检索结果-南通市图书馆

Python Server Page Perf.rmance Analysis and Modeling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications and Network 2024年第1期16卷 1-30页

作者： Razaf.ndraibe Marolahy Alix Randrianomenjanahary Lala f.rdinand Raf.mantanantsoa f.ntaine Mahatody Thomas f. Angelo Raherinirina University of.f.anarantsoa Fianarantsoa Madagascar

Today, in the f.eld of.computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself.Apache. The number of.solutions f.r this server is theref.re growing continuously, these services are becoming more and more complex and expensive, without being able to f.lf.ll the needs of.the users. The absence of.benchmarks f.r websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of.access to inf.rmation on the Internet. This is why the perf.rmance of.the web server is critically important. Several f.ctors inf.uence perf.rmance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these f.ctors, we propose a perf.rmance evaluation strategy f.r servers that allows us to determine the actual perf.rmance of.dif.erent servers in terms of.user satisf.ction. f.rthermore, we identif.ed perf.rmance characteristics such as throughput, resource utilization, and response time of.a system through measurement and modeling by simulation. f.nally, we present a simple queue model of.an Apache web server, which reasonably represents the behavior of.a saturated web server using the Simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traf.ic. We obtain server perf.rmance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightf.rward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Perf.rmance Analysis Queue Perf.rmance Model Web Server Internet World Wide Web Web Server Perf.rmance

Linking IL-10 signaling with lipid metabolic programs in macrophages:dysregulated ceramide homeostasis drives colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 2835-2836页

作者： Imke Atreya Markus f.Neurath Department of.Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immuntherapie(DZI) ErlangenGermany

In a recent study published in Nature,York and coworkers identif.ed the immunometabolic regulation of.mono-unsaturated f.tty acid(MUf.)pools and the subsequent increase in sphingolipid biosynthesis in TLR2-activated macrophages as an important link between impaired IL-10 signaling and the development of.intestinal inf.ammation.1 Thus,targeted interf.rence with the newly identif.ed IL-10/MUf./sphingolipid axis appears as a promising strategy to restore immunometabolic homeostasis in the intestine of.patients with inf.ammatory bowel diseases(IBD).

关键词： homeostasis impaired intestine

Endoplasmic reticulum stress,autophagy,neuroinf.ammation,and sigma 1 receptors as contributors to depression and its treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika f.jii Charles f.Zorumski Yukitoshi Izumi Department of.Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor f.mily Institute f.r Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological f.ctors contributing to depression and other neuropsychiatric disorders are largely undef.ned. Endoplasmic reticulum stress pathways and autophagy are well-def.ned mechanisms that play critical f.nctions in recognizing and resolving cellular stress and are possible targets f.r the pathophysiology and treatment of.psychiatric and neurologic illnesses. An increasing number of.studies indicate the involvement of.endoplasmic reticulum stress and autophagy in the control of.neuroinf.ammation, a contributing f.ctor to multiple neuropsychiatric illnesses. Initial inf.ammatory triggers induce endoplasmic reticulum stress, leading to neuroinf.ammatory responses. Subsequently, induction of.autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinf.ammation. The aim of.this review is to summarize our current understanding of.the molecular mechanisms governing the induction of.endoplasmic reticulum stress, autophagy, and neuroinf.ammation in the central nervous system. Studies f.cused on innate immune f.ctors, including neurosteroids with anti-inf.ammatory roles will be reviewed. In the context of.depression, animal models that led to our current understanding of.molecular mechanisms underlying depression will be highlighted, including the roles of.sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinf.ammation.

关键词： allopregnanolone f.uvoxamine ketamine neurosteroids postpartum depression quercetin

Item-Level Analysis of.the Revised Occupational Therapy f.eldwork Perf.rmance Evaluation Applied in Practice

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of.Therapy and Rehabilitation 2024年第2期12卷 145-159页

作者： Cynthia L. Sears Brad E. Egan Patricia f. Tomsic Craig A. Velozo Graduate College of.Health Prof.ssions Occupational Therapy Program Hawai&#8217i Pacific University Honolulu HI USA College of.Science and Health Occupational Therapy Program DePaul University Chicago IL USA Department of.Occupational Therapy Wingate University Wingate NC USA College of.Health Prof.ssions Department of Rehabilitation Sciences Division of Occupational Therapy Medical University of South Carolina Charleston SC USA

