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Wo.ld Jo.rnal o.0}Ai.S 2020年第2期10卷 141-148页

作者： M. C. o. Ezei.e B. L. Salako.f. i. o. onyeachonam A. Davi. o. o. Ai.a E. Herbertso. M. E. Sanda i. J. o.bo.na E. Kalu N. U. Njo.u M. i. Udo.i.C. A. Akpan Co.lege o.0}Veteri.ary Medi.i.e Michael Okpara University of Agriculture Umudike Nigeria Ni.eri.n i.sti.ute o.4}Medi.al Research Lagos Nigeria

i. veri.0}i.g anti.etro.i.al ef.i.acy o.5}a Ni.eri.n bro.d spectrum anti.i.al medi.i.e (Anti.i.t®), the Ni.eri.n i.sti.ute o.5}Medi.al Research certi.0}ed i. saf. by to.i.o.o.i.al test o. labo.ato.y ani.als, bef.re co.menci.g treatment o.5}three Hi./Ai.S pati.nts who.e vi.al lo.ds vari.d wi.ely (mi.li.ns, hundreds o.5}tho.sands and tho.sands). To.o.erco.e erro.s asso.i.ted wi.h such wi.e di.0}erences i. subject-classes, percentages o.5}vi.al lo.d-reducti.ns were calculated i.stead o.5}co.pari.g thei. vi.al lo.ds. Af.er f.rst mo.th o.5}the Anti.i.t®-treatment, means o.5}ranked vi.al lo.ds o.5}the pati.nts si.ni.0}cantly (P ≤ 0.05) i.creased f.o. 10.00 ± 7.21 to.11.30 ± 5.51 (-41.03% i.f.cti.n-reducti.n rate) i.stead o.5}reduci.g. f.o. seco.d mo.th o.5}the tri.l, thei. vi.al lo.ds started to.reduce, co.ti.uo.sly, so.that thei. i.f.cti.n-reducti.n rates have been i.creasi.g f.o. that -41.03%, to.-38.22% i. the seco.d mo.th;23.98% i. the thi.d mo.th;31.76% i. the f.urth mo.th and 64.12% af.er the f.f.h mo.th.

关键词： Anti.i.t® o.po.i.e Charges’ Electro.tati. Attracti.n Co.ti.uo.s Depleti.n o.2}Hi.-i.f.cti.n Lo.ds

Electro.tati. Mo.pi.g o.2}Vi.uses wi.h Medi.i.al Syntheti. Alumi.um-Magnesi.m Si.i.ate {Al4(Si.4)3+ 3Mg2Si.4→ 2Al2Mg3(Si.4)3}, f.r Qui.k Cure o.2}Co.i.-19: A Better Co.tro. Measure

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o.en Jo.rnal o.0}Epi.emi.lo.y 2021年第3期11卷 278-283页

作者： Madui.e C. o. Ezei.e f.vo.r onyeachonam Mary E. Sanda i.eo.a J. o.bo.na Ekenma Kalu Njo.u U. Njo.u Munachi.Udo.i Co.lege o.0}Veteri.ary Medi.i.e Michael Okpara University of Agriculture Umudike Nigeria

Co.i.-19 vi.us has po.i.i.e electri.al charges. So. parti.les that are negati.ely charged wo.ld, by o.po.i.e charges-electro.tati. attracti.n, i.hi.i. i.s repli.ati.n’s f.rst stage (attachment to.cells) and mo. i.s e... 详细信息

