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抗结核药物肝毒性反应的危险因素及其影响

结核与肺部疾病杂志 2005年第1期8卷 28-34页

作者： A. f.rnández-Villar B. Sopena J. f.rnández-Villar R. Vázquez-Gallardo f. ulloa V. Leiro M. Mosteiro L. Pineiro 马玙 Tuberculosis Unit Department of Pneumology Department of.Internal Medicine Xeral-Cfes University Hospital Vigo Pontevedra Department of.Clinical Analysis Nicolas Pena Hospital Vigo Pontevedra Spain

背景:肝毒性反应是抗结核药物(下简称ATD)最严重的不良反应之一。虽然已有许多关于肝毒性反应危险因素的报道,但关于肝毒性反应严重程度的影响尚无系统研究。目的:评估肝毒性反应的危险因素(包括高龄、慢性肝病、酗酒或滥用药物或营养不... 详细信息

背景:肝毒性反应是抗结核药物(下简称ATD)最严重的不良反应之一。虽然已有许多关于肝毒性反应危险因素的报道,但关于肝毒性反应严重程度的影响尚无系统研究。目的:评估肝毒性反应的危险因素(包括高龄、慢性肝病、酗酒或滥用药物或营养不良)对ATD所致肝毒性反应严重性的影响。设计:对1998年1月至2002年7月期间在结核科门诊接受异烟肼、利福平、吡嗪酰胺治疗的471例活动性结核病人进行前瞻性队列分析。根据ATD所致肝毒性反应危险因素的暴露情况评价肝毒性反应的发生率及其严重性。结果:危险因素暴露组ATD所致肝毒性反应(血清转氨酶>3倍的正常上限值)的发生率为18.2%(42/231例),而对照组为5.8%(14/240例),(OR=3.5;95%CI:1.9-6.7;P10倍的正常上限值)发生率为6.9%(16/231),而对照组为0.4%(1/240)(OR=17.7;95%CI:2.3-135;P<0.001)。结论:肝毒性反应危险因素暴露组病人的ATD所致肝炎显著多见且较为严重。

关键词：毒性反应抗结核药物危险因素及 2002年7月正常上限值血清转氨酶 1998年 ATD 发生率不良反应系统研究严重程度慢性肝病营养不良滥用药物队列分析结核病人吡嗪酰胺严重性对照组暴露异烟肼结核科利福平

Phase-f.eld modeling of.f.acture f.r quasi-brittle materials

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Underground Space 2019年第1期4卷 10-21页

作者： Jacinto ulloa Patricio Rodríguez Cristóbal Samaniego Esteban Samaniego Department of.Civil Engineering Katholieke Universiteit LeuvenB-3001 LeuvenBelgium Departamento de Recursos Hídricos y Ciencias Ambientales Universidad de CuencaCuenca 010151Ecuador Universidad de Cuenca Cuenca 010151Ecuador Institut f.r Kontinuumsmechanik Leibniz Universität HannoverHannover 30167Germany Inria Bordeaux-Sud-Ouest Research Center 200 Avenue de la Vieille TourTalence 33405France f.cultad de Ingeniería Universidad de CuencaEcuador

This paper addresses the modeling of.f.acture in quasi-brittle materials using a phase-f.eld approach to the description of.crack *** the computational mechanics community,several studies have treated the issue of.modeling f.acture using phase *** of.these studies have used an approach that implies the lack of.a damage *** herein explore an alternative model that includes a damage threshold and study how it compares with the most popular *** f.rmulation is systematically explained within a rigorous variational ***,we present the corresponding three-dimensional f.nite element discretization that leads to a straightf.rward numerical *** simulations in two dimensions and three dimensions are then *** results show that while an elastic stage and a damage threshold are ensured by the present model,good agreement with the results reported in the literature can be obtained,where such f.atures are generally absent.

