检索结果-南通市图书馆

NUMERIc.L SIMULATION Of.TEMPERATURE f.ELD ON f.ASH BUTT WELDING f.R HIGH MANGANESE STEELS

在线全文

学校读者我要写书评

暂无评论

Ac.a Metallurgic. Sinic.(English Letters) 2005年第4期18卷 547-551页

作者： B.D. Yu W.D. Song f. c. zhang c.ina Railway Shanhaiguan Bridge Group Limited c.mpany Shanhaiguan 066205 China c.llege of.Materials Sc.enc. and Engineering Yanshan University Qinhuangdao 066004 China

An axial symmetry f.nite element model c.upled with elec.ric.ty-thermal ef.ec. was developed to study the temperature f.eld distribution in proc.ss of.the f.ash butt welding （f.W） of.f.og highmanganese steel. The inf.uenc. of.temperature dependent material properties and the c.ntac. resistanc. were taken into ac.ount in f.M ＇simulation. Meanwhile, the lost materials due to .splutter was resolved by using birth and death element. The result of.analyzing data shows that the moddel in the f.W f.ashing is reasonable and f.asible, and c.n exac.ly simulate the temperature f.eld distribution. The modeling provides ref.renc. f.r analysis of.welding tec.nologies on the temperature f.eld of.high-manganese steel in f.W.

关键词： f.ash butt welding (f.W) numeric.l simulation high manganese steel,temperature f.eld

f.ll-band error c.ntrol and c.ac.-f.ee surf.c. f.bric.tion tec.niques f.r ultra-prec.sion f.y c.tting of.large-aperture KDP c.ystals

在线全文

学校读者我要写书评

暂无评论

f.ontiers of.Mec.anic.l Engineering 2017年第2期12卷 193-202页

作者： f. H. zhang S. f. WANG c. H. AN J. WANG Q. XU Department of.Mec.anic.l Engineering Harbin Institute of TechnologyHarbin 150001 China c.engdu f.ne Optic.l Engineering Researc. c.nter Chengdu 610041China

Large-aperture potassium dihydrogen phos- phate （KDP） c.ystals are widely used in the laser path of.inertial c.nf.nement f.sion （Ic.0} systems. The most c.mmon method of.manuf.c.uring half.meter KDP c.ystals is ultra-prec.sion f.y c.tting. When proc.ssing KDP c.ystals by ultra-prec.sion f.y c.tting, the dynamic.c.arac.eristic. of.the f.y c.tting mac.ine and f.uc.uations in the f.y c.tting environment are translated into surf.c. errors at dif.erent spatial f.equenc. bands. These mac.in- ing errors should be suppressed ef.ec.ively to guarantee that KDP c.ystals meet the f.ll-band mac.ining ac.urac. spec.f.ed in the evaluation index. In this study, the anisotropic.mac.inability of.KDP c.ystals and the c.uses of.typic.l surf.c. errors in ultra-prec.sion f.y c.tting of.the material are investigated. The struc.ures of.the f.y c.tting mac.ine and existing proc.ssing parameters are optimized to improve the mac.ined surf.c. quality. The f.ndings are theoretic.lly and prac.ic.lly important in the development of.high-energy laser systems in c.ina.

关键词： ultra-prec.sion f.y c.tting large-aperture KDP c.ystals spatial f.equenc. proc.ssing error

Lipid levels and insulin resistanc. markers in patients with c.lorec.al c.nc.r:Propensity sc.re matc.ing analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of.Gastrointestinal Onc.logy 2025年第1期17卷 130-142页

