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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa abd el-salam el-Sayed Mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： Mohamed Tharwat elabbasy Mohamed R.Atteya Mai A.Samak Mousa abdelrahman Tahani AlMahmoud M.A.el-Morsy A.A.Menazea M.f.H.abd el-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to characterize the fabricated films including X-ray diffraction(XRD),fourier transform infrared spectroscopy(fTIR),Raman,and scanning electron microscopy(SEM),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocompatibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocompatible Rare earths

A Hybrid Cybersecurity Algorithm for Digital Image Transmission over Advanced Communication Channel Models

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Computers, Materials & Continua 2024年第4期79卷 201-241页

作者： Naglaa f.Soliman fatma E.fadl-Allah Walid el-Shafai Mahmoud I.Aly Maali Alabdulhafith fathi E.abd el-Samie Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of electronics and Communications Faculty of EngineeringZagazig UniversityZagazig44519Egypt Security Engineering Lab Computer Science DepartmentPrince Sultan UniversityRiyadh11586Saudi Arabia Department of electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

The efficient transmission of images,which plays a large role inwireless communication systems,poses a significant challenge in the growth of multimedia ***-quality images require well-tuned communication *** Single Carrier frequency Division Multiple Access(SC-fDMA)is adopted for broadband wireless communications,because of its low sensitivity to carrier frequency offsets and low Peak-to-Average Power Ratio(PAPR).Data transmission through open-channel networks requires much concentration on security,reliability,and *** data need a space away fromunauthorized access,modification,or *** requirements are to be fulfilled by digital image watermarking and *** paper ismainly concerned with secure image communication over the wireless SC-fDMA systemas an adopted communication *** introduces a robust image communication framework over SC-fDMA that comprises digital image watermarking and encryption to improve image security,while maintaining a high-quality reconstruction of images at the receiver *** proposed framework allows image watermarking based on the Discrete Cosine Transform(DCT)merged with the Singular Value Decomposition(SVD)in the so-called DCT-SVD *** addition,image encryption is implemented based on chaos and DNA *** encrypted watermarked images are then transmitted through the wireless SC-fDMA *** linearMinimumMean Square Error(MMSE)equalizer is investigated in this paper to mitigate the effect of channel fading and noise on the transmitted *** subcarrier mapping schemes,namely localized and interleaved schemes,are compared in this *** study depends on different channelmodels,namely PedestrianAandVehicularA,with a modulation technique namedQuadratureAmplitude Modulation(QAM).Extensive simulation experiments are conducted and introduced in this paper for efficient transmission of encrypted watermarked *** addition,different variants of SC-fDMA bas

关键词： Cybersecurity applications image transmission channel models modulation techniques watermarking and encryption

Correlation between Wnt Signalling Inhibitors (Dickkopf-1 & Sclerostin) and the Intimal Medial Thickness in Children on Maintenance Hemodialysis

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Open Journal of Nephrology 2024年第3期14卷 397-412页

作者： Manal abd el-salam Mohamed Hamdi Ali Nadia Youssef Riad Rasha abd el Samad fawaz Shima Mohamed Department of Pediatrics Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt Tbilisi State Medical University Tbilisi Georgia Department of Clinical Pathology National Heart Institute Cairo Egypt Department of Radiology Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt

Background: Wnt signalling inhibitors (Dickkopf-1 and Sclerostin) signalling play a role in vascular development and may contribute to calcification. Aim: To investigate the association between Dickkopf-1 and sclerostin serum concentrations in children undergoing maintenance hemodialysis with intimal medial thickness and peak systolic velocity of the main arteries. Patients and Methods: A study was conducted on 40 children undergoing maintenance hemodialysis and controls of the same age and sex. The study measured the initial medial thickness (IMT) and peak systolic velocity (PSV) of the main vessels (carotid, ulnar, and femoral). Dickkopf-1 and sclerostin serum levels in both groups were assessed, and a routine investigation was performed. Results: The findings indicate that the levels of serum Dickkopf-1 and Sclerostin were significantly higher in the hemodialysis group 2540.65 (2215.4 - 2909.2 pg/ml) and 1.17 (0.85 - 2.03 ng/ml)respectively (P = 0.001), compared to their control group it was 1110.45 (885.45 - 1527.65 pg/ml) and 0.28 (0.25 - 0.32 ng/ml)) respectively P = 0.001. Additionally, there was a significant increase in intima-media thickness (IMT) with a decrease in peak systolic velocity (PSV) in the main blood vessels, including the carotid, ulnar, and femoral arteries. A significant correlation was also observed between Dickkopf-1 and sclerostin levels and IMT of the carotid, ulnar, and femoral arteries. Conclusion: Wnt signalling inhibitors (Dickkopf-1 and Sclerostin) exert effects beyond the bone and significantly contribute to early vascular calcification in pediatric patients undergoing maintenance hemodialysis.

关键词： Wnt Signalling Vascular Calcification Hemodialysis Children

Eco-toxicity and health risk assessment of polycyclic aromatic hydrocarbons in surface sediments of Burullus Lake in Egypt

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China Geology 2024年第3期7卷 460-468页

作者： Hanan E Osman Mohamed H E el-Morsy Hazem T abd el-Hamid Department of Biology Faculty of Applied ScienceUmm Al-Qura UniversityMecca 24382Saudi Arabia Deanship of Scientific Research Umm Al-Qura UniversityMakkah 24372Saudi Arabia National Institute of Oceanography and fisheries(NIOf) Cairo 11865Egypt Botany and Microbiology Department Faculty of ScienceAl-Azhar UniversityCairo 11651Egypt

Polycyclic aromatic hydrocarbons(PAHs)are ubiquitous environmental contaminants of growing concern due to their potential ecological and human health *** study presents a comprehensive assessment of PAHs contamination in the surface sediments of Burullus Lake,a vital and second largest delta lake in *** aim was to evaluate the eco-toxicity and potential health risks associated with the presence of these *** seven sediment samples were collected from various drains in the southern part of Burullus *** extraction method was employed to extract PAHs(16PAHs)from the sediment ***,target compounds were located using *** results showed that samples contained PAHs levels ranging from 0.038×10^(-6)to 0.459×10^(-6),which is considered heavily polluted by the European standard for PAHs ***,there was no apparent source of PAHs in the elKhashah drain or the Brinbal Canal,as HPLC found none of the *** most prevalent compound in sediment samples along the study area was *** diagnostic indices in the present study indicated that the hydrocarbons in the region originated from pyrolytic and man-made sources along the drains of Burullus *** principal component analysis(PCA)and diagnostic ratios revealed that coal combustion and pyrolytic sources were responsible for the PAHs contamination in the surface *** non-carcinogenic risk(HI),which is the product of the HQs for the adult and child populations,respectively,was *** values under 1,therefore,demonstrated that they had no carcinogenic effects on human *** and MEQs in the sediments of Burullus Lake do not have a cancer-causing impact on *** the safety of nearby wildlife,aquatic life,and people,all activities that raise petroleum hydrocarbon levels in Burullus Lake must be adequately regulated and *** to the ecological risk assessment,there is little chance that PAHs will be found

关键词： Polycyclic aromatic hydrocarbons Diagnostic indices Toxicity Delta lake sediment Burullus Lake Human health risk Aquatic ecosystem HPLC Coal combustion

Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

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Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： Manal abd el-salam Marwa Mohamed Anwar Rasha Mahmoud Gouda Naglaa Abou el fattah Nadia Youssef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and Methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status

Langmuir-Schaefer film Investigation and Density functional Theory Band Gap Calculations of Calix[n]arene-Para-Aminobenzoic Acid for Drug Nanosensor Application

