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肿瘤预防与治疗 2017年第1期30卷 9-15页

作者： Silvia Chiesa Milena ferro Stef.no Luzi Barbara Diletto f.ancesco Beghella Bartoli Nicola Dinapoli Gian Carlo Mattiucci Vincenzo f.ascino f.ancesco Miccichè Cesare Colosimo Carmelo Anile Alessandro Olivi Vincenzo Valentini Mario Balducci Department of.Radiation Oncology Catholic University of the Sacred HeartL.go A.Gemelli8 00168-RomeItaly Department of.Radiology Catholic University of the SacredHeartL.go A.Gemelli8 00168-RomeItaly Department of.Neurosurgery Catholic Uni-versity of the Sacred HeartL.go A.Gemelli8 00168-RomeItaly

Background/Aim: To assess saf.ty of.hypo-f.actionated radiotherapy( HyRT) f.llowed by low dose radiation therapy( LD-f.T) plus Temozolomide( TMZ) in naive unresectable Glioblastoma. Methods: Patients( ECOG 18) undergone to biopsy or with gross residual tumor af.er surgery were enrolled. HyRT( 30 Gy in ten f.action) plus TMZ was administered. f.om the second adjuvant cycle of.TMZ,patients received LD-f.T( 0. 40 Gy twice daily over 5 days,every 28 days) f.r two cycles. The primary endpoints were saf.ty and toxicity. Moreover we analyzed response,overall survival( OS) and progression-f.ee survival( Pf.). Results: Twenty patients were enrolled. Median dose of.LD-f.T was 12 Gy. All toxicities were reversible. f.ur out of.20 patients had Partial Response( PR)and 6 experienced a stable disease( SD). Median OS and Pf. were 14 and 11 months,***: HyRT f.llowed by LD-f.T plus TMZ is saf. and shows good clinical outcomes. A new study is ongoing.

关键词：胶质瘤恶性肿瘤临床治疗患者

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Ef.S脑静脉和静脉窦血栓形成治疗指南

国际脑血管病杂志 2007年第10期15卷 721-726页

作者： K.Einhupl M.G.Bousser S.f.T.M.de Bruijn J.M.ferro I.Martinelli f.Masuhr J.Stam 董瑞剑孙继洲李湘青 Department of.Neurology CharitéHumboldt-University BerlinBerlinGermany Department of.Neurology H■pital LariboisièreParisFrance Department of.Neurology Haga Hospital The Hague and LUMCLeidenThe Netherlands Department of.Neurology Hospital Santa MariaLisboaPortugal Bianchi Bonomi Hemophilia and Thrombosis Center IRCCS Maggiore HospitalUniversity of MilanMilanItaly f.om the Department of.Neurology CharitéHumboldt-University BerlinBerlinGermany Department of.Neurology Academic Medical Centre AmsterdamAmsterdamThe Netherlands 山东省淄博市中心医院神经内科 255000

脑静脉和静脉窦血栓形成(CVST)是一种相当少见的疾病,仅占所有卒中的不到1%。由于其临床症状谱广且常呈亚急性或迁延起病,因此往往被漏诊或延误诊断。目前在临床实践中采取的治疗措施包括:抗凝药,如剂量调整的静脉肝素或体质量调整皮下... 详细信息

脑静脉和静脉窦血栓形成(CVST)是一种相当少见的疾病,仅占所有卒中的不到1%。由于其临床症状谱广且常呈亚急性或迁延起病,因此往往被漏诊或延误诊断。目前在临床实践中采取的治疗措施包括:抗凝药,如剂量调整的静脉肝素或体质量调整皮下注射低分子肝素(LMWH);溶栓治疗;对症治疗,包括控制癎性发作和降低颅内压。我们通过MEDLINE(美国国立医学图书馆)、Cochrane对照试验注册中心资料库和Cochrane数据库进行了文献检索,对支持这些治疗措施的证据强度进行了评价,并在现有最佳证据基础上制定了CVST治疗的推荐意见。综述性文献和书籍章节内容亦被包括在内。通过共识达成推荐意见。当缺乏证据但能达成明确的共识时,我们将自己的观点表述为良好临床实践要点(GPP)。无抗凝禁忌证的CVST患者应接受体质量调整皮下注射LMWH或剂量调整静脉肝素治疗(GPP)。伴发CVST相关性颅内出血不是肝素治疗的禁忌证。急性期后口服抗凝药的最佳疗程尚不清楚。如果CVST继发于可迅速消退的危险因素,口服抗凝治疗可持续3个月;对于原发性CVST和存在轻度遗传性血栓形成倾向的患者,则需要治疗6～12个月;对于有过≥2次CVST以及有过1次CVST但存在严重遗传性血栓形成倾向的患者,应考虑永久性抗凝治疗(GPP)。尚无充分的证据支持对CVST患者进行全身或局部溶栓治疗。如果充分抗凝治疗后患者仍然出现病情恶化并且排除了其他导致恶化的因素,溶栓治疗可作为一种治疗选择,尤其是对于那些无颅内出血的病例(GPP)。在重症CVST患者中,关于降低增高的颅内压(伴脑组织移位)的某些治疗措施的风险和益处尚无对照资料。抗水肿治疗应作为挽救生命的干预措施,包括过度通气、渗透性利尿药和颅骨切除术(GPP)。

