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PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分子（英文）

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PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分...

IgH locus suicide recombination does not depend on NHEJ in contrast to CSR in B cells

2024中国肿瘤标志物学术大会暨CACA整合肿瘤学高峰论坛暨第十七届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者：谭哲琼 Pragney Deme Keerti Boyapati Annet A.M.Duivenvoorden ron M.A.Heeren Caitlin M.Tressler Norman James Haughey Kristine Glunde

Background Triple-negative breast cancer(TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery and chemotherapy treatment. Exploring new molecular mechanisms of.TNBC that could lead to the development of.novel molecular targets are critically important f.r improving therapeutic options f.r treating *** We sought to identif. novel therapeutic targets in TNBC by combining genomic and f.nctional studies with lipidomic analysis, which included mechanistic studies to elucidate the pathways that tie lipid prof.le to critical cancer cell properties. Our studies were perf.rmed in a large panel of.human breast cancer cell lines and patient *** Comprehensive lipid prof.ling revealed that phospholipid metabolism is reprogrammed in TNBC cells. We discovered that patatin-like phospholipase domain-containing lipase 8(PNPLA8)is overexpressed in TNBC cell lines and tissues f.om breast cancer patients. Silencing of.PNPLA8disrupted phospholipid metabolic reprogramming in TNBC, particularly af.ecting the levels of.phosphatidylglycerol(PG), phosphatidylcholine(PC), lysophosphatidylcholine(LPC) and glycerophosphocholine(GPC). We showed that PNPLA8 is essential in regulating cell viability,migration and antioxidation in TNBC cells and promoted arachidonic acid and eicosanoid production, which in turn activated PI3K/Akt/Gsk3β and MAPK *** Our study highlights PNPLA8 as key regulator of.phospholipid metabolic reprogramming and malignant phenotypes in TNBC, which could be f.rther developed as a novel molecular treatment target.

关键词： PNPLA8 Breast cancer Triple negative Phospholipid Metabolism reprogramming Eicosanoids Migration Invasion Prolif.ration

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Cellular & Molecular Immunology 2019年第2期16卷 201-202页

作者： Hend Boutouil f.ançois Boyer Jeanne Cook-Moreau Michel Cogné Sophie Péron CRIBL UMR CNRS 7276 INSERM U126287000 LimogesFrance Institut Universitaire de f.ance 75000 ParisFrance

IgH locus suicide recombination(LSR)occurs in activated Blymphocytes and may result in the death of.the concerned B cell,justif.ing the name“locus suicide recombination”.1 LSR,as f.r immunoglobulin(Ig)class switch recombination(CSR),is an intrachromosomal recombination in the Ig heavy chain(IgH)***,LSR somehow appears to be the detrimental counterpart of.CSR in activated B cells,since CSR intends f.r cells to actively participate in immune responses while LSR eliminates B ***,an important question to address is the regulation and the exact molecular mechanism of.LSR.

关键词： CSR eliminate concerned

Synchronous electrogastrographic and manometric study of.the stomach as an esophageal substitute

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World Journal of.Gastroenterology 2005年第8期11卷 1172-1178页

作者： f.renc Izbéki Tibor Wittmann Sándor (O|')dor Balázs Botos (A|')ron Altorjay Department of.Medicine Department of.Surgery

AIM: To investigate the electric and contractile mechanisms involved in the deranged f.nction of.the transposed stomach in relation to the course of.the symptoms and the changes in contractile and electrical parameters over ***: Twenty-one patients af.er subtotal esophagectomy and 18 healthy volunteers were *** were compiled by using a questionnaire, and a symptom score was f.rmed. Synchronous electrogastrography and gastric manometry were perf.rmed in the f.sting state and ***: Eight of.the operated patients were symptomf.ee and 13 had symptoms. The durations of.the postoperative periods f.r the symptomatic (9.1±6.5 mo)and the asymptomatic (28.3±8.8 mo) patients were signif.cantly dif.erent. The symptom score correlated negatively with the time that had elapsed since the operation. The percentages of.the dominant f.equency in the normogastric, bradygastric and tachygastric ranges dif.ered signif.cantly between the controls and the patients.A signif.cant dif.erence was detected between the power ratio of.the controls and that of.the patients. The occurrence of.tachygastria in the symptomatic and the symptom-f.ee patients correlated negatively both with the time that had elapsed and with the symptom score. There was a signif.cant increase in motility index af.er f.eding in the controls, but not in the patients. The contractile activity of.the stomach increased both in the controls and in the symptom-f.ee patients. In contrast, in the group of.symptomatic patients, the contractile activity decreased postprandially as compared with the f.sting ***: The patients' post-operative complaints and symptoms change during the post-operative period and correlate with the parameters of.the myoelectric and contractile activities of.the stomach. Tachygastria seems to be the major pathogenetic f.ctor involved in the contractile dysf.nction.

