner Judith M.Dawes Stefan A.Maier Haoran Ren Chair in Hybrid Nanosystems Nanoinstitute MunichFaculty of PhysicsLudwig-Maximilians-University MunichMunich 80539Germany MQ Photonics Research Centre Department of Physics and AstronomyMacquarie UniversityMacquarie ParkNSW 2109Australia.3Department of PhysicsImperial College LondonLondon SW72AZUK 不详

Hyperbolic metamaterials with a unique hyperbolic dispersion relation allow propagating waves with infinitely largewavevectors and a high density of states. Researchers from Korea and Singapore provide a comprehensive review ofhyperbolic metamaterials, including artificially structured hyperbolic media and natural hyperbolic materials. Theyexplain key nanophotonic concepts and describe a range of applications for these versatile materials.

关键词： materials. hyperbolic infinitely

Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver

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World Journal of Hepatology 2015年第2期7卷 177-188页

作者： Elmar aigner Gunter Weiss Christian Datz Obesity Research Unit Paracelsus Medical University Salzburg5020 Salzburg Austria first Department of Medicine Paracelsus Medical University Salzburg5020 Salzburg Austria Department of Internal Medicine VI Medical University Innsbruck6020 Innsbruck Austria Department of Internal Medicine General Hospital Oberndorf5111 Oberndorf Austria

Elevated iron stores as indicated by hyperferritinemiawith normal or mildly elevated transferrin saturation a n d m o s t l y m i l d h e p a t i c i r o n d e p o s i t i o n a r e a characteristic finding in subjects with non-alcoholic fatty liver disease(NAfLD). Excess iron is observed in approximately one third of NAfLD patients and is commonly referred to as the "dysmetabolic iron overload syndrome". Clinical evidence suggests that elevated body iron stores aggravate the clinical course of NAfLD with regard to liver-related and extrahepatic disease complications which relates to the fact that excess iron catalyses the formation of toxic hydroxylradicals subsequently resulting in cellular damage. Iron removal improves insulin sensitivity, delays the onset of type 2 diabetes mellitus, improves pathologic liver function tests and likewise ameliorates NAfLD histology. Several mechanisms contribute to pathologic iron accumulation in NAfLD. These include impaired iron export from hepatocytes and mesenchymal Kupffer cells as a consequence of imbalances in the concentrations of iron regulatory factors, such as hepcidin, cytokines, copper or other dietary factors. This review summarizes the knowledge about iron homeostasis in NAfLD and the rationale for its therapeutic implications.

关键词： Dysmetabolic iron overload syndrome Hepcidin Iron overload Metabolic syndrome Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

Effective transport width——A methodology to describe the spatial variability of bedload transport

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International Journal of Sediment Research 2023年第2期38卷 294-301页

作者： Rolf Rindler Sabrina Schwarz Marcel Liedermann Dorian Shire-Peterlechner Andrea Kreisler Johann aigner Michael Tritthart Helmut Habersack Institute of Hydraulic Engineering and River Research Department of Water Atmosphere and Environment University of Natural Resources and Life Sciences

The monitoring of bedload transport processes in rivers is a still challenging task in research and the parameter effective transport width(ETW) allows, for the first time, a process description of the local variability of the bedload transport. In this paper, the distribution of bedload transport over a river crosssection was studied by statistically analyzing long-term monitoring data. Using an innovative integrated measurement system, combining geophones distributed over the river width with bedload traps and basket sampling, allows for continuous, high-resolution, long-term monitoring data of bedload transport characteristics to be generated. Geophone data can be used to record and describe bedload transport processes such as intensity, temporal variability, and local variability. One parameter observed was the ETW, which describes the width where bedload transport is taking place for different discharge classes in gravel bed rivers. With the help of a data series recorded over more than a decade, it is now possible, for the first time, to statistically describe the continuously and directly measured ETW. Hence, it became evident that the effective bedload transport width depends on the discharge rate and local transport capacity, and that bedload transport over the entire river width only occurs at high flows that prevail a few days a year.

