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Decreased accumulation of.ultrasound contrast in the liver of.nonalcoholic steatohepatitis rat model

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World Journal of.Gastroenterology 2011年第37期17卷 4191-4198页

作者： Yuki Miyata Takeo Miyahara f.minori moriyasu Department of.Gastroenterology and Hepatology Tokyo Medical University

AIM:To investigate the diagnosis of.nonalcoholic steatohepatitis(NASH) using contrast ultrasonography in the NASH rat ***:The liver in methionine choline-def.cient diet(MCDD) rats,a NASH model constructed by f.eding an MCDD,was examined by contrast ultrasonography at weeks 2,4,8,12 and 16,with late phase images of.contrast ultrasonography(Kupf.er imaging) in which contrast enhancement was achieved by incorporation of.a contrast agent by Kupf.er cells(KCs),and images were compared to those in rats taking a regular ***:Decrease in contrast enhancement was observed f.rst in MCDD rats at week *** were counted based on immunohistochemistry,but their numbers were not reduced and it was assumed that attenuation of.contrast enhancement was attributable to reduced phagocytic activity of.the ***:It is suggested that clinical application of.contrast ultrasonography may be valuable f.r noninvasive diagnosis of.NASH.

关键词： Nonalcoholic steatohepatitis Leptin Kupf.er cell Methionine choline-def.cient diet Contrast ultrasound

A predictive f.ctor f.r the response to S-1 plus cisplatin in gastric cancer

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World Journal of.Gastroenterology 2010年第36期16卷 4575-4582页

作者： Ikuko Miyazaki Takashi Kawai Youji Harada f.minori moriyasu Department of.Gastroenterology and Hepatology Tokyo Medical University Hospital6-7-1 Nishi-ShinjukuShinjuku-kuTokyo 160-0023Japan Endoscope Center Tokyo Medical University Hospital6-7-1 Nishi-ShinjukuShinjuku-kuTokyo 160-0023Japan Department of.Gastroenterology Toda Chuo General Hospital1-19-3 HonchoToda-shiSaitama 335-1132Japan

AIM:To prove that the protein expression level of.thymidylate synthase is a predictive f.ctor f.r the response to S-1/cisplatin(CDDP)chemotherapy in gastric ***:We measured the protein expression levels of.thymidylate synthase(TS),dihydropyrimidine dehydrogenase(DPD),and orotate phosphoribosyltrans-f.rase(OPRT)in advanced gastric *** S-1/CDDP chemotherapy,tumor specimens f.om primary sites were obtained by endoscopic biopsy and analyzed by enzyme-linked immunosorbent *** chemo-therapeutic ef.ects on the primary sites were evaluated by endoscopic biopsy perf.rmed more than once af.er S-1/CDDP *** ef.ects are a predictive f.ctor f.r the response to S-1/CDDP chemotherapy inpatients with advanced gastric cancer,as evaluated by endoscopic biopsy over ***:The protein expression level of.TS was signif.cantly higher(Pf.cantly lower(Pf.TS,DPD and OPRT and chemotherapeutic responses in 7 patients by assessing tumor tissues more than *** the responders,the protein expression level of.TS wasf.cant increases in the protein expression levels of.TS(Pf.er chemotherapy in 3 *** these cases,the patient assessment changed f.om"responder"to"non-responder".In the non-responders,the protein expression level of.TS was>40 ng/mg ***:We have conf.rmed that the protein expression level of.TS is a predictive f.ctor f.r the response to S-1/CDDP chemotherapy in patients with advanced gastric cancer.

关键词： Gastric cancer Thymidylate synthase Dihy-dropyrimidine dehydrogenase Orotate phosphoribosyl-transf.rase Biopsy

Arterial-phase contrast-enhanced ultrasonography f.r evaluating anti-angiogenesis treatment: A pilot study

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World Journal of.Gastroenterology 2011年第8期17卷 1045-1050页

作者： Keiko Yoshida Tomihiko Hirokawa f.minori moriyasu Masahiko Yamada Yasuharu Imai Department of.Gastroenterology and Hepatology Tokyo Medical University

