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Linking IL-10 signaling with lipid metabo.ic pro.rams in macro.hages:dysregulated ceramide ho.eo.tasis drives co.itis

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Signal Transductio. and Targeted Therapy 2024年第7期9卷 2835-2836页

作者： Imke Atreya Markus f.Neurath Department o. Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immuntherapie(DZI) ErlangenGermany

In a recent study published in Nature,Yo.k and co.o.kers identified the immuno.etabo.ic regulatio. o. mo.o.unsaturated fatty acid(MUfA)po.ls and the subsequent increase in sphingo.ipid biosynthesis in TLR2-activated macro.hages as an impo.tant link between impaired IL-10 signaling and the develo.ment o. intestinal inflammatio..1 Thus,targeted interference with the newly identified IL-10/MUfA/sphingo.ipid axis appears as a pro.ising strategy to.resto.e immuno.etabo.ic ho.eo.tasis in the intestine o. patients with inflammato.y bo.el diseases(IBD).

关键词： ho.eo.tasis impaired intestine

Null surfaces o. pseudo.spherical spacelike framed curves in the anti-de Sitter 3-space

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Acta Mathematica Sinica,English Series 2024年

作者： o.o.ulcan TUNCER Department o. Mathematics Hacettepe University

We intro.uce null surfaces (o. nullco.e fro.ts) o. pseudo.spherical spacelike framed curves in the three-dimensio.al anti-de Sitter space. These surfaces are fo.med by the light rays emitted fro. po.nts o. anti-de Sitter spacelike framed curves. We then classify singularities o. the nullco.e fro.t o. a pseudo.spherical spacelike framed curve and sho. ho. these singularities are related to.the singularities o. the asso.iated framed curve. We also.define a family o. functio.s called the Anti-de Sitter distance-squared functio.s to.explain the nullco.e fro.t o. a pseudo.spherical spacelike framed curve as a wavefro.t fro. the viewpo.nt o. the Legendrian singularity theo.y. We finally pro.ide so.e examples to.illustrate the results o. this paper.

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Energy and blast perfo.mance o. beryllium in a mo.el thermo.aric co.po.itio. in co.pariso. with aluminum and magnesium

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Defence Techno.o.y（防务技术） 2024年第6期36卷 13-19页

作者： Tho.as M.Klapo.ke Stanisław Cudziło.Waldemar A.Trzcinski Jo.ef Paszula Energetic Materials Research Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany Military University o. Techno.o.y Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

A direct co.pariso. is made between the effectiveness o. Al,Mg,and Be po.ders as additio.al fuels in mo.el thermo.aric co.po.itio.s co.taining 20%fuel,20%ammo.ium perchlo.ate,and 60%RDX(1,3,5-Trinitro.1,3,5-triazacyclo.exane)passivated with *** determined calo.imetric measurements o. the heat o. deto.atio.,alo.g with the o.erpressure histo.ies in an explo.io. chamber filled with nitro.en,were used to.determine the quasi-static pressure(QSP)under anaero.ic *** measurements were also.perfo.med in a semi-clo.ed bunker,and all blast wave parameters generated after the deto.atio. o. 500 g charges o. the tested explo.ives were *** calo.imetry results,QSP values,and blast wave parameters(pressure amplitude,specific and to.al impulses)clearly indicate that Be is much mo.e effective as an additio.al fuel than either Al o. Mg in bo.h anaero.ic po.t-deto.atio. reactio.s as well as the subsequent aero.ic *** heat o. deto.atio. o. the RDXwax/AP/Be explo.ive mixture is o.er 40%and 50%higher than that o. the mixture co.taining aluminum and magnesium instead o. beryllium,***,the TNT equivalent o. the Be-co.taining co.po.itio. due to.the o.erpressure in the nitro.en-filled explo.io. chamber is 1.66,while the equivalent calculated using an air sho.k wave-specific impulse at a distance o. 2.5 m is equal to.*** high values o. these parameters co.firm the high reactivity o. beryllium in bo.h the anaero.ic and aero.ic stages o. the thermo.aric explo.io..

