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Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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food Science and Human Wellness 2024年

作者： Emily P.Laveriano-Santos Sara castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón Estruch Patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.fernández-Alvira rodrigo fernández-Jiménez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai Department de Nutrició Ciències de l'Alimentació I Gastronomia XIA facultat de farmàcia i Ciències de l'alimentació Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB) Universitat de Barcelona Department of Internal Medicine Hospital Clínic Institutd'Investigacions biomèdiques August Pi I Sunyer (IDIBAPS) University of Barcelona Consorcio CIBER M.P.fisiopatología de la Obesidad y Nutrición (CIBERObn) Instituto de Salud Carlos III (ISCIII) Mediterranean Diet foundation 5. foundation for Science Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend f stilbene intake with lower BG (β=-1.83， 95%CI= -3.103;-0.64， P-for trend for trend=0.034)， and with higher HDL-c (β=2.328， 95%CI= 1.40;3.17， P-for trend=0.466) compared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， espe

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Hepatobiliar manifestations in inflammatory bowel disease: A practical approach

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World Journal of Hepatology 2022年第2期14卷 319-337页

作者： Paulina Núñez f fabiola castro Gabriel Mezzano rodrigo Quera Diego Diaz Lorena castro Universidad de los Andes Inflammatory Bowel Disease ProgramDigestive Disease CenterSantiago 7600976RMChile Inflammatory Bowel Disease Program Hospital San Juan de DiosUniversidad de ChileSantiago 7701230RMChile Universidad de los Andes Hepatology ProgramDigestive Disease CenterSantiago 7600976RMChile Department of Gastroenterology Hospital del Salvador/Universidad de ChileSantiago 7600976RMChile Universidad de los Andes Santiago 770976RMChile

Inflammatory bowel diseases(IBD)are associated with various hepatobiliary *** can occur at any moment in the course of the disease or associated with the *** prevalence of liver dysfunction can reach up to 50%in different *** fatty liver disease is considered the most common hepatobiliary complication in IBD,while primary sclerosing cholangitis is the most *** of hepatic manifestations in IBD involves a multidisciplinary approach that includes a high index of suspicion and joint management with *** medical confrontation with abnormal liver tests must include an exhaustive study to determine if these patterns can be related to IBD,associated diseases or to the therapies used.

关键词： Extraintestinal manifestations Inflammatory bowel disease Sclerosing primary cholangitis Hepatic steatosis Liver toxicity

A Method to Identify Anomalies in Stock Market Trading Based on Probabilistic Machine Learning

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Journal of Autonomous Intelligence 2019年第2期2卷 42-52页

作者： Anderson rodrigo Barretto Teodoro Paulo AndréLima de castro Autonomous Computational Systems Lab Technological Institute of Aeronautics(ITA)Sao Jose dos Campos-SP

financial operations involve a significant amount of resources and can directly or indirectly affect the lives of virtually all *** the efficiency and transparency in this context,it is essential to identify financial crimes and to punish the ***,the large number of operations makes it infeasible for analyzes made exclusively by ***,the application of automated data analysis techniques is *** this scenario,this work presents a method that identifies anomalies that may be associated with operations in the stock exchange market prohibited by ***,we seek to find patterns related to insider *** types of operations can generate big losses for *** this paper,we use the public available information from SEC and CVM,based on real cases on BOVESPA,NYSE and NASDAQ stock exchanges,that it was used as a training *** method includes the creation of several candidate variables and the identification of which are the most *** this definition,classifiers based on decision trees and Bayesian networks are constructed,evaluated and then *** computational cost of performing such tasks can be quite significant,and it grows quickly with the amount of analyzed *** this reason,the method considers the use of machine learning algorithms distributed in a computational *** order to perform such tasks,we use the WEKA framework with modules that allows the distribution of the processing load in a Hadoop *** use of a computational cluster to execute learning algorithms in a large amount of data has been an active area of research,and this work contributes to the analysis of data in the specific context of financial *** obtained results show the feasibility of the approach,although the quality of the results is limited by the exclusive use of publicly available data.

关键词： Data Mining Machine Learning Anomaly Detection

A new technique for separation of partial discharge sources and electromagnetic noise in radiofrequency measurements using energy ratios of different antennas

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High Voltage 2021年第3期6卷 525-530页

作者： Jorge A.Ardila‐Rey Matias Cerda‐Luna rodrigo Rozas‐Valderrama Bruno Albuquerque de castro AndréLuiz Andreoli Benjamin Cevallos Departamento de Ingeniería Eléctrica Universidad Técnica Federico Santa MaríaSantiago de ChileChile Department of Electrical Engineering São Paulo State University(UNESP)School of Engineering BauruBauru‐SPBrazil

One of the main tools for monitoring the condition of high voltage equipment is the measurement of partial discharges(PD).The electromagnetic(EM)radiation originated from this degradation phenomenon can be captured by various types of ultra‐high fre-quency(UHf)antennas carefully designed and optimised for specific frequency ***,the presence of environmental noise may limit the use of this *** types of monopole antennas normally used in UHf PD measurement have been evaluated in order to validate the performance of a novel separation technique of EM ***,a new separation technique based on the energy ratio of the captured signals was developed,considering noise *** results revealed that the new technique allows an adequate separation,even when three sources act simultaneously.

