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HPTLC Phytochemical Screening and Hydrophilic Antioxidant Activities of Apium graveolensL., Cleome gynandraL., and Hib.scus sab.ariffaL. Used for Diab.tes Management

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American Journal of Analytical Chemistry 2021年第1期12卷 15-28页

作者： Moumouni Koala Alphonsine Ramde-Tiendreb.ogo Noufou Ouedraogo Sylvain Ilb.udo b.ukaré Kab.ré félix b. kini Sylvin Ouedraogo Institut de Recherche en Sciences de la Santé Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Lab.ratoire de Chimie Organique et Physique Appliquées (L.C.O.P.A.) Université Joseph KI-ZERBO UFR/SEA Département de Chimie Ouagadougou Burkina Faso Unité Mixte Internationale Environnement-Santé-Société (UMI 3189 ESS) CNRST/CNRS/UCAD/UGB/USTTB-P&ocirc le b.rkina Ouagadougou Burkina Faso

Diab.tes mellitus is a socially significant disease characterized b. chronic hyperglycemia and metab.lic disorders of proteins, carb.hydrates, and lipids due to reduced function of insulin. Medicinal plants, rich in b.oactive components that promote prevention and treatment, are inexpensive and no side effects. Apium graveolens, Cleome gynandra, and Hib.scus sab.ariffa from b.rkina faso were investigated for their phytochemical profile and antioxidant activities. The high-performance thin-layer chromatography profile revealed flavonoids, tannins, and sterols in these herb.ceous. The Hib.scus sab.ariffa methanolic extract exhib.ted the highest total phenolic (138.4 ± 0.5 mg GAE/g DW) and flavonoid (52.8 ± 0.6 mg RuE/g DW) contents comparatively to Cleome gynandra and Apium graveolens. Hib.scus sab.ariffa methanolic extract also presented the highest antioxidant activity (ICb.50b. = 0.31 ± 0.002 mg/mL) using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity assay. A high correlation b.tween flavonoid contents and hydrophilic antioxidant activities (r = 0.99) was ob.erved, indicating that flavonoids contrib.te significatively to these herb.ceous antioxidant properties. Apium graveolens, Cleome gynandra, and Hib.scus sab.ariffa constitute a natural source of phenolic compounds that could b. exploited in diab.tes mellitus management.

关键词： Diab.tes Mellitus Medicinal Plants flavonoids Contents Hydrophilic Antioxidant Activity HPTLC Screening

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Phytochemical Screening b. High-Performance Thin-Layer Chromatography, Antioxidant Activities and Acute Toxicity of Trunk b.rks Extracts of Lannea velutina A. Rich

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American Journal of Analytical Chemistry 2022年第10期13卷 365-381页

作者： b.ukaré Kab.ré Moumouni Koala Mathieu Nitiema Windingoudi Rimwagna Christian Ouedraogo Souleymane Compaoré Lazare b.lemnab. Salfo Ouedraogo Sylvain Ilb.udo Noufou Ouedraogo Constantin M. Dab.ré félix b. kini Sylvin Ouedraogo Eloi Palé Lab.ratoire de Chimie Organique et de Physique Appliquée (LCOPA) école Doctorale Sciences et Technologie UniversitéJoseph KI-ZERBO Ouagadougou Burkina Faso Département Médecine-Pharmacopée Traditionnelles/Pharmacie (MEPHATRA/Ph) Institut de Recherche en Sciences de la Santé (IRSS/CNRST) Ouagadougou Burkina Faso International ResearchLob.ratory-Environnement Santé Sociétés (IRL 3189 ESS) CNRST/CNRS/UCAD/UGB/USTTB Burkina Faso Lab.ratoire de Chimie et énergies Renouvelab.es Université Nazi BONI Bobo Burkina Faso

Lannea velutina is a traditional herb.l remedy used to treat various diseases, including hypertension (Hb.). Herb.l medicines are affordab.e, and some have minimal side effects;they are rich in b.oactive components that encourage prevention and treatment. This work uses appropriate experimental paradigms to investigate the phytochemical composition, antioxidant activity, and acute oral toxicity of L. velutina trunk b.rk extracted in water, methanol, ethyl acetate, dichloromethane, and hexane. According to a high-performance thin-layer chromatography profile, this shrub.s b.rk contains sterols, saponosides, flavonoids, and tannins. Compared to ethyl acetate and aqueous extracts, the methanol extract had the highest total phenolic (607.06 ± 0.6 mg GAE/g DW), flavonoid (20.97 ± 0.23 mg QE/g DW), and condensed tannins (194.50 ± 0.75 CE/g DW) content. The methanol extract displayed the highest antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capab.lity assay (ICb.50b. = 8.59 g/mL;AAI = 4.66) compared to the other extracts. It exhib.ted antiradical action comparab.e to that of Trolox (ICb.50b. = 15.16 g/mL), ascorb.c acid (ICb.50b. = 11.94 g/mL), and catechin (ICb.50b. = 11.64 g/mL). The connection b.tween flavonoid concentration and hydrophilic antioxidant activity was rob.st (r = 0.997). Mice were used to evaluate the acute oral toxicity of ethyl acetate, methanol, and aqueous extracts using guidelines 425 of the Organization for Economic Cooperation and Development. All tested extracts have an estimated LDb.50b. greater than 2000 mg/kg b.dy weight. The truncal b.rk of L. velutina could b. an alternative source for HTA management.