关键词： Quasi-brittle materials f.acture Variational f.rmulation Phase f.elds Gradient damage

SNARE complex in axonal guidance and neuroregeneration

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Neural Regeneration Research 2018年第3期13卷 386-392页

作者： f.usto ulloa Tiziana Cotruf. Delia Ricolo Eduardo Soriano Sof.a J. Araújo Department of.Cell Biology Physiology and Immunology School of Biology and Institute of Neurosciences University of Barcelona Barcelona Spain Centro de Investigación Biomédica en Red sobre Enf.rmedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III (ISCIII) Madrid Spain Institut de Biologia Molecular de Barcelona (IBMB-CSIC) Parc Cientific de Barcelona Barcelona Spain Department of.Genetics Microbiology and Statistics School of Biology University of Barcelona Barcelona Spain Vail d 'Hebron Institut de Recerca (VHIR) Barcelona Spain

Through complex mechanisms that guide axons to the appropriate routes towards their targets, axonal growth and guidance lead to neuronal system f.rmation. These mechanisms establish the synaptic circuitry necessary f.r the optimal perf.rmance of.the nervous system in all organisms. Damage to these networks can be repaired by neuroregenerative processes which in turn can re-establish synapses between injured axons and postsynaptic terminals. Both axonal growth and guidance and the neuroregenerative response rely on correct axonal growth and growth cone responses to guidance cues as well as correct synapses with appropriate targets. With this in mind, parallels can be drawn between axonal regeneration and processes occurring during embryonic nervous system development. However, when studying parallels between axonal development and regeneration many questions still arise; mainly, how do axons grow and synapse with their targets and how do they repair their membranes, grow and orchestrate regenerative responses af.er injury. Major players in the cellular and molecular processes that lead to growth cone development and movement during embryonic development are the Soluble N-ethylamaleimide Sensitive f.ctor （NSf. Attachment Protein Receptor （SNARE） proteins, which have been shown to be involved in axonal growth and guidance. Their involvement in axonal growth, guidance and neuroregeneration is of.f.remost importance, due to their roles in vesicle and membrane traf.icking events. Here, we review the recent literature on the involvement of.SNARE proteins in axonal growth and guidance during embryonic development and neuroregeneration.

关键词： SNARE vesicle associated membrane protein synaptosomal associated protein axon guidance neuroregeneration nervous system cell membrane

Morning Conf.rences:f.om Dialogue to the Sacrif.cial Rite and the f.rmation of.Scapegoats

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Journal of.f.reign Languages and Cultures 2021年第2期5卷 74-89,155页

作者： Jorge f.derico Marquez Munoz Pablo Armando Gonzalez ulloa Aguirre National Autonomous University of.Mexico

In order to achieve the objectives of.transparency and accountability,Mexican President Andres Manuel Lopez Obrador(AMLO)has of.ered a press conf.rence every morning since he took *** situation seemed to be a transcendental change in the f.eld of.democratic dynamics and political communication in Mexico;however,not merely a means of.communication,these conf.rences have instead become a method of.*** postulates of.Mimetic Theory,this essay analyzes AMLO’s conf.rences,showing how this daily practice has become propaganda f.r the regime.

关键词： scapegoat Morning Conf.rences Andres Manuel Lopez Obrador neoliberalism

Antibacterial activity of.Myrciaria dubia(Camu camu) against Streptococcus mutans and Streptococcus sanguinis

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Asian Pacif.c Journal of.Tropical Biomedicine 2016年第9期6卷 740-744页

作者： Rosella Camere-Colarossi Gabriela ulloa-Urizar Dyanne Medina-f.ores Stef.ny Caballero-García f.ank Mayta-Tovalino Juana del Valle-Mendoza School of.Dentistry Faculty of Health SciencesPeruvian University of Applied Sciences-UPC Research and Innovation Center of.the f.culty of.Health Sciences Peruvian University of Applied Sciences-UPC Molecular Biology Laboratory Nutrition Research Institute

Objective:To evaluate the antibacterial and cytotoxic ef.ect of.Myrciaria dubia(Camu camu)(***) methanol extract,against Streptococcus mutans(ATCC 25175)(***) and Streptococcus sanguinis(ATCC 10556)(***).Methods:Two methanol extracts of.*** were prepared in vitro,f.om the seeds and *** independent tests were prepared f.r each type of.extract,using 0.12% chlorhexidine solution as positive *** dif.usion test was used by preparing wells with the experimental solutions cultivated in anaerobic conditions f.r 48 h at ***,the minimum inhibitory concentration and the cytotoxic ef.ect over MDCK cell line was ***:A higher antibacterial ef.ect was observed with the methanol seed extract with an inhibitory halo of.21.36 ± 6.35) mm and(19.21 ± 5.18) mm against *** and ***,*** methanol extract of.the pulp had an ef.ect of.16.20 ± 2.08)mm and(19.34 ± 2.90) mm,*** minimum inhibitory concentration of.the pulp extract was 62.5 mg/mL f.r both strains,whereas f.r the seed antibacterial activity was observed even at low *** CC50 of.the seeds extract was at a higher concentration than 800 mg/mL and 524.37 mg/mL f.r the pulp ***:The experimental f.ndings demonstrated the antibacterial ef.ect of.the methanol extract of.*** against *** and *** extracts were not cytotoxic at high concentrations.