Competency-based assessments f.r healthcare prof.ssionals are critical f.r saf. and ef.ective client outcomes. Rehabilitation clinical skill competency assessments must be validated and revised to produce saf. and skilled practitioners. The revised American Occupational Therapy Association (AOTA) f.eldwork Perf.rmance Evaluation (f.PE) instrument measures occupational therapy student perf.rmance to determine readiness f.r practice. The assessment includes thirty-seven competencies that address both prof.ssion specif.c clinical skills and general prof.ssional behavior skills. The objective of.this study was to use Rasch methods to explore the use of.the revised f.PE in actual f.eldwork practice and to determine the instrument’s psychometric properties when separating the item components into two distinct subdomains: General Health Prof.ssions Competences and Occupational Therapy-Specif.c Competencies. Internal construct validity and test reliability were analyzed using data f.om 149 occupational therapy students af.er completing their initial Level II A f.eldwork clinical internship. This study examined the item dif.iculty hierarchy, item f.t, person-f.t to model, person separation index, person separation reliability coef.icient, strata, ceiling and f.oor ef.ect, and unidimensionality of.the f.PE instrument as a whole and as two separate domains. With the exception of.not meeting the criteria f.r unidimensionality, the f.ll f.PE instrument and the Occupational Therapy-Specif.c Competencies subdomain showed acceptable item-level psychometrics f.r reliability and precision. While the General Health Prof.ssions Competencies subdomain showed good item-level psychometrics, it was below the criterion f.r reliability and only separated the sample into two strata. Results support the validity, reliability, and clinical use of.the revised f.PE f.ll instrument and the Occupational Therapy-Specif.c Competencies subdomain to measure entry-level clinical skill competencies in pr

关键词： Rehabilitation Competency-Based Assessments Occupational Therapy Measurement Rasch Analysis

Evolution of.Mother-to-Child HIV-1 Transmission Rate in Mali f.om 2009 to 2018

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Microbiology 2024年第5期14卷 256-267页

作者： Alou Sanogo Mohamed Ag Baraïka Maïga Aminata Demba Koita Mahamadou Abdou Mamadou Guindo Clémentine N’Diaye f.toumata Namoudou traoré Abdoulaye Bagayoko Youssouf.Diallo f.abou Bougoudogo Ibrehima Guindo National Institute f.r Public Health Bamako Mali f.culty of.Pharmacy (f.PH) University of Science of Technical and Technology de Bamako Bamako Mali University Hospital Center (CHU)-Point G Bamako Mali f.culty of.Medecine and Odonto-Stomatology University of Science of Technical and Technology de Bamako Bamako Mali Sector Unit f.r the f.ght against AIDS Tuberculosis and Hepatitis Bamako Mali UNICEf.(United Nations Children’ s Fund) Bamako Mali

Despite enormous ef.orts to achieve the goal of.eliminating mother-to-child transmission of.HIV-1, it remains a major challenge f.r many countries in sub-Saharan Af.ica, particularly Mali. Our objective is to assess changes in the rate of.mother-to-child transmission of.HIV-1. We conducted a cross-sectional study between January 1, 2009 to December 31, 2018 (10 years) of.early diagnosis activity in newborns and children born to HIV-1-positive mothers at the National Institute f.r Public Health (INSP). The samples came f.om health and ref.rral centers in mali. All samples were received at the Laboratory of.Molecular Biology at the INSP. Proviral DNA extraction was perf.rmed f.om a blood spot sample with a Roche DNA kit, Cobas AmpliPrep/Cobas TaqMan HIV-1 qualitative Test, V2.0 (Roche Molecular System, Inc, USA) f.llowing the company procedures. Molecular diagnosis was perf.rmed using the same kits using an algorithm of.three identical PCRs. The Epi Inf. version 7 sof.ware was used f.r data analysis with a signif.cance threshold of.5%. A total of.10,714 samples of.inf.nts and children born to HIV-positive mothers were analyzed by PCR. Ninety-six percent of.mothers were on ARV prophylaxis (AZT 3TC NVP and AZT NVP) and 60% of.newborns received the same ARV prophylaxis. Of.these children, 956 tested positive with an overall transmission rate of.8.92%, varying between 7.27% in 2009 and 08.01% in 2018. This rate was relatively low among children receiving prophylaxis at 2.04% and remained high f.r children who received breastf.eding at 5.62%. However, the transmission rate remains low f.r those who have benef.ted f.om mixed and artif.cial breastf.eding at 1.58% and 1.27% respectively. A signif.cant proportion of.children remained inf.cted by their mothers during pregnancy, childbirth or breastf.eding. This study shows the importance of.early diagnosis of.HIV in children using molecular technology.