关键词： Thermo.aric explo.ives Beryllium Heat o. deto.atio. Quasi-static o.erpressure Blast wave parameters

Neuro.nflammatio. revisited thro.gh the micro.lial lens

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Neural Regeneratio. Research 2025年第7期20卷 1989-1990页

作者： Renato.So.o.ato.Jo.̃o.B.Relvas Institute o. Research and Inno.atio. in Health(i3S)and Institute fo. Mo.ecular and Cell biolo.y(IBMC) University of PortoPortoPortugal Department o. biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging as a pivo.al field,shedding light o. the intricate dialo.ues between the central nervo.s system(CNS)and the immune *** explo.atio. is particularly significant in understanding micro.lia,the CNS’s innate immune cells,beyo.d the co.ventio.al co.flatio. o.“neuro.nflammatio.”and“micro.lial activatio..”This co.flatio. has clo.ded the true co.plexity o. these pro.esses,po.entially stalling scientific pro.ress and the develo.ment o. new *** challenge the lo.g-standing perspectives that have o.ersimplified these interactio.s,advo.ating fo. a deeper explo.atio. o. the dynamic relatio.ship between neuro.nflammatio. and micro.lial *** dissecting specific mo.ecular pathways,we aim to.illuminate their elabo.ate ro.es in neuro.nflammato.y respo.ses,especially in the co.text o. Alzheimer’s disease(AD).Here,neuro.nflammatio. is no. merely a passive o.server o. a direct antago.ist but a co.plex agent in the disease’s *** article calls fo. a significant paradigm shift to.ards an integrative,multi-o.ics appro.ch to.*** such a co.prehensive framewo.k is crucial fo. advancing o.r understanding o. neuro.nflammato.y co.ditio.s and paving the way fo. targeted therapeutic strategies fo. brain diseases.

关键词： inflammatio. simplified activatio.

An Assessment o. Saltwater Intrusio. in Co.stal Regio.s o. Lago., Nigeria

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Jo.rnal o. Geo.cience and Enviro.ment Pro.ectio. 2024年第1期12卷 93-119页

作者： o.unadike Callistus Akerele D. Daniel Abiodun o. Pelumi o.isah So.to.e o.o.ede Kunle o.unadike S. Echezo.a o.unadike J. Chinenye Department o. Geo.ciences Freiberg University of Mining and Technology Freiberg Germany Department o. Co.structio. Management University of Washington Seattle USA Department o. Civil Engineering Morgen State University Baltimore USA Department o. Geo.raphy University of Lagos Lagos Nigeria Department o. biochemistry Anambra State University Uli Nigeria Department o. Geo.o.y Anambra State University Uli Nigeria

This paper explains vario.s facto.s that co.tribute to.saltwater intrusio., including o.erexplo.tatio. o. freshwater reso.rces and climate change as well as the different techniques essential fo. effective saltwater intrusio. management. The impact o. saltwater intrusio. alo.g co.stal regio.s and its impact o. the enviro.ment, hydro.eo.o.y and gro.ndwater co.taminatio.. It suggests po.ential so.utio.s to.mitigate the impact o. saltwater intrusio., including effective water management and techniques fo. managing SWI. The applicatio. o. A.I (assessment index) serves as a guideline to.co.rectly identify wells with SWI ranging fro. no.intrusio., slight intrusio. and stro.g intrusio.. The challenges o. saltwater intrusio. in Lago. and the salinizatio. o. wells were investigated using the hydro.chemical parameters. The study identifies fo.r wells (“AA”, “CMS”, “o.A” and “VIL”) as having high electric co.ductivities, indicating saline water intrusio., while o.her wells (“EBM”, “IKJ, and “IKo.) with lo.er electric co.ductivities, indicate little o. no.salt-water intrusio., and “AJ” well sho.s slight intrusio.. The elevatio. o. the wells also.played a vital ro.e in the SWI acro.s co.stal regio.s o. Lago.. The study reco.mends co.tinuo.s mo.ito.ing o. co.stal wells to.help sustain and reduce saline intrusio.. The findings o. the study are impo.tant fo. po.icymakers, researchers, and practitio.ers who.are interested in addressing the challenges o. saltwater intrusio. alo.g co.stal regio.s. We assessed the SWI acro.s the eight (8) wells using the Assessment Index to.identify wells with SWI. Wells in “CMS” and “VIL” has stro.g intrusio.s. A pro.o.ed classificatio. system based o. specific io. ratio. catego.izes water quality fro. go.d (+) to.highly (-) co.taminated (refer to.Table 4). These findings undersco.e the need fo. attentio. and effective management strategies to.address gro.ndwater unsuitability fo. vario.s purpo.es.

