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Predictive value of bleeding risk scores in elderly patients with atrial fibrillation and oral anticoagulation

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老年心脏病学杂志:英文版 2023年第9期20卷 684-692页

作者： Pablo domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi Andrea Lizancos-Castro Jose A Parada-Barcia AndréGonzález-García Ana Ledo-Piñeiro Vanesa Noriega-Caro Carla Iglesias-Otero AndrésÍñiguez-Romo Department of Cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain

BACKGROUND The predictive value of bleeding risk scores for atrial fibrillation in older patients is not as well *** goal of this study was to evaluate the predictive value of HASBLED,ORBIT and ATRIA for major bleeding(MB)and intracranial hemorrhage(ICH)in patients≥75 years with atrial fibrillation and oral anticoagulation(OAC).METHODS A retrospective unicenter study including patients≥75 years with atrial fibrillation(Af)and OAC.A total of 7613 patients≥75 years with Af and OAC included between 2014 and 2018(registry:NCT04364516).We analyzed the discriminative value of HASBLED,ATRIA and ORBIT scores for bleeding endpoints(major bleeding as primary endpoint and intracerebral hemorrhage as secondary).Cox regression was used to predict major bleeding with each scale and also for searching other variables potentially predictor of major *** discrimination was assessed using Harrell’s *** was assessed with goodness-of-fit test proposed by Gronnesby and *** During a mean follow up of 4.0 years(IQR:2.4–5.7 years),729 patients developed MB(2.61 per 100 patients/year)and 243 patients developed ICH(0.85 per 100 patients/year).Three scores showed a low discrimination for major bleeding,being ORBIT the best(HASBLED C statistic=0.557;ATRIA C statistic=0.568;ORBIT C statistic=0.595)and also a low discrimination for ICH(HASBLED C statistic=0.509;ATRIA C statistic=0.522;ORBIT C statistic=0.526).Among the variables that are part of the scores and other baseline characteristics,after multivariable adjustment only sex(male),dementia,prior admission for bleeding,anemia and liver disease were found as a predictors of *** In older patients under oral anticoagulation with atrial fibrillation,the risk scores HASBLED,ATRIA and ORBIT showed a weak discrimination for major bleeding and intracranial ***,other better alternatives should be evaluated for this purpose.

关键词： patients bleeding fibrillation

Nanoscale mapping of optically inaccessible bound-states-in-the-continuum

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Light(Science & Applications) 2022年第2期11卷 188-196页

作者： Zhaogang Dong Zackaria Mahfoud Ramón Paniagua-domínguez Hongtao Wang Antonio I.fernández-domínguez Sergey Gorelik Son Tung Ha febiana Tjiptoharsono Arseniy I.Kuznetsov Michel Bosman Joel K.W.Yang Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis Way#08-03 Innovis138634 SingaporeSingapore Department of Materials Science and Engineering National University of Singapore9 Engineering Drive 1117575 SingaporeSingapore Singapore University of Technology and Design 8 Somapah Road487372 SingaporeSingapore Departamento de física Teórica de la Materia Condensada and Condensed Matter Physics Center Universidad Autónoma de Madrid28049 MadridSpain Singapore Institute of food and Biotechnology Innovation A*STAR(Agency for ScienceTechnology and Research)31 Biopolis Way#01-02 Nanos138669 SingaporeSingapore

Bound-states-in-the-continuum(BIC)is an emerging concept in nanophotonics with potential impact in applications,such as hyperspectral imaging,mirror-less lasing,and nonlinear harmonic *** true BIC modes are nonradiative,they cannot be excited by using propagating light to investigate their optical *** this paper,for the 1st time,we map out the strong near-field localization of the true BIC resonance on arrays of silicon nanoantennas,via electron energy loss spectroscopy with a sub-1-nm electron *** systematically breaking the designed antenna symmetry,emissive quasi-BIC resonances become *** gives a unique experimental tool to determine the coherent interaction length,which we show to require at least six neighboring antenna *** importantly,we demonstrate that quasi-BIC resonances are able to enhance localized light emission via the Purcell effect by at least 60 times,as compared to unpatterned *** work is expected to enable practical applications of designed,ultra-compact BIC antennas such as for the controlled,localized excitation of quantum emitters.

关键词： antenna states mapping

Macroscopic Quantum Behaviour of Periodic Quantum Systems

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Journal of Modern Physics 2014年第1期5卷 44-50页

作者： A. Martín-Ruiz J. Bernal Adrián Carbajal-domínguez Instituto de Ciencias Nucleares Universidad Nacional Autónoma de México México D.F. Mexico Universidad Juárez Autónoma de Tabasco División Académica de Ciencias Básicas Cunduacán México

In this paper we introduce a simple procedure for computing the macroscopic quantum behaviour of periodic quantum systems in the high energy regime. The macroscopic quantum coherence is ascribed to a one-particle state, not to a condensate of a many-particle system;and we are referring to a system of high energy but with few degrees of freedom. We show that, in the first order of approximation, the quantum probability distributions converge to its classical counterparts in a clear fashion, and that the interference effects are strongly suppressed. The harmonic oscillator provides a testing ground for these ideas and yields excellent results.