AIM:To verif. whether arterial-phase contrast-enhanced ultrasonography(CEUS) of.tumor parenchymal tissue is usef.l f.r evaluation of.anti-angiogenesis ***:Rabbits with liver tumor were subjected to CEUS,and images of.the nodular maximal diameter in vascular phase were *** analysis was perf.rmed to plot the time intensity curve(TIC) at the tumor parenchyma,which set the diameter of.the region of.interest of.intensity *** TIC was calculated to obtain the time to peak intensity(TPI) and the magnitude of.*** were randomly assigned to a treatment group with soraf.nib and a control *** weeks later,the same ultrasound examination was repeated f.llowed by pathological testing to assess the ef.ect of.soraf.nib on the liver ***:In f.ur rabbits in the treatment group,the rate of.change of.tumor size was decreased comparedwith that of.the control(the rate 2.3 vs 7.9,P = 0.02).The TPI of.the treatment group elongated signif.cantly(the rate 3.1 vs 1.1,P = 0.07 f.r SonoVue,2.0 vs 0.88,P = 0.09 f.r Sonazoid).The magnitude of.PI showed no signif.cant *** pathological examination,capillary diameters in the treatment group were signif.cantly smaller than those in the control group(26.4 vs 42.8 μm,P = 0.013).CONCLUSION:Analysis of.the TIC in the arterial phase of.tumor tissue could evaluate the ef.icacy of.antiangiogenesis drug treatment in liver tumor.

关键词： Liver tumor Ultrasound agent Contrast-enhanced ultrasonography Soraf.nib Animal model

Ef.ectiveness of.narrow-band imaging magnif.cation f.r invasion depth in early colorectal cancer

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World Journal of.Gastroenterology 2010年第14期16卷 1727-1734页

作者： Masakatsu f.kuzawa Yutaka Saito Takahisa Matsuda Toshio Uraoka Takao Itoi f.minori moriyasu Division of.Endoscopy National Cancer Center Hospital Tokyo 1040045 Japan Division of.Gastroenterology and Hepatology Tokyo Medical University Tokyo 1600023 Japan Department of.Endoscopy Okayama University Hospital Okayama 7008558 Japan Microvasculature

AIM: To evaluate the surf.ce microvascular patterns of.early colorectal cancer (ECC) using narrow-band imaging (NBI) with magnif.cation and its ef.ectiveness f.r invasion depth diagnosis. METHODS: We studied 112 ECC lesions [mucosal/ submucosal superf.cial (m/sm-s), 69; sm-deep (sm-d), 43] ≥ 10 mm that subsequently underwent endoscopic or surgical treatment at our hospital. We compared microvascular architecture revealed by NBI with magnif.cation to histological f.ndings and then to magnif.- cation colonoscopy pit pattern diagnosis. RESULTS: Univariate analysis indicated vessel density: non-dense (P f.cantly more of.en with sm-d invasion than m/sm-s invasion. Multivariate analysis showed sm-d invasion was independently associated with vessel density: non-dense[odds ratio (OR) = 402.5, 95% conf.dence interval (CI): 12.4-13 133.1] and vessel regularity: negative (OR = 15.9, 95% CI: 1.2-219.1). Both of.these f.ndings when combined were an indicator of.sm-d invasion with sensitivity, specif.city and accuracy of.81.4%, 100% and 92.9%, respectively. Pit pattern diagnosis sensitivity, specif.city and accuracy, meanwhile, were 86.0%, 98.6% and 93.8%, respectively, thus, the NBI with magnif.cation f.ndings of.non-dense vessel density and negative vessel regularity when combined together were comparable to pit pattern diagnosis. CONCLUSION: Non-dense vessel density and/or negative vessel regularity observed by NBI with magnif.cation could be indicators of.ECC sm-d invasion.

关键词： Colorectal neoplasms Narrow-band imaging Microvasculature

Depletion of.CD25^+CD4^+T cells (Tregs) enhances the HBV-specif.c CD8^+ T cell response primed by DNA immunization

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World Journal of.Gastroenterology 2005年第24期11卷 3772-3777页

作者： Yoshihiro f.ruichi Hirotake Tokuyama Satoshi Ueha Makoto Kurachi f.minori moriyasu Kazuhiro Kakimi f.urth Department of.Internal Medicine (Gastroenterology and Hepatology) Department of.Molecular and Preventive Medicine Department of.Immunotherapeutics (Medinet)