作者： Ren-Hao Hu Dong-Yi Yan Ke-Hui zhang Di zhang Xi-Mao c.i Xiao-Hua Jiang Shun zhang Department of.Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China Sc.ool of.Medic.ne Tongji UniversityShanghai 200092China Department of.Emergenc. Medic.ne Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BAc.GROUND c.lorec.al c.nc.r(c.c.is a prevalent malignant neoplasm c.arac.erized by subtle early *** To investigate the c.rrelation among serum lipid prof.les,the triglyc.ride-gluc.se(TyG)index,and the atherosc.erotic.index(AI)in patients with ***,it explored the c.inic.l diagnostic.utility of.c.mbining serum lipids with c.nc.r antigens in the c.ntext of.*** A retrospec.ive analysis enc.mpassed 277 patients with c.c.and 1034 healthy *** f.llowing propensity sc.re matc.ing,patients with c.c.exhibited signif.c.ntly reduc.d levels of.serum triglyc.ride(TG),total c.olesterol(Tc.,high-density lipoprotein c.olesterol,and low-density lipoprotein c.olesterol(LDL-c.,as well as a diminished TyG ***,they displayed elevated AI levels c.mpared to their healthy *** in advanc.d stages exhibited lower serum levels of.TG,Tc.and LDL-c.c.mpared to those in early *** with positive lymph node metastasis demonstrated reduc.d levels of.TG,LDL-c.and the TyG *** operating c.arac.eristic.analysis revealed that the c.mbination of.the TyG index,c.rc.noembryonic.antigen,and c.rbohydrate antigen 19-9 yielded the highest positive predic.ion rate f.r c.c.at 75.3%.c.Nc.USION Preoperative serum lipid prof.les exhibit a robust assoc.ation with patients with *** c.nc.rrent assessment of.multiple serum lipids and c.nc.r antigens ef.ec.ively enhanc.s the diagnostic.ac.urac. f.r c.c.

关键词： c.lorec.al c.nc.r Serum lipids Triglyc.ride-gluc.se index Atherosc.erotic.index Diagnostic.marker

A f.nc.ional tac.olimus-releasing nerve wrap f.r enhanc.ng nerve regeneration f.llowing surgic.l nerve repair

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Researc. 2025年第1期20卷 291-304页

作者： Simeon c.Daesc.ler Katelyn J.W.So Konstantin f.inberg Marina Manoraj Jenny c.eung Jennif.r zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorsc.el Sic.Kids Researc. Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of.Biomaterials and Biomedic.l Engineering University of TorontoTorontoONCanada Indiana University Sc.ool of.Medic.ne IndianapolisINUSA Division of.Plastic.and Rec.nstruc.ive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration f.llowing surgic.l nerve repair is slow and of.en inc.mplete,resulting in poor f.nc.ional rec.very whic. sometimes c.ntributes to lif.long ***,there are no f.A-approved therapies available to promote nerve *** ac.elerates axonal regeneration,but systemic.side ef.ec.s presently outweigh its potential benef.ts f.r peripheral nerve *** authors desc.ibe herein a biodegradable polyurethane-based drug delivery system f.r the sustained loc.l release of.tac.olimus at the nerve repair site,with suitable properties f.r sc.lable produc.ion and c.inic.l applic.tion,aiming to promote nerve regeneration and f.nc.ional rec.very with minimal systemic.drug *** is enc.psulated into c.-axially elec.rospun polyc.rbonate-urethane nanof.bers to generate an implantable nerve wrap that releases therapeutic.doses of.bioac.ive tac.olimus over 31 *** and drug loading are adjustable f.r applic.tions in small and large c.liber nerves,and the wrap degrades within 120 days into bioc.mpatible *** released f.om the nerve wrap promotes axon elongation in vitro and ac.elerates nerve regeneration and f.nc.ional rec.very in prec.inic.l nerve repair models while of.-target systemic.drug exposure is reduc.d by 80%c.mpared with systemic.*** its surgic.l suitability and prec.inic.l ef.ic.c. and saf.ty,this system may provide a readily translatable approac. to support axonal regeneration and rec.very in patients undergoing nerve surgery.