关键词：脑静脉血栓形成诊断肝素治疗转归溶栓

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氧气顶吹转炉熔炼中低碳锰铁

钢铁 1981年第5期16卷 15-20页

作者：张惠棠贾宗生罗定海苏云清北京钢铁研究总院遵义铁合金厂

氧气顶吹转炉熔炼中低碳锰铁的技术关键是“脱碳保锰”。以液态高碳锰铁为原料,在0.8t转炉内吹炼,通过控制熔池温度在1750～1960℃范围内,供氧量为120～180m3/t,炉渣碱度（CaO/SiO2）为1.1～1.2,炼出合碳<1.5％的中低碳锰铁;锰回收率达8... 详细信息

氧气顶吹转炉熔炼中低碳锰铁的技术关键是“脱碳保锰”。以液态高碳锰铁为原料,在0.8t转炉内吹炼,通过控制熔池温度在1750～1960℃范围内,供氧量为120～180m3/t,炉渣碱度（CaO/SiO2）为1.1～1.2,炼出合碳<1.5％的中低碳锰铁;锰回收率达80％以上。与电硅热法生产中低碳锰铁的工艺进行了技术经济比较,看出本工艺的优越性。

关键词：低碳锰铁氧气顶吹转炉吹氧精炼 BOf. 电热法电硅热法炉渣碱度

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血管性认知障碍+急性微梗死=？

中国卒中杂志 2019年第11期14卷 1184-1185页

作者：韩尚容王伊龙 ferro D A VAN DEN BRINK H EXALTO L G 首都医科大学附属北京天坛医院神经病学中心

2019年3月Neurology上发表了一篇探讨脑微梗死与血管性认知障碍临床相关性的研究,题目是“Clinical relevance of.acute cerebral microinf.rcts in vascular cognitive impairment”。1研究介绍1.1研究背景急性微梗死(acute cerebral microinf.rcts,ACMI)为DWI显示的幕上高信号病灶,对应T2*等/高信号,最长直径<5 mm。随着MRI技术的日益先进,在DWI序列上可以清晰观察到大约2周内发生的ACMI。既往研究发现,在脑淀粉样变患者、脑出血患者及记忆门诊患者中更容易观察到ACMI病灶;但ACMI与血管危险因素、认知水平及临床预后的关系尚未被阐明,存在ACMI的患者,其脑脊液生物标志物水平和影像学相关特征尚无定论。

关键词：微梗死性认知微出血灶协变量

Super modules-based active QR codes f.r smart trackability and IoT:a responsive-banknotes case study

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npj f.exible Electronics 2020年第1期4卷 93-101页

作者： João f.C.B.Ramalho Sandra f.H.Correia Lianshe f. Lília M.S.Dias Pedro Adão Paulo Mateus Rute A.S.f.rreira Paulo S.André Department of.Physics and CICECO-Aveiro Institute of.Materials University of Aveiro3810-193 AveiroPortugal Department of.Computer Science and Engineering and Instituto de Telecomunicações Instituto Superior TécnicoUniversidade de Lisboa1049-001 LisbonPortugal Department of.Mathematics and Instituto de Telecomunicações Instituto Superior TécnicoUniversidade de Lisboa1049-001 LisbonPortugal Department of.Electrical and Computer Engineering and Instituto de Telecomunicações Instituto Superior TécnicoUniversidade de Lisboa1049-001 LisbonPortugal

The general use of.smartphones assigns additional relevance to QR codes as a privileged tool to the Internet of.Things(IoT).Crucial f.r QR codes is the evolution to IoT-connected smart tags with enhanced storage capacity and secure *** the concept of.super-modules(s-modules)built f.om adjacent spatial multiplexed modules with regular geometrical shapes,assisted by colour multiplexing,we modelled and design a single QR code with,at least,the triple storage capacity of.an analogous size black/white QR code,acting as a smart-tag ensuring restrict access and *** s-modules are printed using luminescent low-cost and eco-f.iendly inks based on organic-inorganic hybrids modif.ed by lanthanides with multiplexed colour emission in the orthogonal RGB *** access to the restrict inf.rmation is attained only under UV irradiation and encrypted f.r secure *** concept of.active QR codes f.r smart trackability and IoT was materialised through the development of.a f.ee f.iendly-user mobile app.

