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和心·一味空间——木卡工作室居住空间设计案例

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家具与室内装饰 2024年第3期31卷 60-65页

作者： Mu ka Gong Zuo Shi 木卡工作室

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Biological characteristics and clinical management of.uveal and conjunctival melanoma

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Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA kaŠTELAN ANA DIDOVIĆPAVIČIĆ DARIA PAŠALIĆ TAMARA NIKUŠEVA-MARTIĆ SAMIRČANOVIĆ PETRA KOVAČEVIĆ SUZANA KONJEVODA School of.Medicine University of ZagrebZagreb10000Croatia Department of.Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Department of.Ophthalmology Zadar General HospitalZadar23000Croatia Department of.Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Department of.Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of.Medicine University of SplitSplit21000Croatia Department of.Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of.mortality f.r a large number of.af.ected *** pathogenesis of.melanoma at dif.erent sites is very similar,however,the prognosis f.r patients with ocular melanoma remains unf.vourable,primarily due to its distinctive genetic proﬁle and tumor *** of.considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of.uveal and conjunctival melanoma remains a f.rmidable *** enhance the prospect of.success,collaborative ef.orts involving medical prof.ssionals and researchers in theﬁelds of.ocular biology and oncology are *** data show a lack of.well-designed randomized clinical trials and limited beneﬁts in current f.rms of.treatment f.r these *** advancements in the development of.ef.ective melanoma therapeutic strategies,all current treatments f.r uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisf.ctory,resulting in a poor long-term *** trials of.er hope f.r positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of.the genetic and molecular abnormalities involved in the development and progression of.ocular melanomas opens the way f.r the development of.personalized therapy,with various potential therapeutic targets currently under *** comprehension of.the molecular pathogenesis of.UM and CoM and their speciﬁcities may aid in the development of.new and more ef.ective systemic therapeutic agents,with the hope of.improving the prognosis f.r patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

MEC网络中基于深度确定策略梯度的能效优化

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火力与指挥控制 2024年第7期49卷 44-49页

作者：陈卡驻马店职业技术学院河南驻马店463000

移动边缘计算(mobile edge computing,MEC)技术能为用户提供数据处理服务,但MEC服务器的计算资源有限,用户合理地向MEC服务器迁移任务及MEC服务器基于任务要求给用户合理分配资源是提高用户端能效的关键因素。提出基于深度确定策略梯度... 详细信息

移动边缘计算(mobile edge computing,MEC)技术能为用户提供数据处理服务,但MEC服务器的计算资源有限,用户合理地向MEC服务器迁移任务及MEC服务器基于任务要求给用户合理分配资源是提高用户端能效的关键因素。提出基于深度确定策略梯度的能效优化算法(deep deterministic policy gradient-based energy ef.iciency opti-mization,DDPG-EEO)。在满足时延要求的前提下,建立关于任务卸载率和资源分配策略的最大化能效的优化问题。再将优化问题描述成马尔可夫决策过程(Markov decision process,MDP),并利用深度确定策略梯度求解。仿真结果表明,DDPG-EEO算法降低了UTs端的能耗,并提高了任务完成率。

关键词：移动边缘计算任务卸载资源分配强化学习深度确定策略梯度

Cellular zinc metabolism and zinc signaling:f.om biological f.nctions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan f.da Xie Yigan Zhang Li Liang kam Tong Leung Kwok Wai Lo Jun Yu Gary M.K.Tse Wei kang ka f.i To Department of.Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of.Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of.Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of.Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of.Pediatrics The Chinese University of Hong KongHong KongChina Department of.Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical f.r many biological processes in the body.A key observation is the disruption of.cellular homeostasis,of.en coinciding with disease *** an essential f.ctor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of.disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of.literature investigating zinc’s cellular metabolism,particularly the f.nctions of.zinc transporters and storage mechanisms during cancer *** transportation is under the control of.two major transporter f.milies:SLC30(ZnT)f.r the excretion of.zinc and SLC39(ZIP)f.r the zinc ***,the storage of.this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical f.nctions of.cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special f.cus on *** also compile a summary of.clinical trials involving zinc *** the main localization of.zinc transporters at the cell membrane,the potential f.r targeted therapies,including small molecules and monoclonal antibodies,of.ers promising avenues f.r f.ture exploration.