关键词： Bedload transport Spatial distribution Effective transport width Plate geophones

Perspectives of visualization onboarding and guidance in VA

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Visual Informatics 2022年第1期6卷 68-83页

作者： Christina Stoiber Davide Ceneda Markus Wagner Victor Schetinger Theresia Gschwandtner Marc Streit Silvia Miksch Wolfgang aigner St.Pölten University of Applied Sciences Austria TU Wien Austria Erste Group Bank AG Austria Johannes Kepler University Linz Austria

A typical problem in Visual Analytics(VA)is that users are highly trained experts in their application domains,but have mostly no experience in using VA ***,users often have difficulties interpreting and working with visual *** overcome these problems,user assistance can be incorporated into VA systems to guide experts through the analysis while closing their knowledge *** types of user assistance can be applied to extend the power of VA,enhance the user’s experience,and broaden the audience for *** different approaches to visualization onboarding and guidance in VA already exist,there is a lack of research on how to design and integrate them in effective and efficient ***,we aim at putting together the pieces of the mosaic to form a coherent *** on the Knowledge-Assisted Visual Analytics model,we contribute a conceptual model of user assistance for VA by integrating the process of visualization onboarding and guidance as the two main approaches in this *** a result,we clarify and discuss the commonalities and differences between visualization onboarding and guidance,and discuss how they benefit from the integration of knowledge extraction and ***,we discuss our descriptive model by applying it to VA tools integrating visualization onboarding and guidance,and showing how they should be utilized in different phases of the analysis in order to be effective and accepted by the user.

关键词： User assistance Visual Analytics Conceptual model Visualization onboarding Guidance

Comparative evaluations of visualization onboarding methods

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Visual Informatics 2022年第4期6卷 34-50页

作者： Christina Stoiber Conny Walchshofer Margit Pohl Benjamin Potzmann florian Grassinger Holger Stitz Marc Streit Wolfgang aigner St.Poelten University of Applied Sciences St.PoeltenAustria Johannes Kepler University Linz LinzAustria TU Wien ViennaAustria datavisyn GmbH LinzAustria

Comprehending and exploring large and complex data is becoming increasingly important for a diverse population of users in a wide range of application *** has proven to be well-suited in supporting this endeavor by tapping into the power of human visual ***,non-experts in the field of visual data analysis often have problems with correctly reading and interpreting information from visualization idioms that are new to *** support novices in learning how to use new digital technologies,the concept of onboarding has been successfully applied in other fields and first approaches also exist in the visualization ***,empirical evidence on the effectiveness of such approaches is ***,we conducted three studies with Amazon Mechanical Turk(MTurk)workers and students investigating visualization onboarding at different levels:(1)firstly,we explored the effect of visualization onboarding,using an interactive step-by-step guide,on user performance for four increasingly complex visualization techniques with time-oriented data:a bar chart,a horizon graph,a change matrix,and a parallel coordinates *** performed a between-subject experiment with 596 participants in *** results showed that there are no significant differences between the answer correctness of the questions with and without ***,participants commented that for highly familiar visualization types no onboarding is ***,for the most unfamiliar visualization type—the parallel coordinates plot—performance improvement can be observed with onboarding.(2)Thus,we performed a second study with MTurk workers and the parallel coordinates plot to assess if there is a difference in user performances on different visualization onboarding types:step-by-step,scrollytelling tutorial,and video *** study revealed that the video tutorial was ranked as the most positive on average,based on a sentiment analysis,followed by the scrollyt

关键词： Visualization literacy User onboarding Learning Visual analytic

Low SARS-CoV-2 seroprevalence but high perception of risk among healthcare workers at children’s hospital before second pandemic wave in Germany

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World Journal of Pediatrics 2021年第5期17卷 484-494页

