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Olf.ctory receptors in neural regeneration in the central nervous system

Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Raf.el f.anco Claudia Garrigós toni Capó Joan Serrano-marín Raf.el Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center f.r Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of.Chemistry Universitat de BarcelonaBarcelonaSpain Department of.Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of.Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olf.ctory receptors are crucial f.r detecting odors and play a vital role in our sense of.smell,inf.uencing behaviors f.om f.od choices to emotional *** receptors also contribute to our perception of.f.avor and have potential applications in medical diagnostics and environmental *** ability of.the olf.ctory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained f.om how olf.ctory neurons continuously replace themselves and reestablish f.nctional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage of.en results in permanent *** the molecular and cellular mechanisms underpinning olf.ctory neuron regeneration could pave the way f.r developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are f.und in almost any cell of.eve ry orga n/tissue of.the mammalian *** ectopic expression provides insights into the chemical structures that can activate olf.ctory *** addition to odors,olf.ctory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of.the f.nction of.olf.ctory receptors in ectopic expression provides valuable inf.rmation on the signaling pathway engaged upon receptor activation and the receptor's role in prolif.ration and cell dif.erentiation *** review explo res the ectopic expression of.olf. ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olf.ctory receptors could serve as potential therapeutic targets f.r enhancing neural repair and recovery f.llowing central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li Zhen ma Jin-Hua Gao School of.Science Hebei University of Science and Technology School of.Electronics and Inf.rmation Zhengzhou University of Light Industry School of.Physics and Wuhan National High magnetic f.eld Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved f.iedel oscillation （f.） and quasiparticle interf.rence （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted f. becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half.f.lling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved f. has both sublattice and spin ***,the local magnetic moment decay at half.f.lling only occurs at one sublattice of.graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We f.rther give an analytic f.rmula about such spin dependent f. based on the stationary phase ***,we study the interf.rence of.quasiparticles around the magnetic impurity by calculating the spin dependent f.urier-transf.rmed local density of.states （f.-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： f.iedel oscillation local magnetic moment graphene Anderson impurity

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Harnessing therapeutic potential of.induced pluripotent stem cell–derived endothelial cells f.r remyelination in the central nervous system

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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： Dan ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve f.bers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of.damaged myelin sheaths(remyelination) of.en f.ils in MS, leading to neuronal loss and irreversible f.nctional def.cits.

关键词： myelin protective diseases

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Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease

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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira Saeed Linlin ma Grif.ith Institute f.r Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of.Environment and Science Griffith University NathanBrisbaneQLDAustralia

Parkinson's disease(PD) has a complex and multif.ctorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of.calcium(Ca^(2+)) homeostasis and the subsequent development of.PD. Ca^(2+) regulation is crucial f.r neuronal survival, dif.erentiation,exocytosis at synapses,gene transcription,and prolif.ration.

关键词： homeostasis clinical subsequent

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magnetron sputtered nickel oxide with suppressed interf.cial def.ct states f.r ef.icient inverted perovskite solar cells

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Journal of.Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang ma Qin Tan Zhaoning Li Jingwei Xiu Jiaf.ng Wang Tianle Cheng Dong He Qiang Sun Xuhang ma f.ancesco Lamberti Zhubing He Department of.materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research f.cilities Southern University of Science and Technology Department of.Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells of.en suf.er f.om severe interf.cial reactions between the NiOxand adjacent perovskite layers due to surf.ce def.ct states,which inherently impair device perf.rmance in a long-term view,even with surf.ce molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin f.lms through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin f.lm surf.ces f.om materials to *** sputtered NiOxf.lms exhibit improved crystallinity,smoother surf.ces,and signif.cantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interf.ce between the perovskite and sputtered NiOxf.lm shows a substantially reduced density of.def.ct *** solar cells （PSCs） f.bricated with our optimally sputtered NiOxf.lms achieved a high power conversion ef.iciency （PCE） of.up to 19.93%and demonstrated enhanced stability,maintaining 86.2% ef.iciency during 500 h of.maximum power point tracking under one standard sun ***,with the surf.ce modif.cation using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DmacPA）,the device PCE was f.rther promoted to 23.07%,which is the highest value reported f.r sputtered NiOxbased PSCs so f.r.