关键词： Hydro.Chemical Data Analysis Saline Incursio. Aquifer Sustainability and Management Co.stal Regio.s Gro.nd Water Intrusio.

Endo.lasmic reticulum stress,auto.hagy,neuro.nflammatio.,and sigma 1 recepto.s as co.tributo.s to.depressio. and its treatment

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Neural Regeneratio. Research 2024年第10期19卷 2202-2211页

作者： Chika fujii Charles f.Zo.umski Yukito.hi Izumi Department o. Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylo. family Institute fo. Inno.ative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etio.o.ical facto.s co.tributing to.depressio. and o.her neuro.sychiatric diso.ders are largely undefined. Endo.lasmic reticulum stress pathways and auto.hagy are well-defined mechanisms that play critical functio.s in reco.nizing and reso.ving cellular stress and are po.sible targets fo. the patho.hysio.o.y and treatment o. psychiatric and neuro.o.ic illnesses. An increasing number o. studies indicate the invo.vement o. endo.lasmic reticulum stress and auto.hagy in the co.tro. o. neuro.nflammatio., a co.tributing facto. to.multiple neuro.sychiatric illnesses. Initial inflammato.y triggers induce endo.lasmic reticulum stress, leading to.neuro.nflammato.y respo.ses. Subsequently, inductio. o. auto.hagy by neuro.tero.ds and o.her signaling pathways that co.verge o. auto.hagy inductio. are tho.ght to.participate in reso.ving neuro.nflammatio.. The aim o. this review is to.summarize o.r current understanding o. the mo.ecular mechanisms go.erning the inductio. o. endo.lasmic reticulum stress, auto.hagy, and neuro.nflammatio. in the central nervo.s system. Studies fo.used o. innate immune facto.s, including neuro.tero.ds with anti-inflammato.y ro.es will be reviewed. In the co.text o. depressio., animal mo.els that led to.o.r current understanding o. mo.ecular mechanisms underlying depressio. will be highlighted, including the ro.es o. sigma 1 recepto.s and pharmaco.o.ical agents that dampen endo.lasmic reticulum stress and asso.iated neuro.nflammatio..

关键词： allo.regnano.o.e fluvo.amine ketamine neuro.tero.ds po.tpartum depressio. quercetin

Music as medicine fo. traumatic brain injury:a perspective o. future research directio.s

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Neural Regeneratio. Research 2024年第10期19卷 2105-2106页

作者： Antho.y E.Kline Eleni H.Mo.cho.as Co.ina o.Bo.di Department o. Physical Medicine&Rehabilitatio. University of PittsburghPittsburghPAUSA Safar Center fo. Resuscitatio. Research University of PittsburghPittsburghPAUSA Center fo. Neuro.cience University of PittsburghPittsburghPAUSA Department o. Critical Care Medicine University of PittsburghPittsburghPAUSA Center fo. the Neural Basis o. Co.nitio. University of PittsburghPittsburghPAUSA Department o. Psycho.o.y University of PittsburghPittsburghPAUSA Department o. Neuro.0}lo.y University of PittsburghPittsburghPAUSA

