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Python server Page Perf.rmance Analysis and Modeling

Communications and Network 2024年第1期16卷 1-30页

作者： Razaf.ndraibe Marolahy Alix Randrianomenjanahary Lala f.rdinand Raf.mantanantsoa f.ntaine Mahatody Thomas f. Angelo Raherinirina University of.f.anarantsoa Fianarantsoa Madagascar

Today, in the f.eld of.computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself.Apache. The number of.solutions f.r this server is theref.re growing continuously, these services are becoming more and more complex and expensive, without being able to f.lf.ll the needs of.the users. The absence of.benchmarks f.r websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of.access to inf.rmation on the Internet. This is why the perf.rmance of.the web server is critically important. several f.ctors inf.uence perf.rmance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these f.ctors, we propose a perf.rmance evaluation strategy f.r servers that allows us to determine the actual perf.rmance of.dif.erent servers in terms of.user satisf.ction. f.rthermore, we identif.ed perf.rmance characteristics such as throughput, resource utilization, and response time of.a system through measurement and modeling by simulation. f.nally, we present a simple queue model of.an Apache web server, which reasonably represents the behavior of.a saturated web server using the simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traf.ic. We obtain server perf.rmance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightf.rward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Perf.rmance Analysis Queue Perf.rmance Model Web server Internet World Wide Web Web server Perf.rmance

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Linking IL-10 signaling with lipid metabolic programs in macrophages:dysregulated ceramide homeostasis drives colitis

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signal Transduction and Targeted Therapy 2024年第7期9卷 2835-2836页

作者： Imke Atreya Markus f.Neurath Department of.Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immuntherapie(DZI) ErlangenGermany

In a recent study published in Nature,York and coworkers identif.ed the immunometabolic regulation of.mono-unsaturated f.tty acid(MUf.)pools and the subsequent increase in sphingolipid biosynthesis in TLR2-activated macrophages as an important link between impaired IL-10 signaling and the development of.intestinal inf.ammation.1 Thus,targeted interf.rence with the newly identif.ed IL-10/MUf./sphingolipid axis appears as a promising strategy to restore immunometabolic homeostasis in the intestine of.patients with inf.ammatory bowel diseases(IBD).

关键词： homeostasis impaired intestine

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Body Contour in the Post-Bariatric Male Patient

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Modern Plastic surgery 2024年第2期14卷 15-22页

作者： Erick Zúñiga-Garza Israel salgado-Adame Claudio D. Rojas-Gutiérrez Laura María Rodríguez-Barrios Guillermo Álvarez-sánchez Eduardo Camacho-Quintero Department of.Plastic surgery National Medical Center &#822020 de Noviembre&#8221 Mexico City Mexico

Background: Obesity is currently considered a public health problem. Bariatric procedures have become an important part of.obesity management and, consequently, the number of.male patients seeking post-bariatric reconstructive procedures have increased. Theref.re, the clinical approach and understanding of.the body contour of.this population have become more relevant. The goal of.post-bariatric reconstruction is to enhance the male silhouette through removal of.skin and adipose tissue excess, and abdominal rectus diastasis repair. Material and Methods: We conducted a retrospective study at the Plastic and Reconstructive surgery Department of.the National Medical Center “20 de Noviembre”. All male patients ref.rred to our department to start a post-bariatric reconstruction protocol f.om January 2018 to December 2022 were included in this study. Results: In total, 15 patients who underwent corporal contouring procedures were included;median age was 49.2 years with minimum of.33 years, and a maximum of.57 years. Median Body mass index was 28.4 kg/msup>2sup> with minimum of.22 kg/msup>2sup> and maximum of.38 kg/msup>2sup>. All patients were treated 18 months af.er their bariatric surgery. All patients underwent an abdominoplasty as a body contouring procedure. 4 (26.7%) patients presented complications related to the surgery. Conclusion: We described a comprehensive and systematic approach to massive weight loss f.r male patients, suggesting an abdominal marking based on the patient’s clinical f.atures and the expected results avoiding f.minization of.the abdominal body contour.

