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Role of.nuclear f.ctor kappa B in central nervous system regeneration

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Neural Regeneration Research 2014年第7期9卷 707-711页

作者： Christian engelmann f.lk Weih Ronny Haenold Leibniz Institute f.r Age Research-f.itz Lipmann Institute

Activation of.nuclear f.ctor kappa B （Nf.κB） is a hallmark of.various central nervous system （CNS） pathologies. Neuron-specif.c inhibition of.its transcriptional activator subunit RelA, also ref.rred to as p65, promotes neuronal survival under a range of.conditions, i.e., f.r ischemic or excitotoxic insults. In macro- and microglial cells, post-lesional activation of.Nf.κB triggers a growth-permissive program which contributes to neural tissue inf.ammation, scar f.rmation, and the expression of.axonal growth inhibitors. Intriguingly, inhibition of.such inducible Nf.~B in the neuro-glial compartment, i.e., by genetic ablation of.RelA or overexpression of.a trans- dominant negative mutant of.its upstream regulator IκBa, signif.cantly enhances f.nctional recovery and promotes axonal regeneration in the mature CNS. By contrast, depletion of.the Nf.κB subunit p50, which lacks transcriptional activator f.nction and acts as a transcriptional repressor on its own, causes precocious neuronal loss and exacerbates axonal degeneration in the lesioned brain. Collectively, the data imply that Nf.κB orchestrates a multicellular pro- gram in which κB-dependent gene expression establishes a growth-repulsive terrain within the post-lesioned brain that limits structural regeneration of.neuronal circuits. Considering these subunit-specif.c f.nctions, interf.rence with the Nf.κB pathway might hold clinical potentials to improve f.nctional restoration f.llowing traumatic CNS injury.

关键词： nuclear f.ctor kappa B RelA p65 p50 central nervous system injury axonal regeneration neural regeneration

Clinical practice guidelines f.r acute-on-chronic liver f.ilure: are we ready f.r reaching global consensus?

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 239-243页

作者： Cornelius engelmann Thomas Berg Department of.Hepatology and Gastroenterology CharitéUniversitätsmedizin BerlinBerlinGermany Division of.Hepatology Department of Medicine IILeipzig University Medical CenterLeipzigGermany Berlin Institute of.Health(BIH) BerlinGermany University College London Institute for Liver and Digestive HealthLondonUK

The concept of.acute-on-chronic liver f.ilure(ACLf.has gained increasing awareness during the last *** considers liver cirrhosis as a systemic disease where precipitating events lead to a sudden deterioration,decompensation and extrahepatic organ *** severity is determined by the number and types of.organ f.ilures and patients with ACLf.have a distinct and worse prognosis than patients with acute decompensation but not f.lf.lling ACLf.criteria(1-3).

关键词： Acute-on-chronic liver f.ilure(ACLf. granulocyte-colony stimulating f.ctor(G-CSf. cirrhosis

Dif.erential diagnosis in patients with suspected bile acid synthesis def.cts

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World Journal of.Gastroenterology 2012年第10期18卷 1067-1076页

作者： Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido engelmann Maura Heverin David W Russell Peter T Clayton Georg f.Hof.mann Jürgen G Okun Department of.General Pediatrics Division of Inborn Metabolic Diseases University Children's Hospital Heidelberg D-69120 Germany Department of.Pediatric Endocrinology and Diabetology University Hospital Saarland Homburg D-66421 Germany Department of.General Pediatrics Gastroenterology University Children's Hospital Heidelberg D-69120 Germany Karolinska Institut Karolinska University Hospital Huddinge Huddinge 14186 Sweden Department of.Molecular Genetics UT Southwestern Medical Center Dallas TX 75390-9046 United States Clinical and Molecular Genetics Unit Institute of Child Health London WC1N 1EH United Kingdom

AIM: To investigate the clinical presentations associated with bile acid synthesis def.cts and to describe identif.cation of.individual disorders and diagnostic pitf.lls. METHODS: We describe semiquantitative determination of.16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was perf.rmed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected def.cts in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were f.und in 36 patients. Two patients had bile acid synthesis def.cts but presented with atypical presentations. In 2 other patients who were later shown to be af.ected by biliary atresia and cystic f.brosis the prof.le of.bile acid metabolites was initially suggestive of.a bile acid synthesis def.ct. Three adult patients suf.ered f.om cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of.other cause. CONCLUSION: Screening f.r urinary cholanoids should be done in every inf.nt with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specif.c therapy.