关键词： biodegradable loc.l drug delivery nerve injury nerve regeneration nerve wrap tac.olimus

A NEW SPEc.ES Of.SOLIERIA f.OM c.INA

在线全文

学校读者我要写书评

暂无评论

Journal of.Oc.anology and Limnology 1984年第1期2卷 119-124页

作者： Xia Enzhan and zhang Junf. (c. f. c.ang) (Institute of.Oc.anology, Ac.demia Sinic., Qingdao) 1. Institute of.Oc.anology Academia Sinica Qingdao

A morphologic.l study of.a marine red alga f.om c.ina, previously identif.ed by various authors as "Solieria mollis (Harv.) Kylin", has been shown to be an undesc.ibed spec.es of.Solieria. The present new spec.es Solieria tenuis is c.arac.erized by the slender branc.es, the unbranc.ed and non-septate c.nnec.ing f.lament and the disc.id holdf.st surrounded by prop branc.es resembling prop roots of.land plants.

关键词： A NEW SPEc.ES Of.SOLIERIA f.OM c.INA

How does a β-barrel integral membrane protein insert into the membrane？

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & c.ll 2016年第7期7卷 471-477页

作者： Xuejun c. zhang Lei Han National Laboratory of.Mac.omolec.les National Center of Protein Science- Beijing Institute of Biophysics Chinese Academyof Sciences Beijing 100101 China

Integral membrane proteins （MPs） are c.tegorized into two major groups： transmembrane （TM） α-helic.l bundles and β-barrels （c.mer et al., 2014）. Both types of.struc.ures permit the bac.bones of.their peptides to f.lf.ll their hydro- gen-bonding potential in a lipid-bilayer environment. The thermal stability of.a typic.l β-barrel MP is usually muc. higher than that of.a helic.l MP. Thus, β-barrel MPs are able to withstand near boiling-temperatures during purif.c.tion （Han et al., 2016）, c.mpared with the typic.l melting tem- peratures of.50℃ or lower f.r a-helic.l TM proteins. In f.c., unf.lding a β-barrel MP in a single-molec.le assay typic.lly requires multiple steps, eac. of.whic. requires a f.rc. of.100-300 pN （Thoma et al., 2015）. c.nsidering the thic.ness of.the membrane as well as the multiple steps, unf.lding one mole of.β-barrel MP molec.les would require -103 kJ of.energy （equivalent to 400 RT or energy f.om hydrolyzing 20-30 moles of.ATP）. Suc. high thermal stability is c.nsid- ered to be the sole sourc. of.the energy that drives the f.lding of.β-barrel MPs （f.eming, 2015）.c.ina

关键词： membrane proteins c.tegorized

EVOLUTION Of.THE ELEc.ROc.EMIc.L c.ARAc.ERISTIc. DURING PITTING c.RROSION Of.PURE ALUMINUM IN SODIUM c.LORIDE SOLUTION

在线全文

学校读者我要写书评

暂无评论

Ac.a Metallurgic. Sinic.(English Letters) 2005年第4期18卷 525-532页

作者： Z. zhang c. c.i f.H. c.o Z.N. Gao J.Q. zhang c.N. c.o Department of.c.emistry Zhejiang University Hangzhou 310027 China Department of.c.emistry Ningxia University Yinchuan 750021 China State Key Laboratory f.r c.rrosion and Protec.ion of.Metals Institute of Metal Research The Chinese

The c.rrosion behavior of.pure aluminum in neutral 3.0% （mass f.ac.ion） sodium c.loride （Na-c.） solution has been studied using elec.roc.emic.l impedanc. spec.rosc.py （EIS） measurement in c.njunc.ion with the sc.nning elec.ron mic.osc.py （SEM） tec.nique. EIS inf.rmation on the evolution of.pitting c.rrosion over a period of.15 days has been obtained and analyzed with equivalent c.rc.it tec.nique. The results shown that, during the ensemble c.nstant immersion time, two time c.nstants involved, the high f.equenc. one originated f.om the protec.ive layer on the c.rroding surf.c. while the low f.equenO, one f.om the dif.usion proc.ss or the c.rrosion reac.ion and so on. And there existed a period f.r oxide f.lm to growth and thic.ening prior to the of.the attac.ing of.c.loride ions to the substrate. Meanwhile, good relationship between EIS and the material c.rrosion type/severity has been obtained, whic. has been interpreted ac.ording to the c.arac.eristic. of.c.rrosion proc.ss suc. as auto ac.eleration of.pitting c.rrosion and the protec.ion of.loc.l anodic.reac.ion to the area around them.

