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Ef.ects of.P301l-TAU on post-translational modif.cations of.microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad al Kabbani Christoph Köhler Hans Zempel Institute of.Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center f.r Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of.diseases known as *** are essential f.r neuronal f.nction and regulated via a complex set of.post-translational modif.cations,changes of.which af.ect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of.microtubule-severing *** impairment of.microtubule dynamics causes neuronal dysf.nction,we hypothesize cognitive impairment in human disease to be impacted by impairment of.microtubule *** theref.re aimed to study the ef.ects of.a disease-causing mutation of.TAU(P301l)on the levels and localization of.microtubule post-translational modif.cations indicative of.microtubule stability and dynamics,to assess whether P301l-TAU causes stability-changing modif.cations to *** investigate TAU localization,phosphorylation,and ef.ects on tubulin post-translational modif.cations,we expressed wild-type or P301l-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of.mice transgenic f.r human P301l-TAU(p R5 mice).Human neurons expressing the longest TAU isof.rm(2N4R)with the P301l mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of.microtubules compared with endogenous TAU-expressing neurons.P301l-TAU showed pronounced somatodendritic presence,but also successf.l axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301l-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of.TAU and increased polyglutamylation,but reduced acetylation,of.microtubules compared with non-transgenic *** sum,P301l-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301l pR5 mice TAU tauopathy tubulin code

Antibacterial and antif.ngal activities of.dif.erent parts of.Tribulus terrestris l. growing in Iraq

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Journal of.Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 154-159页

作者： f.ras A. al-BAYATI Hassan f. al-MOlA Department of.Biology College of Education University of Mosul Mosul-00964 Iraq

Antimicrobial activity of.organic and aqueous extracts f.om f.uits, leaves and roots of.Tribulus terrestris l., an Iraqi medicinal plant used as urinary anti-inf.ctive in f.lk medicine, was examined against I l species of.pathogenic and non-pathogenic microorganisms： Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Corynebacterium diphtheriae, Escherichia coli, Proteus vulgaris, Serratia marcescens, Salmonella typhimurium, Klebsiella pneumoniae, Pseudomonas aeruginosa and Candida albicans using microdilution method in 96 multiwell microtiter plates. all the extracts f.om the dif.erent parts of.the plant showed antimicrobial activity against most tested microorganisms. The most active extract against both Gram-negative and Gram-positive bacteria was ethanol extract f.om the f.uits with a minimal inhibitory concentration （MIC） value of.0.15 mg/ml against B. subtilis, B. cereus, P. vulgaris and C. diphtheriae. In addition, the same extract f.om the same plant part demonstrated the strongest antif.ngal activity against C. albicans with an MIC value of.0.15 mg/ml.

关键词： Antimicrobial activity Tribulus terrestris Urinary tract inf.ctions

Experimental study of.f.iction dissipators f.r seismic protection of.building structures

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 475-486页

作者： f. l.pez-al.ansa S.T. de la Cruz C. Taylor Technical University of.Catalonia Architecture Structures Department Universidad Autónoma de Ciudad Juárez Civil and Environmental Engineering Department Civil Engineering Department University of Bristol

This paper presents the results f.om unidirectional shaking table tests of.two reduced scale steel models of.a building f.ame, with one and two f.oors, respectively. These f.ames incorporate f.iction dissipators at every f.oor. The inputs are sine-dwells and artif.cial and registered earthquakes. This study is part of.a larger research project aiming to assess the seismic ef.iciency of.f.iction dissipators by means of.an integrated numerical and experimental approach. Inside this f.amework, the main objectives of.these experiments are to：（i） collect a wide range of.results to calibrate a numerical model derived within the project, （ii） clarif. some of.the most controversial issues about f.iction dissipators （including behavior f.r inputs containing pulses, capacity to reduce resonance peaks, introduction of.high f.equencies in the response, and self. generated eccentricities）, （iii） better understand their dynamic behavior, （iv） provide insight on the f.asibility and reliability of.using simple f.iction dissipators f.r seismic protection of.building structures and （v） characterize the hysteretic behavior of.these devices. Most of.these objectives are satisf.ctorily reached and relevant conclusions are stated.

关键词： building structures earthquake engineering passive control f.iction energy dissipators experimentalverif.cation shaking table tests

Ef.ect of.Zn binding to phytate and humic substances on its uptake by wheat(Triticum durum l.)as af.ected by carbonates and f. oxides

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Pedosphere 2022年第6期32卷 823-832页