关键词： metabolism invasion involvement

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基于模型分割的联邦学习数据隐私保护方法

电信科学 2024年第9期40卷 136-145页

作者：陈卡驻马店职业技术学院河南驻马店463000

在不共享原始数据的前提下,分割学习(split learning,SL)允许客户端同服务端协作训练深度学习模型,进而保护数据隐私。然而,SL仍存在数据隐私泄露问题。为此,提出基于二值分割学习的数据隐私保护(binarized split learning-based data p... 详细信息

在不共享原始数据的前提下,分割学习(split learning,SL)允许客户端同服务端协作训练深度学习模型,进而保护数据隐私。然而,SL仍存在数据隐私泄露问题。为此,提出基于二值分割学习的数据隐私保护(binarized split learning-based data privacy protection,BLDP)算法。将客户端所训练的本地模型进行二值化,降低由分割层输出值引起的数据泄露损失。同时,BLDP算法采用泄露约束训练机制,进一步减少数据泄露损失。该机制以本地数据泄露损失和模型精度损失为总体损失值进行模型训练,进而在维护模型精度的同时,保护数据隐私。以4个常用的基准数据集进行训练,分析BLDP算法的分类准确率以及减少数据隐私泄露损失方面的性能。分析结果表明,所提BLDP算法能在分类准确率和数据隐私泄露损失间达成平衡。

关键词：联邦学习隐私保护分割学习二值化泄露损失

Generation of.millijoule-level sub-5 f. violet laser pulses

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High Power Laser Science and Engineering 2024年第2期12卷 33-40页

作者： Xinhua Xie Yi Hung Yunpei Deng Adrian L.Cavalieri Andrius Baltuška Steven L.Johnson Swissf.L Paul Scherrer InstituteVilligen PSISwitzerland Photonics Institute Technische Universität WienViennaAustria Institute of.Applied Physics University of BernBernSwitzerland Institute f.r Quantum Electronics Physics DepartmentETH ZurichZurichSwitzerland

We demonstrate the generation,spectral broadening and post-compression of.second harmonic pulses using a thin beta barium borate(BBO)crystal on a f.sed-silica substrate as the nonlinear interaction *** combining second harmonic generation in the BBO crystal with self.phase modulation in the f.sed-silica substrate,we ef.iciently generate millijoule-level broadband violet pulses f.om a single optical *** second harmonic spectrum covers a range f.om long wave ultraviolet(down to 310 nm)to visible(up to 550 nm)with a bandwidth of.65 ***,we compress the second harmonic beam to a duration of.4.8 f. with a pulse energy of.0.64 mJ(5 f. with a pulse energy of.1.05 mJ)using chirped *** all-solid f.ee-space apparatus is compact,robust and pulse energy scalable,making it highly advantageous f.r generating intense second harmonic pulses f.om near-inf.ared f.mtosecond lasers in the sub-5 f. regime.

关键词： post-compression second harmonic generation self.phase modulation supercontinuum generation

Ovarian Tumors in Senegalese Women: Impact of.D-Loop Mutations between Healthy and Cancerous Tissues

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Open Journal of.Genetics 2024年第2期14卷 37-46页

作者： Rouguiyatou ka f.timata Mbaye Bineta Kénéme Mbacké Sembène Genomics Laboratory Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal

In Senegal in particular, ovarian cancer, which is one of.the most common gynecological cancers, accounts f.r 2.8% of.deaths. The most important risk f.ctor is genetic, with 10% of.cases occurring in a context of.genetic predisposition. The sequencing of.the human genome, which has led to the discovery of.millions of.sequence variations, makes it possible to study variations within sequences. These variations are limited to Single Nucleotide Polymorphisms (SNPs) and this common f.rm of.polymorphism occurs approximately every 1000 bases in the human genome and 1.8 million SNPs are currently listed according to [1]. The aim of.this study is to gain a better understanding of.the impact of.mutations in the D-loop region of.mtDNA on ovarian cancer in Senegalese women. This study involved searching f.r mutations in our study population af.er DNA extraction and sequencing. Mutations were f.und af.er a comparison of.our sequences with the Cambridge ref.rence sequence (NC_012920). The mutations f.und in the DNA studied extend f.om position 7 to position 16568 and most of.these mutations are located in the hypervariate zones (HV1 and HV2). Heteroplasmy with three mutant alleles was also f.und in certain variants. Common mutations were f.und in both healthy and cancerous tissues, with almost identical f.equencies in both types of.tissue. This enabled us to understand the spread of.tumor cells throughout the ovary.