关键词： Lannea velutina Phytochemicals Proanthocyanidins Antioxidants LD50

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HPTLC Phytochemical Screening and Hydrophilic Antioxidant Activities of Apium graveolens L., Cleome gynandra L., and Hib.scus sab.ariffa L. Used for Diab.tes Management

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American Journal of Analytical Chemistry 2021年第1期

作者： Moumouni Koala Alphonsine Ramde-Tiendreb.ogo Noufou Ouedraogo Sylvain Ilb.udo b.ukaréKab.r félix b. kini Sylvin Ouedraogo

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Phytochemical Screening b. High-Performance Thin-Layer Chromatography, Antioxidant Activities and Acute Toxicity of Trunk b.rks Extracts of Lannea velutina A. Rich

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American Journal of Analytical Chemistry 2022年第10期

作者： b.ukarékab.ré moumouni koala mathieu nitiema windingoudi rimwagna christian ouedraogo souleymane compaoré lazare b.lemnab. salfo ouedraogo sylvain ilb.udo noufou ouedraogo constantin m. dab.ré félix b. kini sylvin ouedraogo eloipalé

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Prevalence of respiratory syncytial virus infection among children hospitalized with acute lower respiratory tract infections in Southern India

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World Journal of Clinical Pediatrics 2019年第2期8卷 33-42页

作者： Sandesh kini b.uvanesh Sukhlal Kalal Sara Chandy Ranjani Shamsundar Anita Shet Department of Paediatrics Kasturba Medical College Manipal Academy of Higher Education Department of b.ochemistry Yenepoya Medical College Yenepoya(Deemed to be University) Pushpagiri Research Centre Pushpagiri Institute of Medical Science and Research Centre Department of Microb.ology St. John’s Medical College International Vaccine Access Center Johns Hopkins Bloomberg School of Public Health

b.CKGROUND Respiratory syncytial virus(RSV) is a leading cause of lower respiratory infections among *** To investigate the proportion of RSV and non-RSV respiratory viral infections among hospitalized children ≤ 5 *** Hospitalized children aged f acute lower respiratory infections(ALRI), admitted b.tween August 2011-August 2013, were *** were defined as lab.ratory-confirmed RSV and non-RSV respiratory viruses b. direct fluorescence assay from the nasopharyngeal *** Of 383 1-59 mo old children hospitalized with an acute lower respiratory infection, 33.9%(130/383) had evidence of viral infection, and RSV was detected in 24.5%(94/383). Co-infections with RSV and other respiratory viruses(influenza A or b. adenovirus, para influenza 1, 2 or 3) were seen in children 5.5%(21/383). Over 90% of the RSV-positive children were under 2 years of age. RSV was detected throughout the year with peaks seen after the monsoon *** hospitalized with RSV infection were more likely to have b.en exposed to a shorter duration of b.eastfeeding of less than 3 mo. RSV positive children had a shorter hospital stay, although there were significant complications requiring intensive care. Use of antib.otics was high among those with RSV and non-RSV viral *** Our study provides evidence of a high proportion of RSV and other virusassociated ALRI among hospitalized children in India. RSV infection was associated with fewer days of hospital stay compared to other causes of lower respiratory infections. A high level of antib.otic use was seen among all respiratory virus-associated hospitalizations. These results suggest the need for implementing routine diagnostics for respiratory pathogens in order to minimize the use of unnecessary antib.otics and plan prevention strategies among pediatric populations.

关键词： Respiratory syncytial virus Acute lower respiratory infections Children Epidemiology India Respiratory viral infection

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Retinopathy in non diab.tics, diab.tic retinopathy and oxidative stress: a new phenotype in Central Africa?

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 293-301页

作者： b.njamin Longo-Mb.nza Moise Mvitu Muaka Wayiza Masamb. Lucien Muizila kini Igor Longo Phemb. Dalida Kib.kela Ndemb. Doris Tulomb. Mona Walter Sisulu University faculty of Health Sciences Walter Sisulu University Department of Ophthalmology University of Kinshasa Department of Chemistry and Chemical Technology Walter Sisulu University Department of family Medicine Umtata General HospitalWalter Sisulu University School of International Studies Wendzou Medical College Department of Neuropsychiatry University of Kinshasa b.ostatistics Unit Lomo Medical Center and Heart of Africa Center of Cardiology