i.Co.i.i.-19 i.vi.usi. has po.i.i.e electri.al charges. So. parti.les that are negati.ely charged wo.ld, by o.po.i.e charges-electro.tati. attracti.n, i.hi.i. i.s repli.ati.n’s f.rst stage (attachment to.cells) and mo. i.s extra-cellular parti.les. Po.i.i.ely charged parti.les wo.ld si.i.arly mo./destro. cells i. i.f.cts because unli.e healthy cells whi.h are neutral, i.f.cted/tumo. cells have negati.e electri.al charges. i.Nano.arti.lesi. (0.96 nm) o.20}Alumi.um-magnesi.m si.i.ate (AMS), WHo.appro.ed medi.i.e/adjuvant have bo.h negati.e and po.i.i.e charged ends. As adjuvant i. i.pro.es anti.i.ro.i.ls’ ef.i.aci.s (cleari.g seco.dary i.f.cti.ns) whi.e as si.i.ate i. enhances i.muni.y. By i.hi.i.i.g vi.al repli.ati.n;mo.pi.g extra-cellular vi.uses/abno.mal cells;cleari.g seco.dary i.f.cti.ns;enhanci.g i.muni.y, AMS termi.ates vi.al-i.f.cti.ns/abno.mal cells’ metastases. Natural AMS has i.puri.i.s and i.s depo.i.s are no. f.und i. Ni.eri.. So. Alumi.um si.i.ate and Magnesi.m si.i.ate (WHo.appro.ed medi.i.es) were used f.r i.Medi.i.al syntheti. AMSi. {MSAMS: Al4 (Si.4)3 + 3Mg2Si.4 → 2Al2Mg3 (Si.4)3}. Si.ce AMS i. un-abso.bable, dextro.e mo.o.ydrate i. i.co.po.ated i. MSAMS-f.rmulati.ns to.co.vey i.s i.Nano.arti.lesi. i.to.blo.d f.r ci.culati.n to.all o.gans/ti.sues (acti.e-transpo.tati.n). The MSAMS achi.ved qui.k cure (wi.hi. 3 days) o.20}all f.ur Co.i.-19 pati.nts used f.r i.s f.rst-phase tri.l (o.e i. Ni.eri., two.i. Camero.n, o.e i. Tanzani.).

关键词： Co.i.-19 Medi.i.al Syntheti. Alumi.um-Magnesi.m Si.i.ate o.po.i.e Charges’ Electro.tati. Attracti.n Qui.k Cure

Anti.i.t^® {Al₄(Si.₄)₃ + 3Mg₂Si.₄ → 2Al₂Mg₃(Si.₄)₃} Cures Co.i.-19 by o.po.i.e Charges’ Electro.tati. Attracti.n

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o.en Jo.rnal o.0}Epi.emi.lo.y 2022年第3期12卷 240-244页

作者： Madui.e C. o. Ezei.e f.vo.r onyeachonam Mary E. Sanda i.eo.a J. o.bo.na Ekenma Kalu Njo.u U. Njo.u Munachi.Udo.i.Clara A. Akpan Co.lege o.0}Veteri.ary Medi.i.e Michael Okpara University of Agriculture Umudike Nigeria

To.cure Co.i.-19, we pro.o.nded mo.pi.g vi.uses/i.f.cted cells by o.po.i.e-charges electro.tati. attracti.n as mechani.m o.4}treatment. RNA vi.uses (i.cludi.g Co.i.-19 vi.us) are po.i.i.ely charged whi.e DNA vi.uses and abno.mal (i.f.cted/tumo.) cells are negati.ely charged but no.mal cells are neutral. Mo.ecules o.4}Alumi.um-magnesi.m si.i.ate (AMS), a WHo. appro.ed medi.i.e, co.si.t o.4}Nano.arti.les that have bo.h negati.ely and po.i.i.ely charged ends. Ultra-small si.e (0.96 nm thi.k) o.4}the Nano.arti.les, allo.s them access to.cells i. all o.gans. Ni.eri. do.s no. have natural AMS-depo.i.s but she has Alumi.um si.i.ate and Magnesi.m si.i.ate, abundantly. These so.i. mi.erals whi.h are WHo.appro.ed medi.i.es to. were used to.f.rmulate an AMS-brand, named, Medi.i.al syntheti. AMS (MSAMS, Vi.UMED®, Anti.i.t®). Dextro.e mo.o.ydrate (si.ple sugar) i. i.co.po.ated i. each MSAMS-f.rmulati.n to.co.vey the electri.ally charged Nano.arti.les acro.s muco.s membranes (acti.e-transpo.tati.n) i.to.blo.d f.r ci.culati.n to.all o.gans. The Anti.i.t® has pro.ed ef.ecti.e agai.st all vi.al and abno.mal-cell di.eases so.f.r tested i.cludi.g Co.i.-19.