关键词： Matrix Density Quantum Interference Classical Limits

Use of Graphene and Cucurbit[7]uril Electrodes for the Determination of Amantadine in Biological fluids

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American Journal of Analytical Chemistry 2015年第7期6卷 623-630页

作者： C. S. H. domínguez P. Hernández facultad de Ciencias de la Salud Universidad Estatal de Milagro Milagro Ecuador Departamento de Química Analítica y Análisis Instrumental Facultad de Ciencias Universidad Autónoma de Madrid Cantoblanco Madrid Spain

A differential pulse voltammetry (DPV) method for amantadine (AT) determination is developed. To this end, all the chemical and instrumental variables affecting the determination of amantadine are optimized. These studies have used three types of glassy-carbon electrode, first electrode which has not undergone surface modification or coating, to then modify the working electrode surface with two kinds of suspensions: graphene and graphene-cucurbit[7]uril (CB[7]). from studies of the mechanisms governing the electrochemical response of amantadine, it was concluded that it is an electrochemically system with a diffusive reduction phenomenon. Under optimal conditions and with the appropriate electrode modification, we proceed to study the relation between the peak intensity with the analyte concentration. Thus, we find that when the electrode surface is covered with graphene-CB[7], two linear sections are obtained, the first one in the concentration range of between 0.05 μg·mL﹣1 and 0.75 μg·mL﹣1;and the second one between 1.00 μg·mL﹣1 and 6.00 μg·mL﹣1, with Er (%) = 87 and R.S.D. = 0.94% (n = 10 at 0.5 μg·mL﹣1 level). The minimum detectable amount was 15 ng·mL﹣1 while a concentration of 44 ng·mL﹣1 was calculated as determination limit. The optimized method was applied to the determination of amantadine in biological fluids.

关键词： Glassy-Carbon Electrode Amantadine Differential Pulse Voltammetry Human Urine

Influence of GSTT1, GSTM1 and GSTP1 Polymorphisms on the Development of Breast Cancer

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Journal of Cancer Therapy 2014年第6期5卷 552-559页

作者： Marisol Rodríguez fernando Mejia Mariana Lecourtois Victoria domínguez Julieta Castillo Centro de Investigación en Ciencias Médicas Universidad Autónoma del Estado de México Toluca de Lerdo México facultad de Odontología Universidad Autónoma del Estado de México Toluca de Lerdo México facultad de Química Universidad Autónoma del Estado de México Toluca de Lerdo México

Introduction: Every year, more than 10 million women are diagnosed worldwide with breast cancer. Breast cancer remains the leading cause of death from malignancy in women. In Mexico about 12 Mexican women die every day from this disease. Glutathione S-transferase (GST) family consists of a group of isoenzymes involved in Phase II detoxification of xenobiotics by glutathione conjugation. There have been reports showing GST polymorphisms as a risk factor for developing cancer. Objective: Determine if the frequencies of polymorphisms of GSTT1, GSTM1 and GSTP1 are associated with breast cancer development. Materials and Methods: We studied 22 women with breast cancer and a control group of 30 women. DNA was extracted from blood. Polymorphisms of T1 and M1 were identified by multiplex PCR. The identification of GSTP1b (exon 5) and GSTP1c (exon 6), was performed separately by RfLP-PCR, using BsmAI and AciI enzymes respectively. Results: frequencies of polymorphisms were as follows: for breast cancer group 33% null GSTT1 vs 40% null in the control, 32% null GSTM1 vs 63% of control;63% heterozygote GSTP1b P1a/P1b and 18% homozygote P1b/P1b, vs 53% heterozygote and 20% homozygote in the control, 41% heterozygote P1a/P1c GSTP1c and 0% homozygote vs 10% heterozygote P1c/P1c and 0% homozygote control. Significant differences were found between GSTM1 and GSTP1c polymorphisms with GSTM1 null percentage higher in the control group and a higher frequency of P1c heterozygotes in the cancer group. Conclusion: As this is a pilot study where the results showed no association with breast cancer, further investigation is required on the involvement of GST genes in neoplasm development.