关键词： antennas separation noise

Comparative Study of the Complications of Pedicular Screw fixation Techniques in the Thoracolumbar Spine: A Systematic Review

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Open Journal of Orthopedics 2023年第8期13卷 343-353页

作者： Vanessa Cavazana Takata João Vitor Lois Balestrieri Pedro bastos Neto rodrigo Eduardo Souza Garcia Idiberto José Zotarelli filho Luis fernando Ricci Boer fabiano Morais Nogueira fAMERP-faculty of Medicine of Sã o José do Rio Preto Orthopedics and Traumatology at Hospital de Base S&atildeo José do Rio Preto S&atildeo Paulo Brazil ABRAN-Brazilian Association of Nutrology Catanduva Sao Paulo Brazil Clinical Research and biostatistical Department College of Palliative Medicine of Sri Lanka Colombo Sri Lanka

Introduction: The use of pedicle screws increases postoperative stability and consolidation of arthrodesis. Pedicle arthrodesis is currently the standard treatment for the thoracolumbar spine, presenting the best fusion and stiffness rates, and among its main indications is the possibility of better correction of spine deformities in the thoracic and lumbar region. However, due to different definitions and the lack of a control group, many of these studies have limited comparative analysis, resulting in the scarcity of comparative studies with standardized methodology. Objective: It was to analyze, through a systematic review, the safety and efficacy of instrumentation with pedicle screws in the spine which have been questioned, despite its wide use for stabilization of the spine, comparing the complications present in the insertion techniques of pedicle screws. Methods: The rules of the Systematic Review-PRISMA were followed. The literary search process was carried out from January to March 2023. A bibliographic search was carried out in MEDLINE, PubMed, and Scielo for articles produced between 2001 and 2023. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. The Cohen test (funnel Plot) and The Heterogeneity Test (Chi-Square Test – X2) were performed, with p Results and Conclusion: A total of 134 articles were found. A total of 67 articles were evaluated in full and 12 were selected to compose the results of this systematic review. According to the GRADE instrument, most studies (X2 = 90.2% > 50%) followed a controlled clinical study model and had a good methodological design, with p f pedicle screws is the most common cause of complications. The surgeon’s skills and the length and diameter of the pedicle screw can also affect the different modes of placement. Robotic computer assistance has the potential to reduce th

关键词： Pedicular Arthrodesis Complications Spinal Instrumentation

SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients

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Journal of Molecular Cell biology 2022年第4期14卷 51-64页

作者： Marjorie C.Pontelli italo A.castro Ronaldo B.Martins Leonardo La Serra flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.f.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.f.Lopes Sabrina S.Batah Li Siyuan rodrigo Luppino-Assad Sergio C.L.Almeida fabiola R.Oliveira Maira N.Benatti Lorena L.f.Pontes rodrigo C.Santana fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha rodrigo T.Calado JoséC.Alves-filho Dario S.Zamboni Alexandre T.fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Celland Molecular biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of biochemistry&Molecular biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Molecular Microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMC) lymphocytes monocytes apoptosis

Crithidia deanei infection in normal and dexamethasone–immunosuppressed Balb/c mice

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Health 2010年第6期2卷 589-594页

作者： Dilvani Oliveira Santos Saulo C. Bourguignon Helena Carla castro Alice Miranda rodrigo Tonioni Vieira Suzana Corte-Real Otílio Machado Pereira bastos 不详

Monoxenous trypanossomatids protozoa are not believed to cause in vivo infection in verte- brate hosts throughout their life cycle. However, there are reports mentioning some cases of HIV- positive patients who have presented opportunistic infections caused by these protozoa. Recently, we have demonstrated the in vitro infection of mouse dermal fibroblasts by these protozoa. The aim of the present work is to investigate the possibility of Crithidia deanei, a endosymbiont-bearing monoxenous trypanossomatid, infect BALB/c mice under or not Dexamethasone treatment. To attend it, distinct gro- ups of adult BALB/c mice were immunosuppressed with 50 mg/kg of Dexamethasone. This immunosuppressor was administered 24 hours before infection and daily, for 15 days after C. deanei inoculation. Control groups: C. deanei–inoculated animals but non-immuno- suppressed and non-inoculated animals but immunosuppressed were also used. Light Microscopy analysis revealed an infection process characterized by the presence of the trypanossomatid inside dermal cells in the groups studied. The experimental inoculation resulted in a non-lethal infection characterized by the presence of the trypanossomatid inside dermal cells in the normal BALB/c mice, but notably, in the C. deanei–inoculated immunosuppressed group. These preliminary results lead to the following conclusions: 1) C. deanei is able to infect normal BALB/c mice;2) the immunosupressed mice seemed to be more susceptible to the C. deanei infection compared to the control group. Besides C. deanei in dexamethasone-immunosuppressed mice provides a useful model for studies of monoxenous trypanosomatids ‘in vivo’ infection, resembling that one presumably occurring in imunodeficient individuals with AIDS.

