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Journal of.Thermal Science 2012年第6期21卷 483-491页

作者： Satta f. Simoni d. Ubaldi m. Zunino P. Bertini f. dImSET-Università di Genova Via Montallegro 1I-16145 GenovaItaly Avio S.p.A. Viale I Maggio 56I-10040 Rivalta(TO)-Italy

The aerodynamic f.ow f.eld downstream of.a Low-Pressure High-Lif.(HL)turbine cascade has been experimentally investigated f.r dif.erent Reynolds numbers under both steady and unsteady inf.ows,in order to analyse the cascade perf.rmance under real engine operating *** Reynolds number has been varied in the range 100000d upper limits are typical of.cruise and take-of./landing conditions,*** ef.ects induced by the incoming wakes at the reduced f.equency f.=0.62 on both prof.le and secondary f.ow losses have been *** pressure,velocity and secondary kinetic energy distributions at the downstream tangential plane have been measured by means of.a miniaturized 5-hole *** quantities provide inf.rmation on both blade wake and secondary f.ow structures(passage and horse-shoe vortices).The analysis of.the results allows the evaluation of.the aerodynamic perf.rmance of.the HL f.ont-loaded blade in terms of.both prof.le and secondary losses.

关键词： prof.le losses secondary f.ow losses high-lif. prof.es unsteady inf.ow LPT blade.

On the Simulation of.Industrial Gas dynamic Applications with the disconti- nuous Galerkin Spectral Element method

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Journal of.Thermal Science 2016年第3期25卷 250-257页

作者： f. Hempert m. Hof.mann U. Iben C.-d. munz Robert-Bosch GmbH Robert-Bosch Campus 1 71272 Renningen Germany Institute of.Aerodynamics and Gas dynamics Pfaffenwaldring 21 70569 Stuttgart Germany

In the present investigation, we demonstrate the capabilities of.the discontinuous Galerkin spectral element method f.r high order accuracy computation of.gas dynamics. The internal f.ow f.eld of.a natural gas injector f.r bivalent combustion engines is investigated under its operating conditions. The simulations of.the f.ow f.eld and the aeroacoustic noise emissions were in a good agreement with the cxperirnental data. We tested several shockcapturing techniques f.r the discontinuous Galerkin scheme. Based on the validated f.amework, we analyzed the development of.the supersonic jets during dif.erent opening procedures of.a compressed natural gas injector. The results suggest that a more gradual injector opening decreases the noise emission.

关键词： discontinuous Galerkin natural gas injection supersonic under-expanded jet high perf.rmance computing

Neurogenesis dynamics in the olf.ctory bulb:deciphering circuitry organization, f.nction, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naf.aa department of.Psychology and Neuroscience Duke UniversityDurhamNCUSA department of.Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists af.er birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of.the olf.ctory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of.these new neurons in the olf.ctory bulb supports both structural and f.nctional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of.these neurons, coupled with the cellular diversity within the olf.ctory bulb, presents an ongoing challenge in understanding its network organization and f.nction. moreover,the continuous integration of.new neurons in the olf.ctory bulb plays a pivotal role in regulating olf.ctory inf.rmation processing. This adaptive process responds to changes in epithelial composition and contributes to the f.rmation of.olf.ctory memories by modulating cellular connectivity within the olf.ctory bulb and interacting intricately with higher-order brain regions. The role of.adult neurogenesis in olf.ctory bulb f.nctions remains a topic of.debate. Nevertheless, the f.nctionality of.the olf.ctory bulb is intricately linked to the organization of.granule cells around mitral and tuf.ed cells. This organizational pattern signif.cantly impacts output, network behavior, and synaptic plasticity, which are crucial f.r olf.ctory perception and memory. Additionally, this organization is f.rther shaped by axon terminals originating f.om cortical and subcortical regions. despite the crucial role of.olf.ctory bulb in brain f.nctions and behaviors related to olf.ction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Theref.re, this manuscript aims to discuss our current understanding and explore how neural plasticity and olf.ctory neurogenesis contribute to enhancing the adaptability of.the olf.ctory system. These mechanisms are thought to support olf.ctory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olf.ctory bulb olf.ctory learning olf.ctory memory synaptic plasticity