关键词： IoT smart modules

Characterization of.Virulence f.ctors in Enteroaggregative and Atypical Enteropathogenic Escherichia coli Strains Isolated f.om Children with Diarrhea

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Advances in Inf.ctious Diseases 2012年第4期2卷 135-142页

作者： Thiago Azevedo f.itosa ferro f.ancyelle Costa Moraes Andreia Meneses da Silva Claude Porcy Leandro Amorim Soares Cristina Andrade Monteiro Nyla Thyara Melo Lobao f.ancisco Amazonas Assis de Mello Valério Monteiro-Neto Patrícia de Maria Silva f.gueiredo Research Group of.Endemic and Parasitic Diseases CEUMA UniversitySao LuisBrazil f.deral Institute of.Maranhao Sao LuisBrazil Health and Biological Sciences Center Federal University of MaranhaoSao LuísBrazil

Enteroaggregative (EAEC) and atypical enteropathogenic (EPEC) Escherichia coli are important bacterial etiologic agents causing diarrhea among children. The aim of.the present study was to examine the impact of.virulence f.ctors predisposes to diarrhea. In this study some virulence properties were examined on 11 EAEC and 8 EPEC strains identif.ed by Polymerase Chain Reaction (PCR), isolated f.om stool samples of.children were analyzed genotypically and phenoltypically f.r the prevalence of.virulence f.ctors. The most f.equently detected f.ctor was resistance to serum (94%), f.llowed by curli f.mbriae (78%), biof.lm production (73%), and gene coding f.r Extended-Spectrum Beta-Lactamase (ESBL) (68%). EPEC isolates showed at least three of.the evaluated properties, while EAEC isolates showed at least two. The prevalence of.these virulence f.ctors between the two strains showed no statistical dif.erence. This study showed the heterogeneity of.the virulence prof.le of.the isolates of.EAEC and atypical EPEC strains and suggests that this diversity may inf.uence in the disease severity.

关键词： E.coli Diarrhea Virulence f.ctors

Hydrogen sulf.de induces keap1 S-sulf.ydration and suppresses diabetes-accelerated atherosclerosis via Nrf.activation

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Hydrogen sulfide induces keap1 S-sulfhydration and suppresse...

第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Xie Liping Gu Yue Wen Mingliang Zhao Shuang Wang Wan Meng Guoliang Wang Yuhui Liu George Moore Philip K. Wang Xin Wang Hong ferro Albert Huang Zhengrong Ji Yong Nanjing Medical University Peking University Health Science Center National University of.Singapore University of.Manchester Temple University School of.Medicine King's College London The f.rst Af.iliated Hospital of.Xiamen University

Hydrogen sulf.de（H S） has been shown to have powerf.l anti-oxidative and anti-inf.ammatory properties which can regulate multiple cardiovascular ***,its precise role in diabetesaccelerated atherosclerosis remains **... 详细信息

关键词： Hydrogen sulf.de induces keap1 S-sulf.ydration and suppresses diabetes-accelerated atherosclerosis via Nrf.activation

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富锰渣冶炼烟尘的综合利用

化学学报 1975年第2期 91-100页

作者： COMPREHENSIVE UTILIZATION WORKSHOP (Shanghai ferro-Alloy Works) GRADUATE PRACTICE GROUP Of.WORKER-PEASANT-SOLDIER STUDENTS AND TEACHERS Of.RARE ELEMENT CHEMISTRY SPECIALITY (f. Tan University) 上海铁合金厂综合利用车间复旦大学稀有元素化学专业工农兵学员毕业实践小组

本试验提出了一个从富锰渣冶炼烟尘中回收某些有价值元素的湿法冶炼工艺。首先烟尘直接用硫酸处理,然后通过控制适当的pH,锌锰被沉淀分离开来。最后,把它们转化为相应的硫酸盐和碳酸盐。在烟尘中的微量元素如镓、铟、铊等是通过萃取法... 详细信息