关键词： MSAMS (Anti.i.t®) Hi./Ai.S Co.i.-19 Tumo.s

Cure f.r Hi./Ai.S wi.h Medi.i.al Syntheti. Alumi.um-Magnesi.m Si.i.ate {Al4(Si.4)3+ 3Mg2Si.4→ 2Al2Mg3(Si.4)3}—A Case Repo.t

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Wo.ld Jo.rnal o.0}Ai.S 2019年第3期9卷 161-166页

作者： M.C.o.Ezei.e N.K.Aneke T.N.o.arezi.f.onyeachonam M.E.Sanda i.J.o.bo.na E.Kalu U.N.Njo.u M.Udo.i.o.E.Ekundayo.o.i.o.i.0}nkwe M.C.i.we T.o.o.bo.o.U.C.Agu Co.lege o.0}Veteri.ary Medi.i.e Michael Okpara University of AgricultureUmudikeNigeria Medi.al Centre Michael Okpara University of AgricultureUmudikeNigeria Centre f.r Mo.ecular Bi.lo.y and Bi.techno.o.y Michael Okpara University of AgricultureUmudikeNigeria Co.lege o.0}Appli.d f.o. Sci.nce and Techno.o.y Michael Okpara University of AgricultureUmudikeNigeria Di.ecto.ate o.1}i.f.rmati.n Co.puter Techno.o.y Michael Okpara University of AgricultureUmudikeNigeria

Hi./Ai.S i. an i.mune def.ci.ncy di.ease, caused by an RNA vi.us (po.i.i.ely charged patho.en). i. i. sti.l bei.g regarded as mysteri.usly i.curable but i. Ni.eri. many pati.nts have been cured (they became Hi.-anti.o.y and anti.en negati.e) by explo.0}i.g electro.tati. attracti.n between patho.ens and o.po.i.e electri.al charges that are o. Nano.arti.les o.4}Medi.i.al syntheti. Alumi.um-magnesi.m si.i.ate (MSAMS) and by usi.g anti.xi.ants to.reli.ve o.i.ati.e stress. To.co.f.rm the cure, as permanent, a pati.nt (adult male) who.e CD4 co.nt i.creased (P f.o. 685 to.820 whi.e hi. vi.al lo.d became undetectable (i.-negati.e (anti.o.y and anti.en) f.llo.i.g the treatment, was tested, every mo.th, po.t treatment, f.r Hi.-anti.o.y. He has remai.ed Hi.-negati.e f.r 10 mo.ths wi.ho.t bei.g o. any anti.etro.i.al medi.i.e (ARV). Lo.gest wi.do. peri.d (peri.d Hi.-i.f.cted perso. may test anti.o.y-negati.e) i. o.ly 6 mo.ths. These results co.f.rm that treatment wi.h the MSAMS and anti.xi.ants no.mali.es i.muni.y and termi.ates Hi.-i.f.cti.ns.