Traumatic brain injury(TBI) impacts 69 millio. individuals glo.ally each year and is a leading cause o. death and disability(Dewan et al.,2019).The majo.ity o. mo.erate-to.severe TBI survivo.s endure lo.g-lasting disturbances in mo.o.,co.nitive,and affect that negatively impacts their *** a pletho.a o. research o. pharmaco.o.ical interventio.s fo. TBI has been co.ducted,no.e has translated to.the clinic,thus advo.ating fo. the evaluatio. o. no.pharmaco.o.ical therapeutic appro.ches that may increase translatio.al success.

关键词： injury traumatic

Myelin histo.o.y:a key to.l in nervo.s system research

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Neural Regeneratio. Research 2024年第2期19卷 277-281页

作者： Óscar Darío.García-García Vícto. Carriel Jesús Chato.Astrain Department o. Histo.o.y Tissue Engineering GroupUniversity of Granada&Instituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain

The myelin sheath is a lipo.ro.ein-rich,multilayered structure capable o. increasing co.ductio. velo.ity in central and peripheral myelinated nerve *** to.the co.plex structure and co.po.itio. o. myelin,vario.s histo.o.ical techniques have been develo.ed o.er the centuries to.evaluate myelin under no.mal,patho.o.ical o. experimental ***,metho.s to.assess myelin integrity o. co.tent are key to.ls in bo.h clinical diagno.is and neuro.cience *** this review,we pro.ide an updated summary o. the co.po.itio. and structure o. the myelin sheath and discuss so.e histo.o.ical pro.edures,fro. tissue fixatio. and pro.essing techniques to.the mo.t used and practical myelin histo.o.ical staining *** the lipo.ro.ein nature o. myelin,the main features and technical details o. the different available metho.s that can be used to.evaluate the lipid o. pro.ein co.po.ents o. myelin are described,as well as the precise ultrastructural techniques.

关键词： fluo.escence micro.co.y histo.o.y light micro.co.y lipid histo.hemistry metallo.raphic techniques myelin histo.hemistry myelin immuno.isto.hemistry myelin structure&co.po.itio. myelin ultrastructural evaluatio. tissue fixatio.&pro.essing

Understanding the neighbo.ho.ds’in-between spaces o. spatial perceptio.,so.ial interactio.,and security

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fro.tiers o. Architectural Research 2024年第1期13卷 21-36页

作者： Lizeth félix Mariel o.ganista Auto.o.o.s University o. Baja Califo.nia Ensenada 22860Mexico

This study reflects o. the impact that the neighbo.ho.ds’in-between spaces have o.:spatial perceptio.,so.ial interactio.,and *** sites,characterized by their abando.ment and deterio.atio.,can also.be seen as crucial spaces o. o.po.tunity fo. cities,in the architectural,urban and landscape *** paper aims to.analyze the so.io.patial relatio.ships in the neighbo.ho.ds’in-between spaces and examine the impact o. inbetween space co.figuratio. o. urban *** investigatio. draws o. a survey o. perceptio. to.residents abo.t the requirements fo. a suitable so.ial interactio. in these *** study was develo.ed in a neighbo.ho.d in the city periphery,characterized by their so.ial dynamics and lo.atio. in a nature co.servatio. *** findings indicate that the appro.riatio. pro.ess,activities,and co.lective practices are dependent o. the spatial legibility,in this case when this increases,gives rise to.impro.e the habitability and the rehabilitatio. o. the in-between ***,the lack o. design o. in-between spaces substantially affects the use o. these spaces and the so.ial interactio. amo.g residents.

关键词： In-between spaces So.io.spatial relatio.ships Habitability Neighbo.ho.ds Security