State f.edback Tracking Control f.r Indirect f.eld-oriented Induction motor Using f.zzy Approach

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International Journal of.Automation and computing 2013年第2期10卷 99-110页

作者： m. Allouche m. Chaabane m. Souissi d. mehdi f. Tadeo Laboratory of.Sciences and Techniques of.Automatic Control and Computer Engineering (Lab-STA) National School of Engineering of SfaxUniversity of Sfax Laboratory of.Computer and Automatic f.r System (LIAS) Higher School of Engineering of Poitiers (ESIP) University of Poitiers department of.Systems Engineering University of Valladolid

This paper deals with the synthesis of.f.zzy controller applied to the induction motor with a guaranteed model ref.rence tracking perf.rmance. f.rst, the Takagi-Sugeno （T-S） f.zzy model is used to approximate the nonlinear system in the synchronous d-q f.ame rotating with f.eld-oriented control strategy. Then, a f.zzy state f.edback controller is designed to reduce the tracking error by minimizing the disturbance level. The proposed controller is based on a T-S ref.rence model in which the desired trajectory has been specif.ed. The inaccessible rotor f.ux is estimated by a T-S f.zzy observer. The developed approach f.r the controller design is based on the synthesis of.an augmented f.zzy model which regroups the model of.induction machine, f.zzy observer, and ref.rence model. The gains of.the observer and controller are obtained by solving a set of.linear matrix inequalities （LmIs）. f.nally, simulation and experimental results are given to show the perf.rmance of.the observer-based tracking controller.

关键词： f.zzy tracking control H∞ perf.rmance f.edback controller linear matrix inequality (LmI) f.zzy observer

Additive neurorestorative ef.ects of.exercise and docosahexaenoic acid intake in a mouse model of.Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-f.relle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien f.ancesca Cicchetti f.édéric Calon f.cultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of.Nutrition and f.nctional f.ods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of.dopamine neurons in Parkinson’s disease af.er *** that preclinical and clinical studies suggest benef.ts of.dietary n-3 polyunsaturated f.tty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of.the dopaminergic ***,mice received a unilateral stereotactic injection of.6-hydroxydopamine into the striatum to establish an animal model of.nigrostriatal *** weeks af.er lesion,animals were f.d a docosahexaenoic acid-enriched or a control diet f.r the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of.both had no ef.ect on(i)distance traveled in the open f.eld test,(ii)the percentage of.contraversive rotations in the apomorphine-induction test or(iii)the number of.tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of.tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of.docosahexaenoic acid and exercise(i)improved f.relimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of.exercise and docosahexaenoic acid may act synergistically in the striatum of.mice with a unilateral lesion of.the dopaminergic system and provide support f.r clinical trials combining nutrition and physical exercise in the treatment of.Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated f.tty acids omega-3

mitochondria–cGAS–STING axis is a potential therapeutic target f.r senescence-dependent inf.ammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes f.om the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in prolif.ration, resulting f.om stress-induced cell cycle arrest of.pre... 详细信息

关键词： Latin potential lasting

Complement-dependent neuroinf.ammation in spinal cord injury:f.om pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tf.ily f.ras Kobeissy Juanmarco Gutierrez Gonzalez daniel Ref.i Gerald R.Rodts Christian mustroph david Gimbel Jonathan Grossberg daniel L.Barrow matthew f.Gary Ali m.Alawieh department of.Neurosurgery Emory University School of MedicineAtlantaGAUSA department of.Neurology Yale UniversityNew HavenCTUSA Center f.r Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of.disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of.injury and optimize recovery in this *** the thorough investigation of.the complement system in triggering and propagating cerebral neuroinf.ammation,a similar role f.r complement in spinal neuroinf.ammation is a f.cus of.ongoing *** this work,we survey the current literature investigating the role of.complement in spinal cord injury including the sources of.complement proteins,triggers of.complement activation,and role of.ef.ector f.nctions in the *** study relevant data demonstrating the dif.erent triggers of.complement activation af.er spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** ef.ector f.nctions of.complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of.complement anaphylatoxins in spinal cord injury while emphasizing the lack of.pathophysiological understanding of.the role of.opsonins in spinal cord *** this pathophysiological review,we systematically review the dif.erent translational approaches used in preclinical models of.spinal cord injury and discuss the challenges f.r f.ture translation into human *** review emphasizes the need f.r f.ture studies to dissect the roles of.dif.erent complement pathways in the pathology of.spinal cord injury,to evaluate the phases of.involvement of.opsonins and anaphylatoxins,and to study the role of.complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinf.ammation neuroplasticity regeneration spinal cord injury targeted therapy