AIM: Persistent hepatitis B virus (HBV) inf.ction is characterized by a weak CD8+ T cell response to HBV. Immunotherapeutic strategies that overcome tolerance and boost these suboptimal responses may f.cilitate viral clearance in chronically inf.cted individuals. Theref.re, we examined whether CD25+CD4+ regulatory T (Treg) cells might be involved in a inhibition of.CD8+T cell priming or in the modulation of.the magnitude of.the 'peak' antiviral CD8+ T cell response primed by DNA immunization. METHODS: B10.D2 mice were immunized once with plasmid pCMV-S. Mice received 500 μg of.anti-CD25 mAb injected intraperitoneally 3 d bef.re DNA immunization to deplete CD25+ cells. Induction of.HBV-specif.c CD8+ T cells in peripheral blood mononuclear cells (PBMCs) was measured by S28-39 peptide loaded DimerX staining and their f.nction was analyzed by intracellular If.-γ staining. RESULTS: DNA immunization induced HBV-specif.c CD8+ T cells. At the peak T cell response (d 10), 7.1±2.0% of.CD8+ T cells were HBV-specif.c af.er DNA immunization, whereas 12.7±3.2% of.CD8+ T cells were HBV-specif.c in Treg-depleted mice, suggesting that DNA immunization induced more antigen-specif.c CD8+ T cells in the absence of.CD25+ Treg cells (n = 6, Pf.wer HBV specif.c memory T cells were detected in the presence of.these cells (1.3±0.4%) in comparison to Treg-depleted mice (2.6±0.9%) on d 30 af.er DNA immunization (n - 6, Pf.-γ production and the avidity of.the HBV-specif.c CD8+ T cell response to antigen were higher in HBV-specif.c CD8+ T cells induced in the absence of.Treg cells. CONCLUSION: CD25+ Treg cells suppress priming and/or expansion of.antigen-specif.c CD8+ T cells during DNA immunization and the peak CD8+ T cell response is enhanced by depleting this cell population. f.rthermore, Treg cells appear to be involved in the contraction phase of.the CD8+ T cell response and may af.ect the quality of.memory T cell pools. The elimination of.Treg cells or the

关键词： Hepatitis B virus Regulatory T cell (Treg) Cytotoxic T lymphocyte DNA immunization Vaccine

Endoscopic resection of.carcinoid of.the minor duodenalpapilla

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World Journal of.Gastroenterology 2007年第27期13卷 3763-3764页

作者： Takao Itoi Atsushi Sof.ni f.mihide Itokawa Takayoshi Tsuchiya Toshio Kurihara f.minori moriyasu Department of.Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan

We encountered a 65-year-old man with a carcinoid tumor of.the minor duodenal papilla. Since he had liver cirrhosis and completely ref.sed surgery, we perf.rmed an endoscopic snare papillectomy. The papillectomy was perf.rmed successf.lly without procedure-related complication. The specimens revealed a carcinoid tumor showing that the margin of.the tumor was positive. One week later, upper GI endoscopy was perf.rmed and the biopsy specimens obtained f.om base of.ulcer showed no neoplastic cells. We perf.rmed a duodenoscopy and CT 3, 6 and 18 mo later, and there was no macroscopic or microscopic evidence of.tumor recurrence af.er more than 4 years.

关键词： Endoscopic papillectomy Carcinoid tumor Minor duodenal papilla Papilla of.Vater tumor Duodenal papilla

Radiologic-pathologic correlation of.three-dimensional shear-wave elastographic f.ndings in assessing the liver ablation volume af.er radiof.equency ablation

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World Journal of.Gastroenterology 2014年第33期20卷 11850-11855页

作者： Katsutoshi Sugimoto Hisashi Oshiro Saori Ogawa Mitsuyoshi Honjo Takeshi Hara f.minori moriyasu Department of.Gastroenterology and Hepatology Tokyo Medical University Tokyo 160-0023 Japan Department of.Pathology Tokyo Medical University Tokyo 160-0023 Japan Department of.Intelligent Image Inf.rmation Gifu University Graduate School of Medicine Gifu 501-1193 Japan

AIM: To evaluate the usef.lness of.three-dimensional (3D) shear-wave elastography (SWE) in assessing the liver ablation volume af.er radiof.equency (Rf. ablation.