关键词： Massive Weight Loss Post-Bariatric Male Abdominoplasty Contouring

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Comparative analysis of.microstructure,mechanical,and corrosion properties of.biodegradable Mg-3Y alloy prepared by selective laser melting and spark plasma sintering

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Journal of.Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková s.Šašek J.Dittrich M.Knapek f.Lukáˇc D.Koutný J.Jaroš R.Král f.culty of.Mathematics and Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of.Plasma Physics of.the Czech Academy of.sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of.Machine and Industrial Design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of.biodegradable magnesium alloy Mg-3Y preparation by two modern powder metallurgy techniques–spark plasma sintering(sPs)and selective laser melting(sLM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the sLM material and unmeasurably low porosity in the sPs *** main aim of.the study was the thorough microstructure characterisation and interrelation between the microstructure and the f.nctional properties,such as mechanical strength,def.rmability,and corrosion *** materials showed comparable strength of.110 MPa in tension and compression and relatively good def.rmability of.9%and∼21%f.r the sLM and sPs materials,*** corrosion resistance of.the sPs material in 0.1 M NaCl solution was superior to the sLM one and comparable to the conventional extruded *** digital image correlation during loading and the cross-section analysis of.the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative ef.ect on the f.nctional properties of.the sLM *** the other hand,one of.the primary outcomes of.this study is that the sPs consolidation method is very ef.ective in the preparation of.the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might f.nd practical applications.

关键词： Magnesium Yttrium Powder metallurgy Microstructure Mechanical strength Corrosion resistance

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Enhancing f.tigue perf.rmance of.AZ31 magnesium alloy components f.bricated by cold metal transf.r-based wire arc directed energy deposition through LPB

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Journal of.Magnesium and Alloys 2024年第4期12卷 1638-1662页

作者： shambhu Kumar Manjhi srikanth Bontha A.s.s.Balan Department of.Mechanical Engineering National Institute of Technology KarnatakaSurathkalSrinivasanagarMangaloreKarnataka 575025India

Cold Metal Transf.r-Based Wire Arc Directed Energy Deposition(CMT-WA-DED)presents a promising avenue f.r the rapid f.brication of.components crucial to automotive,shipbuilding,and aerospace ***,the susceptibility to f.tigue of.CMT-WA-DED-produced AZ31 Mg alloy components has impeded their widespread adoption f.r critical load-bearing *** this study,a comprehensive investigation into the f.tigue behaviour of.WA-DED-f.bricated AZ31 Mg alloy has been carried out and compared to commercially available wrought AZ31 *** f.ndings indicate that the as-deposited parts exhibit a lower f.tigue lif. than wrought Mg alloy,primarily due to poor surf.ce f.nish,tensile residual stress,porosity,and coarse grain microstructure inherent in the WA-DED *** Plasticity Burnishing(LPB)treatment is applied to mitigate these issues,which induce signif.cant plastic def.rmation on the *** treatment resulted in a remarkable improvement of.f.tigue lif. by 42%,accompanied by a reduction in surf.ce roughness,grain ref.nement and enhancement of.compressive residual stress ***,during cyclic def.rmation,WA-DED specimens exhibited higher plasticity and dislocation density compared to both wrought and WA-DED+LPB specimens.A higher f.action of.Low Angle Grain Boundaries(LAGBs)in WA-DED specimens contributed to multiple crack initiation sites and convoluted crack paths,ultimately leading to premature *** contrast,wrought and WA-DED+LPB specimens displayed a higher percentage of.High Angle Grain Boundaries(HAGBs),which hindered dislocation movement and resulted in f.wer crack initiation sites and less complex crack paths,thereby extending f.tigue *** f.ndings underscore the ef.ectiveness of.LPB as a post-processing technique to enhance the f.tigue perf.rmance of.WA-DED-f.bricated AZ31 Mg alloy *** study highlights the importance of.LPB surf.ce treatment on AZ31 Mg components produced by CMT-WA-DED to remove surf.ce d

关键词： Wire arc additive manuf.cturing AZ31 Mg alloy Low plasticity burnishing Low cycle f.tigue test strain amplitude