关键词： Transposed stomach Electrogastrography Gastric manometry Post-operative complaints Contractile dysf.nction Tachygastria

Geostatistical modelling and mapping of.nematode-based soil ecological quality indices in a polluted nature reserve

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Pedosphere 2021年第5期31卷 670-682页

作者： Israel O.IKOYI Gerard B.M.HEUVELINK ron G.M.DE GOEDE Wageningen University&Research Soil Biology GroupWageningen 6700 AA(The Netherlands) Current address:University of.Limerick School of Natural SciencesDepartment of Biological SciencesLimerick V94T9PX(Ireland) Wageningen University&Research Soil Geography and Landscape GroupWageningen 6700 AA(The Netherlands)

Nematodes are indicators of.soil quality and soil *** of.the relationships between nematode-based soil quality indices and environmental properties is benef.cial f.r assessing environmental threats on soil *** study evaluated the spatial distribution of.nematode-based soil quality indices in a 23-ha heavy metal-polluted nature reserve using geostatistical *** expected that a selection of.abiotic soil properties(pH and moisture,clay,organic matter,cadmium(Cd),and zinc(Zn)contents)could explain a signif.cant portion of.the spatial variation of.the indices and that regression kriging could more accurately model their spatial distribution than ordinary kriging.A stratif.ed simple random sampling scheme was used to select 80 locations where soil samples were taken to extract nematodes and derive the *** area had a distinct gradient in soil properties with Cd and Zn content ranging f.om 0.07 to 68.9 and 5.3 to 1329 mg kg^(-1),*** regression models were f.tted to describe the relationships between the indices and soil *** also modelling the spatial correlation structure of.regression residuals using spherical semivariograms,regression kriging was used to produce maps of.the *** regression models explained between 21% and 44% of.the total original variance in the *** pH was a signif.cant explanatory variable in almost all cases,while heavy metal conent had a remarkably low *** some cases,the regression residuals had spatial *** validation indicated that in all cases,regression kriging perf.rmed slightly better because of.having lower values of.the root mean square prediction error and a mean prediction error closer to zero than ordinary *** study showed the importance of.soil properties in explaining the spatial distribution of.biological soil quality indices in ecological risk assessment.

关键词： ecological risk assessment heavy metals model validation regression kriging semivariance analysis soil property spatial structure

Demography, reproductive biology and diet of.the bushveld gerbil Tatera leucogaster (Rodentia: Gerbillinae) in the Lake Rukwa valley, south-western Tanzania

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Integrative Zoology 2008年第1期3卷 31-37页

作者： Richard O.ODHIAMBO Rhodes H.MAKUNDI Herwig LEIRS ron VERHAGEN Pest Management Centre Sokoine University of AgricultureMorogoroTanzania Evolutionary Biology Department of BiologyUniversity of AntwerpAntwerpBelgium Danish Pest Inf.station Laboratory Danish Institute of Agricultural SciencesKongens LyngbyDenmark

Seasonal abundance, reproductive biology and f.eding ecology of.the bushveld gerbil Tatera leucogaster (Peters,1852) were investigated in small-scale maize f.eld–f.llow land mosaics in south-western Tanzania. The gerbilswere collected over a 2-year period using Sherman live and Victor hold-f.st snap traps in permanent 4.5-ha grids. Atotal of.664 individuals were captured over 13 650 trap nights, giving an overall trap success rate of.4.9%. Trapsuccess varied between seasons with and without crops in the f.eld but not between habitat types. At this site, thebreeding activity of.this species is seasonal. All individuals whose stomachs were analyzed ate a wide range of.tems, indicating omnivory in this species at this site;however, seeds were the most pref.rred diet category, with amean contribution of.50.4%, f.llowed by arthropods, with a mean contribution of.25.7%. Other plant materialsbecame important during the very dry periods.