作者： Ana M.GARCÍA-l.pez Ramiro RECENA Antonio DElGADO Department of.Agronomy ETSIAUniversity of SevilleSeville 41013(Spain)

although complexation with soil organic matter may improve zinc(Zn)bioavailability to plants,the ef.ect of.Zn sorbent surf.ce on the use of.complexed Zn by plants remains *** objective of.this research was to elucidate how Zn complexation with humic substances(HS)and phytate af.ects the uptake of.Zn by wheat plants depending on the main sorbent surf.ce in growth media,i.e.,carbonates and f. *** this end,two pot experiments were perf.rmed,one using f. oxide-coated siliceous as the siliceous growth medium sand and the other using a mixture of.calcareous sand and siliceous sand as the calcareous growth *** experiment involved three Zn sources,Zn-HS complex,Zn phytate,and ZnSO_(4).all sources were applied with surf.ce irrigation at two Zn rates(0.25 and 2 mg kg^(-1) growth medium).The Zn-HS complex signif.cantly increased Zn uptake by plants in both media,relative to the other two Zn sources,but no signif.cant dif.erence was observed between Zn phytate and ZnSO_(4).In the calcareous medium,Zn-HS complex and Zn phytate resulted in signif.cantly higher dry biomass yields of.wheat than ZnSO_(4).In the siliceous medium,spike and shoot dry biomass yields with Zn-HS complex at the low rate and Zn phytate at both rates were not signif.cantly dif.erent f.om those with ZnSO_(4) at the high *** harvest,approximately 50%of.the Zn applied as Zn-HS complex remained extractable by diethylenetriaminepentaacetic acid(DTPA),while this proportion was less than 20%f.r the other Zn ***,Zn-HS complex and Zn phytate are sources of.available Zn f.r plants,and they are more ef.ective than ZnSO_(4) in increasing plant growth,particularly when carbonates are the main Zn sorbent surf.ce.

关键词： calcareous growth medium micronutrient organic matter organic phosphorus Zn availability Zn def.ciency Zn sorbent surf.ce Zn source

l-shell x-ray f.uorescence relative intensities f.r elements with 62≤Z≤83 at 18 keV and 23 keV by synchrotron radiation

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Chinese Physics B 2023年第8期32卷 270-273页

作者： M alqadi S al-Humaidi H alkhateeb f.alzoubi Department of.Physics Jordan University of Science and TechnologyIrbidJordan

The relative intensities of.l-subshell x-ray f.uorescence(XRf.f.r elements with atomic numbers 62≤Z≤83 were measured at two excitation energies,18 keV and 23 keV,using a synchrotron radiation source at a beamline of.the Synchrotron light Center f.r Experimental Science and Applications in the Middle East(SESAME),*** experimentally measured results of.the relative intensities were compared with the calculated results using the subshell f.uorescence yield and the Coster-Kronig transition probabilities recommended by Campbell and the values based on the Dirac-Hartree-Slater model by *** experimental and theoretical results are in *** this work,l XRf.relative intensities f.r the elements Sm,Gd,Tb,Er,Ta,W,Re,Hg,Pb and Bi at energies of.18 keV and 23 keV were measured.

关键词： l shell x-ray f.uorescence(XRf. relative intensities synchrotron radiation

Use of.High-Yielding Bioenergy Plant Castor Bean(Ricinus communis l.) as a Potential Phytoremediator f.r Copper-Contaminated Soils

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Pedosphere 2013年第5期23卷 651-661页

作者： R. ANDREAZZA l. BORTOlON S. PIENIZ f. A. O. CAMARGO Department of.Soil Federal University of Rio Grande do Sul Laboratory of Soil Microbiology Center of.Engineer Federal University of Pelotas EMBRAPA - Brazilian Agricultural Research Corporation National Research Center of Fisheries Aquaculture and Agricultural Systems Department of.Technology and f.od Microbiology Federal University of Rio Grande do Sul

Copper （Cu） contamination in the environment has been increased during the years with agricultural and industrial activities. Biotechnological approaches are needed f.r bioremediation in these areas. The aims of.this study were i） to evaluate the phytoreme- diation capacity of.the high-yielding bioenergy plant castor bean （Ricinus communis l.） in vineyard soils （Inceptisol and Mollisol） contaminated with Cu and a Cu mining waste; ii） to characterize the castor bean as a Cu phytoremediation plant; and iii） to evaluate the nutrient uptake by castor bean. Castor bean plants cultivated in soil with toxic levels of.Cu f.r 57 d exhibited high phytomass production, a high tolerance index of.roots＇ f.esh mass and shoots＇ dry mass, a high level of.Cu phytoaccumulation in the roots and also, a robust capacity f.r Cu phytostabilization. f.rthermore, castor bean plants did not signif.cantly deplete soil nutrients （such as N, P, and Mg） during cultivation. Plants cultivated in Inceptisol, Mollisol and Cu mining waste exhibited a strong potential f.r Cu phytoaccumulation, with values of.5900, 3 052 and 2805 g ha-1, respectively. In addition, the castor bean＇s elevated phytomass production and strong growth in Cu-contaminated soils indicated a high level of.Cu phytoaccumulation and a potential application in biof.els. These f.ndings indicate that the castor bean is a ef.icient hyperaccumulator of.Cu and a potential candidate plant f.r the phytoremediation of.Cu-contaminated soil.