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金闪闪的生活玫瑰金公寓

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室内设计与装修 2024年第9期 46-50页

作者： [西班牙]Raúl sánchez JoséHevia(摄影) coco(编译) Raúl sánchez

玫瑰金公寓位于巴塞罗那,夹在En#sanche Derecho宽敞的内部庭院和Enric Granados街之间,面积为85m^(2)。原平面很方正,标准的公寓户型,只在入口处有一个很小的L形的入户庭院。设计师希望能充分利用这个入户庭院,将它与公寓最里面的阳台... 详细信息

玫瑰金公寓位于巴塞罗那,夹在En#sanche Derecho宽敞的内部庭院和Enric Granados街之间,面积为85m^(2)。原平面很方正,标准的公寓户型,只在入口处有一个很小的L形的入户庭院。设计师希望能充分利用这个入户庭院,将它与公寓最里面的阳台贯通,使空气对流。重新布局后的公寓,通道位于中心位置,连通阳台和入户庭院。从入户庭院开始,穿过两侧的卧室,到达宽敞的公共空间,包括一侧的客厅和另一侧的餐厅厨房。

关键词：空气对流巴塞罗那玫瑰金公寓公共空间庭院

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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of.nuclear f.ctor erythroid 2-related f.ctor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： f.haid H.A.L-Hashem salah O.Bashir Amal f.Dawood Moutasem s.Aboonq Ismaeel Bin-Jaliah Abdulaiziz M.Al-Garni Mohamed D.Morsy Department of.Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of.Basic Medical sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of.Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of.Medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of.hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inf.ammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of.the nuclear f.ctor erythroid 2-related f.ctor 2(Nrf.) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into f.ve groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf.inhibitor) *** ef.ectively attenuated CdCl_(2)-induced damage in the dental gyrus of.the hippocampus and improved the memory f.nction assessed by the Morris Water Maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of.inf.ammatory biomarkers(interleukin-6,tumor necrosis f.ctor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of.reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with signif.cant elevation of.nuclear Nrf. mRNA and protein expression in hippocampal *** the protective ef.ects of.vanillylacetone we re substantially blocked by the co-administration of.brusatol(a selective N rf. inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription f.ctor ***,vanillylacetone exerted its potent antioxidant and antiinf.ammatory actions.

关键词： hippocampus neuroprotective Nrf. gene oxidative stress vanillylacetone

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Multi-timescale Modeling and Dynamic stability Analysis f.r sustainable Microgrids:state-of.the-art and Perspectives

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Protection and Control of.Modern Power systems 2024年第3期9卷 1-35页

作者： Mingyue Zhang Yang Han Yuxiang Liu Amr s.Zalhaf.Ensheng Zhao Karar Mahmoud Mohamed M.f.Darwish f.ede Blaabjerg the school of.Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China IEEE 不详 the University of.Electronic science and Technology of.China(UEsTC) ChengduChina Aswan University the school of.Electrical Engineering Aalto UniversityFinland the Department of.Electrical Engineering Faculty of Engineering at ShoubraBenha University the Department of.EEA School of Electrical EngineeringAalto University

The increasing trend f.r integrating renewable energy sources into the grid to achieve a cleaner energy system is one of.the main reasons f.r the development of.sustainable microgrid(MG)*** typical power-electronized power systems,MGs make extensive use of.power electronics converters,which are highly controllable and f.exible but lead to a prof.und impact on the dynamic perf.rmance of.the whole *** with traditional large-capacity power systems,MGs are less resistant to perturbations,and various dynamic variables are coupled with each other on multiple timescales,resulting in a more complex system instability *** meet the technical and economic challenges,such as active and reactive power-sharing,voltage,and f.equency deviations,and imbalances between power supply and demand,the concept of.hierarchical control has been introduced into MGs,allowing systems to control and manage the high capacity of.renewable energy sources and ***,as the capacity and scale of.the MG system increase,along with a multi-timescale control loop design,the multi-timescale interactions in the system may become more signif.cant,posing a serious threat to its saf. and stable *** investigate the multi-timescale behaviors and instability mechanisms under dynamic inter-actions f.r AC MGs,existing coordinated control strategies are discussed,and the dynamic stability of.the system is def.ned and classif.ed in this ***,the modeling and assessment methods f.r the stability analysis of.multi-timescale systems are also ***,an outlook and discussion of.f.ture research directions f.r AC MGs are also presented.