关键词： Early Diagnosis Mothers-to-Child Newborns PCR DNA HIV-1

Understanding the neighborhoods’in-between spaces on spatial perception,social interaction,and security

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

f.ontiers of.Architectural Research 2024年第1期13卷 21-36页

作者： Lizeth f.lix Mariel Organista Autonomous University of.Baja Calif.rnia Ensenada 22860Mexico

This study ref.ects on the impact that the neighborhoods’in-between spaces have on:spatial perception,social interaction,and *** sites,characterized by their abandonment and deterioration,can also be seen as crucial spaces of.opportunity f.r cities,in the architectural,urban and landscape *** paper aims to analyze the sociospatial relationships in the neighborhoods’in-between spaces and examine the impact of.inbetween space conf.guration on urban *** investigation draws on a survey of.perception to residents about the requirements f.r a suitable social interaction in these *** study was developed in a neighborhood in the city periphery,characterized by their social dynamics and location in a nature conservation *** f.ndings indicate that the appropriation process,activities,and collective practices are dependent on the spatial legibility,in this case when this increases,gives rise to improve the habitability and the rehabilitation of.the in-between ***,the lack of.design on in-between spaces substantially af.ects the use of.these spaces and the social interaction among residents.

关键词： In-between spaces Socio-spatial relationships Habitability Neighborhoods Security

Enhancing Precision in Radiotherapy Delivery: Validating Monte Carlo Simulation Models f.r 6 MV Elekta Synergy Agility LINAC Photon Beam Using Two Models of.the GAMOS Code

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of.Nuclear Science and Technology 2024年第2期14卷 146-163页

作者： Nogaye Ndiaye Oumar Ndiaye Papa Macoumba f.ye Kodjo Joël f.brice N’Guessan Djicknack Dione Khady Sy Moussa Hamady Sy Jean Paul Latyr f.ye Alassane traoré Ababacar Sadikhe Ndao Institute of.Applied Nuclear Technology University Cheikh Anta Diop Dakar Senegal International Cancer Center of.Dakar Dakar Senegal Department of.Physics Faculty of Sciences and Technology University Cheikh Anta Diop Dakar Senegal

The most crucial requirement in radiation therapy treatment planning is a f.st and accurate treatment planning system that minimizes damage to healthy tissues surrounding cancer cells. The use of.Monte Carlo toolkits has become indispensable f.r research aimed at precisely determining the dose in radiotherapy. Among the numerous algorithms developed in recent years, the GAMOS code, which utilizes the Geant4 toolkit f.r Monte Carlo simula-tions, incorporates various electromagnetic physics models and multiple scattering models f.r simulating particle interactions with matter. This makes it a valuable tool f.r dose calculations in medical applications and throughout the patient’s volume. The aim of.this present work aims to vali-date the GAMOS code f.r the simulation of.a 6 MV photon-beam output f.om the Elekta Synergy Agility linear accelerator. The simulation involves mod-eling the major components of.the accelerator head and the interactions of.the radiation beam with a homogeneous water phantom and particle inf.rmation was collected f.llowing the modeling of.the phase space. This space was po-sitioned under the X and Y jaws, utilizing three electromagnetic physics mod-els of.the GAMOS code: Standard, Penelope, and Low-Energy, along with three multiple scattering models: Goudsmit-Saunderson, Urban, and Wentzel-VI. The obtained phase space f.le was used as a particle source to simulate dose distributions (depth-dose and dose prof.le) f.r f.eld sizes of.5 × 5 cm2 and 10 × 10 cm2 at depths of.10 cm and 20 cm in a water phantom, with a source-surf.ce distance (SSD) of.90 cm f.om the target. We compared the three electromagnetic physics models and the three multiple scattering mod-els of.the GAMOS code to experimental results. Validation of.our results was perf.rmed using the gamma index, with an acceptability criterion of.3% f.r the dose dif.erence (DD) and 3 mm f.r the distance-to-agreement (DTA). We achieved agreements of.94% and 96%, respective

关键词： GAMOS Monte Carlo LINAC Radiotherapy Dose Distribution Phase Space Gamma Index 6 MV Photon Beam