关键词： Cholestatic liver disease Bile acid synthesis def.cts Biliary atresia Electrospray-ionization tandemmass-spectrometry

Human Rights and Nanotechnologies： Limits and Possibilities Between Technological Innovation and Rights of.the Human

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Sociology Study 2011年第2期1卷 101-114页

作者： Wilson engelmann University of.the Sinos Valley Rio Grande do Sul Brazil

Nanotechnology currently represents one of.the most f.scinating human discoveries. With creativity, nanotechnology looks f.r increasingly smaller spaces in nature to meet the needs and interests of.the individuals and of.the society. Considering that the researches aim to create techniques to move and combine atoms and molecules, a question arises, how will these atoms and molecules behave in the new arrangement. This is the great challenge and this article attempts to bring some benef.ts to the subiect. It also intends to bring the human sciences, particularly law, to the scenery of.this scientif.c revolution. The lack of.regulatory f.ameworks does not allow humans to search and produce anything without limits. Thus, human rights should be considered an ethical f.undation f.r nanotechnology discoveries, as they represent the ＂rights＂ that, at least, humans should have respected.

关键词： Human rights nanotechnology regulatory f.ameworks risks environment

Ef.ect of.24-Epibrassinolide on Growth of.in VitroShoot Tips of.Dif.erent Yam (DioscoreaSpp.) Species

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American Journal of.Plant Sciences 2013年第11期4卷 2271-2274页

作者： Isabelle engelmann-Sylvestre f.orent engelmann IRD UMR DIADE Agropolis Montpellier France

In this work we compared the ef.ect of.the growth regulator content of.the culture medium on the growth of.in vitro shoot tips of.f.ve yam accessions belonging to f.ur yam species (one Dioscorea alata, one D. rotundata, one D. cayenensis and two D. trif.da). Medium S contained 0.6 μM benzyl adenine, 1.07 μM naphthalene acetic acid and 0.23 μM gibberellic acid while medium EBR contained 0.23 μM gibberellic acid and 0.1 μM 24-epibrassinolide. Af.er 2 months of.culture, oxidation level was signif.cantly reduced on medium EBR compared to medium S f.r f.ur of.the f.ve accessions tested. By contrast, medium EBR did not have any positive ef.ect on shoot length since length of.shoots produced af.er 2 months of.culture on medium S and EBR were similar, except with accession 3-45T, f.r which shoot length was shorter on medium S compared to medium EBR. These results underline the potential of.24-epibrassinolide to reduce oxidation phenomena during in vitro culture and call f.r its utilization f.r regeneration of.cryopreserved yam shoot tips, which is of.en impeded by oxidation phenomena.

关键词： Yam Dioscorea Spp. 24-Epibrassinolide Oxidation Shoot Tip In Vitro Culture Cryopreservation

Improved spontaneous erectile f.nction in men with mild-tomoderate arteriogenic erectile dysf.nction treated with a nightly dose of.sildenaf.l f.r one year： a randomized trial

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Asian Journal of.Andrology 2007年第1期9卷 134-141页

作者： f.ank Sommer Theodor Klotz Udo engelmann Department of.Men＇s Health University Medical Center Hamburg-Eppendorf Hamburg 20214 Germany Department of.Urology University Medical Center Hamburg-Eppendorf Hamburg 20214 Germany Department of.Urology Klinikum Weiden Weiden 92637 Germany Department of.Urology University of Cologne Cologne 50924 Germany

Aim： To test the hypothesis that sildenaf.l （50 mg nightly f.r one year） can improve spontaneous erectile f.nction （Ef. in men with mild-to-moderate arteriogenic erectile dysf.nction （ED） responsive to erectogenic treatment. Methods： In a prospective open-label trial, 112 men with ED were randomized to sildenaf.l 50 mg nightly or sildenaf.l 50 or 100 mg as needed f.r 12 months, f.llowed by one-month and 6-month non-medicated periods. Non-randomized, non-medicated men with ED were also assessed. The Ef.domain of.the International Index of.Erectile f.nction （IIEf.Ef. and the peak systolic velocity （PSV） of.penile cavernous arteries were used to measure the ef.icacy. Results： Af.er sildenaf.l treatment and a subsequent non-medicated month, IIEf.Ef.was normal in 29 of.48 （60.4%, 95% conf.dence interval [CI]： 45.3-74.2%） of.the nightly group vs. 4 of.49 （8.2%, 95% CI： 2.3-19.6%） of.the as-needed group. PSV improved by 11.2 cm/s （95% CI： 4.7-21.4; P = 0.012） in the nightly group but only by 3.4 cm/s （-5.1- 14.7; P = 0.435） in the as-needed group. IIEf.Ef.normalized in 1 of.18 （5.6%, 95% CI： 0.1-27.3%） non-medicated men and the PSV declined slightly. Six months af.er treatment, the IIEf.Ef.remained normal and PSV was stabilized in most （28/29, 97%） nightly group men who had initially normalized. Conclusion： Sildenaf.l nightly f.r one year resulted in ED regression that persisted well beyond the end of.treatment, so that spontaneous Ef.was characterized as normal on the IIEf.in most men. The results f.om this open-label, randomized trial warrant verif.cation under double-blind, placebo-controlled conditions.

