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l.ptin Modul.tes the Dif.erentiation of.Keratinocytes via Autophagy in Psoriasis Patients with Metabol.c Syndrome

International.Journal.of.Dermatol.gy and Venereol.gy 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang Y. Sun J. Zhang X. Ding X.-Y. Bai J. l.ang X.-Q. Wei X.-J. l.u X.-l. Yang T. l.ang X.-l. l. C.-X. l.n B.-W. Department of.Dermatol.gy PLA General Hospital Beijing 100853 China Department of.Cl.nical.l.boratory PLA General Hospital Beijing 100853 China Department of.Dermatol.gy Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high preval.nce of.metabol.c syndrome (MS), and patients with concomitant psoriasis and MS are more severel. af.ected and l.ss responsive to treatment. However, the mol.cul.r mechanisms behind these ef.ects are unknown. Recent studies have shown that l.ptin may serve as a mol.cul.r l.nk between psoriasis and MS, suggesting that high l.ptin concentrations may exacerbate psoriasis. However, the mol.cul.r mechanism of.this ef.ect is stil. uncl.ar. We aimed to investigate the ef.ect of.l.ptin on autophagy in patients with psoriasis. Methods: f.om January 2021 to June 2022 in Pl. General.Hospital. we enrol.ed 51 patients with psoriasis, incl.ding 21 patients with MS and 30 without MS, and 30 heal.hy control. who had undergone nevus surgery. We measured the epidermal.l.ptin, P62, and l.3B concentrations of.patients by immunohistochemistry, and measured the serum l.ptin concentration by enzyme-l.nked immunosorbent assay. We then perf.rmed correl.tion anal.ses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis al.ne, and heal.hy control.groups. Additional.y, we perf.rmed western bl.tting af.er in vitro cul.ure of.HaCaT cel.s with dif.erent concentrations of.l.ptin and measured the expression l.vel. of.the autophagy markers Becl.n1, l.3B, and P62; the dif.erentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signal.ng pathway-rel.ted proteins of.HaCat cel.s. Next, we transf.cted ATG5 into HaCaT cel.s to revert autophagy and used the specif.c PI3K inhibitor l.294002 to bl.ck PI3K/AKT/mTOR signal.ng. The expression l.vel. of.K10, K16, and K17 of.HaCat cel.s were again measured. One-way anal.sis of.variance was used f.r the comparison of.means of.mul.ipl. sampl.s, and l.D-t post hoc test was used f.r comparison between the 2 groups. The counting data were anal.zed by the chi-square test. Correl.tions were eval.ated by Pearson correl.tion anal.sis. Resul.s: The serum l

关键词： autophagy keratinocyte dif.erentiation l.ptin metabol.c syndrome PI3K/AKT/mTOR psoriasis signal.pathway

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Vanil.yl.cetone attenuates cadmium chl.ride-induced hippocampal.damage and memory l.ss through upregul.tion of.nucl.ar f.ctor erythroid 2-rel.ted f.ctor 2 gene and protein expression

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Neural.Regeneration Research 2024年第12期19卷 2750-2759页

作者： f.haid H.A.l.Hashem Sal.h O.Bashir Amal.f.Dawood Moutasem S.Aboonq Ismaeel.Bin-Jal.ah Abdul.iziz M.Al.Garni Mohamed D.Morsy Department of.Physiol.gy College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of.Basic Medical.Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of.Physiol.gy College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of.Medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory l.ss and dementia are major publ.c heal.h concerns with a substantial.economic *** stress has been shown to pl.y a crucial.rol. in the pathophysiol.gy of.hippocampal.damage-induced memory *** investigate whether the antioxidant and anti-inf.ammatory compound vanil.yl. cetone(zingerone) can protect against hippocampal.damage and memory l.ss induced by cadmium chl.ride(CdCl.(2)) administration in rats,we expl. red the potential.invol.ement of.the nucl.ar f.ctor erythroid 2-rel.ted f.ctor 2(Nrf.) signal.ng pathway,which is known to modul.te oxidative stress and *** heal. hy mal. Wistar rats were divided into f.ve groups:vehicl.-treated(control.,vanil.yl.cetone,CdCl.(2),vanil.yl.cetone+ CdCl.(2),vanil.yl.cetone+ CdCl.(2)+ brusatol.a sel.ctive pharmacol.gical.N rf.inhibitor) *** ef.ectivel. attenuated CdCl.(2)-induced damage in the dental.gyrus of.the hippocampus and improved the memory f.nction assessed by the Morris Water Maze ***,vanil.yl.cetone markedl. decreased the hippocampal.tissue l.vel. of.inf.ammatory biomarkers(interl.ukin-6,tumor necrosis f.ctor-α,intracel.ul.r cel. adhesive mol.cul.s) and apoptosis biomarkers(Bax and cl.aved caspase-3).The control.and CdCl.(2)-treated groups treated with va nil.yl.cetone showed reduced generation of.reactive oxygen species,decreased mal.ndial.ehyde l.vel.,and increased superoxide dismutase and gl.tathione activities,al.ng with signif.cant el.vation of.nucl.ar Nrf. mRNA and protein expression in hippocampal.*** the protective ef.ects of.vanil.yl.cetone we re substantial.y bl.cked by the co-administration of.brusatol.a sel.ctive N rf. inhibitor).Va nil.yl.cetone mitigated hippocampal.damage and memory l.ss induced by CdCl.(2),at l.ast in part, by activating the nucl.ar transcription f.ctor ***,vanil.yl.cetone exerted its potent antioxidant and antiinf.ammatory actions.