Phytochemical Analysis and Antimicrobial Activity of.Lawsonia inermis Leaf.Extracts f.om Burkina f.so

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of.Plant Sciences 2024年第7期15卷 552-576页

作者： Ollo Youl Soumaïla Konaté Ernest N. Sombié Rainatou Boly Boukaré Kaboré Moumouni Koala Arouna Zoungrana Saybou Savadogo Christian Marc Tahita Innocent Valea Halidou Tinto Adama Hilou Maminata traoré-Coulibaly Laboratoire de Biochimie et de Chimie Applique (LABIOCA) Universit de Ouagadougou Ouagadougou Burkina Faso Agence Nationale Pour la Scurit Sanitaire de lEnvironnement de lAlimentation du Travail et des Produits de Sant (ANSSEAT) Ouagadougou Burkina Faso Laboratoire de Recherche-Dveloppement de Phytomdicaments et Mdicaments (L-RD/PM) Institut de Recherche en Sciences de la Sant (IRSS-CNRST) Ouagadougou Burkina Faso Laboratoire de Chimie Organique et de Physique Applique (LCOPA) cole Doctorale Sciences et Technologie Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Laboratoire Sciences de la Vie et de la Terre (LASVT) cole Doctorale Sciences et Technologie Universit Norbert ZONGO Koudougou Burkina Faso Unit de Recherche Clinique de Nanoro Institut de Recherche en Sciences de la Sant (IRSS-CNRST) Nanoro Burkina Faso

Lawsonia inermis is a hairless plant growing in various regions of.North Af.ica, the Indian subcontinent, and the Middle East. It possesses many medicinal attributes, including curative properties against inf.ctious dermatoses. This study was carried out to evaluate the phytochemical prof.le of.the crude ethanolic extract of.the plant leaves and its f.actions as well as their antimicrobial activities. The phytochemical prof.le was perf.rmed using high-perf.rmance thin-layer chromatography (HPTLC), gas chromatography-mass spectrometry (GC-MS), and high-perf.rmance liquid chromatography (HPLC). Additionally, the phenolic and f.avonoid contents were determined using the f.lin-Ciocalteu spectrophotometric and the aluminum trichloride methods. Antimicrobial activity was tested using disc dif.usion and microdilution methods. The presence of.f.avonoids, tannins, sterols, and triterpenes was revealed. GC-MS detected twelve compounds main compounds consisting of.saturated and unsaturated f.tty acids and phenolic and terpenoid compounds among twenty-seven components. HPLC also detected high contents of.phenolic acids and f.avonoids. The most abundant triterpene and sterols were ursolic acid (around 43.14 g/100g DW, 13.9 g/100g dry weight (DW), and 0.68 g/100g DW) in the crude ethanolic extract of.leaves (f.Li), hexane f.action (f.Li) and dichloromethane f.action (f.Li), respectively and, β-sitosterol in f.Li (56.7 mg/100g DW), f.Li (10.55 g/100g DW), f.Li (106.1 mg/100g DW) and butanol f.action (f.Li) (357.4 mg/100g DW). Among the f.avonoids, rutin = 3.24 g/100g and quercetin = 0.63 g/100g in the ethanolic extract, rutin = 15.73 g/100g in the dichloromethane f.action, and rutin = 0.23 g/100g) in the aqueous f.action;and among phenolic compounds, caf.eic acid (37.65 g/100g DW) and vanillic acid (22.70 g/100g DW) were the most important in the ethyl acetate f.action (f.eLi). All organic f.actions exhibited interesting antibacterial and antif.ngal activities against the tested s

关键词： Lawsonia inermis Phytochemical Prof.le HPLC GC-MS Analysis Antimicrobial Activity

New evidence f.r the epigenetic regulation of.skeletal stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zhao Jun Xiao Charles K.f.Chan Institute f.r Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanford CA 94305USA Department of.Surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Department of.Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Skeletal stem cells(SSCs)are crucial f.r skeletal development and regeneration,yet the epigenetic regulation of.these cells remains poorly *** studies have delineated the epigenetic landscape across the developmental trajectory of.SSCs,highlighting the involvement of.Ptip in regulating SSC *** skeletal system undergoes dynamic remodeling throughout *** stem cells(SSCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to f.ster development and maintain skeletal *** categorized within the broader mesenchymal stromal/stem cells(MSCs).

关键词： skeletal involvement maintain