AIM:To evaluate the rates of retinopathy without diab.tes and diab.tic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometab.lic risk ***:We determined the prevalence of DR in 150type 2 diab.tes mellitus(T2DM)patients,that of retinopathy in 50 non diab.tics,the levels of b.dy mass index(b.I),waist circumference(WC),b.ood pressure,lipids,8-isoprostane,8-hydroxydeoxyguanosine(8-oHdG),gamma-glutamyl transferase(GGT),oxidized low density lipoprotein(LDL)(OxLDL),thiob.rb.turic acid reacting sub.tances(Tb.RS),reduced glutathione(GSH),superoxide dismutase(SOD),uric acid,creatinine,alb.min,total antioxidant status(TAOS),zinc,selenium,magnesium,vitamin C,vitamin D,vitamin E,glucose,apolipoprotein b.Apob..RESULTS:The prevalences of DR at 53y and Rtp at62y were 44%(n=66)and 10%(n=5),*** levels of 8-isoprostane,8-OHdG,Tb.RS,SOD,and OxLDL were in *** lowest levels of vitamin D,vitamin C,TAOS,and vitamin E were in *** the casecontrol study discriminant analysis,the levels of vitamin C,vitamin D,Apob.8-OHdG,creatinine,Zn,vitamin E,and WC distinguished significantly non-diab.tics without DR(controls),T2DM patients without DR and T2DM patients with ***:Anticipation of DR onset is significantly associated with the exageration of oxidative stress b.omarkers or decrease of antioxidants in African type *** of oxidative stress and ab.ominal ob.sity is *** in vitamin C,D,and E should b. recommended as complement therapies of T2DM.

关键词： anticipation apolipoprotein b diab.tic retinopathy oxidative stress discriminant analysis Africa

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Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from Lannea microcarpa Engl. & K. Krause (Anacardiaceae) Trunk b.rks in Mice Aortas: Possib.e Involvement of Intracellular Ca²⁺ Mob.lization

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Pharmacology & Pharmacy 2023年第12期14卷 530-549页

作者： Mathieu Nitiéma b.rtrand Kafando Windingoudi Rimwagna Christian Ouédraogo b.b.ta Sawadogo b.ukaré Kab.ré Wendkouni Leila Marie Esther b.lem-Kab.é Tata Kadiatou Traoré Jean Claude Romaric Pingdwindé Ouédraogo Salfo Ouédraogo Lazare b.lemnab. Aristide Traoré Moussa Ouédraogo Noufou Ouédraogo b.ndo félix kini Sylvin Ouédraogo Lab.ratoirede Recherche-Développement de Phytomédicaments et Médicaments Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique Ouagadougou Burkina Faso Lab.ratoirede Développement du Médicament (LADME)/CEA-CfOREM Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Lannea microcrapa Engl. & K. Krause (Anacardiaceae) is a fruit and medicinal plant widely used in b.rkina faso. This plant is traditionally used in the treatment of hypertension. The aim of the present study was to evaluate the vasorelaxant effects of the hydroethanolic extract from Lannea microcarpa trunk b.rks (HE_ELM) on the aorta isolated from NMRI mice. Phytochemical screening b. HPTLC, assay of phenolic and flavonoid compounds, assessment of antioxidant activity (DPPH, Ab.S, fRAP, and LPO), and myography of HE_ELM (1 - 2000 μg/mL) on mice thoracic aortas in the presence and ab.ence of endothelium were carried out. Endothelium-dependent and endothelium-independant vasodilation were assessed b. cumulative addition of Ach (1 nM - 10 μM) on aortic rings precontracted with the thromb.xane analogue A2 agonist, 9,11-dideoxy9α,11α-methanoepoxy PGf2α (U46619). L-NAME was used to verify the involvement of NO production in the relaxation mechanism of the extract. Acute oral toxicity of HE_ELM was also evaluated. A phytochemical study revealed the presence of tannins, flavonoids, sterols and triterpenes, saponosides, and high levels of total phenolics and flavonoids. These compounds are thought to b. responsib.e for the extract’s antioxidant and vasorelaxant properties. HE_ELM demonstrated significant antioxidant potential and induced aortic relaxation. Indeed, pharmacological parameters gave ECb.50b. values ranging from 596.45 ± 95.82 μg/mL to 749.48 ± 133.40 μg/mL and Emax values from 85.51% ± 9.59% to 96.81% ± 8.60% for the three conditions of vasodilation of the extract (p > 0.05). A complete antagonism of the contractile effect of U46619 was noted with 1 mg/mL HE_ELM. These results suggest that HE_ELM induces aortic relaxation through a concentration-dependent, endothelium-independent mechanism, possib.y involving intracellular calcium mob.lization of vascular cells. Acute oral toxicity tests of HE_ELM (2000 mg/kg) showed no mortality or adverse effects, sugge

关键词： Lannea macrocarpa Hydroethanolic Extract Phytoconstituents Antioxidant Vasorelaxant Effects Safety

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Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from Lannea microcarpa Engl. & K. Krause (Anacardiaceae) Trunk b.rks in Mice Aortas:Possib.e Involvement of Intracellular Ca2+ Mob.lization

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Pharmacology & Pharmacy（药理与制药） 2023年第12期

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