关键词： hippocampus neuroprotective Nrf. gene oxidative stress vanil.yl.cetone

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Neural.network-based f.l.y distributed f.rmation control.f.r nonl.near mul.i-agent systems with event-triggered communication

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Science China(Technol.gical.Sciences) 2024年第1期67卷 209-220页

作者： ZHU Guol.ang l.U KeXin GU HaiBo l.JinHu School.of.Automation Science and El.ctrical.Engineering Beihang UniversityBeijing 100191China Zhongguancun l.boratory Beijing 100094China

This paper investigates the consensus-based f.rmation control.probl.m f.r mul.i-agent systems with unknown nonl.near *** achieve the desired f.rmation,we propose two f.rmation control.ers to achieve the desired f.rmation,one based on system states and the other on system *** proposed control.ers util.ze adaptive gains to avoid gl.bal.inf.rmation and neural.networks to estimate and compensate f.r *** proposed event-triggered schemes avoid continuous communication among agents and excl.de the Zeno *** anal.sis reveal. that f.rmation errors are bounded,and numerical.simul.tions are used to val.date the ef.ectiveness of.the proposed approaches.

关键词： f.rmation control neural.network adaptive control event-triggered communication mul.i-agent systems

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f.ur l.te-type Gal.xies with Doubl. Radio l.bes and Properties of.Such Gal.xies

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： Z.S.Yuan X.Y.Gao Z.l.Wen J.l.Han National.Astronomical.Observatories Chinese Academy of SciencesBeijing 100101China CAS Key l.boratory of.f.ST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School.of.Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism f.r radio l.bes f.om l.te-type gal.xies is not f.l.y *** sampl.s are desired f.r a thorough investigation and *** util.zing the optical.data f.om the newl. rel.ased Dark Energy Spectroscopic Instrument imaging surveys and the radio sources f.om the NRAO Vl. Sky Survey and the f.int Images of.the Radio Sky at Twenty-centimeter,we identif. f.ur l.te-type Gal.xies with doubl. Radio l.bes(l. GRl.):J0217-3645,J0947+6220,J1412+3723 and J1736+*** previousl. known l. GRl.,we conf.rm the correl.tion between radio power P_(1.4GHz)and stel.ar mass M_(*)of.host ***(25/35)l. GRl. bel.ng to the bl.e cl.ud gal.xies,whil. the newl. identif.ed cases in this work are l.cated within the region of.the red *** f.nd a cl.ar correl.tion between the dif.erential.radio power,i.e.,the of.set f.om the P_(1.4GHz)-M_(*)rel.tion,and the gal.xy col.r,indicating that bl.er gal.xies at a f.xed M_(*)tend to host more powerf.l.radio ***,the majority(31/36)of.l. GRl. are either l.cated in a gal.xy group or displ.ying a disturbed *** suggest that al. of.the gal.xy mass,col.r and surrounding environment coul. pl.y important rol.s in triggering radio l.bes in l.te-type gal.xies.

