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Small molecular decoys in Alzheimer's disease

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Neural Regeneration Research 2024年第8期19卷 1658-1659页

作者： Sho Oasa Valentina L.Kouznetsova Igor f.Tsigelny Lars Terenius Department of.Clinical Neuroscience Center for Molecular MedicineKarolinska InstitutetStockholmSweden San Diego Supercomputer Center University of California San DiegoLa JollaCAUSA Department of.Neurosciences University of California San DiegoLa JollaCAUSA Department of.Clinical Neuroscience Karolinska University HospitalKarolinska InstitutetStockholmSweden

Recent progress in the treatment of.Alzheimer’s disease(AD)using antibodies against amyloid sustains amyloid generation as a key process in *** f.rmation starts with two amyloidbeta(Aβ)molecules interacting(dimer f.rmation)f.llowed by an accelerating build-up of.socalled protof.brils,which turn into f.brils,which accumulate in the characteristic plaques.

关键词： Alzheimer decoy Aβ

The Ef.ects of.Zinc Sulf.te on the in Vitro Digestibility of.f.eds in Cervids

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Open Journal of.Animal Sciences 2024年第3期14卷 157-167页

作者： Reese J. Thibodeaux Philip M. Urso Stanley f. Kelley Marcy M. Beverly Chris R. Stewart Ian C. Dunn Gentech Diagnostics Dallas Texas USA Department of.Animal Science South Dakota State University Brookings South Dakota USA School of.Agricultural Sciences Sam Houston State University Huntsville Texas USA 3-S Texas Outdoors/3-S Whitetails Bedias Texas USA

The captive white-tailed deer industry has an estimated impact of.1.6 billion USD in the state of.Texas alone. However, nutritional requirements f.r cervids are determined through research based on sheep and goats. The objective of.this study was to determine the ef.ects of.zinc on dif.erences in dry matter digestibility in vitro f.r white-tailed does (Odocoileus virginianus). Deer (n = 2) were ethically harvested, rumens were collected, and placed into a cooler containing warm water. Rumen contents were agitated, and f.uid was f.ltered using cheese cloth while applying CO2. f.uid was placed into f.ur separate incubator jars with f.lter bags containing a 1:1 alf.lf. to coastal hay blend. Zinc doses of.0.073 mg/kg/d equivalents were added to two of.the jars ( Zn), and the additional two jars received 0.00 mg/kg/d (CON). f.llowing 48 h of.incubation, in vitro true digestibility (IVTD) showed no signif.cant dif.erences between the control and the treatment groups. Average dry matter digested in vitro was 91.87% and 95.13%, respectively. There were no dif.erences detected in ADf. NDf. IVTD, or OM between the treatment groups. While no detectable dif.erences were observed in this study, this methodology did prove to be viable and f.nctional f.r microbial digestion in vitro. This study can be replicated with multiple experimental units to conf.rm the observations of.increased digestibility. f.rmal nutritional guidelines can be created to allow f.r more ef.icient f.eding of.cervids thereby reducing f.ed costs and continuing the growth of.the captive deer industry.

关键词： Zinc IVDMD In Vitro Cervids

Thermoluminescence characterization of.natural and synthetic irradiated Ce-monazites

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Journal of.Rare Earths 2024年第4期42卷 643-650页

作者： V.Correcher C.Boronat J.Garcia-Guinea J.f.Benavente T.Rivera-Montalvo CIEMAT Av.Complutense 4028040MadridSpain MNCN-CSIC J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The thermoluminescence(TL)emission of.synthetic and natural Ce-monazites was characterized here to determine the potential application in the identif.cation of.microscopic def.cts f.om a qualitative point of.view trying to link each TL peak to a chemical-physical *** kinetic parameters that lead the luminescence processes were calculated by means of.variable heating rate and computing glow curve deconvolution methods and allow identif.ing three groups of.components at~90,130 and 290℃(f.r the mineral sample)and~90,170,220,270 and 320℃(f.r the synthetic CePO_(4):Nd_(0.20),La_(0.25)).The main dif.erences appreciated in these complex TL curves are mainly due to(i)the content of.impurities(natural sample contains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degree of.crystallinity of.the samples which is directly related to the type of.impurities(synthetic monazite relies only on Nd and La).The behavior of.the dose response in the range of.1-8 Gy is similar f.r both samples;the TL intensity increases linearly as the dose increases without changes in the position of.the maxima,denoting f.rst-order kinetic luminescence *** peak could be mostly associated with structural def.cts(i.e.,phase transitions),chemical reactions(i.e.,Ce3+?Ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic def.cts(i.e.,f.enkel def.cts,ODCs or NBOHCs).