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： WONG Yeong Yi f L Supian A Radzwan M Musa N f N abd Karim Department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the Langmuir method and first-principle density functional theory(DfT).Using the Langmuir-Schaefer(LS)technique,an ultrathin film composed of calix[n]arenes and their complexes with PABA was deposited on various *** on the Langmuir study,the PABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the LS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),fourier-transform infrared spectroscopy(fTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHNS).The band gap reduction obtained in the DfT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory Langmuir-Schaefer PABA sensor

Optimization of Cooperative RelayingMolecular Communications for Nanomedical Applications

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1259-1275页

作者： Eman S.Attia Ashraf A.M.Khalaf fathi E.abd el-Samie Saied M.abd el-atty Konstantinos A.Lizos Osama Alfarraj Heba M.el-Hoseny Department of electrical Engineering Faculty of EngineeringMinia UniversityMinia61111Egypt Department of electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Computer science The Higher Future Institute for Specialized Technological StudiesEl ShoroukEgypt

Recently,nano-systems based on molecular communications via diffusion(MCvD)have been implemented in a variety of nanomedical applications,most notably in targeted drug delivery system(TDDS)***,because the MCvD is unreliable and there exists molecular noise and inter symbol interference(ISI),cooperative nano-relays can acquire the reliability for drug delivery to targeted diseased cells,especially if the separation distance between the nano transmitter and nano receiver is *** this work,we propose an approach for optimizing the performance of the nano system using cooperative molecular communications with a nano relay scheme,while accounting for blood flow effects in terms of drift *** fractions of the molecular drug that should be allocated to the nano transmitter and nano relay positioning are computed using a collaborative optimization problem solved by theModified Central force Optimization(MCfO)*** the previous work,the probability of bit error is expressed in a closed-form *** is used as an objective function to determine the optimal velocity of the drug molecules and the detection threshold at the nano *** simulation results show that the probability of bit error can be dramatically reduced by optimizing the drift velocity,detection threshold,location of the nano-relay in the proposed nano system,and molecular drug budget.

关键词： Nanomedical system molecular communication cooperative relay optimization

Depositional Environment,Petrophysical Evaluation and electrical Properties of Zeit formation,Northwestern Shore of Gulf of Suez,Egypt

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Journal of Earth Science 2024年第5期35卷 1720-1737页

作者： Mohamed M.Gomaa Emad A.abd el Aziz Geophysical Sciences Department National Research CentreEl-Behoos St.DokkiCairo 12622Egypt

The Zeit sand reservoir is one of the most prolific formations at Northwestern side of the Gulf of *** this research we will try to coordinate between electrical,petrophysical properties,depositional environment and facies discrimination in order to evaluate the hydrocarbon potentiality of studied Zeit *** statistical parameters for potassium(K),thorium(Th)and Th/U ratio contents have a general increase towards northwestern parts,whereas uranium(U)content has a general increase towards southeastern *** sandstone facies is distinguished from the other facies by its thorium content>4 ppm.U has high carbonate content(U≥1 ppm).Rocks'electrical properties vary greatly depending on a number of *** measurements were taken at frequencies range of(5×10^(-4)Hz-100 kHz)for fully saturated samples(clayey sandstone)with NaCl(20 gm/L).As salinity,clay content,and frequency increase,consequently does the electrical *** continental condition are present in northwestern part(back-sea)which is distinguished by high K percent,high Th,high Th/U ratio,and low U *** K,Th,and Th/U ratio contents,with high U contents,characterize the marine depositional environment that existed around the east and southeastern parts(foresea coincide with the dipping of strata).furthermore,the studied Zeit formation has good petrophysical properties that coincide with marine *** middle and eastern parts(around ISS-94 and CSS-288)is a good reservoir(porosity 36%-39%,shale contentfeet).

关键词： Zeit formation petrophysical evaluation depositional environment Spectral Gamma Ray electrical properties gulf of Suez sedimentology