关键词： biof.els phytoaccumulation phytoremediation phytostabilization

Application of.Nejayote as a f.liar and Edaphic f.rtiliser to Native Blue Maize (Zea mays l.) Crops

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American Journal of.Plant Sciences 2016年第15期7卷 2221-2238页

作者： Victoria Téllez Jesús f. l.pez Agustín Aragón Teresa Zayas Posgrado en Manejo Sostenible de Agroecosistemas BUAP Puebla México Centro de Agroecología BUAP Puebla México Posgrado en Ciencias Ambientales Instituto de Ciencias Benemérita Universidad Autónoma de Puebla (BUAP) Puebla México

Raw and treated “nejayote” were assessed as f.liar and edaphic f.rtilisers f.r native blue maize (Zea mays l.) crops in the municipality of.Amozoc de Mota, Puebla, Mexico, during the 2015 agricultural cycle. Treated nejayote ref.rs to raw nejayote subjected to a coagulation-f.occulation process. Two states of.nejayote were established (raw and treated nejayote) with dif.erent physicochemical properties. f.liar bio-f.rtilisers were prepared f.om raw and treated nejayote and mixed with organic matter (OM) to promote a f.rmentation process. The f.liar treatments used were: BNC5, BNC15, BNC30 (raw nejayote-based bio-f.rtiliser at 5%, 15%, and 30%), BNCQ5, and NCQ30 (nejayote treated by chemical coagulation at 5% and 30%), with BT as a control (traditional bio-f.rtiliser). The edaphic treatments used were: NC50, NC75, and NC100 (raw nejayote at 50%, 75%, 100%), with AP as a control (drinking water), thus giving rise to 10 treatments in terms of.content of.raw or treated nejayote. f.liar and edaphic f.eld treatments applied to native blue maize crops were statistically assessed using the f.llowing response variables: plant height, stem diameter, number of.leaves, and grain yield. The experiment was laid out in a randomised complete block design (RCBD) with f.ve replications of.each treatment. The results obtained showed, that f.liar or edaphic application at the dif.erent stages of.development did not produce statistically signif.cant dif.erences, at P ≤ 0.05, in terms of.response variables. The most signif.cant ef.ects occurred at the early stage of.plant development and were mainly ref.ected in the stem diameter with f.liar treatment NCQ30 and in the number of.leaves with f.liar treatment BNC5. At the f.nal stage of.crop development, the highest yield (0.639 ± 0.121 t·ha-1) was obtained with treatment BNC5, which produced a statistically signif.cant dif.erence (b) in relation to the rest of.the f.liar and edaphic treatments (Tukey P ≤ 0.05).

关键词： Maize Crop f.liar-Edaphic f.rtiliser Raw Nejayote Treated Nejayote

Erbium photoluminescence response related to nanoscale heterogeneities in sol-gel silicates

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Journal of.Rare Earths 2013年第1期31卷 18-26页

作者： H.C.Vasconcelos M.G.Meirelles f.Rivera-l.pez Department of.Technological Sciences and Development Azores University CEf.TEC-Centre of.Physics and Technological Research Physics Department of FCT/UNL Department of.f.ndamental and Experimental Physics Electronics and SystemsUniversity of La Laguna

Sol-gel glassy f.lms of.the SiO2-TiO2-PO2.5-ErO2.5 system containing nanocrystallites of.ErPO4, were obtained through suitable heat treatments. Variations in the shape and intensity of.the Er3＋ photoluminescent signal around 1500 nm were linked to the nature of.the host environment of.the active ions; the specif.c f.atures of.the photoluminescent emission spectrum of.the erbium 4113/2 metastable level were interpreted in terms of.structural changes in the glassy f.lms. The photoluminescent spectrum was f.und to be sensitive to the order （crystalline） or disorder （amorphous） of.the Er3＋ ions neighbour within the glassy matrix. An amorphous envi- ronment led to a broadening of.Er3＋ Pl emission band while a crystalline one was responsible f.r a drastic photoluminescent band- width narrowing. The presence of.nanoscale heterogeneities caused a drastic photoluminescence intensity decrease. Changes in the shape of.the decay curve of.f.uorescence lif.time were f.und also structurally dependent on volumetric def.cts, occurrence of.phase separation and Er3＋-Er3＋ clustering ef.ects as well.

关键词： sol-gel Er3+ optical probe nanoscale heterogeneities photoluminescence ErPO4 rare earths

Recent progress on isospin breaking corrections and their impact on the muon g-2 value

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Chinese Physics C 2010年第6期34卷 712-717页

作者： Gabriel l.pez Castro Departamento de f.sica CinvestavApartado Postal 14-74007000 MxicoD.F Mxico

We describe some recent results on isospin breaking corrections which are of.relevance f.r predictions of.the leading order hadronic contribution to the muon anomalous magnetic moment aμ^*** when using τ lepton data. When these corrections are applied to the new combined data on the π^±π^0 spectral f.nction, the prediction f.r aμ^*** based on τ lepton data gets closer to the one obtained using e^＋e^- data.

关键词： isospin breaking tau decays muon magnetic moment radiative corrections