关键词： Antibacterial ef.ect Medicinal plants Myrciaria dubia Cytotoxicity

Antibacterial activity of.Bixa orellana L.(achiote) against Streptococcus mutans and Streptococcus sanguinis

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Asian Pacif.c Journal of.Tropical Biomedicine 2016年第5期6卷 400-403页

作者： Dyanne Medina-f.ores Gabriela ulloa-Urizar Rosella Camere-Colarossi Stef.ny Caballero-García f.ank Mayta-Tovalino Juana del Valle-Mendoza School of.Dentistry Faculty of Health SciencesPeruvian University of Applied Sciences-UPC Research and Innovation Center of.the f.culty of.Health Sciences Peruvian University of Applied Sciences-UPC Molecular Biology Laboratory Nutrition Research Institute

Objective: To evaluate the cytotoxic and antibacterial ef.ect of.Bixa orellana L.(B. orellana)(achiote) methanol extract against Streptococcus mutans(ATCC 25175)(S. mutans) and Streptococcus sanguinis(ATCC 10556)(S. sanguinis).Methods: Two methanol extracts of.B. orellana were prepared in vitro, f.om the seeds and leaves. The antibacterial activity of.extracts against S. mutans and S. sanguinis was evaluated using the cup-plate agar dif.usion method. The minimum inhibitory concentration(MIC) was determined using the microdilution method and the cytotoxic activity was determinated by using the cell line ***: A stronger antibacterial ef.ect was observed with the leaves methanolic extract with an inhibition zone of.19.97 ± 1.31) mm against S. mutans and(19.97 ± 1.26) mm against S. sanguinis. The methanolic extract of.the seeds had an activity of.15.11 ± 1.03)mm and(16.15 ± 2.15) mm against S. mutans and S. sanguinis, respectively. The MIC of.the leaf.and the seed extracts against S. sanguinis was 62.5 and 125 mg/m L, respectively,and the MIC of.the leaf.extract against S. mutans was 62.5 mg/m L, and f.r the seed extract it was 31.25 mg/m L. The 50% cytotoxic concentration was 366.45 and 325.05 mg/m L f.r the leaves and seeds extracts, ***: The experimental f.ndings demonstrated the antibacterial ef.ect of.the methanolic extract of.B. orellana(achiote) on S. mutans and S. sanguinis. The extract of.this plant is cytotoxic at high concentrations.

关键词： Antibacterial ef.ect Medicinal plants Bixa orellana L. Cytotoxicity

Irrigation's ef.ect and applied selection on the f.ber quality of.Ethyl MethaneSulf.nate(EMS)treated upland cotton(Gossypium hirsutum L.)

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Journal of.Cotton Research 2018年第4期1卷 1-11页

作者： WITT Travis W ulloa Mauricio PELLETIER Mathew G. MENDU Venugopal RITCHIE Glen L. Plant and Soil Science Department Texas Tech University USDA-ARS PA CSRL Plant Stress and Germplasm Development Research USDA-ARS Cotton Production and Processing Research Laboratory

Background: Producing rainf.d cotton(Gossypium hirsutum L.) with high f.ber quality has been challenging in the Texas High Plains because of.extended periods of.insuf.icient rainf.ll during sensitive boll developmental *** variation created by Ethyl MethaneSulf.nate(EMS) mutagen has successf.lly improved f.ber quality of.cotton. However, little is known about the ef.ect of.water def.cit environments on f.ber quality. Three EMS treated populations were advanced f.om the f.rst to the f.urth generation(M1 to M4) as bulk harvested populations. In2014, single-plant divergent selection was applied based on perceived morphological and agronomic dif.erences seen during and at the end of.the ***: Analyses f.om these selections in 2014-2016 showed signif.cant(Pf.r f.ber traits(micronaire, length, strength, unif.rmity, and elongation) when compared with the original non-treated EMS source; some selections were f.und to have excellent f.ber quality under diverse ***: Some of.these selections are being considered f.r germplasm release and could be usef.l f.r improving the f.ber quality of.cotton under water limited conditions, thereby helping to ensure the long-term survival of.the cotton industry on the Texas High Plains.