关键词： Ovarian Cancer Mutations D-Loop Heteroplasmy

Nomogram to predict severe retinopathy of.prematurity in Southeast China

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International Journal of.Ophthalmology(English edition) 2024年第2期17卷 282-288页

作者： Dan Liu Xing-Yong Li Hong-Wu He ka-Lu Jin Ling-Xia Zhang Yang Zhou Zhi-Min Zhu Chen-Chen Jiang Hai-Jian Wu Sui-Lian Zheng Department of.Ophthalmology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital and School of.Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Taizhou Optometry Hospital Taizhou 318001Zhejiang ProvinceChina Department of.Ophthalmology Jiaxing Maternity and Child Health Care HospitalJiaxing 314009Zhejiang ProvinceChina Department of.Ophthalmology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318001Zhejiang ProvinceChina Clinical Medical Research Center the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of.Ophthalmology Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

AIM:To def.ne the predictive f.ctors of.severe retinopathy of.prematurity(ROP)and develop a nomogram f.r predicting severe ROP in southeast ***:Totally 554 inf.nts diagnosed with ROP hospitalized in the Second Af.iliated Hospital and Yuying Children’s Hospital of.Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were *** data and 43 candidate predictive f.ctors of.ROP inf.nts were collected *** regression model was used to identif. predictive f.ctors of.severe ROP and to propose a nomogram f.r individual risk prediction,which was compared with WINROP model and Digirop-Birth ***:Inf.nts f.om the Second Af.iliated Hospital and Yuying Children’s Hospital of.Wenzhou Medical University(n=478)were randomly allocated into training(n=402)and internal validation group(n=76).Inf.nts f.om Taizhou Women and Children’s Hospital were set as external validation group(n=76).Severe ROP were f.und in 52 of.402 inf.nts,12 of.76 inf.nts,and 7 of.76 inf.nts in training group,internal validation group,and external validation group,*** weight[odds ratio(OR),0.997;95%conf.dence interval(CI),0.996-0.999;Pf.ed as predictive f.ctors f.r the prediction of.severe ROP,by univariate analysis and multivariate *** predicting severe ROP based on the internal validation group,the areas under receiver operating characteristic curve(AUC)was 78.1(95%CI,64.2-92.0)f.r the nomogram,32.9(95%CI,15.3-50.5)f.r WINROP model,70.2(95%CI,55.8-84.6)f.r Digirop-Birth *** external validation group,AUC of.the nomogram was also higher than that of.WINROP model and Digirop-Birth model(80.2 versus 51.1 and 63.4).The decision curve analysis of.the nomogram demonstrated better clinical ef.icacy than that of.WINROP model and Digirop-Birth *** calibration curves demonst

关键词： retinopathy of.prematurity nomogram predictive f.ctor birth weight multiple births non-invasive ventilation

Elimination of.GGTA1,CMAH,β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions

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Animal Models and Experimental Medicine 2024年第4期7卷 584-590页

作者： Jing Xu Jilong Ren kai Xu Minghui f.ng Meina ka f.i Xu Xin Wang Jing Wang Zhiqiang Han Guihai f.ng Ying Zhang Tang Hai Wei Li Zheng Hu State Key Laboratory of.Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Key Laboratory of.Organ Regeneration and Reconstruction Chinese Academy of SciencesBeijingChina University of.Chinese Academy of.Sciences BeijingChina Beijing Institute f.r Stem Cell and Regenerative Medicine BeijingChina Key Laboratory of.Organ Regeneration and Transplantation of.the Ministry of.Education The First HospitalJilin UniversityChangchunChina Beijing f.rm Animal Research Center Institute of ZoologyChinese Academy of SciencesBeijingChina

Background:Pig organ xenotransplantation is a potential solution f.r the severe organ shortage in clinic,while immunogenic genes need to be eliminated to im-prove the immune compatibility between humans and *** knockout strat-egies are mainly aimed at the genes causing hyperacute immune rejection(HAR)that occurs in the f.rst f.w hours while adaptive immune reactions orchestrated by CD4 T cell thereaf.er also cause graf. f.ilure,in which process the MHC II molecule plays critical ***:Thus,we generate a 4-gene(GGTA1,CMAH,β4GalNT2,and CIITA)knockout pig by CRISPR/Cas9 and somatic cell nuclear transf.r to compromise HAR and CD4 T cell reactions ***:We successf.lly obtained 4KO piglets with def.ciency in all alleles of.genes,and at cellular and tissue ***,the saf.ty of.our animals af.er gene editing was verif.ed by using whole-genome sequencing and *** have survived f.r more than one year in the barrier,and also survived f.r more than 3 months in the conventional environment,suggesting that the piglets without MHC II can be raised in the barrier and then gradually mated in the conventional ***:4KO piglets have lower immunogenicity,are saf. in genomic level,and are easier to breed than the model with both MHC I and II deletion.

关键词： CD4 T cell genetically edited pig immune rejection major histocompatibility complex II xenotransplantation