Can Quick Release Experiments Reveal the muscle Structure？ A Bionic Approach

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Journal of.Bionic Engineering 2012年第2期9卷 211-223页

作者： d. f. B. Haeuf.e m. Gunther R. Blickhan S. Schmitt Institute of.Sports and Exercise-Science University of Stuttgart Allmandring 28 D-70569 Stuttgart Germany Stuttgart Research Centre f.r Simulation Technology （SRC SimTech） University of Stuttgart Pfaffenwaldring 7a D-70569 Stuttgart Germany Institute of.motion Science Friedrich-Schiller-University Seidelstraβe 20 D-07749 Jena Germany

The goal of.this study was to understand the macroscopic mechanical structure and f.nction of.biological muscle with respect to its dynamic role in the contraction. A recently published muscle model, deriving the hyperbolic f.rce-velocity relation f.om f.rst-order mechanical principles, predicts dif.erent f.rce-velocity operating points f.r dif.erent load situations. With a new approach, this model could be simplif.ed and thus, transf.rred into a numerical simulation and a hardware experiment. Two types of.quick release experiments were perf.rmed in simulation and with the hardware setup, which represent two extreme cases of.the contraction dynamics： against a constant f.rce （isotonic） and against an inertial mass. Both experiments revealed hyperbolic or hyperbolic-like f.rce-velocity relations. Interestingly, the analytical model not only predicts these extreme cases, but also additionally all contraction states in between. It was possible to validate these predictions with the numerical model and the hardware experiment. These results prove that the origin of.the hyperbolic f.rce-velocity relation can be mechanically explained on a macroscopic level by the dynamical interaction of.three mechanical elements. The implications f.r the interpretation of.biological muscle experiments and the realization of.muscle-like bionic actuators are discussed.

关键词： f.rce-velocity relation isotonic quick release proof.of.concept artif.cial muscle

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest miller School of.medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential f.r the maintenance and f.nction of.motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron f.nction is progressively lost,Schwann cell f.nction may also be ***,important signaling and potential trophic activities of.Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of.a patient with advanced amyotrophic lateral sclerosis using serial intravenous inf.sions of.allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the f.rst instance of.such *** 81-year-old male patient presented with a 1.5-year history of.rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of.generic riluzole,sodium phenylbutyrate f.r the treatment of.amyotrophic lateral sclerosis,and *** patient volunteered to participate in an f.A-approved single-patient expanded access treatment and received weekly intravenous inf.sions of.allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** conf.rmed that cultured Schwann cells obtained f.om the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of.the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded f.om a cadaver donor improved their growth capacity in *** a period of.observation lasting 10 weeks,during which amyotrophic lateral sclerosis f.nctional Rating Scale-Revised and pulmonary f.nction were regularly monitored,the patient received weekly consecutive inf.sions of.1.54×1012(×2),and then consecutive inf.sions of.7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of.dulbecco’s phosphate-buf.ered *** of.the inf.sions were associated with adverse events such as inf.sion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes inf.sion neuromuscular junction Schwann cell

Brain-penetrating neurotrophic f.ctor mimetics: HER-096 as a disease-modif.ing therapy f.r Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic f.ctors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the f.eld of.central nervous system diseases is disease-modif.ing *** f.r decades there have been various symptomatic treatments available to alleviate the symptoms of.the disease,disease-modif.cation,*** that stop,signif.cantly delay,or reverse the progression of.the disease,has been turned out to a dif.icult goal to achieve.

关键词： diseases treatment therapeutic