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现代生物医学进展 2017年第6期17卷 I0004-I0004页

作者： Wen Yang Koji Nagasawa Christian Münch Yingjie Xu Kyle Satterstrom Seungmin Jeong Sebastian D. Hayes Mark P. Jedrychowski f. sejal vyas Elma Zaganjor Virginia Guarani Alison E. Ringel Steven P. Gygi J. Wade Harper Marcia C. Haigis Vascular Biology Program Boston Children’s Hospital Harvard Medical School Boston MA 02115 USA

就蛋白而言，去乙酰化酶（sirtuin）是令人喜欢的，而且因它们与衰老和年龄相关疾病相关联而受到人们的广泛关注。作为去乙酰化酶的来源，线粒体，也因在健康和疾病中的作用而闻名于世。来自美国哈佛医学院的Marcia Haigis和她的团队从... 详细信息

就蛋白而言，去乙酰化酶（sirtuin）是令人喜欢的，而且因它们与衰老和年龄相关疾病相关联而受到人们的广泛关注。作为去乙酰化酶的来源，线粒体，也因在健康和疾病中的作用而闻名于世。来自美国哈佛医学院的Marcia Haigis和她的团队从事基础研究。提出了一个较为深刻的问题：在细胞中。哪些蛋白与去乙酰化酶进行交谈？

关键词：线粒体 Cell 健康去乙酰化酶相关疾病基础研究医学院蛋白

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CARBON NITRIDE f.LMS PREPARED AT DIf.ERENT N_2/Ar RATIOS BY CLOSED f.ELD UNBALANCED REACTIVE MAGNETRON SPUTTERING

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 280-288页

作者： A. vyas Department of.Manuf.cturing Engineering and Engineering Management (MEEM) City University of Hong Kong Kowloon Hong Kong China

Carbon nitride (CNx) thin f.lms have been deposited onto Si(100) (f.r structural and mechanical analyses) and M42 high-speed-steel (f.r tribological measurement s) substrates at room temperature by closed-f.eld unbalanced magnetron sputterin g. The mechanical and tribological properties of.these f.lms were highly depende nt on the N/C concentration ratio that was adjusted by the f.N2)/f.Ar) f.ow-rate ratio at f.xed substrate biasing of.-60V during deposition. The f.lms were char acterized by employing scanning electron microscopy (SEM), atomic f.rce microsco py (Af.), nano-indentation measurements, X-ray photoelectron spectroscopy (XPS), Raman scattering and f.urier transf.rm inf.ared (f.IR) spectroscopy, pin-on-dis c tribometer, scratch tester, and Rockwell-C tester. The results showed that the N content in the f.lms increased with the N2 pressure. However, the maximum N/C ratio obtained was 0.25. The nanohardness was measured to be in the range of.11 .7-20.8GPa depending on the N/C ratios. The XPS N 1s spectra showed the existenc e of.both N-C sp2 and N-C sp3 bonds in f.lms. Raman and f.IR spectra exhibited t hat N-C bonds were f.wer when compared to other N-C bonds. The f.iction coef.ici ent of.the f.lm deposited onto steel substrate with N/C=0.26 was measured to be ~0.08 and f.r f.lm with N/C=0.22 a high critical load of.70N was obtained. The t ribological data also showed that the wear rates of.these f.lms were in the rang e of.~10-16m3/Nm, indicating excellent wear resistance f.r CNx f.lms.

关键词： carbon nitride X-ray photoelectron spectroscopy Raman spectroscop y pin-on disc wear test tribology

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A novel design of.optimal intelligent f.zzy TID controller employing GA f.r nonlinear level control problem subject to actuator and system component f.ult

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International Journal of.Intelligent Computing and Cybernetics 2021年第1期14卷 17-32页

作者： Himanshukumar R.Patel sejal K.Raval Vipul A.Shah Instrumentation and Control Engineering Department Faculty of TechnologyDharmsinh Desai UniversityNadiadIndia Government Polytechnic Gujarat Technological UniversityAhmedabadIndia

Purpose–The purpose of.this article is about the design of.controllers f.r conical two-tank noninteracting level(CTTNL)system in *** linearization around the equilibrium point has been done f.r the nonlinear CTTNL system to obtain a linearized model transf.r ***/methodology/approach–This article deals with the design of.novel optimal f.actional-order tiltintegral-derivative(TID)controller using type-1 f.zzy set f.r the CTTNL prototype *** this study,type-1 f.zzy TID controller parameters have been optimized through genetic algorithm(GA)and those set of.values have been employed f.r the design of.proportional-integral-derivative(PID)***–A perf.rmance comparison between f.ID and PID controller is then *** analysis shows the superiority of.f.ID controller over PID controller in terms of.integral absolute error(IAE),integral square error(ISE),integral of.time multiplied absolute error(ITAE)and integral of.time multiplied squared error(ITSE)integral *** transient and steady state perf.rmance of.the f.ID controller are superior as compared to conventional PID *** f.ture,the f.ID controller f.ult-tolerance capability tested on CTTNL system subject to actuator and system component(leak)*** detailed study of.robustness in presence of.model uncertainties will be incorporated as a scope of.f.rther ***/value–A perf.rmance comparison between f.ID and PID controller is then *** analysis shows the superiority of.f.ID controller over PID controller in terms of.IAE,ISE,ITAE and ITSE integral ***,f.ult-tolerant perf.rmance of.the proposed controller evaluated with f.ult-recovery time(f.(rt))*** transient and steady state perf.rmance of.the f.ID controller are superior as compared to conventional PID controller.

关键词： f.zzy logic Genetic algorithms f.ult-tolerant control

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Robotic in situ bioprinting f.r cartilage tissue engineering

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International Journal of.Extreme Manuf.cturing 2023年第3期5卷 118-142页

作者： Yaxin Wang Rúben f.Pereira Chris Peach Boyang Huang Cian vyas Paulo Bartolo Department of.Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUnited Kingdom Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto4050-313PortoPortugal Instituto de Investigacao e Inovaao em Saúde Universidade do Porto4200-135PortoPortugal Instituto de Engenharia Biomédica Universidade do Porto4200-135PortoPortugal Manchester University NHS f.undation Trust ManchesterUnited Kingdom Singapore Centre f.r 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore639798Singapore

Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in signif.cant pain,mobility issues,and *** surgical treatments have a limited capacity f.r ef.icacious cartilage repair,and long-term patient outcomes are not ***-dimensional bioprinting has been used to f.bricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue ***,conventional in vitro bioprinting has limitations due to the challenges associated with the f.brication and implantation of.bioprinted constructs and their integration with the native cartilage *** situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional *** this review,we f.cus on the new f.ontier of.robotic-assisted in situ bioprinting surgical systems f.r cartilage *** outline existing clinical approaches and the utilization of.robotic-assisted surgical *** and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are def.ned and ***,we discuss the challenges and potential f.ture perspectives of.in situ bioprinting f.r cartilage applications.

关键词： in situ bioprinting cartilage tissue engineering robotic in situ bioprinting minimally invasive surgery bioinks

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