关键词： Thermoluminescence Kineticparameters Phosphate Ce-monazite Def.cts Rare earths

Microstructure evolution and shape memory behaviors of.Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with dif.erent prestrain levels

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Journal of.Materials Science & Technology 2024年第4期171卷 80-93页

作者： Y.H.Zhang H.Li Z.W.Yang X.Liu Q.f.Gu State Key Laboratory of.Solidif.cation Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of.High-Perf.rmance Precision f.rming Technology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)shape memory alloy(SMA)is a promising material in the aerospace f.eld due to its wide transf.rmation *** application of.shape memory ef.ect depends on multistep thermomechan-ical loading,viz.,low-temperature def.rmation and subsequent heating to ***-temperature def.rmation prestrain plays a pivotal role in shape memory properties tailoring of.SMA ***,microstructure evolution and def.rmation mechanisms of.Ni_(47)Ti_(44)Nb_(9)SMA subjected to vari-ous prestrain levels are still *** this end,microstructure evolution and shape memory behaviors of.Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with prestrain levels of.8%-16%at-28℃(M_(s)+30℃)were *** results demonstrate that the stress-strain curve of.the specimen exhibits f.ur distinct stages at a maximal prestrain of.16%.Whereas stageⅡand stageⅢend at prestrains of.8%and∼12%,*** stageⅡ,the stress-induced martensitic transf.rmation is accompanied by the dislocation slip of.the NiTi matrix andβ-Nb *** stageⅢ,in addition to the higher density of.dislocations and f.rther growth of.stress-induced martensite variants(SIMVs),(001)compound twins are introduced as a result of.the(001)def.rmation twinning in stress-induced ***{20-1}martensite twins are gradually introduced in stageⅣ.Correspondingly,af.er subsequent unloading and heating,a higher density of.114}austenite twins f.rm in the specimen with a larger prestrain of.16%.With increasing prestrain f.om 8%to 16%,the recoverable strainε_(re)^(T)upon heating increases f.rst and then ***ε_(re)^(T)obtains a maximum of.7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase of._(re)^(T)can be attributed to the f.rmation of.new SIMVs,the f.rther growth of.existing SIMVs,and the recoverable(001)compound *** the decrease of._(re)^(T)is mainly associated with the irrecoverable strain by{20−1}martensite *** ef.e

关键词： Ni_(47)Ti_(44)Nb_(9)shape memory alloy Wide transf.rmation hysteresis Thermomechanical loading Microstructure evolution Shape memory behaviors Stress-induced martensitic transf.rmation Def.rmation twinning

Stochastic seismic inversion and Bayesian f.cies classif.cation applied to porosity modeling and igneous rock identif.cation

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Petroleum Science 2024年第2期21卷 918-935页

作者： f.bio Júnior Damasceno f.rnandes Leonardo Teixeira Antonio f.rnando Menezes f.eire Wagner Moreira Lupinacci Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsFederal Fluminense UniversityNiter oiRJ24210-346Brazil Petrobras Rio de JaneiroRJ20231-030Brazil National Institute of.Science and Technology of.Petroleum Geophysics(INCT-GP/CNPQ) Niter oiRJ24210-346Brazil