关键词： Monoxenous Trypanossomatid 'In Vivo’ Infection Immunosuppression

Metabolic-associated fatty liver disease is associated with low muscle mass and strength in patients with chronic hepatitis B

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World Journal of Hepatology 2022年第8期14卷 1652-1666页

作者： Cecy Maria de Lima Santos Matheus Duarte Brito Pedro Alves Soares Vaz de castro Thais Pontello de Vries Nataly Lopes Viana Marta Paula Pereira Coelho Olívio Brito Malheiro Tatiana Bering Maria Cristina Gonzalez Rosangela Teixeira rodrigo Dias Cambraia Gifone Aguiar Rocha Luciana Diniz Silva Sciences Applied to Adult Health Care Post-Graduate Programme faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Locomotor System Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of food and Nutrition Universidade Federal de Mato GrossoCuiabá78060-900Mato GrossoBrazil Postgraduate Program in Health and Behaviour Catholic University of PelotasPelotas 96015-560Rio Grande do SulBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Internal Medicine Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Although the prognostic relevance of sarcopenia has been increasingly recognised in the context of liver disease,there is a paucity of data evaluating body composition in patients with chronic hepatitis B(CHB).Beyond virus-related factors,nutritional and metabolic aspects can be associated with skeletal muscle abnormalities in these patients and should not be *** To evaluate the association between components of sarcopenia and demographic,clinical,lifestyle,nutritional,and biochemical variables in CHB *** Dual-energy X-ray absorptiometry(DXA)was used to assess muscle mass by quantifying appendicular lean mass(ALM)adjusted for body mass index(ALMBMI).Muscle function was evaluated by hand grip strength(HGS)and the timed up and go ***-associated fatty liver disease(MAfLD)was defined according to the criteria proposed by an international expert panel.A body shape index and the International Physical Activity Questionnaire were used to assess central obesity and physical activity level,*** This cross-sectional study included 105 CHB outpatients followed at the tertiary care ambulatory centre(mean age,48.5±12.0 years;58.1%males;76.2%without cirrhosis;23.8%with compensated cirrhosis).The DXA-derived fat mass percentage was inversely correlated with the ALMBMI(r=-0.87)and HGS(r=-0.63).In the multivariable analysis,MAfLD,sedentarism and central obesity were positively and independently associated with low *** and central obesity were independently associated with low *** MAfLD and central obesity were associated with low muscle mass and strength in patients with chronic hepatitis B,independent of the liver disease stage.

关键词： Chronic hepatitis B Appendicular lean mass Muscle strength Metabolic associated fatty liver disease Central obesity Physical performance

Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia

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World Journal of Gastroenterology 2016年第18期22卷 4567-4575页

作者： Roberto Herrera-Goepfert Luis f Onate-Ocana José Luis Mosqueda-Vargas Luis A Herrera Clementina castro Julia Mendoza rodrigo González-Barrios Department of Pathology Instituto Nacional de Cancerologia (INCan) 10480 Mexico DF Mexico Clinical Research Division Instituto Nacional de Cancerologia (INCan) 10480 Mexico DF Mexico Unidad de Investigacion biomedica en Cancer Instituto Nacional de Cancerologia (INCan)-Instituto de Investigaciones Biomedicas (IIB) Universidad Nacional Autonoma de Mexico (UNAM) 14080 Mexico DF Mexico

AIM: To explore methylation of DAPK, THBS1, CDH-1, and p14 genes, and Helicobacter pylori(H. pylori) status in individuals harboring esophageal columnar ***: Distal esophageal mucosal samples obtained by endoscopy and histologically diagnosed as gastric-type(non-specialized) columnar metaplasia, were studied thoroughly. DNA was extracted from paraffin blocks, and methylation status of deathassociated protein kinase(DAPK), thrombospondin-1(THBS1), cadherin-1(CDH1), and p14 genes, was examined using a methyl-sensitive polymerase chain reaction(MS-PCR) and sodium bisulfite modification protocol. H. pylori cag A status was determined by ***: In total, 68 subjects(33 females and 35 males), with a mean age of 52 years, were included. H. pylori cag A positive was present in the esophageal gastric-type metaplastic mucosa of 18 individuals. DAPK, THSB1, CDH1, and p14 gene promoters were methylated by MS-PCR in 40(58.8%), 33(48.5%), 46(67.6%), and 23(33.8%) cases of the 68 esophageal samples. H. pyloristatus was associated with methylation of DAPK(P = 0.003) and THBS1(P = 0.019).CONCLUSION: DNA methylation occurs in cases of gastric-type(non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cag A positive infection.

关键词： DNA methylation Esophageal columnar metaplasia Thrombospondin-1 Death-associated protein kinase Heli