关键词： sustainable microgrid hierarchical control modeling model simplif.cation multi-timescale dynamic stability analysis timescale decomposition.

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Endoplasmic reticulum stress,autophagy,neuroinf.ammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika f.jii Charles f.Zorumski Yukitoshi Izumi Department of.Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor f.mily Institute f.r Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological f.ctors contributing to depression and other neuropsychiatric disorders are largely undef.ned. Endoplasmic reticulum stress pathways and autophagy are well-def.ned mechanisms that play critical f.nctions in recognizing and resolving cellular stress and are possible targets f.r the pathophysiology and treatment of.psychiatric and neurologic illnesses. An increasing number of.studies indicate the involvement of.endoplasmic reticulum stress and autophagy in the control of.neuroinf.ammation, a contributing f.ctor to multiple neuropsychiatric illnesses. Initial inf.ammatory triggers induce endoplasmic reticulum stress, leading to neuroinf.ammatory responses. subsequently, induction of.autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinf.ammation. The aim of.this review is to summarize our current understanding of.the molecular mechanisms governing the induction of.endoplasmic reticulum stress, autophagy, and neuroinf.ammation in the central nervous system. studies f.cused on innate immune f.ctors, including neurosteroids with anti-inf.ammatory roles will be reviewed. In the context of.depression, animal models that led to our current understanding of.molecular mechanisms underlying depression will be highlighted, including the roles of.sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinf.ammation.

关键词： allopregnanolone f.uvoxamine ketamine neurosteroids postpartum depression quercetin

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Item-Level Analysis of.the Revised Occupational Therapy f.eldwork Perf.rmance Evaluation Applied in Practice

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Open Journal of.Therapy and Rehabilitation 2024年第2期12卷 145-159页

作者： Cynthia L. sears Brad E. Egan Patricia f. Tomsic Craig A. Velozo Graduate College of.Health Prof.ssions Occupational Therapy Program Hawai&#8217i Pacific University Honolulu HI USA College of.science and Health Occupational Therapy Program DePaul University Chicago IL USA Department of.Occupational Therapy Wingate University Wingate NC USA College of.Health Prof.ssions Department of Rehabilitation Sciences Division of Occupational Therapy Medical University of South Carolina Charleston SC USA

Competency-based assessments f.r healthcare prof.ssionals are critical f.r saf. and ef.ective client outcomes. Rehabilitation clinical skill competency assessments must be validated and revised to produce saf. and skilled practitioners. The revised American Occupational Therapy Association (AOTA) f.eldwork Perf.rmance Evaluation (f.PE) instrument measures occupational therapy student perf.rmance to determine readiness f.r practice. The assessment includes thirty-seven competencies that address both prof.ssion specif.c clinical skills and general prof.ssional behavior skills. The objective of.this study was to use Rasch methods to explore the use of.the revised f.PE in actual f.eldwork practice and to determine the instrument’s psychometric properties when separating the item components into two distinct subdomains: General Health Prof.ssions Competences and Occupational Therapy-specif.c Competencies. Internal construct validity and test reliability were analyzed using data f.om 149 occupational therapy students af.er completing their initial Level II A f.eldwork clinical internship. This study examined the item dif.iculty hierarchy, item f.t, person-f.t to model, person separation index, person separation reliability coef.icient, strata, ceiling and f.oor ef.ect, and unidimensionality of.the f.PE instrument as a whole and as two separate domains. With the exception of.not meeting the criteria f.r unidimensionality, the f.ll f.PE instrument and the Occupational Therapy-specif.c Competencies subdomain showed acceptable item-level psychometrics f.r reliability and precision. While the General Health Prof.ssions Competencies subdomain showed good item-level psychometrics, it was below the criterion f.r reliability and only separated the sample into two strata. Results support the validity, reliability, and clinical use of.the revised f.PE f.ll instrument and the Occupational Therapy-specif.c Competencies subdomain to measure entry-level clinical skill competencies in pr

关键词： Rehabilitation Competency-Based Assessments Occupational Therapy Measurement Rasch Analysis

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