We apply stochastic seismic inversion and Bayesian f.cies classif.cation f.r porosity modeling and igneous rock identif.cation in the presalt interval of.the Santos Basin. This integration of.seismic and well-derived inf.rmation enhances reservoir characterization. Stochastic inversion and Bayesian classif.cation are powerf.l tools because they permit addressing the uncertainties in the model. We used the ES-MDA algorithm to achieve the realizations equivalent to the percentiles P10, P50, and P90 of.acoustic impedance, a novel method f.r acoustic inversion in presalt. The f.cies were divided into f.ve: reservoir 1,reservoir 2, tight carbonates, clayey rocks, and igneous rocks. To deal with the overlaps in acoustic impedance values of.f.cies, we included geological inf.rmation using a priori probability, indicating that structural highs are reservoir-dominated. To illustrate our approach, we conducted porosity modeling using f.cies-related rock-physics models f.r rock-physics inversion in an area with a well drilled in a coquina bank and evaluated the thickness and extension of.an igneous intrusion near the carbonate-salt interf.ce. The modeled porosity and the classif.ed seismic f.cies are in good agreement with the ones observed in the wells. Notably, the coquinas bank presents an improvement in the porosity towards the top. The a priori probability model was crucial f.r limiting the clayey rocks to the structural lows. In Well B, the hit rate of.the igneous rock in the three scenarios is higher than 60%, showing an excellent thickness-prediction capability.

关键词： Stochastic inversion Bayesian classif.cation Porosity modeling Carbonate reservoirs Igneous rocks

Hyperhomocysteinemia and Associated Biological Markers in a Congolese Population of.Type 2 Diabetes Mellitus in Brazzaville

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Open Journal of.Endocrine and Metabolic Diseases 2024年第6期14卷 123-134页

作者： V. R. Ikia Monde A. L. M. Boumba E. Mokondjimobe H. Poaty G. Loubano-Voumbi W. f. Ondongo A. G. Mayindou Kimbangu K. Onanga f. Elilie Mawa Ongoth E. Bouenizabila C. Andres H. G. Monabeka Biochemistry Laboratory Service University Hospital Center Brazzaville Congo f.culty of.Health Sciences Marien NGOUABI University Brazzaville Congo Research Area of.Pointe-Noire National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Congo Microbiology and Molecular Biology Department Loandjili General Hospital Pointe-Noire Congo LOMO Research University Kinshasa DRC Department of.Statistics Health Information and Epidemiology Surveillance Departmental Directorate of Health Care and Services Brazzaville Congo Department of.Endocrinology University Hospital Center Brazzaville Congo Department of.Biochemistry and Molecular Biology Bretonneau Regional University Hospital Tours France

The search f.r new biomarkers predictive of.type 2 diabetes currently constitutes a research avenue in Bioclinical. Total homocysteine remains a pref.rred target due to its involvement in the occurrence of.degenerative complications in type 2 diabetics. The aim of.this work was to study hyperhomocysteinemia and other biochemical markers associated with T2D in the Congolese population. This was an analytical case-control study carried out between October 2022 and October 2023. The study population consisted of.150 subjects including 100 T2D patients and 50 control subjects. The main clinical data were collected on a pre-established f.rm. Homocysteine determination was carried out by the sandwich ELISA method. The other biochemical markers were measured by colorimetric enzymatic methods. Hyperhomocysteinemia was present in 27.3% (41/150) of.the entire study population. Type 2 diabetics had a f.equency of.hyperhomocysteinemia of.36% (36/100) and control 10% (5/50) (p = 0.001). The mean hyperhomocysteinemia concentration was 31.9 μmol/l with extremes ranging f.om 18 to 103 μmol/l. Means of.biological markers between diabetics and controls showed a statistically signif.cant dif.erence (p = 0.01). The risk f.ctors associated with this HHcy were: sex (OR = 3.5), age (OR = 9.4), sedentary lif.style (OR = 3.4) and glycosylated hemoglobin (OR = 12) with a p-value f.Congolese type 2 diabetic patients.

关键词： Hyperhomocysteinemia Biological Markers T2DM Brazzaville

Estimation of.monthly global solar radiation over twelve major cities of.Libya

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Energy and Built Environment 2024年第1期5卷 46-57页

作者： Alhassan Ali Teyabeen Najeya B.Elhatmi Akram A.Essnid f.Mohamed Libyan Center f.r Solar Energy Research and Studies TripoliLibya Libyan Authority of.Scientif.c Research TripoliLibya

This study aims to estimate monthly averaged daily horizontal global solar *** climatological data collected at twelve major cities located across Libya’s map were used to establish 7 dif.erent empirical *** empirical coef.icients of.the models were calculated using the least square *** accuracy of.the models was evaluated using dif.erent statistical criteria such as Taylor diagram,mean absolute percentage error,MAPE,and root mean square error,*** results indicated that the sunshine duration-based models are more accurate than air temperature-based models,and the best perf.rmance was obtained by the quadratic regression model f.r all twelve Libyan ***,this regression model can be used f.r the prediction of.monthly mean horizontal global solar radiation at a specif.c site across Libya’s regions with minimum ***,the results of.the global solar irradiance produced by this method can be used f.r designing solar systems applications.