关键词： MSAMS Anti.i.al/Anti.ancer f.atures/Mechani.ms Si.e (Smaller than Vi.uses/Cancer-Cells) Electro.tati.-Bo.di.g i.mune-Sti.ulati.n Ef.i.acy-Enhanci.g

Resto.i.g Ef.i.acy to.Co.ri.o.azo.e, agai.st Resi.tant <i.gt;Salmo.ella pullo.um, </i.gt;wi.h <i.gt;Medi.i.al Syntheti. Alumi.um-Magnesi.m Si.i.ate ®</i.gt;[MSAMS: Al4(Si.4)3+ 3Mg2Si.4→ 2Al2Mg3(Si.4)3]

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Health 2019年第9期11卷 1162-1168页

作者： Madui.e Chi.hi.ra o.wubi.o.Ezei.e Ani.f.o. Emerso. Udo. o.i.geri.f.vo.r onyeachonam i.eo.a Jo. o.bo.na Co.lege o.0}Veteri.ary Medi.i.e Michael Okpara University of Agriculture Umudike Nigeria

To.resto.e ef.i.acy (≥95% i.f.cti.n-reducti.n) to.drugs agai.st resi.tant i.f.cti.ns (no., po.i.g a bi.ger medi.al challenge, glo.ally, than even Hi./Ai.S), Co.ri.o.azo.e was f.rmulated wi.h a syntheti. Alumi.um-magnesi.m si.i.ate (Medi.i.al mi.eral whi.h mo.ecules are made o.0}Nano.arti.les, that i. already i. use as pharmaceuti.al-stabi.i.i.g agent) and used wi.h anti.xi.ants to.treat Co.ri.o.azo.e-resi.tant Salmo.ella pulo.um i.f.cted chi.ks. Chi.k-gro.ps A, B and C were f.d anti.xi.ants-f.rti.0}ed f.ed whi.e gro.ps D, E, f. G and H were no.. The treatment-gro.ps and thei. Co.ri.o.azo.e do.es/f.rmulati.ns were: A and D (100%/MSAMS-Co.ri.o.azo.e);B and E (75%/MSAMS-Co.ri.o.azo.e);C and f.(50%/MSAMS-Co.ri.o.azo.e) and G (100%/Co.ri.o.azo.e). i.f.cti.n-reducti.ns (96.23% and 94.98%) o.0}the gro.ps o.0}75%/MSAMS-Co.ri.o.azo.e/anti.xi.ants and 75%/MSAMS-Co.ri.o.azo.e were si.ni.0}cantly (P ≤ 0.05) better than 76.99% (100%/Co.ri.o.azo.e);10.04% (50%/MSAMS-Co.ri.o.azo.e/anti.xi.ants);1.60% (50%/MSAMS-Co.ri.o.azo.e);&mi.us;212.60% (100%/MSAMS-Co.ri.o.azo.e/anti.xi.ants) and &mi.us;230.96% (100%/MSAMS-Co.ri.o.azo.e).

关键词： Cure f.r Resi.tant i.f.cti.ns Salmo.ello.i. MSAMS

Reduci.g Si.e Ef.ects o.2}Chlo.o.ui.e wi.h <i.gt;Medi.i.al Syntheti. Alumi.um-Magnesi.m Si.i.ate</i.gt;®[Msams: Al4(Si.4)3+ 3Mg2Si.4→2Al2Mg3(Si.4)3] bef.re Assessi.g i.s Anti.Co.i.-19 Ef.i.acy

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Health 2020年第4期12卷 368-377页

作者： Madui.e Ezei.e f.vo.r onyeachonam i.eo.a o.bo.na Clara Akpan Mary Sanda Ekenma Kalu Njo.u Njo.u Munachi.Udo.i.Ugo.hukwu Agu Co.lege o.0}Veteri.ary Medi.i.e M’ichael Okpara University of Agriculture Umudike Nigeria Di.ecto.ate o.1}i.f.rmati.n Co.puter Techno.o.y Michael Okpara University of Agriculture Umudike Nigeria

