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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 33-34页

作者： Boye T. Terrier J.-P. Coillot C. f. carsuzaa 焦婷 Service de Dermatologie HIA Sainte-Anne 83800 Toulon Naval

Background. The presence of.inorganic f.reign bodies in granulomatous cutaneous lesions is not inf.equent. In this paper, we describe the f.rst case of.cerium-induced cutaneous granulomatous dermatitis. Case report. A 57-year-old woman seriously burned f.ur years ago presented with papulonodular lesions af.ecting only the burned areas treated with topical cerium nitrate-silver sulf.diazine cream (f.ammacé rium ). Biopsies revealed sarcoidal granuloma associated with exogenous particles. Electron probe X-ray microanalysis demonstrated a high cerium content. Screening f.r systemic sarcoidosis was negative. The patient was treated with hydroxychloroquine. Af.er f.ur months of.f.llow-up, clinical and histological evidence of.decreased inf.ltrate was noted. Discussion. Cerium nitratesilver sulf.diazine cream (f.ammacé rium ) is widely used f.r the topical treatment of.burns. The main ef.ect of.cerium is to create superf.cial calcif.cation, which decreases wound colonization and prevents the f.rmation of.granulation tissue (no hypertrophic scar f.rmation) in bur-ns. Prior to our case, no cutaneous side-ef.ects of.cerium had been encountered. Inoculation of.f.reign matter may or may not induce granuloma f.rmation or sarcoidosis in dif.erent subjects, according to their immunologic status. The f.vorable outcome in this case could in f.ct be due to a change in the pattern of.cytokinin production (TH1→ TH2) rather than the ef.ects of.hydroxychloroquine therapy.

关键词：肉芽肿性系统性结节病硝酸铈浅表性钙化烧伤部位严重烧伤磺胺嘧啶银乳膏丘疹结节硫酸羟氯喹

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手部嗜中性皮肤病:Sweet综合征的局限性亚型3例

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 23-23页

作者： Boye T. Terrier J.-P. Guennoc B. f. carsuzaa 周少娜 Service de Dermatologie HIA Ste Anne BP 600 83800 Toulon

Introduction. The term “ pustular vasculitis of.the hands” described by Strutton f.r an acute eruption of.the hands was recently revisited[1]. “ Neutrophilic dermatosis of.the hands” has been pref.rred. We observed 3 new cases. Observations. Two women and a man, without notable past history, consulted f.r an acute and painf.l eruption of.both handswith f.ver. Clinical examination showed erythematous papular or nodular or bullous lesions developed on thenar and hypothenar eminences, and on the f.nger. Histological f.ndings were predominantly neutrophilic inf.ltration in the dermis, papillary dermal edema, with or without the presence of.leukocytoclastic vasculitis. Diagnosis was Sweet s syndrome. No disease was associated. With indometacine (50- 100 mg per day), all the lesions disappeared rapidly without relapse. Discussion. These 3 cases add to 19 other cases (review of.literature) which conf.rm the existence of.a homogenous entity that we think it a localized subset of.Sweet s Syndrome, with a f.st healing. Our observations are specif.c by the f.rst localization on thenar and hypothenar eminences and by the excellent response to treatment with a non steroidal antiinf.ammatory agents such indometacine (50- 100 mg per day). This treatment could be proposed as a f.rst line therapy.

关键词： Sweet综合征嗜中性皮肤病手部白细胞碎裂性血管炎中性粒细胞浸润亚型真皮乳头组织学检查新发病例女性患者

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