关键词： Radiof.equency ablation Liver Ultrasound Shear-wave elastography Three-dimensional

Impairment of.If.-a production capacity in patients with hepatitis C virus and the risk of.the development of.hepatocellular carcinoma

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World Journal of.Gastroenterology 2005年第46期11卷 7330-7334页

作者： Kazuko Uno Yoshiki Suginoshita Kazuhiro Kakimi f.minori moriyasu Mayumi Hirosaki Taro Shirakawa Tsunataro Kishida Louis Pasteur Center f.r Medical ResearchKyoto Japan Department of.Gastroenterology and Hepatologyf.culty of.Medicine Kyoto UniversityKyotoJapan Department of.Health Promotion and Human BehaviorKyoto University Graduate School of.Public Health KyotoJapan

AIM: To determine the utility of.interf.ron (If.) -αproduction capacity in patients with hepatitis C virus (HCV) inf.ction f.r the measurement of.immunosurveillance potential and f.r the early detection of.hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated If.-α production capacity of.patients with HCV ***: HVJ stimulated If.-α production was determined in a large number of.patients with HCV inf.ction and the development of.HCC was monitored f.r 3 years in patients with liver cirrhosis (LC).RESULTS: If.-α production capacity decreases gradually with the progression of.liver disease f.om chronic hepatitis (CH) to HCC. A signif.cant correlation between the duration of.HCV inf.ction and impaired If.-α production capacity was observed. If.-α production in patients who developed HCC within 3 years was signif.cantly lower than that of.patients who remained in LC without developing ***: Measurement of.If.-α production in LC patients may be usef.l f.r the early detection of.HCC.

关键词： If.-α production capacity Hepatitis C virus Hepatocellular carcinoma

Assessment of.the validity of.the clinical pathway f.r colon endoscopic submucosal dissection

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World Journal of.Gastroenterology 2012年第28期18卷 3721-3726页

作者： Takaya Aoki Takeshi Nakajima Yutaka Saito Takahisa Matsuda Taku Sakamoto Takao Itoi Yassir Khiyar f.minori moriyasu Endoscopy Division National Cancer Center Hospital Tokyo 104-0045 Japan Department of.Gastroenterology and Hepatology Tokyo Medical University Tokyo 160-0023 Japan

AIM: To determine the ef.ective hospitalization period as the clinical pathway to prepare patients f.r endoscopic submucosal dissection (ESD). METHODS: This is a retrospective observational study which included 189 patients consecutively treated by ESD at the National Cancer Center Hospital f.om May 2007 to March 2009. Patients were divided into 2 groups; patients in group A were discharged in 5 d and patients in group B included those who stayed longer than 5 d. The f.llowing data were collected f.r both groups: mean hospitalization period, tumor site, median tumor size, post-ESD rectal bleeding requiring urgent endoscopy, perf.ration during or af.er ESD, abdominal pain, f.ver above 38 ℃, and blood test results positive f.r inf.ammatory markers bef.re and af.er ESD. Each parameter was compared af.er data collection. RESULTS: A total of.83% (156/189) of.all patients could be discharged f.om the hospital on day 3 postESD. Complications were observed in 12.1% (23/189) of.patients. Perf.ration occurred in 3.7% (7/189) of.patients. All the perf.rations occurred during the ESD procedure and they were managed with endoscopic clipping. The incidence of.post-operative bleeding was 2.6% (5/189); all the cases involved rectal bleeding. We divided the subjects into 2 groups: tumor diameter ≥ 4 cm and f.cant dif.erence between the 2 groups (P = 0.93, χ 2 test with Yates correction). The incidence of.abdominal pain was 3.7% (7/189). All the cases occurred on the day of.the procedure or the next day. The median white blood cell count was 6800 ± 2280 (cells/μL; ± SD) f.r group A, and 7700 ± 2775 (cells/μL; ± SD) f.r group B, showing a statistically signif.cant dif.erence (P = 0.023, t-test). The mean C-reactive protein values the day af.er ESD were 0.4 ± 1.3 mg/dL and 0.5 ± 1.3 mg/dL f.r groups A and B, respectively, with no signif.cant dif.erence between the 2 groups (P = 0.54, t -test). CONCLUSION: One-day admission is suf.icient in the absence of.compl

关键词： Clinical pathway Colon Complication Endoscopic submucosal dissection Hospitalization period Rectum