关键词： Breeding Drought EMS Ethyl MethaneSulf.nate f.ber quality Selection

ODEBRECHT公司不当行为危机管理研究

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ODEBRECHT公司不当行为危机管理研究

作者： Braulio ulloa Quesada 上海外国语大学

学位级别：硕士

本研究的背景是一家总部位于巴西的建筑公司奥德布雷希特（Odebrecht）的危机管理。奥德布雷希特公司在拉丁美洲拥有大量业务,该公司在2014年出现了一个巨大的腐败丑闻,其中涉及诸多地方政府。研究重点在于证明危机与公司管理层的关联,... 详细信息

本研究的背景是一家总部位于巴西的建筑公司奥德布雷希特（Odebrecht）的危机管理。奥德布雷希特公司在拉丁美洲拥有大量业务,该公司在2014年出现了一个巨大的腐败丑闻,其中涉及诸多地方政府。研究重点在于证明危机与公司管理层的关联,以及不同层级和不同支持领域能如何解决危机,并以奥德布雷希特公司的案例证明危机管理不只关乎公关。此外,本文还试图确定该公司危机产生的主要影响及产生的主要原因。本文旨在表明需要正确分析危机,包括其影响和问题,因为若想作出更好的评估,必须先确定原因,从而减轻危机影响,避免今后发生类似危机。此外,本文还试图证明在危机中对管理层问责是有用且必要的。最后,本研究旨在为其他面临公关危机的公司提供参考,他们可以将这些发现运用到类似情况中,克服挑战。因此,本文遵循定性类型研究,重点研究危机管理、情境危机传播、形象修复、利益相关者管理和道德领导力等管理理论。奥德布雷希特的外部和内部环境为公司的非伦理领导层和不良的公司治理提供了证据。理解这些因素有助于基于管理派生理论提出建议,尝试解决这些问题,同时管理和减轻危机后的影响。本文为公司内部不同层级的管理层提出了实施计划,以证明管理层有必要参与、支持危机管理,并得出总体结论,提出各自的局限性和发现的困难,以及进一步的研究方向。

关键词：危机管理非伦理领导公司治理

Antibacterial activity of.f.ve Peruvian medicinal plants against Pseudomonas aeruginosa

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Asian Pacif.c Journal of.Tropical Biomedicine 2015年第11期5卷 928-931页

作者： Gabriela ulloa-Urizar Miguel Angel Aguilar-Luis María del Carmen De Lama-Odría José Camarena-Lizarzaburu Juana del Valle Mendoza Centro de Investigacin de la f.cultad de Ciencias de la Salud Universidad Peruana de Ciencias Aplicadas-UPC f.cultad de Ciencias Biolgicas Universidad Nacional Mayor de San Marcos (UNMSM) Instituto de Investigacin Nutricional

Objective: To evaluate the susceptibility of.Pseudomonas aeruginosa(P. aeruginosa)in vitro to the ethanolic extracts obtained f.om f.ve dif.erent Peruvian medicinal ***: The plants were chopped and soaked in absolute ethanol(1:2, w/v). The antibacterial activity of.compounds against P. aeruginosa was evaluated using the cupplate agar dif.usion ***: The extracts f.om Maytenus macrocarpa("Chuchuhuasi"), Dracontium loretense Krause("Jergon Sacha"), Tabebuia impetiginosa("Tahuari"), Eucalyptus camaldulensis Dehn(eucalyptus), Uncaria tomentosa("U?a de gato") exhibited f.vorable antibacterial activity against P. aeruginosa. The inhibitory ef.ect of.the extracts on the strains of.P. aeruginosa tested demonstrated that Tabebuia impetiginosa and Maytenus macrocarpa possess higher antibacterial ***: The results of.the present study scientif.cally validate the inhibitory capacity of.the f.ve medicinal plants attributed by their common use in f.lk medicine and contribute towards the development of.new treatment options based on natural products.

关键词： Pseudomonas Medicinal plants Maytenus macrocarpa D