关键词： Monthly global solar radiation Clearness index Empirical models Perf.rmance evaluation Taylor diagram Libya

RPLP0/TBP are the most stable ref.rence genes f.r human dental pulp stem cells under osteogenic dif.erentiation

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World Journal of.Stem Cells 2024年第6期16卷 656-669页

作者： Daniel B f.rreira Leticia M Gasparoni Cristiane f.Bronzeri Katiucia B S Paiva Laboratory of.Extracellular Matrix Biology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000São PauloBrazil

BACKGROUND Validation of.the ref.rence gene(RG)stability during experimental analyses is essential f.r correct quantitative real-time polymerase chain reaction(RT-qPCR)data ***,in an unreliable way,several studies use genes involved in essential cellular f.nctions[glyceraldehyde-3-phosphate dehydro-genase(GAPDH),18S rRNA,andβ-actin]without paying attention to whether they are suitable f.r such experimental conditions or the reason f.r choosing such ***,such studies use only one gene when Minimum Inf.rmation f.r Publication of.Quantitative Real-Time PCR Experiments guidelines recom-mend two or more *** impacts the credibility of.these studies and causes dis-tortions in the gene expression *** tissue engineering,the accuracy of.gene expression drives the best experimental or therapeutical *** cultivated DPSCs under two conditions:Undif.erentiated and osteogenic dif.f.rentiation,both f.r 35 *** evaluated the gene expression of.10 candidates f.r RGs[ribosomal protein,large,P0(RPLP0),TATA-binding protein(TBP),GAPDH,actin beta(ACTB),tubulin(TUB),aminolevulinic acid synthase 1(ALAS1),tyro-sine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,zeta(YWHAZ),eukaryotic translational elongation f.ctor 1 alpha(Ef.a),succinate dehydrogenase complex,subunit A,f.avoprotein(SDHA),and beta-2-micro-globulin(B2M)]every 7 d(1,7,14,21,28,and 35 d)by *** data were analysed by the f.ur main algorithms,ΔCt method,geNorm,Normf.nder,and BestKeeper and ranked by the Ref.inder *** subdivided the samples into eight *** All of.the data sets f.om clonogenic and osteogenic samples were analysed using the Ref.inder *** f.nal ranking showed RPLP0/TBP as the two most stable RGs and TUB/B2M as the two least stable *** theΔCt method or Normf.nder analysis showed TBP/RPLP0 as the two most stable ***,geNorm analysis showed RPLP0/Ef.αin the f.rst *** algorithms’two least stab

关键词： Dental pulp stem cells Ref.rence gene Housekeeping gene Endogenous gene Osteogenic dif.erentiation Ref.inder

MicroRNAs in hepatocellular carcinoma treatment:Charting the path f.rward

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World Journal of.Gastroenterology 2024年第11期30卷 1470-1474页

作者： Hong T Lin Antonio f.Alvarez Castaneda Somashekar G Krishna Khalid Mumtaz Division of.Gastroenterology Hepatology and NutritionDepartment of MedicineThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

MicroRNAs(miRNAs)are recognized f.r their involvement in the regulation of.gene expression and exhibit signif.cant potential in both the prognostic assessment and treatment of.hepatocellular carcinoma(HCC).HCC,like other tumors,seldom occurs in isolation;instead,it evolves within a microenvironment f.aturing oncogenic and tumor-suppressive *** combined with suitable delivery vehicles,miRNA technology provides the capability to directly engage with these elements,thereby hindering tumor f.rmation and *** research in this domain holds the promise of.enabling a more ef.icacious and multi-modal treatment approach f.r HCC in the near f.ture.

关键词： Hepatocellular carcinoma Tumor microenvironment MicroRNA Mesenchymal stem cell Exosome