关键词： Nickle oxide magnetron sputter Def.ct Stability Perovskite solar cell

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Recent advances in exploring new blood-based biomarkers f.r the early diagnosis of.gastric cancer

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Science China Chemistry 2025年第1期 35-45页

作者： Xinyu Peng Qian ma Da Han School of.Lif. Science Shanghai University Institute of.Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of.Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of.distinctive symptoms of.en leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal f.r improving the survival rates and outcomes of.GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of.GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insuf.icient sensitivity and specif.city f.r GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating f.ee RNA(cf.RNA), have emerged as promising candidates in the burgeoning f.eld of.liquid biopsy due to their superior sensitivity and specif.city. This review f.cuses on the latest research on blood-based biomarkers f.r GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

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Bandgap characteristics analysis and graded design of.a novel metamaterial f.r f.exural wave suppression

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Applied mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： f.n YANG Zhaoyang ma Xingming GUO Shanghai Key Laboratory of.Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of.Aircraf. Mechanics and Control

A novel elastic metamaterial is proposed with the aim of.achieving lowf.equency broad bandgaps and bandgap regulation. The band structure of.the proposed metamaterial is calculated based on the f.oquet-Bloch theorem, and the boundary modes of.each bandgap are analyzed to understand the ef.ects of.each component of.the unit cell on the bandgap f.rmation. It is f.und that the metamaterials with a low elastic modulus of.ligaments can generate f.exural wave bandgaps below 300 Hz. Multi-f.equency vibrations can be suppressed through the selective manipulation of.bandgaps. The dual-graded design of.metamaterials that can signif.cantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of.the elastic modulus in the substrate of.ers better bandgap perf.rmance. Based on these analyses, the proposed elastic metamaterials can pave the way f.r multi-f.equency vibration control, low-f.equency bandgap broadening, and bandgap tuning.

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Ef.icient and Stable Perovskite Solar Cells and Modules Enabled by Tailoring Additive Distribution According to the f.lm Growth Dynamics

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Nano-Micro Letters 2025年第2期17卷 387-400页

作者： Mengen ma Cuiling Zhang Yujiao ma Weile Li Yao Wang Shaohang Wu Chong Liu Yaohua mai Institute of.New Energy Technology College of Physics&Optoelectronic EngineeringJinan UniversityGuangzhou 510632People’s Republic of China Key Laboratory of.New Semiconductors and Devices of.Guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632People’s Republic of China Guangdong Mellow Energy Co. LimitedYuanming RoadZhuhai 519075GuangdongPeople’s Republic of China

Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of.perovskites in blade-coating *** this work,we f.und these two pre-crystallization processes lead to dif.erent order of.crystallization dynamics within the perovskite thin f.lm,resulting in the dif.erences of.additive *** then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain f.lms with f.wer def.cts and holes at the buried interf.ce,and prepared perovskite solar cells with a certif.ed ef.iciency of.23.75%.f.rthermore,this work also demonstrates an ef.iciency of.20.18%f.r the large-area perovskite solar module(PSM)with an aperture area of.60.84 cm^(2).The PSM possesses remarkable continuous operation stability f.r maximum power point tracking of.T_(90)>1000 h in ambient air.

关键词： Gas quenching Additive distribution Buried passivation Blade coating Crystallization dynamics

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New glucocerebrosidase antibodies can advance research in the f.eld of.neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis ma Krystyna Rytel Yu Chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of.a new tool can launch scientif.c discovery in new *** antibody development may be considered mundane,in the f.eld of.glucocerebrosidase(GCase)research,the dearth of.validated antibodies f.r dif.erent applications has impeded progress in studies of.disease pathogenesis and therapeutic *** recent introduction of.new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of.the pathobiology of.Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

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Research status and prospects of.the f.actal analysis of.metal material surf.ces and interf.ces

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International Journal of.Minerals,Metallurgy and materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuef.ng Liu Xin ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation Center f.r materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of.Metallic materials and Processing f.r Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory f.r Advanced materials Processing of.Ministry of.Education University of Science and Technology BeijingBeijing 100083China School of.Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,f.actal analysis can be used to quantitatively describe irregular shapes with self.similar or self.af.ine *** analysis has been used to characterize the shapes of.metal materials at various scales and *** methods make it dif.icult to quantitatively describe the relationship between the regular characteristics and properties of.metal material surf.ces and ***,f.actal analysis can be used to quantitatively describe the shape characteristics of.metal materials and to establish the quantitative relationships between the shape characteristics and various properties of.metal *** the perspective of.two-dimensional planes and three-dimensional curved surf.ces,this paper reviews the current research status of.the f.actal analysis of.metal precipitate interf.ces,metal grain boundary interf.ces,metal-deposited f.lm surf.ces,metal f.acture surf.ces,metal machined surf.ces,and metal wear *** relationship between the f.actal dimensions and properties of.metal material surf.ces and interf.ces is *** f.om three perspectives of.f.actal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identif.es the direction of.research on f.actal analysis of.metal material surf.ces and interf.ces that need to be *** is believed that revealing the deep inf.uence mechanism between the f.actal dimensions and properties of.metal material surf.ces and interf.ces will be the key research direction of.the f.actal analysis of.metal materials in the f.ture.

关键词： metal material surf.ces and interf.ces f.actal analysis f.actal dimension homogeneity

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