关键词： phosphodiesterase sexual dysf.nctions psychological sildenaf.l citrate erectile f.ncion

Metal Complexes:Novel Chiral Dopants with High Helical Twisting Power in Liquid Crystals

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复旦学报（自然科学版） 2007年第5期46卷 724-725页

作者： Manf.ed Braun R.f.eischer A.Hahn M.engelmann S.Schlecht Institute of.Organic and Macromolecular Chemistry University of DuesseldorfD-40225 DuesseldorfGermany

1 Introduction A particularly ef.icient and elegant route to chiral mesophases is based on the addition of.small amounts of.an enantiomerically pure dopant to a nematic phase so that the latter is converted into a cholesteric phase(See f.g.1).f.g.1 A nematic phase is converted into a cholesteric phase f.g.2 Bis-chelated imine-alkoxy-titanium complexes2 ExperimetalBis-chelated imine-alkoxy-titanium complexes like 1 and 2 (f.g.2) have been synthesizedstarting f.om triphenyl-substituted aminoethanols, T...

关键词： metal complexes novel chiral dopants liguid crystals

Cautious *** Little Threat f.om Euro

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当代外语研究 1999年第1期 15-16页

作者： Knut engelmann 沈默

欧元伴随1999年新年钟声而诞生。她在世界各地的国际外汇交易市场的亮相的消息成为新闻传媒的一个亮点。1999年1月4日上海一家大报的头条新闻是:上海金融界“欧元总动员”。打开1999年1月5日清晨的Internet,首先映入眼帘的消息是:欧元... 详细信息

欧元伴随1999年新年钟声而诞生。她在世界各地的国际外汇交易市场的亮相的消息成为新闻传媒的一个亮点。1999年1月4日上海一家大报的头条新闻是:上海金融界“欧元总动员”。打开1999年1月5日清晨的Internet,首先映入眼帘的消息是:欧元闪亮登场,美元不见惊慌。这篇文章写得精彩,信息丰富。美元,在本文称为“the worl’s most sought-af.er reserve currency”,对于欧元的面世,自然别有一番滋味在心头。这种微妙的心情在本文表现得淋漓尽致。当然,在种种复杂的情绪中,文章披露的两条倒也不无道理: 1....Europe might turn its back on(不理睬)Problems elsewhere in theworld economy as it concentrates on making its unprecedented currency unionwork. 2....the f.cus on the euro must not def.ect(使偏斜)f.om structuralref.rms to reduce sky-high unemployment rates m much of.Europe. 美国人的担心(The euro will start to challenge the dollar as the world’slead currency)是否会成为现实,何时会成为现实。国人尚须拭目以待。现在就下结论,未免为时过早。此外,本文有几处措辞极为成功,读者不妨细读慢赏。】

关键词： Cautious U.S.Sees Little Threat f.om Euro

Addressing the Negative Self.Concept in Posttraumatic Stress Disorder by a Three-Session Programme of.Cognitive Restructuring and Imagery Modif.cation (CRIM-PTSD): A Case Study

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Journal of.Behavioral and Brain Science 2018年第5期8卷 319-327页

作者： Meike Müller-engelmann Kerstin Hadouch Regina Steil Department of.Clinical Psychology and Psychotherapy Institute of Psychology Goethe University Frankfurt Main Frankfurt/Main Germany

Background: Cognitive restructuring and imagery modif.cation f.r posttraumatic stress disorder (CRIM-PTSD) is a new intervention that involves only three sessions and f.cuses on the self.concept. It combines cognitive restructuring of.core trauma-related dysf.nctional belief. and mental imagery. The ef.ectiveness of.CRIM-PTSD has recently been demonstrated in a pilot study. Method: This article presents a step-by-step description of.the administration of.CRIM-PTSD in a f.male survivor of.childhood sexual abuse (CSA) suf.ering f.om PTSD and major depressive disorder related to strong self.blame. Results: The intervention showed substantial reductions in PTSD symptoms and depression in the patient comparable to those observed in the pilot study. Conclusions: CRIM-PTSD might provide an economical tool f.r reducing PTSD symptoms when only a short time is available f.r intervention. f.rthermore, this tool could be included in well-established PTSD treatments. In addition to the pilot study, a randomized controlled trial is needed to f.rther explore the f.asibility and ef.ectiveness of.this short intervention.

关键词： Posttraumatic Stress Disorder Cognitive Restructuring Imagery Self.Concept