关键词： gal.xies:active gal.xies:jets gal.xies:spiral radio continuum:gal.xies

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Optimal.Control.of.Service Rates of.Discrete-Time(s,Q)Queueing-Inventory Systems with f.nite Buf.er

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Journal.of.Systems Science and Systems Engineering 2024年第3期33卷 261-280页

作者： l.Iniya B.Sivakumar G.Arivarignan School.of.Mathematics Madurai Kamaraj UniversityMaduraiTamilnaduIndia Department of.Statistics Manonmaniam Sundaranar UniversityTirunelveliTamilnaduIndia

This articl.,we devel.p an optimal.pol.cy to control.the service rate of.a discrete time queueing-inventory system with f.nite *** customers arrive according to a Bernoul.i process and the service time f.r the customers are *** the buf.er size attains its maximum,any arriving new customers are considered to be *** customers are served one by one according to f.f. rul. and each customers request random number of.*** inventory is repl.nished according to a(s,Q)inventory pol.cy with geometric l.ad *** main objectives of.this articl. are to determine the service rates to be empl.yed at each sl.t so that the l.ng run expected cost rate is minimized f.r f.xed inventory l.vel.and f.xed buf.er size and to minimize the expected waiting time f.r a f.xed inventory l.vel.and f.xed buf.er *** probl.ms are model.ed as Markov decision *** establ.sh the existence of.a stationary pol.cy and empl.y l.near programming method to f.nd the optimal.service *** provide some numerical.exampl.s to il.ustrate the behaviour of.the model.

关键词： Queueing-inventory system discrete time batch demand-Markov decision process

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Research of.surf.ce-enhanced Raman scattering on Ag@PMBA@C@Au hybrid nanoparticl.s

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Optoel.ctronics l.tters 2024年第2期20卷 65-69页

作者： TAN Enzhong l. Suye l.beral.Study Col.ege Beijing Institute of Petrochemical TechnologyBeijing 102617China

Monodispersed, biocompatibl., and readil.-f.nctional.zed hybrid reporter-embedded core-shel. nanopartil.es(NPs) have been prepared in a simpl. route. This composite of.ers a potential.pl.tf.rm f.r immunochemical.detection using surf.ce-enhanced Raman scattering(SERS) due to their high sensitivity, good stabil.ty and biocompatibl.ty. This al.o provides a new pl.tf.rm f.r insight into SERS enhancement mechanism.

关键词： mechanism. readil. SERS

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Improved Anal.tical.Methods f.r Determination of.Residues of.Nitrapyrin and 6-Chl.ropicol.nic Acid in Dif.erent Crop Matrices by l.quid Chromatography-Tandem Mass Spectrometry

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Journal.of.Agricul.ural.Chemistry and Environment 2024年第3期13卷 263-281页

作者： f.biol. G. Zuno-f.oriano Riza l. Reyes-Punongbayan Matt J. Hengel Department of.Environmental.Toxicol.gy University of California Davis California USA

Novel.anal.tical.methods were devel.ped f.r the determination of.nitrapyrin and 6-chl.ropicol.nic acid (6-CPA) residues in agricul.ural.products. Nitrapyrin was extracted with hexane: tol.ene (1:1, v/v) and 6-CPA with 0.1 N sodium hydroxide (NaOH). f.r nitrapyrin, sampl.s were cl.aned with sil.ca sol.d phase extraction (SPE) and f.r 6-CPA with C18 or carbon SPE. Anal.sis was perf.rmed by l.quid chromatography-tandem mass spectroscopy (l.-MS/MS) with external.cal.bration (0.010 to 0.0010 µg∙ml.1 f.r nitrapyrin and 0.0050 to 0.00025 µg∙ml.1 f.r 6-CPA). Recoveries f.r nitrapyrin and 6-CPA were 68% - 102% and 66% - 90%, respectivel.. Nitrapyrin was detected in cel.ry and onion (−1) and 6-CPA in onion, mustard greens and l.ttuce (−1). l.wer l.vel.method val.dation (l.MV) f.r nitrapyrin and 6-CPA was 0.020 µg∙g−1 and 0.050 µg∙g−1, respectivel.. The methods presented in this study are robust and were util.zed f.r the registration of.nitrapyrin on agricul.ural.commodities in the United States.

关键词： Herbicide Agricul.ural.Products External.Cal.bration l.-MS/MS Registration

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l. DEMI-SICl., DE MOÏSE AU f.SCUS IUDAICUS. HISTOIRE D’UNE TÉl.Ol.GIE

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Journal.of.Ancient Civil.zations 2024年第1期39卷 73-98,124页

作者： Michaël.Girardin Universitédu l.ttoral.Côte d’Opal.

Many sources are brought together in schol.rship in order to write the l.near story of.a specif.c tax,the hal.0}shekel.tax paid each year by the Jews to the Templ. of.Jerusal.m and,then,conf.scated by the f.scus Iudaicus in Roman *** do these sources ref.r to the same tax?In this paper,I def.nd the idea that the l.nearity of.this story is a *** taxes were l.vied and justif.ed by the memory of.a Bibl.cal.tax,but they are al. dif.erent in meaning,in administration and sometimes even in *** story is a pol.tical.one:how to justif. a tax in ancient Judaism?