关键词： Breast Cancer Polymorphisms GSTM1 GSTT1 GSTP1

Bayesian Posterior Predictive Probability Happiness

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Applied Mathematics 2016年第8期7卷 753-764页

作者： Gabriela Rodríguez-Hernández Galileo domínguez-Zacarías Carlos Juárez Lugo Universidad Autónoma del Estado de México Ecatepec Mexico

We propose to determine the underlying causal structure of the elements of happiness from a set of empirically obtained data based on Bayesian. We consider the proposal to study happiness as a multidimensional construct which converges four dimensions with two different Bayesian techniques, in the first we use the Bonferroni correction to estimate the mean multiple comparisons, on this basis it is that we use the function t and a z-test, in both cases the results do not vary, so it is decided to present only those shown by the t test. In the Bayesian Multiple Linear Regression, we prove that happiness can be explained through three dimensions. The technical numerical used is MCMC, of four samples. The results show that the sample has not atypical behavior too and that suitable modifications can be described through a test. Another interesting result obtained is that the predictive probability for the case of sense positive of life and personal fulfillment dimensions exhibit a non-uniform variation.

关键词： Bayesian Inference Posterior Predictive Distribution MCMC Happiness

Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients

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World Journal of Gastroenterology 2019年第11期25卷 1409-1420页

作者： Ana florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios domínguez-flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea f González Angel Cebolla-Ramirez Eduardo Mauri?o Elena f Verdú Julio César Bai Small Bowel Section Department of MedicineDr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1263Argentina Department of Immunology Biomedal S.L.Sevilla 41092Spain farncombe family Digestive Health Research Institute McMaster UniversityHamiltonON L8S4L8Canada Research Institutes Universidad del SalvadorBuenos Aires 1050Argentina

BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully *** To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GfD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GfD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GfD during the study *** forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GfD. Overall, 83 sets of stool and/or urine samples were *** out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GfD by dietary *** GIP dete

关键词： Celiac disease follow-up Gluten-free diet Gluten immunogenic peptide excretion Rapid tests

Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity,cardiovascular disease and cancer

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Cellular & Molecular Immunology 2021年第4期18卷 919-935页

作者： Pilar Martin Rafael Blanco-dom fnguez Raquel Sanchez-Diaz Vascular Pathophysiology Area Centro Nacional de Investigaciones Cardiovasculares(CNIC)MadridSpain CIBERCV MadridSpain

In the last decade,approaches based on T cells and their immunomodulatory receptors have emerged as a solid improvement in treatments for various types of ***,the roles of these molecules in the therapeutic context of autoimmune and cardiovascular diseases are still relatively ***,we review the best known and most com m only used immunomodulatory T cell receptors in clinical practice(PD-1 and CTLA-4),along with the rest of the receptors with known functions in animal models,which have great potential as modulators in human pathologies in the medium *** ong these other receptors is the receptor CD69,which has recently been described to be expressed in mouse and human T cells in autoimmune and cardiovascular diseases and ***,inhibition of these receptors individually or in combination by drugs or monoclonal antibodies generates a loss of immunological tolerance and can trigger multiple autoimmune disorders in different organs and immune-related adverse *** the coming decades,knowledge on the functions of different immunomodulatory receptors will be pivotal for the development of new and better therapies with less harmful side *** this review,we discuss the roles of these receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases,such as systemic lupus erythematosus,autoimmune diabetes and rheumatoid arthritis,and cardiovascular diseases,such as atherosclerosis,acute myocardial infarction,and myocarditis.

关键词： Immunomodulatory receptors Autoimmune diseases T cells Immunotherapy

Proactive optimization of transmission power and 3D trajectory in UAV-assisted relay systems with mobile ground users

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Chinese Journal of Aeronautics 2021年第5期34卷 129-144页

作者： Jiangchun GU Guoru DING Yitao XU Haichao WANG Qihui WU School of Communications Engineering Army Engineering University of PLANanjing 210007China School of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In this paper,an Unmanned Aerial Vehicle(UAV)-assisted relay communication system is studied,where a UAV is served as a flying relay to maintain a communication link between a mobile source node and a remote destination ***,an average outage probability minimization problem is formulated firstly,with the constraints on the transmission power of the source node,the maximum energy consumption budget,the transmission power,the speed and acceleration of the flying UAV ***,the closed-form of outage probability is derived,under the hybrid line-of-sight and non-line-of-sight probability channel *** deal with the formulated nonconvex optimization,a long-term proactive optimization mechanism is *** particular,firstly,an approximation for line-of-sight probability and a reformulation of the primal problem are given,***,the reformulated problem is transformed into two subproblems:one is the transmission power optimization with given UAV’s trajectory and the other is the trajectory optimization with given transmission power ***,two subproblems are tackled via tailoring primal–dual subgradient method and successive convex approximation,***,a proactive optimization algorithm is proposed to jointly optimize the transmission power allocation and the three-dimensional ***,simulation results demonstrate the performance of the proposed algorithm under various parameter configurations.

关键词： Outage probability Primal-dual subgradient Proactive optimization Successive convex approximation Unmanned Aerial Vehicle(UAV)relay