作者： Marietta Neumann Annette aigner Eileen Rossow David Schwarz Maria Marschallek Jorg Steinmann Ralf Stucker Ingo Koenigs Philippe Stock Department of Paediatrics Altona Children's HospitalUniversitat HamburgAltonaer KinderkrankenhausBleickenallee 3822763 HamburgGermany Corporate Member of freie Universitat Berlin and Humboldt-Universitat Zu Berlin Institute of Biometry and Clinical Epidermiology BerlinCharite-Universitatsmedizin BerlinBerlinGermany Department of Neonatology and Paediatric Intensive Care Medicine Altona Children's HospitalHamburgGermany Department of Paediatric Surgery Altona Children's HospitalHamburgGermany Labor Dr.fenner and Colleagues Hamburg.Germany Department of Paediatric Orthopaedics Altona Children's HospitalHamburgGermany Department of Paediatric Surgery University Medical Centre Hamburg Eppendorf(UKE)HamburgGermany Department of Paediatrics Altona Children's HospitalHamburgGermany

Background Healthcare workers are considered a particularly high-risk group during the coronavirus disease 2019(COVID-19)*** workers in paediatries are a unique subgroup:they come into frequent contact with children,who often experience few or no symptoms when infected with severe acute respiratory syndrome coronavirus 2(SARS CoV-2)and,therefore,may transmit the disease to unprotected *** Germany,no studies exist evaluating the risk of COVID-19 to healthcare workers in paediatric *** We tested the staff at a large children's hospital in Germany for immunoglobulin(Ig)G antibodies against the nucle-ocapsid protein of SARS CoV-2 in a period between the first and second epidemic wave in *** used a questionnaire to assess each individual's exposure risk and his/her own perception of having already been infected with *** We recruited 619 participants from all sectors,clinical and non-clinical,constituting 70%of the entire *** seroprevalence of SARS CoV-2 antibodies was 0.325%(95%confidence interval 0.039-I.168).Self-perceived risk of a previ-ous SARS-CoV-2 infection decreased with age(odds ratio,0.81;95%confidence interval,0.70-0.93).Having experienced symptoms more than doubled the odds of a high self-perceived risk(odds ratio,2.18;95%confidence interval,1.59--3.00).There was no significant difference in self perceived risk between men and *** Seroprevalence was low among healtheare workers at a large children's hospital in Germany before the second epidemic wave,and it was far from a level that confers herd ***-perceived risk of infection is often overestimated.

关键词： Health personnel SARS CoV-2 Seroepidemiologic studies Pediatrics

Entanglement-based quantum key distribution with a blinking-free quantum dot operated at a temperature up to 20 K

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Advanced Photonics 2021年第6期3卷 31-37页

作者： Christian Schimpf Santanu Manna Saimon f.Covre da Silva Maximilian aigner Armando Rastelli Johannes Kepler University Linz Institute of Semiconductor and Solid State PhysicsLinzAustria

Entanglement-based quantum key distribution(QKD)promises enhanced robustness against eavesdropping and compatibility with future quantum *** other sources,semiconductor quantum dots(QDs)can generate polarization-entangled photon pairs with near-unity entanglement fidelity and a multiphoton emission probability close to zero even at maximum *** properties have been demonstrated under resonant two-photon excitation(TPE)and at operation temperatures below 10 ***,source blinking is often reported under TPE conditions,limiting the maximum achievable photon *** addition,operation temperatures reachable with compact cryocoolers could facilitate the widespread deployment of QDs,e.g.,in satellite-based quantum *** demonstrate blinking-free emission of highly entangled photon pairs from GaAs QDs embedded in a p-i-n *** fidelity entanglement persists at temperatures of at least 20 K,which we use to implement fiber-based QKD between two buildings with an average raw key rate of 55 bits/s and a qubit error rate of 8.4%.We are confident that by combining electrical control with already demonstrated photonic and strain engineering,QDs will keep approaching the ideal source of entangled photons for real world applications.

关键词： quantum optics quantum dots nanophotonics quantum cryptography

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