To.reduce Chlo.o.ui.e’s (CQ) si.e ef.ects, so.that i.creasi.g i.s durati.n f.r anti.Co.i.-19 tri.ls co.ld be saf., the drug was po.enti.ted by stabi.i.i.g i. wi.h Medi.i.al syntheti. Alumi.um-magnesi.m si.i.ate (MSAMS). CQ-treatment f.r f.ve Plasmo.i.m berghi.-i.f.cted mi.e-gro.ps were: 7 mg/kg (no.mal do.e);7 mg/kg (CQ-MSAMS);7 mg/kg (CQ-MSAMS + B-vi.ami.s), 5.25 mg/kg (CQ-MSAMS + B-vi.ami.s) and the co.tro.. Means o.2}parasi.aemi., 42.00 ± 15.74 o.2}the no.mal-do.e gro.p, 37.22 ± 11.88 o.2}the 7 mg/kg (CQ-MSAMS) gro.p and 33.57 ± 12.62 o.2}the 7 mg/kg (CQ-MSAMS + B-vi.ami.s) gro.p sho.ed no.si.ni.0}cant (P ≥ 0.05) reducti.n f.o. 52.50 ± 11.99 o.2}the co.tro., but the 5.25 mg/kg (CQ-MSAMS + B-vi.ami.s) do.e, cleared (P ≤ 0.01) the parasi.eami. (00.00 ± 00.00), sho.i.g that MSAMS-po.enti.ted Chlo.o.ui.e, has best ef.i.acy at 75% o.2}the reco.mended do.e. f.ver and anemi. were absent at that 5.25 mg/kg, suggesti.g that lo.er do.es o.2}CQ have reduced si.e ef.ects.

关键词： Anti.i.al Treatment wi.h Chlo.o.ui.e Lo.er Do.es Reducti.n o. Si.e Ef.ects MSAMS

Prevalence and Characeri.ai.n o.2}<i.gt;Salmo.ella pullo.um</i.gt;f.o. Day o.d Chi.ks Di.tri.uted to.f.rms i. Akwa i.o. State, Ni.eri.

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Health 2019年第12期11卷 1573-1580页

作者： Madui.e Chi.hi.ra o.wubi.o.Ezei.e Ani.f.o. Emerso. Udo. o.i.geli.f.vo.r onyeachonam i.eo.a Jo. o.bo.na Clara Amaka Akpan o.i.nuju Nki.uka o.o.o.f.r Co.lege o.0}Veteri.ary Medi.i.e Michael Okpara University of Agriculture Umudike Nigeria Department o.0}Veteri.ary Medi.i.e University of Nigeria Nsukka Nigeria

To.i.vesti.ate so.rces o.2}Salmo.ella pullo.um i.f.cti.ns that cause f.equent o.tbreaks o.2}baci.lary whi.e di.rrhea i. po.ltry and spo.adi. human f.o. po.0}o.i.g i. Ni.eri., prevalence o.2}the i.f.cti.n amo.g day-o.d-chi.ks i. Akwa-i.o. State, so.th-so.th Ni.eri., was studi.d. f.o. each depo./hatchery, 30 day-o.d chi.ks were rando.ly selected f.r thei. li.ers, spleens, ki.neys, hearts, yo.k sacs and i.testi.es whi.h were pro.essed and cultured o. appro.ri.te bacteri.l medi.. Co.o.i.s that grew f.o. the speci.ens were characteri.ed based o. thei. mo.pho.o.i.s, stai.i.g characteri.ti.s, bi.chemi.al reacti.ns and cultural characteri.ti.s. Gram po.i.i.e i.o.ates that were: sho.t, plum shaped, ro.s, no.-spo.e f.rmi.g and no.-capsulated were i.enti.0}ed as Salmo.ella speci.s. Mo.i.i.y test and bi.chemi.al tests o. the Salmo.ella co.o.i.s i.enti.0}ed tho.e that were S. pullo.um. f.ve percent o.2}chi.ks bei.g di.tri.uted i. Akwa-i.o. State, Ni.eri. were i.f.cted wi.h S. pullo.um, the agent o.2} baci.lary whi.e di.rrhea (whi.h causes hi.h mo.tali.y i. chi.ks) and f.o. po.0}o.i.g i. man.

关键词： Baci.lary Whi.e Di.rrhea f.o. Po.0}o.i.g