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Role of mmP-2 and mmP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 570-579页

作者： Jacek Kurzepa Agnieszka m?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof celiński Weronika Kazmierak maria S?omka Department of medical Chemistry Medical University of Lublin Chod?ki 4a Lublin 20-093 Poland Department of Gastrology Medical University of Lublin Jaczweskiego 8 Lublin 20-954 Poland 1st Department of Radiology University Hospital No. 4 Jaczewskiego 8 Lublin 20-954 Poland

BACKGROUND： There is a growing evidence that matrix metalloproteinase （mmP）-2 and mmP-9 （gelatinases） play an important role in the pathogenesis of numerous disorders, especially with inflammatory etiology and extracellular matrix （ECm） remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation. DATA SOURCES： We carried out a Pubmed search of Englishlanguage articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases. RESULTS： The decreased activity of gelatinases, especially mmP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECm remodeling. Similar situation can be found in chronic pancreatitis; however, reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in mmP-9 activity elevation. CONCLUSION： The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases is observed, but the exact role of these enzymes demands further studies.

关键词： matrix metalloproteinase liver fibrosis chronic pancreatitis non-specific inflammatory bowel diseases

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Characterization of organic-rich mineral debris revealed by rapid glacier retreat, Indren Glacier, European Alps

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Journal of mountain Science 2021年第6期18卷 1521-1536页

作者： fREPPAZ michele WILLIAmS mark W. GABRIELI Jacopo GORRA Roberta mANIA Ilaria ASCHER-JENULL Judith EGLI markus celi Luisella Department of Agriculture Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 210095 Grugliasco(TO)Italy NatRisk Research Centre on Natural Risks in mountain and Hilly Environments University of TurinLargo Paolo Braccini 210095 Grugliasco(TO)Italy Institute of Arctic and Alpine Research and Department of Geography University of Colorado at BoulderUCB 450BoulderCO 80309USA CNR-ISP(Consiglio Nazionale delle Ricerche Istituto di Scienze Polari)via Torino 15530172 Venezia-MestreItaly Institute of microbiology University of InnsbruckTechnikerstraße 256020 InnsbruckAustria Department of Geography University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland

In the summer of 2003 and 2004, characterized by a rapid glacier retreat, a stony surface covered by well-structured organic-rich mineral debris was observed very close to the Indren glacier terminus(monte Rosa massif, NW Italy, 3100 m ASL), on an area covered by the glacier tongue till the year before. The origin and type of this organicrich material were investigated, in order to detect their characteristics, potential sources and fate within the foreland system. The deposits were dated using Carbon-14 and analyzed for the chemical characteristics of the organic component, the elemental composition of the mineral fraction and presence of microbial markers. The material, granular and dark in color, had a total organic carbon(TOC) content ranging between 17.4 ± 0.39 and 28.1 ± 0.63 g kg^(-1) dry weight(dw), significantly higher than the surrounding glacial till(~ 1.4 g kg^(-1) dw), although only 0.33% of it was in water soluble form. microbial carbon(C) and nitrogen(N) accounted for 10.6% and 3.13% of TOC and total N, respectively. Dissolved nitrogen(N), mainly present as ammonium, represented 2.40% of the total N. The low aromatic component and large presence of nitrogen(N)-derived compounds suggested that most of the organic carbon(OC) in these organic-rich mineral deposits was derived from microbial cells, although the high average radiocarbon age of about 2900 years may also point to the contribution of aeolian depositions of anthropogenic or natural origin. Elemental composition and the crustal enrichment factor of trace elements in the mineral fraction of the aggregates corroborated the hypothesis that most part of the accumulated material derived from ice meltwater. Some indicators of the colonization of these deposits by microbial communities were also reported, from the abundance of DNA and phylogenetic markers, to the presence of bacterial taxa commonly able to thrive in similar habitats. All these elements suggested that such kind of deposits may have a p

关键词： Glacier foreland Dissolved organic carbon Organic matter q PCR microbial community Trace elements

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蒙药草乌及其炮制品的六种生物碱类成分血浆中含量测定

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中国民族医药杂志 2017年第1期23卷 42-45页

作者：策力木格聂颖兰梁慧张小峰松林图雅内蒙古医科大学蒙医药学院内蒙古呼和浩特010110 中国中医科学院医学实验中心北京100700 中国中医科学院数据中心北京100700

目的:建立血浆中,草乌及其诃子汤炮制品的6种生物碱类成分LC-mS含量测定的方法。方法:血浆样品用加25%氨水、乙醚萃取后,采用ZORbax-Extend-C18 4.6×250mm 5-micron 80A柱子检测,流动相水相为10mmol醋酸铵水溶液(氨水调ph=9.0)有机相... 详细信息

目的:建立血浆中,草乌及其诃子汤炮制品的6种生物碱类成分LC-mS含量测定的方法。方法:血浆样品用加25%氨水、乙醚萃取后,采用ZORbax-Extend-C18 4.6×250mm 5-micron 80A柱子检测,流动相水相为10mmol醋酸铵水溶液(氨水调ph=9.0)有机相为乙腈,选择离子检测m/z 604(苯甲酰乌头原碱)、m/z 590(苯甲酰新乌头原碱)、m/z 574(苯甲酰次乌头原碱)m/z 632(新乌头碱)、m/z 646(乌头碱)、m/z 616(次乌头碱)。结果:本方法 6种成分线性关系均良好,精密度、稳定性、基质效应RSD都低于10%,加样回收率为59.11%~96.57%。结论:此样品处理快速简便、检测方法精密度高,适用于血浆中新乌头碱、次乌头碱、乌头碱、苯甲酰新乌头原碱、苯甲酰次乌头原碱、苯甲酰乌头原碱检测,以其为草乌及诃子汤炮制草乌的进一步药代毒代动力学研究提供参考。

关键词：草乌炮制诃子制草乌含量测定

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Amifostine对环磷酰胺衍生物所致正常造血祖/干细胞毒性的保护作用

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中国实验血液学杂志 1995年第4期3卷 406-410页

作者：陈虎 Luc Douay m-C Giarratana N-C Gorin 北京北太平路医院血液科 Cell Culture Laboratory CHU Saint-Antoine 27 Rue de Chaligny 75012 Paris France

为了估价Amifostine(WR-2721)对正常造血干细胞的保护作用,我们用不同剂量的环磷酰胺衍生物(4-HC,ASTA-Z)对13例正常造血干细胞进行了体外处理,并测定其PCm-CfU-Gm,5R-CfU-Gm和LTO-IC的LD_(95),发现在处理前经过WR-2721孵育的13例中10例... 详细信息

为了估价Amifostine(WR-2721)对正常造血干细胞的保护作用,我们用不同剂量的环磷酰胺衍生物(4-HC,ASTA-Z)对13例正常造血干细胞进行了体外处理,并测定其PCm-CfU-Gm,5R-CfU-Gm和LTO-IC的LD_(95),发现在处理前经过WR-2721孵育的13例中10例LD_(95)明显增加(P<0.05),显示了明确的保护效果,而在9例白血病祖细胞组中,这种保护效果却没有被发现。相反,经过WR-2721孵育9例白血病祖细胞对化疗的敏感性都有不同程度的增加。

关键词： Amifostine 骨髓移植造血祖/干细胞白血病

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