关键词： didrachm f.scus Iudaicus hal.0}shekel Jerusal.m Templ. Roman Judea taxation tel.ol.gy

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Dual.Additives f.r Stabil.zing l. Deposition and SEI f.rmation in Anode-f.ee l.-Metal.Batteries

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Energy & Environmental.Material. 2024年第3期7卷 84-92页

作者： Baol.n Wu Chunguang Chen Dmitri l.Danil.v Zhiqiang Chen Ming Jiang Rüdiger-A.Eichel.Peter H.l.Notten f.rschungszentrum Jül.ch(IEK-9) D-52425Jülich Germany RWTH Aachen University D-52074Aachen Germany l.M Institute of MechanicsChinese Academy of SciencesBeijing 100190China School.of.Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China Eindhoven University of.Technol.gy P.O.Box 5135600 MBEindhoven The Netherlands School.of.El.ctronics and Inf.rmation Institute of Carbon Neutrality and New EnergyHangzhou Dianzi UniversityHangzhou 310018China University of.Technol.gy Sydney BroadwaySydney NSW 2007Australia

Anode-f.ee l.-metal.batteries are of.signif.cant interest to energy storage industries due to their intrinsical.y high ***,the accumul.tive l. dendrites and dead l. continuousl. consume active l. during *** resul.s in a short l.f.time and l.w Coul.mbic ef.iciency of.anode-f.ee l.-metal.*** ef.ective el.ctrol.te additives can improve the l. deposition homogeneity and sol.d el.ctrol.te interphase(SEI)stabil.ty f.r anode-f.ee l.-metal.***,we reveal.that introducing dual.additives,composed of.l.Asf. and f.uoroethyl.ne carbonate,into a l.w-cost commercial.carbonate el.ctrol.te wil. boost the cycl. l.f. and average Coul.mbic ef.iciency of.NMC‖Cu anode-f.ee l.-metal.*** NMC‖Cu anode-f.ee l.-metal.batteries with the dual.additives exhibit a capacity retention of.about 75%af.er 50 cycl.s,much higher than those with bare el.ctrol.tes(35%).The average Coul.mbic ef.iciency of.the NMC‖Cu anode-f.ee l.-metal.batteries with additives can maintain 98.3%over 100 *** contrast,the average Coul.mbic ef.iciency without additives rapidl. decl.ne to 97%af.er onl. 50 *** situ Raman measurements reveal.that the prepared dual.additives f.cil.tate denser and smoother l. morphol.gy during l. *** dual.additives signif.cantl. suppress the l. dendrite growth,enabl.ng stabl. SEI f.rmation on anode and cathode *** resul.s provide a broad view of.devel.ping l.w-cost and high-ef.ective f.nctional.el.ctrol.tes f.r high-energy and l.ng-l.f. anode-f.ee l.-metal.batteries.

关键词： anode-f.ee l.thium metal.battery dual.additives in situ Raman l. growth SEI f.rmation

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Soil.Pore Characterization Using f.ee Sof.ware and a Portabl. Optical.Microscope

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Pedosphere 2013年第4期23卷 503-510页

作者： l. f. PIRES f. S. BORGES S. PASSONI A. B. PEREIRA Department of.Physics State University of Ponta Grossa (UEPG) Department of.Soil.Science State University of Ponta Grossa (UEPG)

Total.porosity （TP）, determined by image anal.sis, pore type and pore size distribution were eval.ated on impregnated soil.bl.cks f.om an undisturbed Brazil.an sandy l.am soil.using a digital.portabl. optical.microscope. The f.ee sof.ware Image J （version 1.40g） was used f.r image anal.sis. Procedures f.r soil.image col.ection and anal.sis were presented. The image anal.sis al.owed the eval.ation of.pore sizes with diameters ranging f.om 20 to 〉 1 000 μm. The f.l.owing types of.pores were al.o obtained： rounded, el.ngated and intermediate. The resul.s M[owed the characterization of.the soil.as moderatel. porous （TP = 21.6%）. Rounded, intermediate and el.ngated pores were responsibl. f.r 11.6%, 31.7% and 56.7% of.TP. In rel.tion to pore size 51.1% of.TP was in the 100-500μm size cl.ss and a third of.TP came f.om the pores l.rger than 500μm.

关键词： image anal.sis soil.porosity soil.structure pore size distribution

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