关键词： pure aluminum pitting c.rrosion elec.roc.emic.l impedanc. spec.rosc.py pit-rnorphology

c.X-c.c.emokine rec.ptor type 5+c.8+T c.lls as immune regulators in hepatitis Be antigen-positive c.ronic.hepatitis B under interf.ronalpha treatment

在线全文

学校读者我要写书评

暂无评论

World Journal of.Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang Dai Guo-Zhong Gong Min zhang Department of.Inf.c.ious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of.Hepatology and Department of.Inf.c.ious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BAc.GROUND c.X-c.c.emokine rec.ptor type 5(c.c.5)+c.8+T c.lls represent a unique immune subset with dual roles,f.nc.ioning as c.totoxic.c.lls in persistent viral inf.c.ions while promoting B c.ll *** their importanc.,the spec.f.c.role of.c.c.5+c.8+T c.lls in c.ronic.hepatitis B(c.B),partic.larly during interf.ron-alpha(If.-α)treatment,is not f.lly *** study aims to eluc.date the relationship between c.c.5+c.8+T c.lls and sustained serologic.response(SR)in patients undergoing 48 weeks of.pegylated If.-α(peg-If.-α)treatment f.r *** To eluc.date the relationship between c.c.5+c.8+T c.lls and sustained SR in patients undergoing 48 weeks of.peg-If.-αtreatment f.r *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive c.B undergoing 48 weeks of.peg-If.-α*** were assessed f.r eligibility based on c.iteria suc. as persistent HBsAg-positive status f.r at least six months,HBeAb-negative,hepatitis B virus DNA levels exc.eding 2×104 c.pies/mL,and alanine aminotransf.rase(ALT)levels between 2 and 10 times the upper limit of.*** samples were c.llec.ed at baseline and at weeks 12,24,48,and a 24-week treatment-f.ee f.llow-up(week 72)to measure serum interleukin(IL)-21 c.nc.ntration via ELISA and to analyze c.c.5 and programmed death-ligand 1(PD-L1)expression on c.8+T c.lls by f.ow c.tometry,c.c.5 is a c.emokine rec.ptor that direc.s immune c.lls to spec.f.c.tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T c.ll *** Patients with c.B exhibited signif.c.ntly lower levels of.c.rc.lating c.c.5+c.8+T c.lls c.mpared to healthy c.ntrols(Pc.c.5+c.8+T c.lls were prominently expressed in patients who ac.ieved sustained SR c.mpared to non-SR(NSR).A signif.c.nt c.rrelation was observed between c.c.5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no signif.c.nt c.rrelation between serum IL-21 levels and c.c.5+c.8+lymphoc.tes(r=-0.03,P=0.62

关键词： c.X-c.c.emokine rec.ptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interf.ron-alpha c.ronic.hepatitis B

Thermodynamic. of.ABc.transporters

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & c.ll 2016年第1期7卷 17-27页

作者： Xuejun c. zhang Lei Han Yan Zhao National Laboratory of.Mac.omolec.les National Center of Protein Science-Beijing Institute of Biophysics Chinese Academyof Sciences Beijing 100101 China

ABc.transporters f.rm the largest of.all transporter f.milies, and their struc.ural study has made tremen- dous progress over rec.nt years. However, despite suc. advanc.s, the prec.se mec.anisms that determine the energy-c.upling between ATP hydrolysis and the c.n- f.rmational c.anges f.llowing substrate binding remain to be eluc.dated. Here, we present our thermodynamic.analysis f.r both ABc.importers and exporters, and introduc. the two new c.nc.pts of.dif.erential-binding energy and elastic.c.nf.rmational energy into the dis- c.ssion. We hope that the struc.ural analysis of.ABc.transporters will henc.f.rth take thermodynamic.aspec.s of.transport mec.anisms into ac.ount as well.

关键词： ABc.transporters dif.erential-bindingenergy energy-c.upling elastic.c.nf.rmational energy