关键词： f.eding ecology reproduction seasonal abundance Tanzania Tatera leucogaster

Understanding the importance of.autophagy in human diseases using Drosophila

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Journal of.Genetics and Genomics 2019年第4期46卷 157-169页

作者： Arindam Bhattacharjee áron Szabó Tamás Csizmadia Hajnalka Laczkó-Dobos Gábor Juhász Institute of.Genetics Biological Research Centre of the Hungarian Academy of Sciences Department of.Anatomy Cell and Developmental BiologyE€otv€os Loránd University

Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in the pathogenesis of.various human diseases, either positively or negatively impacting disease outcomes depending on the specif.c context. The majority of.medical conditions including cancer, neurodegenerative diseases, inf.ctions and immune system disorders and inf.ammatory bowel disease could probably benef.t f.om therapeutic modulation of.the autophagy machinery. Drosophila represents an excellent model animal to study disease mechanisms thanks to its sophisticated genetic toolkit, and the conservation of.human disease genes and autophagic processes. Here, we provide an overview of.the various autophagy pathways observed both in f.ies and human cells(macroautophagy, microautophagy and chaperone-mediated autophagy), and discuss Drosophila models of.the above-mentioned diseases where f.y research has already helped to understand how def.cts in autophagy genes and pathways contribute to the relevant pathomechanisms.

关键词： Drosophila Neurodegeneration Alzheimer’s disease Parkinson’s disease Cancer Inf.ammatory bowel disease Autophagy

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艾滋病在非洲的流行

科学（中文版） 1996年第7期 21-28页

作者： cald.,JC 任智澳大利亚国立堪培拉大学全国流行病学和人民健康中心的健康转变中心

西屋公司在激励器和波形发生器技术上的最新发展

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电光系统 1993年第3期 46-54页

作者： cald.,SP 张杰

COVID-19-associated diarrhea

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World Journal of.Gastroenterology 2021年第23期27卷 3208-3222页

作者： Klara Megyeri Áron Dernovics Zaid I I Al-Luhaibi András Rosztóczy Department of.Medical Microbiology and Immunobiology University of SzegedSzeged 6720CsongradHungary Division of.Gastroenterology Department of Internal MedicineUniversity of SzegedSzeged 6720CsongradHungary

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)recently emerged as a highly virulent respiratory pathogen that is known as the causative agent of.coronavirus disease 2019(COVID-19).Diarrhea is a common early symptom in a signif.cant proportion of.patients with SARS-CoV-2 ***-CoV-2 can inf.ct and replicate in esophageal cells and enterocytes,leading to direct damage to the intestinal *** inf.ction decreases the level of.angiotensinconverting enzyme 2 receptors,thereby altering the composition of.the gut ***-CoV-2 elicits a cytokine storm,which contributes to gastrointestinal *** direct cytopathic ef.ects of.SARS-CoV-2,gut dysbiosis,and aberrant immune response result in increased intestinal permeability,which may exacerbate existing symptoms and worsen the *** exploring the elements of.pathogenesis,several therapeutic options have emerged f.r the treatment of.COVID-19 patients,such as biologics and biotherapeutic ***,the presence of.SARS-CoV-2 in the f.ces may f.cilitate the spread of.COVID-19 through f.cal-oral transmission and contaminate the *** gastrointestinal SARS-CoV-2 inf.ction has important epidemiological *** development of.new therapeutic and preventive options is necessary to treat and restrict the spread of.this severe and widespread inf.ction more ***,we summarize the key elements involved in the pathogenesis and the epidemiology of.COVID-19-associated diarrhea.

关键词： COVID-19 Diarrhea Ionic imbalance Viroporin Angiotensin-converting enzyme type 2 Leaky gut