本试验提出了一个从富锰渣冶炼烟尘中回收某些有价值元素的湿法冶炼工艺。首先烟尘直接用硫酸处理,然后通过控制适当的pH,锌锰被沉淀分离开来。最后,把它们转化为相应的硫酸盐和碳酸盐。在烟尘中的微量元素如镓、铟、铊等是通过萃取法分别提取的。试验表明,辛醇-(2)和N,N-二(1′-甲基庚基)乙酰胺是有效的萃取剂。

关键词：价值元素金属离子沉淀分离低酸度辛醇一元醇反萃剂三烷基胺稀散元素分散元素 NaOH 富锰渣冶金渣

本校近期发表If.4．0的SCI论文摘要（英文）——Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity

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南京医科大学学报（自然科学版） 2009年第9期29卷 1281-1281页

作者： Xie Liping Liu Zhen Ji Yong O'Kane Peter Jackson Graham Queen Lindsay ferro Albert Nanjing Med Univ Atherosclerosis Res Ctr Key Lab Human Funct Genom Nanjing 210029 Peoples R China Guys & St Thomas NHS f.n Trust Dept Cardiol London England Kings Coll London Div Cardiovasc Dept Clin Pharmacol London SE1 9NH England.

Aims Acute administration of.aspirin increases nitric oxide (NO) synthesis by platelets, an ef.ect not shared by other non- steroidal anti-inf.ammatory drugs. The aim of.the present study was to determine the mechanism by which aspirin acutely increases the activity of.NO synthase type 3 (NOS-3), the predominant NOS isof.rm expressed by platelets, and specif.cally whether this occurs through an increase in its acetylation. Methods and results Platelets isolated f.om the blood of.healthy human subjects were exposed in vitro to vehicle or aspirin at dif.erent concentrations (5 mu mol/L-4 mmol/L). Changes in intraplatelet Ca^2+ concentration were determined f.om f.ra-2 f.uorescence. f.llowing immunoprecipitation of.NOS-3 f.om platelet lysates, its activity was determined f.om L-[H-3]arginine to L-[H-3 ]citrulline conversion, and its serine phosphorylation quantif.ed by western blotting. Acetylatiou of.NOS-3 in platelets was assessed by the incorporation of.radioactivity into the immunoprecipitated enzyme f.om [acetyl-C-14] aspirin. f.llowing transf.ction of.HeLa cells with NOS-3, NO biosynthesis in response to aspirin was determined f.om cyclic GMP measurement, and sites of.NOS-3 acetylation were ascertained by liquid chromatography-tandem mass spectrometry. At all concentrations tested, aspirin increased the activity of.NOS-3 f.om platelets. This was not associated with any measurable change in intraplatelet Ca2+ concentration. Serine phosphorylation of.NOS-3 in platelets was decreased, and this was especially marked f.r serine-1177 phosphorylation, whereas acetylation of.NOS-3 was increased, by aspirin incubation. HeLa ceils transf.cted with NOS-3 exhibited an increase in NO biosynthesis f.llowing aspirin exposure, and this was associated with acetylation of.the enzyme on both serine-765 and serine-771. Conclusion Aspirin acetylates NOS-3 acutely in platelets, and this causes an increase in its activity as well as a decrease in its phosphorylation. It is also possibl

关键词：阿司匹林氧化氮合酶血小板活性抗生素

原因不明的脑卒中患者心房纤维化增加:心脏磁共振成像研究

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中华高血压杂志 2018年第3期26卷 252-252页

作者：刘莉叶鹏 f.nseca AC Alves P Inácio N Marto JP Viana-Baptista M Pinho-E-Melo T ferro JM Almeida AG

一些被归类为原因不明的缺血性脑卒中患者可能有左心房和左心耳结构或功能的改变,增加了他们的血栓栓塞风险。该研究使用心脏磁共振成像比较不同病因的缺血性脑卒中患者的左心房和左心耳结构及功能。研究人员前瞻性连续纳入缺血性脑卒... 详细信息

一些被归类为原因不明的缺血性脑卒中患者可能有左心房和左心耳结构或功能的改变,增加了他们的血栓栓塞风险。该研究使用心脏磁共振成像比较不同病因的缺血性脑卒中患者的左心房和左心耳结构及功能。研究人员前瞻性连续纳入缺血性脑卒中患者样本。

关键词：心脏磁共振成像脑卒中患者原因不明心房纤维化缺血性脑卒中左心房血栓栓塞患者样本